메뉴 건너뛰기




Volumn 59, Issue 2, 2011, Pages 229-235

O6 -methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: A review of current status

Author keywords

Glioblastoma; glioma; O 6 methylguanine DNA methyltransferase

Indexed keywords

CARMUSTINE; EPIDERMAL GROWTH FACTOR RECEPTOR; LOMUSTINE; MESSENGER RNA; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; TEMOZOLOMIDE;

EID: 79955382989     PISSN: 00283886     EISSN: 19984022     Source Type: Journal    
DOI: 10.4103/0028-3886.79128     Document Type: Review
Times cited : (21)

References (53)
  • 5
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 2009;10:459-66.
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    Van Den Bent, M.J.4    Taphoorn, M.J.5    Janzer, R.C.6
  • 7
    • 73349121355 scopus 로고    scopus 로고
    • MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: A report from EORTC Brain Tumor Group Study 26951
    • van den Bent MJ, Dubbink HJ, Sanson M, van der Lee-Haarloo CR, Hegi M, Jeuken JW, et al. MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: A report from EORTC Brain Tumor Group Study 26951. J Clin Oncol 2009;27:5881-6.
    • (2009) J Clin Oncol , vol.27 , pp. 5881-5886
    • Van Den Bent, M.J.1    Dubbink, H.J.2    Sanson, M.3    Van Der Lee-Haarloo, C.R.4    Hegi, M.5    Jeuken, J.W.6
  • 8
    • 73349134695 scopus 로고    scopus 로고
    • NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide
    • Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, et al. NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol 2009;27:5874-80.
    • (2009) J Clin Oncol , vol.27 , pp. 5874-5880
    • Wick, W.1    Hartmann, C.2    Engel, C.3    Stoffels, M.4    Felsberg, J.5    Stockhammer, F.6
  • 12
    • 33749075532 scopus 로고    scopus 로고
    • Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03
    • Herrlinger U, Rieger J, Koch D, Loeser S, Blaschke B, Kortmann RD, et al. Phase II trial of lomustine plus temozolomide chemotherapy in addition to radiotherapy in newly diagnosed glioblastoma: UKT-03. J Clin Oncol 2006;24:4412-4.
    • (2006) J Clin Oncol , vol.24 , pp. 4412-4414
    • Herrlinger, U.1    Rieger, J.2    Koch, D.3    Loeser, S.4    Blaschke, B.5    Kortmann, R.D.6
  • 13
    • 33847364433 scopus 로고    scopus 로고
    • MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
    • DOI 10.1002/pbc.20803
    • Donson AM, Addo-Yobo SO, Handler MH, Gore L, Foreman NK. MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastomas. Pediatric Blood Cancer 2007;48:403-7. (Pubitemid 46340105)
    • (2007) Pediatric Blood and Cancer , vol.48 , Issue.4 , pp. 403-407
    • Donson, A.M.1    Addo-Yobo, S.O.2    Handler, M.H.3    Gore, L.4    Foreman, N.K.5
  • 16
    • 43749094544 scopus 로고    scopus 로고
    • MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients
    • Brandes AA, Franceschi E, Tosoni A, Blatt V, Pession A, Tallini G, et al. MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients. J Clin Oncol 2008;26:2192-7.
    • (2008) J Clin Oncol , vol.26 , pp. 2192-2197
    • Brandes, A.A.1    Franceschi, E.2    Tosoni, A.3    Blatt, V.4    Pession, A.5    Tallini, G.6
  • 17
    • 33746860420 scopus 로고    scopus 로고
    • 6-Methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: Results from the CCG-945 cohort
    • DOI 10.1200/JCO.2006.05.7265
    • Pollack IF, Hamilton RL, Sobol RW, Burnham J, Yates AJ, Holmes EJ, et al. O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 cohort. J Clin Oncol 2006;24:3431-7. (Pubitemid 46638900)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.21 , pp. 3431-3437
    • Pollack, I.F.1    Hamilton, R.L.2    Sobol, R.W.3    Burnham, J.4    Yates, A.J.5    Holmes, E.J.6    Zhou, T.7    Finlay, J.L.8
  • 19
    • 62449258056 scopus 로고    scopus 로고
    • Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: Correlation with MGMT promoter methylation status
    • Brandes AA, Tosoni A, Franceschi E, Sotti G, Frezza G, Amistà P, et al. Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: Correlation With MGMT promoter methylation status. J Clin Oncol 2009;27:1275-9.
    • (2009) J Clin Oncol , vol.27 , pp. 1275-1279
    • Brandes, A.A.1    Tosoni, A.2    Franceschi, E.3    Sotti, G.4    Frezza, G.5    Amistà, P.6
  • 20
    • 57749180408 scopus 로고    scopus 로고
    • MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma
    • Sadones J, Michotte A, Veld P, Chaskis C, Sciot R, Menten J, et al. MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma. Eur J Cancer 2009;45:146-53.
    • (2009) Eur J Cancer , vol.45 , pp. 146-153
    • Sadones, J.1    Michotte, A.2    Veld, P.3    Chaskis, C.4    Sciot, R.5    Menten, J.6
  • 21
    • 73349103157 scopus 로고    scopus 로고
    • Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: A prospective translational study of the German Glioma Network
    • Weller M, Felsberg J, Hartmann C, Berger H, Steinbach JP, Schramm J, et al. Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: A prospective translational study of the German Glioma Network. J Clin Oncol 2009;27:5743-50.
    • (2009) J Clin Oncol , vol.27 , pp. 5743-5750
    • Weller, M.1    Felsberg, J.2    Hartmann, C.3    Berger, H.4    Steinbach, J.P.5    Schramm, J.6
  • 22
    • 79955453343 scopus 로고    scopus 로고
    • Temozolomide in the treatment of high-grade gliomas in children: A report from the Children's Oncology Group
    • Cohen KJ, Pollack IF, Zhou T, Buxton A, Holmes EJ, Burger PC, et al. Temozolomide in the treatment of high-grade gliomas in children: A report from the Children's Oncology Group. Neuro Oncol 2011;13:317-23.
    • (2011) Neuro Oncol , vol.13 , pp. 317-23
    • Cohen, K.J.1    Pollack, I.F.2    Zhou, T.3    Buxton, A.4    Holmes, E.J.5    Burger, P.C.6
  • 23
    • 78650179843 scopus 로고    scopus 로고
    • A clinicopathological and molecular analysis of glioblastoma multiforme with long-term survival
    • Das P, Puri T, Jha P, Pathak P, Joshi N, Suri V, et al. A clinicopathological and molecular analysis of glioblastoma multiforme with long-term survival. J Clin Neurosci 2011;18:66-70.
    • (2011) J Clin Neurosci , vol.18 , pp. 66-70
    • Das, P.1    Puri, T.2    Jha, P.3    Pathak, P.4    Joshi, N.5    Suri, V.6
  • 24
    • 74849116114 scopus 로고    scopus 로고
    • MGMT as a potential stratification marker in relapsed high-grade glioma of children: The HIT-GBM experience
    • Schlosser S, Wagner S, Muhlisch J, Hasselblatt M, Gerss J, Wolff JE, et al. MGMT as a potential stratification marker in relapsed high-grade glioma of children: the HIT-GBM experience. Pediatr Blood Cancer 2010;54:228-37.
    • (2010) Pediatr Blood Cancer , vol.54 , pp. 228-237
    • Schlosser, S.1    Wagner, S.2    Muhlisch, J.3    Hasselblatt, M.4    Gerss, J.5    Wolff, J.E.6
  • 25
    • 11144349554 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors
    • DOI 10.1002/ijc.20575
    • Möllemann M, Wolter M, Felsberg J, Collins VP, Reifenberger G. Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors. Int J Cancer 2005;113:379-85. (Pubitemid 40038704)
    • (2005) International Journal of Cancer , vol.113 , Issue.3 , pp. 379-385
    • Mollemann, M.1    Wolter, M.2    Felsberg, J.3    Collins, V.P.4    Reifenberger, G.5
  • 27
    • 0036938633 scopus 로고    scopus 로고
    • Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas
    • DOI 10.1007/s004010100464
    • Watanabe T, Nakamura M, Kros JM, Burkhard C, Yonekawa Y, Kleihues P, et al. Phenotype versus genotype correlation in oligodendrogliomas and low-grade diffuse astrocytomas. Acta Neuropathol 2002;103:267-75. (Pubitemid 36075328)
    • (2002) Acta Neuropathologica , vol.103 , Issue.3 , pp. 267-275
    • Watanabe, T.1    Nakamura, M.2    Kros, J.M.3    Burkhard, C.4    Yonekawa, Y.5    Kleihues, P.6    Ohgaki, H.7
  • 28
    • 67650001339 scopus 로고    scopus 로고
    • Correlation of chromosomes 1p and 19q status and expressions of O6-methylguanine DNA methyltransferase (MGMT) p53 and Ki-67 in diffuse gliomas of World Health Organization (WHO) grades II and III: A clinicopathological study
    • Huang L, Jiang T, Yuan F, Li GL, Cui Y, Liu EZ, et al. Correlation of chromosomes 1p and 19q status and expressions of O6-methylguanine DNA methyltransferase (MGMT), p53 and Ki-67 in diffuse gliomas of World Health Organization (WHO) grades II and III: A clinicopathological study. Neuropathol Appl Neurobiol 2009;35:367-79.
    • (2009) Neuropathol Appl Neurobiol , vol.35 , pp. 367-379
    • Huang, L.1    Jiang, T.2    Yuan, F.3    Li, G.L.4    Cui, Y.5    Liu, E.Z.6
  • 29
    • 70249097408 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1codon 132 mutation is an important prognostic biomarker in gliomas
    • Sanson M, Marie Y, Paris S, Idbaih A, Laffaire J, Ducray F, et al. Isocitrate dehydrogenase 1codon 132 mutation is an important prognostic biomarker in gliomas. J Clin Oncol 2009;27:4150-4.
    • (2009) J Clin Oncol , vol.27 , pp. 4150-4154
    • Sanson, M.1    Marie, Y.2    Paris, S.3    Idbaih, A.4    Laffaire, J.5    Ducray, F.6
  • 30
    • 77953028158 scopus 로고    scopus 로고
    • Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing
    • Felsberg J, Wolter M, Seul H, Friedensdorf B, Göppert M, Sabel MC, et al. Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing. Acta Neuropathol 2010;119:501-7.
    • (2010) Acta Neuropathol , vol.119 , pp. 501-507
    • Felsberg, J.1    Wolter, M.2    Seul, H.3    Friedensdorf, B.4    Göppert, M.5    Sabel, M.C.6
  • 33
    • 78650510699 scopus 로고    scopus 로고
    • O6- methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: First Indian report with review of challenges for use in customized treatment
    • Jha P, Suri V, Jain A, Sharma MC, Pathak P, Jha P, et al. O6- methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: First Indian report with review of challenges for use in customized treatment. Neurosurgery 2010;67:1681-91.
    • (2010) Neurosurgery , vol.67 , pp. 1681-1691
    • Jha, P.1    Suri, V.2    Jain, A.3    Sharma, M.C.4    Pathak, P.5    Jha, P.6
  • 38
    • 63449115574 scopus 로고    scopus 로고
    • MGMT analysis at DNA, RNA and protein levels in glioblastoma tissue
    • Preusser M. MGMT analysis at DNA, RNA and protein levels in glioblastoma tissue. Histol Histopathol 2009;24:511-8.
    • (2009) Histol Histopathol , vol.24 , pp. 511-518
    • Preusser, M.1
  • 40
    • 33745666856 scopus 로고    scopus 로고
    • Methylation enrichment pyrosequencing: Combining the specificity of MSP with validation by pyrosequencing
    • Shaw RJ, Akufo-Tetteh EK, Risk JM, Field JK, Liloglou T. Methylation enrichment pyrosequencing: Combining the specificity of MSP with validation by pyrosequencing. Nucleic Acids Res 2006;34:e78.
    • (2006) Nucleic Acids Res , vol.34
    • Shaw, R.J.1    Akufo-Tetteh, E.K.2    Risk, J.M.3    Field, J.K.4    Liloglou, T.5
  • 42
    • 70350314719 scopus 로고    scopus 로고
    • The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas
    • Cao VT, Jung TY, Jung S, Jin SG, Moon KS, Kim IY, et al. The correlation and prognostic significance of MGMT promoter methylation and MGMT protein in glioblastomas. Neurosurgery 2009;65:866-75.
    • (2009) Neurosurgery , vol.65 , pp. 866-875
    • Cao, V.T.1    Jung, T.Y.2    Jung, S.3    Jin, S.G.4    Moon, K.S.5    Kim, I.Y.6
  • 44
    • 79251536531 scopus 로고    scopus 로고
    • Comprehensive analysis of MGMT promoter methylation: Correlation with MGMT expression and clinical response in GBM
    • Shah N, Lin B, Sibenaller Z, Ryken T, Lee H, Yoon JG, et al. Comprehensive analysis of MGMT promoter methylation: Correlation with MGMT expression and clinical response in GBM. PLoS One. 2011;6:e16146.
    • (2011) PLoS One , vol.6
    • Shah, N.1    Lin, B.2    Sibenaller, Z.3    Ryken, T.4    Lee, H.5    Yoon, J.G.6
  • 45
    • 67649873216 scopus 로고    scopus 로고
    • Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy
    • Dunn J, Baborie A, Alam F, Joyce K, Moxham M, Sibson R, et al. Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy. Br J Cancer 2009;101:124-31.
    • (2009) Br J Cancer , vol.101 , pp. 124-131
    • Dunn, J.1    Baborie, A.2    Alam, F.3    Joyce, K.4    Moxham, M.5    Sibson, R.6
  • 46
    • 77956432698 scopus 로고    scopus 로고
    • MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome
    • Hassel JC, Sucker A, Edler L, Kurzen H, Moll I, Stresemann C, et al. MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome. Br J Cancer 2010;103:820-6.
    • (2010) Br J Cancer , vol.103 , pp. 820-826
    • Hassel, J.C.1    Sucker, A.2    Edler, L.3    Kurzen, H.4    Moll, I.5    Stresemann, C.6
  • 47
    • 34247849498 scopus 로고    scopus 로고
    • Methylation-sensitive high resolution melting (MS-HRM): A new approach for sensitive and high-throughput assessment of methylation
    • Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): A new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res 2007;35:e41.
    • (2007) Nucleic Acids Res , vol.35
    • Wojdacz, T.K.1    Dobrovic, A.2
  • 48
    • 0041719983 scopus 로고    scopus 로고
    • A rapid, quantitative, non-radioactive bisulfite-SNuPE-IP RP HPLC assay for methylation analysis at specific CpG sites
    • El-Maarri O, Herbiniaux U, Walter J, Oldenburg J. A rapid, quantitative, non-radioactive bisulfite-SNuPE-IP RP HPLC assay for methylation analysis at specific CpG sites. Nucleic Acids Res 2002;30:e25.
    • (2002) Nucleic Acids Res , vol.30
    • El-Maarri, O.1    Herbiniaux, U.2    Walter, J.3    Oldenburg, J.4
  • 49
    • 68949149010 scopus 로고    scopus 로고
    • Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas
    • Everhard S, Tost J, El Abdalaoui H, Crinière E, Busato F, Marie Y, et al. Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas. Neuro Oncol 2009;11:348-56.
    • (2009) Neuro Oncol , vol.11 , pp. 348-356
    • Everhard, S.1    Tost, J.2    El Abdalaoui, H.3    Crinière, E.4    Busato, F.5    Marie, Y.6
  • 51
    • 51249098488 scopus 로고    scopus 로고
    • Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: Observer variability and lack of association with patient survival impede its use as clinical biomarker
    • Preusser M, Charles Janzer R, Felsberg J, Reifenberger G, Hamou MF, Diserens AC, et al. Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker. Brain Pathol 2008;18:520-32.
    • (2008) Brain Pathol , vol.18 , pp. 520-532
    • Preusser, M.1    Charles Janzer, R.2    Felsberg, J.3    Reifenberger, G.4    Hamou, M.F.5    Diserens, A.C.6
  • 53
    • 49249118859 scopus 로고    scopus 로고
    • Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: Relationship between immunohistochemistry and methylation analysis
    • Sasai K, Nodagashira M, Nishihara H, Aoyanagi E, Wang L, Katoh M, et al. Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: relationship between immunohistochemistry and methylation analysis. Am J Surg Pathol 2008;32:1220-7.
    • (2008) Am J Surg Pathol , vol.32 , pp. 1220-1227
    • Sasai, K.1    Nodagashira, M.2    Nishihara, H.3    Aoyanagi, E.4    Wang, L.5    Katoh, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.