-
1
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F: Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-141. (Pubitemid 27180337)
-
(1997)
Cell
, vol.88
, Issue.1
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
Smith, F.J.11
Campfield, L.A.12
Burn, P.13
Frank, L.14
-
2
-
-
0034456398
-
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
-
DOI 10.1210/en.141.9.3518
-
Butler AA, Kesteson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M, Cone RD: A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 2000; 141: 3518-3521. (Pubitemid 32269044)
-
(2000)
Endocrinology
, vol.141
, Issue.9
, pp. 3518-3521
-
-
Butler, A.A.1
Kesterson, R.A.2
Khong, K.3
Cullen, M.J.4
Pelleymounter, M.A.5
Dekoning, J.6
Baetscher, M.7
Cone, R.D.8
-
3
-
-
0033818103
-
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
-
Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LHT: Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 2000; 26: 97-102.
-
(2000)
Nat Genet
, vol.26
, pp. 97-102
-
-
Chen, A.S.1
Marsh, D.J.2
Trumbauer, M.E.3
Frazier, E.G.4
Guan, X.M.5
Yu, H.6
Rosenblum, C.I.7
Vongs, A.8
Feng, Y.9
Cao, L.10
Metzger, J.M.11
Strack, A.M.12
Camacho, R.E.13
Mellin, T.N.14
Nunes, C.N.15
Min, W.16
Fisher, J.17
Gopal-Truter, S.18
De, M.19
Chen, H.Y.20
Van Der Ploeg Lht21
more..
-
4
-
-
0037456768
-
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene
-
DOI 10.1056/NEJMoa022050
-
Farooqi IS, Keogh JM, Yeo GSH, Lank EJ, Cheetham T, ORahilly S: Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003; 348: 1085-1095. (Pubitemid 36337319)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.12
, pp. 1085-1095
-
-
Farooqi, I.S.1
Keogh, J.M.2
Yeo, G.S.H.3
Lank, E.J.4
Cheetham, T.5
O'Rahilly, S.6
-
5
-
-
61849161252
-
Association of functionally significant melanocortin-4 but not melanocortin-receptor mutations with severe adult obesity in a large North American case control study
-
Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C: Association of functionally significant melanocortin-4 but not melanocortin-receptor mutations with severe adult obesity in a large North American case control study. Hum Mol Genet 2009; 18: 1140-1147.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1140-1147
-
-
Ma, C.1
Ersoy, B.A.2
Zhang, S.3
Kane, J.P.4
Malloy, M.J.5
Pullinger, C.R.6
Bromberg, Y.7
Pennacchio, L.A.8
Dent, R.9
McPherson, R.10
Ahituv, N.11
Vaisse, C.12
-
6
-
-
0036963510
-
A novel melanocortin 3 receptor gene (MC3R) Mutation associated with severe obesity
-
Lee YS, Poh LK-S, Loke KY: A novel melanocortin 3 receptor gene (MC3R) Mutation associated with severe obesity. J Clin Endocrinol Metab 2002; 87: 1423-1426.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 1423-1426
-
-
Lee, Y.S.1
Lk-S, P.2
Loke, K.Y.3
-
7
-
-
3242795783
-
Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity
-
DOI 10.1016/j.bbadis.2004.03.009, PII S0925443904000523
-
Rached M, Buronfosse A, Begeot M, Penhoat A: Inactivation and intracellular retention of the human I183N mutated melanocortin 3 receptor associated with obesity. Biochim Biophys Acta 2004; 1689: 229-234. (Pubitemid 38981600)
-
(2004)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1689
, Issue.3
, pp. 229-234
-
-
Rached, M.1
Buronfosse, A.2
Begeot, M.3
Penhoat, A.4
-
8
-
-
36649035294
-
Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects
-
Tao YX: Functional characterization of novel melanocortin-3 receptor mutations identified from obese subjects. Biochim BiophysActa 2007; 1772: 1167-1174.
-
(2007)
Biochim BiophysActa
, vol.1772
, pp. 1167-1174
-
-
Tao, Y.X.1
-
9
-
-
42649092119
-
Sporadic mutations in melanocortin receptor 3 in morbid obese individuals
-
DOI 10.1038/sj.ejhg.5202005, PII 5202005
-
Mencarelli M, Walker GE, Maestrini S, Alberti L, Verti B, Brunani A, Petroni ML, Tagliaferri M, Liuzzi A, Di Blasio AM: Sporadic mutations in melanocortin receptor 3 in morbid obese individuals. Eur J Hum Genet 2008; 16: 581-586. (Pubitemid 351594124)
-
(2008)
European Journal of Human Genetics
, vol.16
, Issue.5
, pp. 581-586
-
-
Mencarelli, M.1
Walker, G.E.2
Maestrini, S.3
Alberti, L.4
Verti, B.5
Brunani, A.6
Petroni, M.L.7
Tagliaferri, M.8
Liuzzi, A.9
Di Blasio, A.M.10
-
10
-
-
0033977437
-
Melanocortin 3 receptor (MC3R) gene variants in extremely obese women
-
Li W, Joo E, Furlong E, Galvin M, Abel K, Bell C, Price R: Melanocortin 3 receptor (MC3R) gene variants in extremely obese women. Int J Obes Relat Metab Disord 2000; 24: 206-210. (Pubitemid 30107570)
-
(2000)
International Journal of Obesity
, vol.24
, Issue.2
, pp. 206-210
-
-
Li, W.-D.1
Joo, E.-J.2
Furlong, E.B.3
Galvin, M.4
Abel, K.5
Bell, C.J.6
Arlen Price, R.7
-
11
-
-
0037255271
-
Melanocortin-3-receptor gene variants in morbid obesity
-
DOI 10.1038/sj.ijo.0802184
-
Schalin-Jantti C, Valli-Jaakola K, Oksanen L, Martelin E, Laitinen K, Krusius T, Mustajoki P, Heikinheimo M, Kontula K: Melanocortin-3-receptor gene variants in morbid obesity. Int J Obes Relat Metab Disord 2003; 27: 70-74. (Pubitemid 36152782)
-
(2003)
International Journal of Obesity
, vol.27
, Issue.1
, pp. 70-74
-
-
Schalin-Jantti, C.1
Valli-Jaakola, K.2
Oksanen, L.3
Martelin, E.4
Laitinen, K.5
Krusius, T.6
Mustajoki, P.7
Heikinheimo, M.8
Kontula, K.9
-
12
-
-
0035380668
-
Comment: Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians
-
DOI 10.1210/jc.86.6.2895
-
Hani EH, Dupont S, Durand E, Dina C, Gallina S, Gantz I, Froguel P: Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians. J Clin Endocrinol Metab 2001; 86: 2895-2898. (Pubitemid 32545758)
-
(2001)
Journal of Clinical Endocrinology and Metabolism
, vol.86
, Issue.6
, pp. 2895-2898
-
-
Hani, E.H.1
Dupont, S.2
Durand, E.3
Dina, C.4
Gallina, S.5
Gantz, I.6
Froguel, P.7
-
13
-
-
0036021083
-
Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes
-
DOI 10.1016/S0168-8227(02)00126-2, PII S0168822702001262
-
Wong J, Love DR, Kyle C, Daniels A, White M, Stewart AW, Schnell AH, Elston RC, Holdaway IM, Mountjoy KG: Melanocortin-3 receptor gene variants in a Maori kindred with obesity and early onset type 2 diabetes. Diabetes Res Clin Pract 2002; 58: 61-71. (Pubitemid 34823626)
-
(2002)
Diabetes Research and Clinical Practice
, vol.58
, Issue.1
, pp. 61-71
-
-
Wong, J.1
Love, D.R.2
Kyle, C.3
Daniels, A.4
White, M.5
Stewart, A.W.6
Schnell, A.H.7
Elston, R.C.8
Holdaway, I.M.9
Mountjoy, K.G.10
-
14
-
-
24144443764
-
Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity
-
DOI 10.2337/diabetes.54.9.2663
-
Feng N, Young SF, Aguilera G, Puricelli E, Adler-Wailes DC, Sebring NG, Yanovski JA: Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Diabetes 2005; 54: 2663-2667. (Pubitemid 41233588)
-
(2005)
Diabetes
, vol.54
, Issue.9
, pp. 2663-2667
-
-
Feng, N.1
Young, S.F.2
Aguillera, G.3
Puricelli, E.4
Adler-Wailes, D.C.5
Sebring, N.G.6
Yanovski, J.A.7
-
15
-
-
70349785440
-
Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor
-
Savastano DM, Tanofsky-Kraff M, Han JC, Ning C, Sorg RA, Roza CA, Wolkoff LE, Anandalingam K, Jefferson- George KS, Figueroa RE, Sanford EL, Brady S, Kozlosky M, Schoeller DA, Yanovski JA: Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. Am J Clin Nutr 2009; 90: 912-920.
-
(2009)
Am J Clin Nutr
, vol.90
, pp. 912-920
-
-
Savastano, D.M.1
Tanofsky-Kraff, M.2
Han, J.C.3
Ning, C.4
Sorg, R.A.5
Roza, C.A.6
Wolkoff, L.E.7
Anandalingam, K.8
Jefferson-George, K.S.9
Figueroa, R.E.10
Sanford, E.L.11
Brady, S.12
Kozlosky, M.13
Schoeller, D.A.14
Yanovski, J.A.15
-
16
-
-
34147179330
-
Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity
-
Santoro N, Perrone L, Cirillo G, Raimondo P, Amato A, Brienza C, del Giudice EM: Effect of the melanocortin-receptor C17A and G241A variants on weight loss in childhood obesity. Am J Clin Nutr 2007; 85: 950-953. (Pubitemid 46557907)
-
(2007)
American Journal of Clinical Nutrition
, vol.85
, Issue.4
, pp. 950-953
-
-
Santoro, N.1
Perrone, L.2
Cirillo, G.3
Raimondo, P.4
Amato, A.5
Brienza, C.6
Miraglia Del Giudice, E.7
-
17
-
-
4043093705
-
Functional characterization of melanocortin-3 receptor variants identify a loss-of-function mutation involving an amino acid critical for g protein-coupled receptor activation
-
DOI 10.1210/jc.2004-0367
-
Tao YX, Segaloff DL: Functional characterization of melanocortin-3 receptor variants identify a loss-offunction mutation involving an amino acid critical for G protein-coupled receptor activation. J Clin Endocrinol Metab 2004; 89: 3936-3942. (Pubitemid 39071496)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.8
, pp. 3936-3942
-
-
Tao, Y.-X.1
Segaloff, D.L.2
-
18
-
-
33747361810
-
N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors
-
Grosse J, Tarnow P, Römpler H, Schneider B, Sedlmeier R, Huffstadt U, Korthaus D, Nehls M, Wattler S, Schöneberg T, Biebermann H, Augustin M: N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors. Physiol Genomics 2006; 26: 209-217.
-
(2006)
Physiol Genomics
, vol.26
, pp. 209-217
-
-
Grosse, J.1
Tarnow, P.2
Römpler, H.3
Schneider, B.4
Sedlmeier, R.5
Huffstadt, U.6
Korthaus, D.7
Nehls, M.8
Wattler, S.9
Schöneberg, T.10
Biebermann, H.11
Augustin, M.12
-
19
-
-
30944462134
-
Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34
-
DOI 10.1016/j.ygeno.2005.10.001, PII S0888754305002910
-
Engemaier E, Römpler H, Schöneberg T, Schulz A: Genomic and supragenomic structure of the nucleotidelike G-protein-coupled receptor GPR34. Genomics 2006; 87: 254-264. (Pubitemid 43117446)
-
(2006)
Genomics
, vol.87
, Issue.2
, pp. 254-264
-
-
Engemaier, E.1
Rompler, H.2
Schoneberg, T.3
Schulz, A.4
-
20
-
-
5044229348
-
Molecular mechanisms of translational control
-
DOI 10.1038/nrm1488
-
Gebauer F, Hentze MW: Molecular mechanisms of translational control. Nat Rev Mol Cell Biol 2004; 5: 827-835. (Pubitemid 39336276)
-
(2004)
Nature Reviews Molecular Cell Biology
, vol.5
, Issue.10
, pp. 827-835
-
-
Gebauer, F.1
Hentze, M.W.2
-
21
-
-
0019852740
-
Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes
-
Kozak M: Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res 1981; 9: 5233-5252. (Pubitemid 12206565)
-
(1981)
Nucleic Acids Research
, vol.9
, Issue.20
, pp. 5233-5252
-
-
Kozak, M.1
-
22
-
-
0021770224
-
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
-
Kozak M: Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res 1984; 12: 857-872.
-
(1984)
Nucleic Acids Res
, vol.12
, pp. 857-872
-
-
Kozak, M.1
-
23
-
-
0035577382
-
A reassessment of the translation initiation codon in vertebrates
-
DOI 10.1016/S0168-9525(01)02493-3, PII S0168952501024933
-
Peri S, Pandey A: A reassessment of the translation initiation codon in vertebrates. Trends Genet 2001; 17: 685-687. (Pubitemid 33097510)
-
(2001)
Trends in Genetics
, vol.17
, Issue.12
, pp. 685-687
-
-
Peri, S.1
Pandey, A.2
|