-
1
-
-
0014187276
-
Fibrin and atherosclerosis
-
Vastesaeger, E. [Fibrin and atherosclerosis]. Acta Cardiol. 22, 581-586 (1967).
-
(1967)
Acta Cardiol.
, vol.22
, pp. 581-586
-
-
Vastesaeger, E.1
-
2
-
-
0031038213
-
Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT
-
DOI 10.1016/S0140-6736(96)09145-3
-
Julian, D.G. et al. Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT. European Myocardial Infarct Amiodarone Trial Investigators. Lancet 349, 667-674 (1997). (Pubitemid 27107744)
-
(1997)
Lancet
, vol.349
, Issue.9053
, pp. 667-674
-
-
Julian, D.G.1
Camm, A.J.2
Frangin, G.3
Janse, M.J.4
Munoz, A.5
Schwartz, P.J.6
Simon, P.7
-
4
-
-
0020516741
-
Relationships between amiodarone dosage, drug concentrations, and adverse side effects
-
Heger, J.J., Prystowsky, E.N. & Zipes, D.P. Relationships between amiodarone dosage, drug concentrations, and adverse side effects. Am. Heart J. 106, 931-935 (1983). (Pubitemid 13010828)
-
(1983)
American Heart Journal
, vol.106
, Issue.4
, pp. 931-935
-
-
Heger, J.J.1
Prystowsky, E.N.2
Zipes, D.P.3
-
5
-
-
0020453282
-
Amiodarone pulmonary toxicity
-
Marchlinski, F.E., Gansler, T.S., Waxman, H.L. & Josephson, M.E. Amiodarone pulmonary toxicity. Ann. Intern. Med. 97, 839-845 (1982). (Pubitemid 13240564)
-
(1982)
Annals of Internal Medicine
, vol.97
, Issue.6
, pp. 839-845
-
-
Marchlinski, F.E.1
Gansler, T.S.2
Waxman, H.L.3
Josephson, M.E.4
-
6
-
-
0022648619
-
Amiodarone hepatotoxicity. A clinicopathologic study of five patients
-
Rigas, B. et al. Amiodarone hepatotoxicity. A clinicopathologic study of five patients. Ann. Intern. Med. 104, 348-351 (1986). (Pubitemid 16163612)
-
(1986)
Annals of Internal Medicine
, vol.104
, Issue.3
, pp. 348-351
-
-
Rigas, B.1
Rosenfeld, L.E.2
Barwick, K.W.3
-
7
-
-
0021211480
-
Thyrotoxicosis induced by amiodarone, a new efficient antiarrhythmic drug with high iodine content
-
Dickstein, G., Amikam, S., Riss, E. & Barzilai, D. Thyrotoxicosis induced by amiodarone, a new efficient antiarrhythmic drug with high iodine content. Am. J. Med. Sci. 288, 14-17 (1984). (Pubitemid 14053220)
-
(1984)
American Journal of the Medical Sciences
, vol.288
, Issue.1
, pp. 14-17
-
-
Dickstein, G.1
Amikam, S.2
Riss, E.3
Barzilai, D.4
-
8
-
-
0034530765
-
Antiarrhythmic agents: Drug interactions of clinical significance
-
Trujillo, T.C. & Nolan, P.E. Antiarrhythmic agents: drug interactions of clinical significance. Drug Saf. 23, 509-532 (2000). (Pubitemid 32001513)
-
(2000)
Drug Safety
, vol.23
, Issue.6
, pp. 509-532
-
-
Trujillo, T.C.1
Nolan, P.E.2
-
9
-
-
0028236315
-
Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: Contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone
-
Funck-Brentano, C. et al. Variable disposition kinetics and electrocardiographic effects of flecainide during repeated dosing in humans: contribution of genetic factors, dose-dependent clearance, and interaction with amiodarone. Clin. Pharmacol. Ther. 55, 256-269 (1994).
-
(1994)
Clin. Pharmacol. Ther.
, vol.55
, pp. 256-269
-
-
Funck-Brentano, C.1
-
10
-
-
0027273448
-
Cyclosporineamiodarone interaction
-
Chitwood, K.K., Abdul-Haqq, A.J. & Heim-Duthoy, K.L. Cyclosporineamiodarone interaction. Ann. Pharmacother. 27, 569-571 (1993).
-
(1993)
Ann. Pharmacother.
, vol.27
, pp. 569-571
-
-
Chitwood, K.K.1
Abdul-Haqq, A.J.2
Heim-Duthoy, K.L.3
-
11
-
-
0026720377
-
Amiodaronecyclosporine interaction in a heart transplant patient
-
Nicolau, D.P., Uber, W.E., Crumbley, A.J. 3rd & Strange, C. Amiodaronecyclosporine interaction in a heart transplant patient. J. Heart Lung Transplant. 11, 564-568 (1992).
-
(1992)
J. Heart Lung Transplant.
, vol.11
, pp. 564-568
-
-
Nicolau, D.P.1
Uber, W.E.2
Crumbley Iii., A.J.3
Strange, C.4
-
12
-
-
0025990904
-
Influence of amiodarone on genetically determined drug metabolism in humans
-
Funck-Brentano, C., Jacqz-Aigrain, E., Leenhardt, A., Roux, A., Poirier, J.M. & Jaillon, P. Influence of amiodarone on genetically determined drug metabolism in humans. Clin. Pharmacol. Ther. 50, 259-266 (1991).
-
(1991)
Clin. Pharmacol. Ther.
, vol.50
, pp. 259-266
-
-
Funck-Brentano, C.1
Jacqz-Aigrain, E.2
Leenhardt, A.3
Roux, A.4
Poirier, J.M.5
Jaillon, P.6
-
13
-
-
62549151771
-
Warfarin potentiation: A review of the FAB-4significant drug interactions
-
Thi, L., Shaw, D. & Bird, J. Warfarin potentiation: a review of the "FAB-4" significant drug interactions. Consult. Pharm. 24, 227-230 (2009).
-
(2009)
Consult. Pharm.
, vol.24
, pp. 227-230
-
-
Thi, L.1
Shaw, D.2
Bird, J.3
-
14
-
-
35248819130
-
Atrial fibrillation and stroke prevention
-
DOI 10.1016/S1474-4422(07)70264-8, PII S1474442207702648
-
Lip, G.Y. & Lim, H.S. Atrial fibrillation and stroke prevention. Lancet Neurol. 6, 981-993 (2007). (Pubitemid 47566414)
-
(2007)
Lancet Neurology
, vol.6
, Issue.11
, pp. 981-993
-
-
Lip, G.Y.1
Lim, H.S.2
-
15
-
-
0023726356
-
The incidence, magnitude, and time course of the amiodarone-warfarin interaction
-
Kerin, N.Z., Blevins, R.D., Goldman, L., Faitel, K. & Rubenfire, M. The incidence, magnitude, and time course of the amiodarone-warfarin interaction. Arch. Intern. Med. 148, 1779-1781 (1988).
-
(1988)
Arch. Intern. Med.
, vol.148
, pp. 1779-1781
-
-
Kerin, N.Z.1
Blevins, R.D.2
Goldman, L.3
Faitel, K.4
Rubenfire, M.5
-
16
-
-
0036152996
-
Clinical observations with the amiodarone/warfarin interaction: Dosing relationships with long-term therapy
-
DOI 10.1378/chest.121.1.19
-
Sanoski, C.A. & Bauman, J.L. Clinical observations with the amiodarone/warfarin interaction: dosing relationships with long-term therapy. Chest 121, 19-23 (2002). (Pubitemid 34114223)
-
(2002)
Chest
, vol.121
, Issue.1
, pp. 19-23
-
-
Sanoski, C.A.1
Bauman, J.L.2
-
17
-
-
0023276451
-
Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans
-
O'Reilly, R.A., Trager, W.F., Rettie, A.E. & Goulart, D.A. Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans. Clin. Pharmacol. Ther. 42, 290-294 (1987). (Pubitemid 17155734)
-
(1987)
Clinical Pharmacology and Therapeutics
, vol.42
, Issue.3
, pp. 290-294
-
-
O'Reilly, R.A.1
Trager, W.F.2
Rettie, A.E.3
Goulart, D.A.4
-
18
-
-
0026575955
-
The mechanism of the interaction between amiodarone and warfarin in humans
-
Heimark, L.D. et al. The mechanism of the interaction between amiodarone and warfarin in humans. Clin. Pharmacol. Ther. 51, 398-407 (1992).
-
(1992)
Clin. Pharmacol. Ther.
, vol.51
, pp. 398-407
-
-
Heimark, L.D.1
-
19
-
-
33748886840
-
Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles
-
DOI 10.1124/dmd.106.010678
-
Kumar, V., Locuson, C.W., Sham, Y.Y. & Tracy, T.S. Amiodarone analogdependent effects on CYP2C9-mediated metabolism and kinetic profiles. Drug Metab. Dispos. 34, 1688-1696 (2006). (Pubitemid 44427471)
-
(2006)
Drug Metabolism and Disposition
, vol.34
, Issue.10
, pp. 1688-1696
-
-
Kumar, V.1
Locuson, C.W.2
Sham, Y.Y.3
Tracy, T.S.4
-
20
-
-
0034015751
-
Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: Prediction of in vivo drug interactions
-
DOI 10.1046/j.1365-2125.2000.00134.x
-
Ohyama, K., Nakajima, M., Suzuki, M., Shimada, N., Yamazaki, H. & Yokoi, T. Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions. Br. J. Clin. Pharmacol. 49, 244-253 (2000). (Pubitemid 30150986)
-
(2000)
British Journal of Clinical Pharmacology
, vol.49
, Issue.3
, pp. 244-253
-
-
Ohyama, K.1
Nakajima, M.2
Suzuki, M.3
Shimada, N.4
Yamazaki, H.5
Yokoi, T.6
-
21
-
-
0026519541
-
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
-
Rettie, A.E. et al. Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem. Res. Toxicol. 5, 54-59 (1992).
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 54-59
-
-
Rettie, A.E.1
-
22
-
-
0021999559
-
Amiodarone and desethylamiodarone elimination kinetics following withdrawal of long-term amiodarone maintenance therapy
-
DOI 10.1002/bdd.2510060211
-
Marchiset, D., Bruno, R., Djiane, P., Cano, J.P., Benichou, M. & Serradimigni, A. Amiodarone and desethylamiodarone elimination kinetics following withdrawal of long-term amiodarone maintenance therapy. Biopharm. Drug Dispos. 6, 209-215 (1985). (Pubitemid 15092221)
-
(1985)
Biopharmaceutics and Drug Disposition
, vol.6
, Issue.2
, pp. 209-215
-
-
Marchiset, D.1
Bruno, R.2
Djiane, P.3
-
23
-
-
0035713129
-
Role of desethylamiodarone in the anticoagulant effect of concurrent amiodarone and warfarin therapy
-
Naganuma, M., Shiga, T., Nishikata, K., Tsuchiya, T., Kasanuki, H. & Fujii, E. Role of desethylamiodarone in the anticoagulant effect of concurrent amiodarone and warfarin therapy. J. Cardiovasc. Pharmacol. Ther. 6, 363-367 (2001). (Pubitemid 34141821)
-
(2001)
Journal of Cardiovascular Pharmacology and Therapeutics
, vol.6
, Issue.4
, pp. 363-367
-
-
Naganuma, M.1
Shiga, T.2
Nishikata, K.3
Tsuchiya, T.4
Kasanuki, H.5
Fujii, E.6
-
24
-
-
14144256218
-
Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients
-
DOI 10.1016/j.ejps.2004.10.015
-
Ha, H.R., Bigler, L., Wendt, B., Maggiorini, M. & Follath, F. Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients. Eur. J. Pharm. Sci. 24, 271-279 (2005). (Pubitemid 40283509)
-
(2005)
European Journal of Pharmaceutical Sciences
, vol.24
, Issue.4
, pp. 271-279
-
-
Ha, H.R.1
Bigler, L.2
Wendt, B.3
Maggiorini, M.4
Follath, F.5
-
25
-
-
0043027305
-
-
M?ecine et sciences internationales: Paris, France
-
Harris, L. & Roncucci, R.R. Amiodarone: Pharmacology, Pharmacokinetics, Toxicology, Clinical Effects (M?ecine et sciences internationales: Paris, France, 1986).
-
(1986)
Amiodarone: Pharmacology, Pharmacokinetics, Toxicology, Clinical Effects
-
-
Harris, L.1
Roncucci, R.R.2
-
26
-
-
0037636387
-
A new class of CYP2C9 inhibitors: Probing 2C9 specificity with high-affinity benzbromarone derivatives
-
Locuson, C.W. 2nd, Wahlstrom, J.L., Rock, D.A., Rock, D.A. & Jones, J.P. A new class of CYP2C9 inhibitors: probing 2C9 specificity with high-affinity benzbromarone derivatives. Drug Metab. Dispos. 31, 967-971 (2003).
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 967-971
-
-
Locuson II, C.W.1
Wahlstrom, J.L.2
Rock, D.A.3
Rock, D.A.4
Jones, J.P.5
-
27
-
-
33751097730
-
Preparation and purification of desethylamiodarone hydrochloride
-
DOI 10.1080/00397910600941406, PII Q02W37157743KVR0
-
Lucas, A.N., Tanol, M., McIntosh, M.P. & Rajewski, R.A. Preparation and purification of desethylamiodarone hydrochloride. Synth. Commun. 36, 3371-3376 (2006). (Pubitemid 44764424)
-
(2006)
Synthetic Communications
, vol.36
, Issue.22
, pp. 3371-3376
-
-
Lucas, A.N.1
Tanol, M.2
McIntosh, M.P.3
Rajewski, R.A.4
-
28
-
-
33751166410
-
Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives
-
Waldhauser, K.M. et al. Hepatocellular toxicity and pharmacological effect of amiodarone and amiodarone derivatives. J. Pharmacol. Exp. Ther. 319, 1413-1423 (2006).
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.319
, pp. 1413-1423
-
-
Waldhauser, K.M.1
-
29
-
-
55249125403
-
Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites
-
Snead, A.N., Miyakawa, M., Tan, E.S. & Scanlan, T.S. Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. Bioorg. Med. Chem. Lett. 18, 5920-5922 (2008).
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 5920-5922
-
-
Snead, A.N.1
Miyakawa, M.2
Tan, E.S.3
Scanlan, T.S.4
-
30
-
-
0036396095
-
Synthesis of two metabolites of the antiarrythmicum amiodarone
-
DOI 10.1002/1522-2675(200209)85:9<2990::AID-HLCA2990>3.0.CO;2-R
-
Wendt, B., Ha, H.R. & Hesse, M. Synthesis of two metabolites of the antiarrythmicum amiodarone. Helv. Chim. Acta 85, 2990-3001 (2002). (Pubitemid 35177814)
-
(2002)
Helvetica Chimica Acta
, vol.85
, Issue.9
, pp. 2990-3001
-
-
Wendt, B.1
Ha, H.R.2
Hesse, M.3
-
31
-
-
79956118493
-
Identification of amiodarone metabolites in human bile by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry
-
Deng, P., You, T.G., Chen, X.Y., Yuan, T., Huang, H.H. & Zhong, D.F. Identification of amiodarone metabolites in human bile by ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry. Drug Metab. ispos. 39, 1058-1069 (2011).
-
(2011)
Drug Metab. Ispos.
, vol.39
, pp. 1058-1069
-
-
Deng, P.1
You, T.G.2
Chen, X.Y.3
Yuan, T.4
Huang, H.H.5
Zhong, D.F.6
-
32
-
-
0021273876
-
Binding of amiodarone by serum proteins and the effects of drugs, hormones, and other interacting ligands
-
Lalloz, M.R., Byfield, P.G., Greenwood, R.M. & Himsworth, R.L. Binding of amiodarone by serum proteins and the effects of drugs, hormones and other interacting ligands. J. Pharm. Pharmacol. 36, 366-372 (1984). (Pubitemid 14104814)
-
(1984)
Journal of Pharmacy and Pharmacology
, vol.36
, Issue.6
, pp. 366-372
-
-
Lalloz, M.R.A.1
Byfield, P.G.H.2
Greenwood, R.M.3
Himsworth, R.L.4
-
33
-
-
84948987104
-
Guidance for industry drug interaction studies-study design data analysis, and implications for dosing and labeling
-
Rockville, MD
-
US Food and Drug Administration. Guidance for industry drug interaction studies-study design, data analysis, and implications for dosing and labeling. Draft guidance. (Rockville, MD, 2006).
-
(2006)
Draft Guidance
-
-
-
34
-
-
78650513090
-
Are circulating metabolites important in drug-drug interactions?: Quantitative analysis of risk prediction and inhibitory potency
-
Yeung, C.K., Fujioka, Y., Hachad, H., Levy, R.H. & Isoherranen, N. Are circulating metabolites important in drug-drug interactions?: quantitative analysis of risk prediction and inhibitory potency. Clin. Pharmacol. Ther. 89, 105-113 (2011).
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 105-113
-
-
Yeung, C.K.1
Fujioka, Y.2
Hachad, H.3
Levy, R.H.4
Isoherranen, N.5
-
35
-
-
1942421309
-
Qualitative and quantitative assessment of drug-drug interaction potential in man, based on Ki, IC50 and inhibitor concentration
-
DOI 10.2174/1389200043489072
-
Blanchard, N., Richert, L., Coassolo, P. & Lav? T. Qualitative and quantitative assessment of drug-drug interaction potential in man, based on Ki, IC50 and inhibitor concentration. Curr. Drug Metab. 5, 147-156 (2004). (Pubitemid 38515244)
-
(2004)
Current Drug Metabolism
, vol.5
, Issue.2
, pp. 147-156
-
-
Blanchard, N.1
Richert, L.2
Coassolo, P.3
Lave, T.4
-
36
-
-
84971395861
-
Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data?
-
Ito, K. et al. Which concentration of the inhibitor should be used to predict in vivo drug interactions from in vitro data? AAPS PharmSci 4, E25 (2002).
-
(2002)
AAPS PharmSci
, vol.4
-
-
Ito, K.1
-
37
-
-
0031466149
-
Nonspecific binding to microsomes: Impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol
-
Obach, R.S. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Drug Metab. Dispos. 25, 1359-1369 (1997). (Pubitemid 28010921)
-
(1997)
Drug Metabolism and Disposition
, vol.25
, Issue.12
, pp. 1359-1369
-
-
Obach, R.S.1
-
38
-
-
77952312729
-
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: Opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem
-
Hanson, K.L., VandenBrink, B.M., Babu, K.N., Allen, K.E., Nelson, W.L. & Kunze, K.L. Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem. Drug Metab. Dispos. 38, 963-972 (2010).
-
(2010)
Drug Metab. Dispos.
, vol.38
, pp. 963-972
-
-
Hanson, K.L.1
Vandenbrink, B.M.2
Babu, K.N.3
Allen, K.E.4
Nelson, W.L.5
Kunze, K.L.6
-
39
-
-
69249220270
-
Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9 CYP2D6 and CYP3A using human liver microsomes at an early stage of drug development
-
Mori, K., Hashimoto, H., Takatsu, H., Tsuda-Tsukimoto, M. & Kume, T. Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development. Xenobiotica. 39, 415-422 (2009).
-
(2009)
Xenobiotica
, vol.39
, pp. 415-422
-
-
Mori, K.1
Hashimoto, H.2
Takatsu, H.3
Tsuda-Tsukimoto, M.4
Kume, T.5
-
41
-
-
0026473006
-
Stereoselective sulfoxidation by human flavin-containing monooxygenase. Evidence for catalytic diversity between hepatic, renal, and fetal forms
-
Sadeque, A.J., Eddy, A.C., Meier, G.P. & Rettie, A.E. Stereoselective sulfoxidation by human flavin-containing monooxygenase. Evidence for catalytic diversity between hepatic, renal, and fetal forms. Drug Metab. Dispos. 20, 832-839 (1992).
-
(1992)
Drug Metab. Dispos.
, vol.20
, pp. 832-839
-
-
Sadeque, A.J.1
Eddy, A.C.2
Meier, G.P.3
Rettie, A.E.4
-
42
-
-
1842534877
-
Evaluation of the Protein Binding Ratio of Drugs by A Micro-Scale Ultracentrifugation Method
-
DOI 10.1002/jps.20012
-
Nakai, D., Kumamoto, K., Sakikawa, C., Kosaka, T. & Tokui, T. Evaluation of the protein binding ratio of drugs by a micro-scale ultracentrifugation method. J. Pharm. Sci. 93, 847-854 (2004). (Pubitemid 38420397)
-
(2004)
Journal of Pharmaceutical Sciences
, vol.93
, Issue.4
, pp. 847-854
-
-
Nakai, D.1
Kumamoto, K.2
Sakikawa, C.3
Kosaka, T.4
Tokui, T.5
-
43
-
-
37549070318
-
Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo
-
Templeton, I.E. et al. Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. Clin. Pharmacol. Ther. 83, 77-85 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 77-85
-
-
Templeton, I.E.1
|