메뉴 건너뛰기




Volumn 36, Issue 22, 2006, Pages 3371-3376

Preparation and purification of desethylamiodarone hydrochloride

Author keywords

Amiodarone; Chloroethyl chloroformate; Dealkylation; Desethylamiodarone; Metabolite

Indexed keywords

1 CHLOROETHYL CHLOROFORMATE; AMIODARONE; DESETHYLAMIODARONE HYDROCHLORIDE; FORMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

EID: 33751097730     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910600941406     Document Type: Article
Times cited : (3)

References (17)
  • 3
    • 0037453022 scopus 로고    scopus 로고
    • Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: Insights into the mechanism of the superior efficacy of amiodarone
    • Shinagawa, K.; Shiroshita-Takeshita, A.; Schram, G.; Nattel, S. Effects of antiarrhythmic drugs on fibrillation in the remodeled atrium: Insights into the mechanism of the superior efficacy of amiodarone. Circulation 2003, 107, 1440-1446.
    • (2003) Circulation , vol.107 , pp. 1440-1446
    • Shinagawa, K.1    Shiroshita-Takeshita, A.2    Schram, G.3    Nattel, S.4
  • 4
    • 0019968057 scopus 로고
    • Identification and measurement of desethylamiodarone in blood plasma specimens from amiodarone-treated patients
    • Flanagan, R. J.; Storey, G. C.; Holt, D. W.; Farmer, P. B. Identification and measurement of desethylamiodarone in blood plasma specimens from amiodarone-treated patients. J. Pharm. Pharmacol. 1982, 34, 638-643.
    • (1982) J. Pharm. Pharmacol. , vol.34 , pp. 638-643
    • Flanagan, R.J.1    Storey, G.C.2    Holt, D.W.3    Farmer, P.B.4
  • 5
    • 0022499510 scopus 로고
    • Pharmacodynamic studies of amiodarone and its active n-desethyl metabolite
    • Nattel, S. Pharmacodynamic studies of amiodarone and its active n-desethyl metabolite. J. Cardiovasc. Pharmacol. 1986, 8, 771-777.
    • (1986) J. Cardiovasc. Pharmacol. , vol.8 , pp. 771-777
    • Nattel, S.1
  • 6
    • 0029945687 scopus 로고    scopus 로고
    • Effects of desethylamiodarone on the electrocardiogram in conscious feely moving animals: Pharmacokinetic and pharmacodynamic modeling using computer-assisted radio telemetry
    • Kharidia, J.; Eddington, N. D. Effects of desethylamiodarone on the electrocardiogram in conscious feely moving animals: Pharmacokinetic and pharmacodynamic modeling using computer-assisted radio telemetry. Biopharm. Drug Dispos. 1996, 17, 93-106.
    • (1996) Biopharm. Drug Dispos. , vol.17 , pp. 93-106
    • Kharidia, J.1    Eddington, N.D.2
  • 7
    • 0024415230 scopus 로고
    • Correlation of amiodarone dosage, heart rate, QT interval and corneal microdeposits with serum amiodarone and desethylamiodarone concentrations
    • Pollak, P. T.; Sharma, A. D.; Carruthers, S. G. Correlation of amiodarone dosage, heart rate, QT interval and corneal microdeposits with serum amiodarone and desethylamiodarone concentrations. Am. J. Cardiol. 1989, 64, 1138-1143.
    • (1989) Am. J. Cardiol. , vol.64 , pp. 1138-1143
    • Pollak, P.T.1    Sharma, A.D.2    Carruthers, S.G.3
  • 9
    • 0025825322 scopus 로고
    • Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused guinea pig hearts
    • Stark, G.; Stark, U.; Windisch, M.; Vicenzi, M.; Eggemeich, U.; Nagl, S.; Kral, K.; Pilger, E.; Tritthart, H. A. Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused guinea pig hearts. Basic Res. Cardiol. 1991, 86, 136-147.
    • (1991) Basic Res. Cardiol. , vol.86 , pp. 136-147
    • Stark, G.1    Stark, U.2    Windisch, M.3    Vicenzi, M.4    Eggemeich, U.5    Nagl, S.6    Kral, K.7    Pilger, E.8    Tritthart, H.A.9
  • 10
    • 0022634794 scopus 로고
    • Interrelationships between serum levels of amiodarone, desethylamiodarone, reverse t3 and the QT interval during long-term amiodarone treatment
    • Baerman, J. M.; Annesley, T.; DiCarlo, L. A., Jr.; Foley, M. K.; Nicklas, J. M.; Crevey, B. J.; Morady, F. Interrelationships between serum levels of amiodarone, desethylamiodarone, reverse t3 and the QT interval during long-term amiodarone treatment. Am. Heart. J. 1986, 111, 644-648.
    • (1986) Am. Heart. J. , vol.111 , pp. 644-648
    • Baerman, J.M.1    Annesley, T.2    DiCarlo Jr., L.A.3    Foley, M.K.4    Nicklas, J.M.5    Crevey, B.J.6    Morady, F.7
  • 11
    • 0023258359 scopus 로고
    • The relationship between the QT interval and plasma amiodarone concentration in patients on long-term therapy
    • Burgess, C. D.; Siebers, R. W.; Purdie, G. L.; Taylor, C.; Maling, T. J. The relationship between the QT interval and plasma amiodarone concentration in patients on long-term therapy. Eur. J. Clin. Pharmacol. 1987, 33, 115-118.
    • (1987) Eur. J. Clin. Pharmacol. , vol.33 , pp. 115-118
    • Burgess, C.D.1    Siebers, R.W.2    Purdie, G.L.3    Taylor, C.4    Maling, T.J.5
  • 12
    • 2142660225 scopus 로고    scopus 로고
    • QT prolongation and fatal arrhythmias: A review of clinical implications and effects of drugs
    • Cubeddu, L. X. QT prolongation and fatal arrhythmias: A review of clinical implications and effects of drugs. Am. J. Ther. 2003, 10, 452-457.
    • (2003) Am. J. Ther. , vol.10 , pp. 452-457
    • Cubeddu, L.X.1
  • 13
    • 0021260262 scopus 로고
    • A new reagent for the selective, high-yield n-dealkylation of tertiary-amines-improved syntheses of naltrexone and nalbuphine
    • Olofson, R. A.; Martz, J. T.; Senet, J. P.; Piteau, M.; Malfroot, T. A new reagent for the selective, high-yield n-dealkylation of tertiary-amines- improved syntheses of naltrexone and nalbuphine. J. Org. Chem. 1984, 49, 2081-2082.
    • (1984) J. Org. Chem. , vol.49 , pp. 2081-2082
    • Olofson, R.A.1    Martz, J.T.2    Senet, J.P.3    Piteau, M.4    Malfroot, T.5
  • 14
    • 0034903983 scopus 로고    scopus 로고
    • DNA adduct formation and mutant induction in-Sprague-Dawley rats treated with tamoxifen and its derivatives
    • da Costa, G. G.; McDaniel-Hamilton, L. P.; Heflich, R. H.; Marques, M. M.; Beland, F. A. DNA adduct formation and mutant induction in-Sprague-Dawley rats treated with tamoxifen and its derivatives. Carcinogenesis 2001, 22, 1307-1315.
    • (2001) Carcinogenesis , vol.22 , pp. 1307-1315
    • Costa, G.G.1    McDaniel-Hamilton, L.P.2    Heflich, R.H.3    Marques, M.M.4    Beland, F.A.5
  • 15
    • 0031567153 scopus 로고    scopus 로고
    • Preparation of n-demethylated drug metabolites for analytical purposes using 1-chloroethyl chloroformate
    • Pelander, A.; Ojanpera, I.; Hare, T. A. Preparation of n-demethylated drug metabolites for analytical purposes using 1-chloroethyl chloroformate. Forensic Sci. Int. 1997, 85, 193-198.
    • (1997) Forensic Sci. Int. , vol.85 , pp. 193-198
    • Pelander, A.1    Ojanpera, I.2    Hare, T.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.