Folate malabsorption is associated with down-regulation of folate transporter expression and function at colon basolateral membrane in rats

British Journal of Nutrition

Volumn 107, Issue 6, 2012, Pages 800-808

  Wani, Nissar Ahmad ^a   Hamid, Abid ^b   Khanduja, Krishan Lal ^a   Kaur, Jyotdeep ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Alcohol; Colon; Folate; Lipid rafts; Proton coupled folate transporter; Rats; Reduced folate carrier

Indexed keywords

ALCOHOL; FOLATE TRANSPORTER; FOLIC ACID; MESSENGER RNA; PROTON COUPLED FOLATE TRANSPORTER; REDUCED FOLATE CARRIER;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; BINDING AFFINITY; COLON; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FOLIC ACID DEFICIENCY; LIPID RAFT; MALABSORPTION; MALE; NONHUMAN; NUTRIENT TRANSPORT; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TRANSPORT KINETICS;

ALCOHOLISM; ANIMALS; CELL MEMBRANE; COLON; DOWN-REGULATION; FOLIC ACID; FOLIC ACID DEFICIENCY; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; KINETICS; MALABSORPTION SYNDROMES; MALE; MEMBRANE MICRODOMAINS; MEMBRANE TRANSPORT PROTEINS; PROTON-COUPLED FOLATE TRANSPORTER; RANDOM ALLOCATION; RATS; RATS, WISTAR; REDUCED FOLATE CARRIER PROTEIN; RNA, MESSENGER; TETRAHYDROFOLATES;

RATTUS; RATTUS NORVEGICUS;

EID: 84858778099     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511003710     Document Type: Article

References (40)

1. Wani NA, Hamid A & Kaur J (2008) Folate status in various pathophysiological conditions. IUBMB Life 60, 834-842.
2. Zhao R, Matherly LH & Goldman ID (2009) Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Rev Mol Med 11, e4.
3. Choi SW & Mason JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 132, 2413S-2418S. (Pubitemid 34848118)
4. Kim YI (1999) Folate and carcinogenesis: evidence, mechanisms, and implications. J Nutr Biochem 10, 66-88.
5. Kim YI (2003) Role of folate in colon cancer development and progression. J Nutr 133, 3731S-3739S.
6. Qiu A, Jansen M, Sakaris A, et al. (2006) Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 127, 917-928. (Pubitemid 44792250)
7. Wani NA & Kaur J (2011) Reduced levels of folate transporters (PCFT and RFC) in membrane lipid rafts result in colonic folate malabsorption in chronic alcoholism. J Cell Physiol 226, 579-587.
8. Nguyen TT, Dyer DL, Dunning DD, et al. (1997) Human intestinal folate transport: cloning, expression, and distribution of complementary RNA. Gastroenterology 112, 783-791. (Pubitemid 27113804)
9. Hamid A, Wani NA & Kaur J (2009) New perspectives on folate transport in relation to alcoholism-induced folate malabsorption-association with epigenome stability and cancer development. FEBS J 276, 2175-2191.
10. Egan MG, Sirlin S, Rumberger BG, et al. (1995) Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation. J Biol Chem 270, 5462-5468.
11. Dudeja PK, Kode A, Alnounou M, et al. (2001) Mechanism of folate transport across the human colonic basolateral membrane. Am J Physiol Gastrointest Liver Physiol 281, G54-G60.
12. Sakuta H & Suzuki T (2005) Alcohol consumption and plasma homocysteine. Alcohol 37, 73-77.
13. Hamid A & Kaur J (2009) Role of signaling pathways in the regulation of folate transport in ethanol-fed rats. J Nutr Biochem 20, 291-297.
14. Bode C & Bode JC (2003) Effect of alcohol consumption on the gut. Best Pract Res Clin Gastroenterol 17, 575-592.
15. De Marco P, Calevo MG, Moroni A, et al. (2003) Reduced folate carrier polymorphism (80A ! G) and neural tube defects. Eur J Hum Genet 11, 245-252. (Pubitemid 36511863)
16. Hamid A, Kaur J & Mahmood A (2007) Evaluation of the kinetic properties of the folate transport system in intestinal absorptive epithelium during experimental ethanol ingestion. Mol Cell Biochem 304, 265-271. (Pubitemid 47456875)
17. Hamid A & Kaur J (2007) Long-term alcohol ingestion alters the folate-binding kinetics in intestinal brush border membrane in experimental alcoholism. Alcohol 41, 441-446. (Pubitemid 47538902)
18. Hamid A, Wani NA, Rana S, et al. (2007) Down-regulation of reduced folate carrier may result in folate malabsorption across intestinal brush border membrane during experimental alcoholism. FEBS J 274, 6317-6328. (Pubitemid 350215923)
19. McMartin KE (1984) Increased urinary folate excretion and decreased plasma folate levels in the rat after acute ethanol treatment. Alcohol Clin Exp Res 8, 172-178. (Pubitemid 14134044)
20. McMartin KE & Collins TD (1983) Relationship of alcohol metabolism to folate deficiency produced by ethanol in the rat. Pharmacol Biochem Behav 18, Suppl. 1, 257-262.
21. Scalera V, Storelli C, Storelli-Joss C, et al. (1980) A simple and fast method for the isolation of basolateral plasma membranes from rat small-intestinal epithelial cells. Biochem J 186, 177-181. (Pubitemid 10152084)
22. Hamid A, Kiran M, Rana S, et al. (2009) Low folate transport across intestinal basolateral surface is associated with downregulation of reduced folate carrier in in vivo model of folate malabsorption. IUBMB Life 61, 236-243.
23. Dev S, Ahmad Wani N & Kaur J (2011) Regulatory mechanisms of intestinal folate uptake in a rat model of folate oversupplementation. Br J Nutr 105, 827-835.
24. Towbin H, Staehelin T & Gordon J (1992) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. 1979. Biotechnology 24, 145-149.
25. Said HM, Chatterjee N, Haq RU, et al. (2000) Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency. Am J Physiol Cell Physiol 279, C1889-C1895.
26. Hanwell D, Ishikawa T, Saleki R, et al. (2002) Trafficking and cell surface stability of the epithelial Na + channel expressed in epithelial Madin-Darby canine kidney cells. J Biol Chem 277, 9772-9779. (Pubitemid 34968080)
27. Oliferenko S, Paiha K, Harder T, et al. (1999) Analysis of CD44-containing lipid rafts: recruitment of annexin II and stabilization by the actin cytoskeleton. J Cell Biol 146, 843-854. (Pubitemid 29408909)
28. Zhang Y, Shao JS, Xie QM, et al. (1996) Immunolocalization of alkaline phosphatase and surfactant-like particle proteins in rat duodenum during fat absorption. Gastroenterology 110, 478-488. (Pubitemid 26043881)
29. Sobierajska K, Glos J, Daborowska J, et al. (2010) Visualization of the interaction between Gbetagamma and tubulin during light-induced cell elongation of Blepharisma japonicum. Photochem Photobiol Sci 9, 1101-1110.
30. Zhao R, Gao F, Wang Y, et al. (2001) Impact of the reduced folate carrier on the accumulation of active thiamin metabolites in murine leukemia cells. J Biol Chem 276, 1114-1118. (Pubitemid 32096535)
31. Anderson RG & Jacobson K (2002) A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains. Science 296, 1821-1825. (Pubitemid 34596260)
32. Simons K & Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1, 31-39.
33. Annaba F, Sarwar Z, Kumar P, et al. (2008) Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts. Am J Physiol Gastrointest Liver Physiol 294, G489-G497. (Pubitemid 351253334)
34. Kumar CK, Nguyen TT, Gonzales FB, et al. (1998) Comparison of intestinal folate carrier clone expressed in IEC-6 cells and in Xenopus oocytes. Am J Physiol 274, C289-C294.
35. Inoue K, Nakai Y, Ueda S, et al. (2008) Functional characterization of PCFT/HCP1 as the molecular entity of the carriermediated intestinal folate transport system in the rat model. Am J Physiol Gastrointest Liver Physiol 294, G660-G668. (Pubitemid 351468755)
36. Zhao R, Qiu A, Tsai E, et al. (2008) The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol 74, 854-862.
37. Hamid A & Kaur J (2006) Chronic alcoholism alters the transport characteristics of folate in rat renal brush border membrane. Alcohol 38, 59-66. (Pubitemid 43817398)
38. Hamid A & Kaur J (2005) Kinetic characteristics of folate binding to rat renal brush border membrane in chronic alcoholism. Mol Cell Biochem 280, 219-225. (Pubitemid 41829821)
39. Yang CH, Peterson RH, Sirotnak FM, et al. (1979) Folate analog transport by plasma membrane vesicles isolated from L1210 leukemia cells. J Biol Chem 254, 1402-1407. (Pubitemid 9148367)
40. Kaur M, Kaur J, Gupta R, et al. (2004) Ethanol-induced changes in lipid composition of intestinal microvillus membrane in rats fed different dietary fats. Ann Nutr Metab 48, 221-227. (Pubitemid 39382379)