Discovery of a new binding mode for a series of liver X receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2407-2410

  Kopecky, David J ^a   Jiao, Xian Yun ^a   Fisher, Ben ^a   McKendry, Sharon ^a   Labelle, Marc ^a   Piper, Derek E ^a   Coward, Peter ^a   Shiau, Andrew K ^a   Escaron, Patrick ^a   Danao, Jean ^a   Chai, Anne ^a   Jaen, Juan ^a   Kayser, Frank ^a  

^a AMGEN INC   (United States)

Author keywords

Agonist; LXR; Nuclear receptor; Pyrrole; SAR

Indexed keywords

LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; N METHOXYETHYL PYRROLE; N METHYLSULFONAMIDE; PYRROLE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BINDING; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CACO-2 CELLS; CRYSTALLOGRAPHY, X-RAY; GENES, REPORTER; HEK293 CELLS; HUMANS; ORPHAN NUCLEAR RECEPTORS; PROTEIN BINDING; PROTEIN ISOFORMS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 84858706659     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.028     Document Type: Article

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