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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 7, 2012, Pages 2572-2578

Design of oxobenzimidazoles and oxindoles as novel androgen receptor antagonists

(10) Guo, Chuangxing a Pairish, Mason a Linton, Angelica a Kephart, Susan a Ornelas, Martha a Nagata, Asako a Burke, Benjamin a Dong, Liming a Engebretsen, Jon a Fanjul, Andrea N a

a PFIZER INC (United States)

Author keywords

Androgen receptor; AR antagonist; CRPC; LBD; Ligand efficiency; NHR; Prostate cancer

Indexed keywords

ANDROGEN RECEPTOR ANTAGONIST; OXINDOLE; OXOBENZIMIDAZOLE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; LIGAND BINDING;

ANDROGEN RECEPTOR ANTAGONISTS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL LINE, TUMOR; DRUG DESIGN; DRUG DISCOVERY; HUMANS; INDOLES; LIGANDS; MALE; MODELS, MOLECULAR; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ANDROGEN; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858706450 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.01.116 Document Type: Article

Times cited : (24)

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