Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery

Journal of Medicinal Chemistry

Volumn 53, Issue 11, 2010, Pages 4422-4427

  Mitchell, Lorna H ^a   Johnson, Theodore R ^a   Lu, Guang Wei ^a   Du, Daniel ^a   Datta, Kaushik ^a   Grzemski, Felicity ^a   Shanmugasundaram, Veerabahu ^a   Spence, Julie ^a   Wade, Kim ^a   Wang, Zhi ^a   Sun, Kevin ^a   Lin, Kristin ^a   Hu, Lain Yen ^a   Sexton, Karen ^a   Raheja, Neil ^a   Kostlan, Catherine ^a   Pocalyko, David ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 BENZYL 4,4 DIMETHYL 2 OXOPYRROLIDIN 3 YLOXY) 2 (TRIFLUOROMETHYL)BENZONITRILE; ANTIANDROGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFICACY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG SAFETY; DRUG SELECTIVITY; DRUG TOLERABILITY; HUMAN; MINIPIG; MOUSE; NONHUMAN; RAT; SEBUM SECRETION; SYRIAN HAMSTER;

ADMINISTRATION, TOPICAL; ANIMALS; CRICETINAE; DRUG DESIGN; DRUG TOXICITY; HAIR FOLLICLE; HUMANS; MALE; MESOCRICETUS; NITRILES; PHYSICOCHEMICAL PROCESSES; RECEPTORS, ANDROGEN; SEBUM;

EID: 77953178796     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9018004     Document Type: Article

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