Emodepside and SL0-1 potassium channels: A review

Experimental Parasitology

Volumn 132, Issue 1, 2012, Pages 40-46

  Martin, R J ^a   Buxton, S K ^a   Neveu, C ^b   Charvet, C L ^b   Robertson, A P ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b UR1282   (France)

Author keywords

Ascaris suum; Caenorhabditis elegans; Emodepside; SLO 1; Voltage activated potassium currents

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ANTHELMINTIC AGENT; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYCLO(DEXTRO LACTYL N METHYLLEUCYL DEXTRO 3 PHENYLLACTYL N METHYLLEUCYL DEXTRO LACTYL N METHYLLEUCYL DEXTRO 3 PHENYLLACTYL N METHYLLEUCYL); EMODEPSIDE; FEBANTEL; IVERMECTIN; LEVAMISOLE; NEUROPEPTIDE; NICOTINIC RECEPTOR BLOCKING AGENT; PF1 PROTEIN; PF2 PROTEIN; SLO 1 PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANTHELMINTIC ACTIVITY; ARTICLE; ASCARIS SUUM; CAENORHABDITIS ELEGANS; DRUG EFFICACY; DRUG STRUCTURE; GASTROINTESTINAL INFECTION; GENE; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HYPERPOLARIZATION; LATROPHILIN 1 RECEPTOR GENE; LATROPHILIN 2 RECEPTOR GENE; MICROBIAL ACTIVITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TARGETING; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SLO 1 GENE;

ANIMALS; ANTHELMINTICS; CAENORHABDITIS ELEGANS; DEPSIPEPTIDES; DRUG RESISTANCE; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE POTENTIALS; MUSCLE CONTRACTION; NEMATODA; NEMATODE INFECTIONS; NEUROMUSCULAR JUNCTION; NEUROPEPTIDES; RECEPTORS, PEPTIDE;

ANIMALIA; ASCARIS SUUM; CAENORHABDITIS ELEGANS; MICROFILARIA (NEMATODE GENUS); NEMATODA;

EID: 84858700738     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2011.08.012     Document Type: Article

References (43)

1. Bolotina V.M., Najibi S., Palacino J.J., Pagano P.J., Cohen R.A. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 1994, 368:850-853.
2. Bull K., Cook A., Hopper N.A., Harder A., Holden-Dye L., Walker R.J. Effects of the novel anthelmintic emodepside on the locomotion, egg-laying behaviour and development of Caenorhabditis elegans. Int J Parasitol 2007, 37:627-636.
3. Buxton, S. K., Neveu, C., Charvet, c.l., Robertson, A.P., and Martin, R.J., 2011. On the Mode of Action of Emodepside: Slow Effects on Membrane Potential and Voltage-Activated Currents in Ascaris suum. British Journal of Pharmacology. doi: doi:10.1111/j.1476-5381.2011.01428.x.
4. Chen W., Terada M., Cheng J.T. Characterization of subtypes of gamma-aminobutyric acid receptors in an Ascaris muscle preparation by binding assay and binding of PF1022A, a new anthelmintic, on the receptors. Parasitol Res 1996, 82:97-101.
5. Chen B., Qian G., Xiano-Ming X., Ping P., Wang S.J., Zhan H., Eipper B.A., Zhao-Wen W.A. A novel Auxiliary Subunit Critical to BK channel function in Caenorhabditis elegans. J. Neuroscience 2010, 20:16651-16661.
6. Crisford, C., Marray, C., O'Connor, V., Edwards, R. J., Kruger, N., Samson-Himmelstjerna, G. v., Harder, A., Walker, R. J., and Holden-Dye, L., 2011. Selective Toxicity of the Anthelmintic Emodepside Revealed by Heterologous Expression of Human KCNMA1 in Caenorhabditis elegans. Molecular Pharmacology.
7. de Silva N.R., Brooker S., Hotez P.J., Montresor A., Engels D., Savioli L. Soil-transmitted helminth infections: updating the global picture. Trends Parasitol 2003, 19:547-551.
8. Fellowes R.A., Maule A.G., Marks N.J., Geary T.G., Thompson D.P., Halton D.W. Nematode neuropeptide modulation of the vagina vera of Ascaris suum: in vitro effects of PF1, PF2, PF4, AF3 and AF4. Parasitology 2000, 120:79-89.
9. Franks C., Holden-Dye L., Williams R., Pang F., Walker R. A nematode FMRFamide-like peptide, SDPNFLRFamide (PF1), relaxes the dorsal muscle strip preparation of Ascaris suum. Parasitology 1994, 108:229-236.
10. Geary T.G., Woo K., McCarthy J.S., Mackenzie C.D., Horton J., Prichard R.K., de Silva N.R., Olliaro P.L., Lazdins-Helds J.K., Engels D.A., Bundy D.A. Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 2009, 40:1-13.
11. GeBner G., Meder S., Rink T., Boheim G., Harder A., Jeschke P., Scherkenbeck J., Londershausen M. Ionophore and Anthelmintic Activity of PF1022A, a Cyclooctadepsipeptide, are not related. Pestic Sci 1996, 48:399-407.
12. Ghatta S., Nimmagadda D., Xu X., O'Rourke S.T. Large-conductance, calcium-activated potassium channels: Structural and functional implications. Pharmacol Ther 2006, 110:103-116.
13. Guest M., Bull K., Walker R.J., Amliwala K., O'Connor V., Harder A., Holden-Dye L., Hopper N.A. The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol 2007, 37:1577-1588.
14. Harder A., Holden-Dye L., Walker R., Wunderlich F. Mechanisms of action of emodepside. Parasitol Res 2005, 97:S1-S10.
15. Harder A., Schmitt-Wrede H.P., Krucken J., Marinovski P., Wunderlich F., Willson J., Amliwala K., Holden-Dye L., Walker R. Cyclooctadepsipeptides-an anthelmintically active class of compounds exhibiting a novel mode of action. Int J Antimicrob Agents 2003, 22:318-331.
16. Holden-Dye L., O'Connor V., Hopper N.A., Walker R.J., Harder A., Bull K., Guest M. SLO, SLO, quick, quick, slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for anthelmintics. Invert Neurosci 2007, 7:199-208.
17. Jospin M., Mariol M.C., Segalat L., Allard B. Characterization of K(+) currents using an in situ patch clamp technique in body wall muscle cells from Caenorhabditis elegans. J Physiol 2002, 544:373-384.
18. Knaus H.G., Garcia-Calvo M., Kaczorowski G.J., Garcia M.L. Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels. J Biol Chem 1994, 269:3921-3924.
19. Lim H.H., Park B.J., Choi H.S., Park C.S., Eom S.H., Ahnn J. Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca(2+)-activated K(+) channels. Gene 1999, 240:35-43.
20. Martin R.J. Electrophysiological effects of piperazine and diethylcarbamazine on Ascaris suum somatic muscle. Br J Pharmacol 1982, 77:255-265.
21. Martin R.J., Harder A., Londershausen M., Jeschke P. Anthelmintic Actions of the Cyclic Depsipeptide PF1022A and its Electrophysiological Effects on Muscle Cells of Ascaris suum. Pestic Sci 1996, 48:343-349.
22. Miro G., Mateo M., Montoya A., Vela E., Calonge R. Survey of intestinal parasites in stay dogs in the Madrid area and comparison of the efficacy of three anthelmintics in naturally infected dogs. Parasitol Res 2006, 100:317-320.
23. Ca) in smooth muscle cells isolated from the rat mesenteric artery. Br J Pharmacol 1998, 124:1131-1140.
24. Muhlfeld S., Schmitt-Wrede H.-P., Harder A., Wunderlich F. FMRFamide-like neuropeptides as putative ligands of the latrophilin-like HC110-R from Haemonchus contortus. Mol Biochem Parasitol 2009, 164:162-164.
25. Pemberton D., Franks C., Walker R., Holden-Dye L. Characterization of Glutamate-Gated Chloride Channels in the Pharynx of Wild-Type and Mutant Caenorhabditis elegans Delineates the Role of the Subunit GluCl-alpha2 in the Function of the Native Receptor. Mol Pharmacol 2001, 59:1037-1043.
26. Qian H., Martin R.J., Robertson A.P. Pharmacology of N-, L- and B-subtypes of nematode nAChR resolved at the single-channel in Ascaris suum. FASEB J 2006, 20:E2108-E2116.
27. Qian H., Robertson A.P., Powell-Coffman J.A., Martin R.J. Levamisole resistance resolved at the single-channel level in Caenorhabditis elegans. FASEB J 2008, 22:3247-3254.
28. Saeger B., Schmitt-Wrede H.P., Dehnhardt M., Benten W.P., Krucken J., Harder A., Von Samson-Himmelstjerna G., Wiegand H., Wunderlich F. Latrophilin-like receptor from the parasitic nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A. FASEB J 2001, 15:1332-1334.
29. Salkoff L., Butler A., Ferreira G., Santi C., Wei A. High-conductance potassium channels of the SLO family. Nat Rev Neurosci 2006, 5:921-931.
30. Samson-Himmelstjerna von G., Harder A., Sangster N.C., Coles G.C. Efficacy of two cyclooctadepsipeptides, PF1022A and emodepside, against anthelmintic-resistant nematodes in sheep and cattle. Parasitology 2005, 130:343-347.
31. Sasaki T., Takagi M., Yaguchi T., Miyadoh S., Okada T., Koyama M. A new anthelmintic cyclodepsipeptide, PF1022A. J Antibiot 1992, 45:692-697.
32. Schreiber M., Salkoff L. A novel calcium-sensing domain in the BK channel. Biophys J 1997, 73:1355-1363.
33. Terada M. Neuropharmacological mechanism of action of PF1022A, an antinematode anthelmintic with a new structure of cyclic depsipeptide, on Angiostrongylus cantonensis and isolated frog rectus. Jpn J Parasitol 1992, 41:107-108.
34. Verma S., Robertson A.P., Martin R.J. The nematode neuropeptide, AF2 (KHEYLRF-NH(2)), increases voltage-activated calcium currents in Ascaris suum muscle. Br J Pharmacol 2007, 151:888-899.
35. Verma S., Robertson A.P., Martin R.J. Effects of SDPNFLRF-amide (PF1) on voltage-activated currents in Ascaris suum muscle. Int J Parasitol 2009, 39:315-326.
36. Wallner M., Meera P., Toro L. Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additional transmembrane region at the N terminus. Proc Natl Acad Sci U S A 1996, 93:14922-14927.
37. Wang J., Zhou Y., Wen H., Levitan I.B. Simultaneous binding of two protein kinases to a calcium-dependent potassium channel. J Neurosci 1999, 19:1-7.
38. Wang Z.W., Saifee O., Nonet M.L., Salkoff L. SLO-1 potassium channels control quantal content of neurotransmitter release at the C. Elegans neuromuscular junction. Neuron 2001, 32:867-881.
39. Wei A., Jegla T., Salkoff L. Eight potassium channel families revealed by the C. Elegans genome project. Neuropharmacology 1996, 35:805-829.
40. Welz C., Kruger N., Schniederjans M., Miltsch S.M., Krucken J., Guest M., Holden-dye L., Harder A., von Samson-Himmelstjerna G. SLO-1-Channels of Parasitic Nematodes Reconstitute Locomotor Behaviour and Emodespide Sensitivity in Caenorhhabdidtis elegans slo-1 Loss of Function mutants. 2011. PLoS Pathogens 2011, 7:e100133.
41. Willson J., Amliwala K., Harder A., Holden-Dye L., Walker R.J. The effect of the anthelmintic emodepside at the neuromuscular junction of the parasitic nematode Ascaris suum. Parasitology 2003, 126:79-86.
42. Willson J., Amliwala K., Davis A., Cook A., Cuttle M.F., Kriek N., Hopper A.A., O'Connor V., Harder A., Walker R.J., Holden-dye L. Latrotoxin Receptor Signaling Engages the UNC-13-Dependent Vesicle-Priming Pathway in C. elegans. Current Biol 2004, 14:1374-1379.
43. Wolstenholme A.J., Fairweather I., Prichard R., von Samson-Himmelstjerna G., Sangster N.C. Drug resistance in veterinary helminths. Trends Parasitol 2004, 20:469-476.