Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles

International Journal of Epidemiology

Volumn 41, Issue 1, 2012, Pages 210-217

  Pearce, Mark S ^a   Mcconnell, James C ^a   Potter, Catherine ^a   Barrett, Laura M ^a   Parker, Louise ^b   Mathers, John C ^a   Relton, Caroline L ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Cohort study; Global DNA methylation; Glucose; HDL LDL cholesterol; Insulin; LINE 1; Triglyceride

Indexed keywords

CHOLESTEROL; DNA; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

BIOMARKER; BLOOD; COHORT ANALYSIS; DNA; ENZYME ACTIVITY; GLUCOSE; HYPOTHESIS TESTING; LIPID; METHYLATION; SAMPLING;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LONG INTERSPERSED NUCLEOTIDE ELEMENT 1; LONG INTERSPERSED REPEAT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

BIOLOGICAL MARKERS; BLOOD GLUCOSE; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; HUMANS; LIPIDS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE; METABOLIC DISEASES; MIDDLE AGED;

EID: 84858676427     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dys020     Document Type: Article

References (44)

1. Rakyan VK, Preis J, Morgan HD, Whitelaw E. The marks, mechanisms and memory of epigenetic states in mammals. Biochem J 2001;356:1-10.
2. Waterland RA, Jirtle RL. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 2003;23:5293-300.
3. Belancio VP, Roy-Engel AM, Pochampally RR, Deininger P. Somatic expression of LINE-1 elements in human tissues. Nucleic Acids Res 2010;38:3909-22.
4. Bollati V, Schwatz J, Wright R et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2009;130:234-39.
5. Wu HC, Delgado-Cruzata L, Flom JD et al. Global methylation profiles in DNA from different blood cell types. Epigenetics 2011;6:76-85.
6. Ogino S, Nosho K, Kirkner GJ et al. A cohort study of tumoural LINE-1 hypomethylation and prognosis in colon cancer. J Natl Cancer Inst 2008;100:1734-38.
7. Ahn JB, Chung WB, Maeda O et al. DNA methylation predicts recurrence from resected stage III proximal colon cancer. Cancer 2011;117:1847-54.
8. Jintaridth P, Mutirangura A. Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences. Physiol Genomics 2010; doi:10.1152/physiolgenomics.00146.2009 [Epub 9 February 2010].
9. Schernhammer ES, Giovannucci E, Kawasaki T, Rosner B, Fuchs CS, Ogino S. Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut 2010;59:794-99.
10. Baccarelli A, Wright R, Bollati V et al. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology 2010;21:819-28.
11. Wang L, Wang F, Guan J et al. Relation between hyomethylation of long interspersed nucleotide elements and risk of neural tube defects. J Clin Nutr 2010;91: 1359-67.
12. Mathers JC, Strathdee G, Relton CL. Induction of epigenetic alterations by dietary and other environmental factors. Adv Genet 2010;71:3-39.
13. Wan YJ, Li YY, Xia W et al. Alterations in tumor biomarker GSTP gene methylation patterns induced by prenatal exposure to PFOS. Toxicology 2010;274:57-64.
14. Breton CV, Byun HM, Wenten M, Pan F, Yang A, Gilliland FD. Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med 2009;180:462-67.
15. Liu F, Killian JK, Yang M et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 2010; 29:3650-64.
16. Wright RO, Schwartz J, Wright RJ et al. Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ Health Perspect 2010;118:790-95.
17. Pilsner JR, Hu H, Ettinger A et al. Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ Health Perspect 2009;117:1466-71.
18. Baccarelli A, Wright RO, Bollati V et al. Rapid DNA methylation changes after exposure to traffic particles. Am J Resp Crit Care Med 2009;179:572-78.
19. Fryer AA, Emes RD, Ismail MK et al. Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics 2011;6:86-94.
20. Pearce MS, Unwin NC, Parker L, Craft AW. Cohort profile: The Newcastle Thousand Families Study. Int J Epidemiol 2009;38:932-37.
21. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge. Clin Chem 1972;18:499-502.
22. Pearce MS, Unwin NC, Relton CL, Alberti KGMM, Parker L. Lifecourse determinants of fasting and post-challenge glucose at age 49-51 years: The Newcastle Thousand Families Study. Eur J Epidemiol 2005;20:915-23.
23. Pearce MS, Unwin NC, Parker L, Alberti KGMM. Life course determinants of insulin secretion and sensitivity at age 50 years: The Newcastle Thousand Families Study. Diabetes Metab Res Rev 2006;22:118-25.
24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-19.
25. Phillips DIW, Clark PM, Hales CN, Osmond C. Understanding oral glucose tolerance: Comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med 1994;11: 286-92.
26. World Health Organization. Organisation, Monitoring Trends and Determinants in Cardiovascular Disease Project. MONICA Manual, Part III. Geneva, Switzerland: World Health Organization, 1990.
27. Choi SH, Worswick S, Byun HM et al. Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer. Int J Cancer 2009;125: 723-29.
28. Bollati V, Baccarelli A, Hou L et al. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res 2007;67:876-80.
29. Feinberg AP. Epigenetics at the epicenter of modern medicine. JAMA 2008;299:1345-50.
30. Mathers JC. Session 2: personalised nutrition. Epigenomics: a basis for understanding individual differences. Proc Nutr Soc 2008;67:390-94.
31. Turan N, Katari S, Coutifaris C, Sapienza C. Explaining inter-individual variability in phenotype: is epigenetics up to the challenge? Epigenetics 2010;5:16-19.
32. Nathan DM, Davidson MB, DeFronzo RA et al. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diab Care 2007;30:753-59.
33. Sarwar N, Danesh J, Eiriksdottir G et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 2007;115:450-58.
34. Baccarelli A, Tarantini L, Wright RO et al. Repetitive element DNA methylation and circulating endothelial and inflammation markers in the VA normative aging study. Epigenetics 5; doi:10.4161/epi.5.3.11377 [Epub 1 April 2010].
35. Rönn T, Poulsen P, Hansson O et al. Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle. Diabetologia 2008;51:1159-68.
36. Hernandez DG, Nalls MA, Gibbs JR et al. Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet 2011;20: 1164-72.
37. Sharma P, Kumar J, Garg G et al. Detection of altered global DNA methylation in coronary artery disease patients. DNA Cell Biol 2008;27:357-65.
38. Li Y, Liu L, Tollefsbol TO. Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression. FASEB J 2010;24:1442-53.
39. Relton CL, Davey Smith G. Epigenetic epidemiology of common complex disease: prospects for prediction, prevention and treatment. PLoS Med 2010;7:e1000356.
40. Inouye M, Silander K, Hamalainen E et al. An immune response network associated with blood lipid levels. PLoS Genet 2010;6:e1001113.
41. McKay JA, Xie L, Harris S, Wong YK, Ford D, Mathers JC. Blood as a surrogate marker for tissue-specific DNA methylation and changes due to folate depletion in post-partum female mice. Mol Nutr Food Res 2011;55:1026-35.
42. Bjornsson HT, Sigurdsson MI, Fallin MD et al. Intra-individual change over time in DNA methylation with familial clustering. JAMA 2008;299:2877-93.
43. Maegawa S, Hinkal G, Kim HS et al. Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res 2010;20:332-40.
44. Rakyan VK, Down TA, Maslau S et al. Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res 2010;20: 434-39.