-
2
-
-
30344446981
-
Gene expression analysis of the hepatotoxicant methapyrilene in primary rat hepatocytes: an interlaboratory study
-
Beekman J.M., Boess F., Hildebrand H., Kalkuhl A., Suter L. Gene expression analysis of the hepatotoxicant methapyrilene in primary rat hepatocytes: an interlaboratory study. Environ. Health Perspect. 2006, 114:92-99.
-
(2006)
Environ. Health Perspect.
, vol.114
, pp. 92-99
-
-
Beekman, J.M.1
Boess, F.2
Hildebrand, H.3
Kalkuhl, A.4
Suter, L.5
-
3
-
-
0022612736
-
Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies
-
Blazak W.F., Stewart B.E., Galperin I., Allen K.L., Rudd C.J., Mitchell A.D., Caspary W.J. Chromosome analysis of trifluorothymidine-resistant L5178Y mouse lymphoma cell colonies. Environ. Mutagen. 1986, 8:229-240.
-
(1986)
Environ. Mutagen.
, vol.8
, pp. 229-240
-
-
Blazak, W.F.1
Stewart, B.E.2
Galperin, I.3
Allen, K.L.4
Rudd, C.J.5
Mitchell, A.D.6
Caspary, W.J.7
-
4
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
5
-
-
0021349102
-
A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay
-
Budroe J.D., Shaddock J.G., Casciano D.A. A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay. Mutat. Res. 1984, 135:131-137.
-
(1984)
Mutat. Res.
, vol.135
, pp. 131-137
-
-
Budroe, J.D.1
Shaddock, J.G.2
Casciano, D.A.3
-
6
-
-
0021324775
-
Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay
-
Casciano D.A., Schol H.M. Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay. Cancer Lett. 1984, 21:337-341.
-
(1984)
Cancer Lett.
, vol.21
, pp. 337-341
-
-
Casciano, D.A.1
Schol, H.M.2
-
7
-
-
0023732831
-
The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats
-
Casciano D.A., Shaddock J.G., Talaska G. The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats. Mutat. Res. 1988, 208:129-135.
-
(1988)
Mutat. Res.
, vol.208
, pp. 129-135
-
-
Casciano, D.A.1
Shaddock, J.G.2
Talaska, G.3
-
8
-
-
0025736679
-
The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation
-
Casciano D.A., Talaska G., Clive D. The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation. Mutat. Res. 1991, 263:127-132.
-
(1991)
Mutat. Res.
, vol.263
, pp. 127-132
-
-
Casciano, D.A.1
Talaska, G.2
Clive, D.3
-
9
-
-
68349125412
-
A novel and simple method of screening compounds for interaction with DNA: a validation study
-
Garas A., Webb E., Pillay V., MacPhee D., Denny W., Zeller H., Cotton R. A novel and simple method of screening compounds for interaction with DNA: a validation study. Mutat. Res. 2009, 678:20-29.
-
(2009)
Mutat. Res.
, vol.678
, pp. 20-29
-
-
Garas, A.1
Webb, E.2
Pillay, V.3
MacPhee, D.4
Denny, W.5
Zeller, H.6
Cotton, R.7
-
10
-
-
84858617517
-
-
Least Squares Means in the Fixed-Effects General Linear Model, SAS Technical Report No. R-103, SAS Institute.
-
Goodnight, J.H., Harvey, W.R., 1978. Least Squares Means in the Fixed-Effects General Linear Model, SAS Technical Report No. R-103, SAS Institute.
-
(1978)
-
-
Goodnight, J.H.1
Harvey, W.R.2
-
11
-
-
47949133634
-
Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore
-
Graham E.E., Walsh R.J., Hirst C.M., Maggs J.L., Martin S., Wild M.J., Wilson I.D., Harding J.R., Kenna J.G., Peter R.M., Williams D.P., Park B.K. Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore. J. Pharmacol. Exp. Ther. 2008, 326:657-671.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.326
, pp. 657-671
-
-
Graham, E.E.1
Walsh, R.J.2
Hirst, C.M.3
Maggs, J.L.4
Martin, S.5
Wild, M.J.6
Wilson, I.D.7
Harding, J.R.8
Kenna, J.G.9
Peter, R.M.10
Williams, D.P.11
Park, B.K.12
-
12
-
-
77957179440
-
Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology
-
Graichen M.E., Neptun D.A., Dent J.G., Popp J.A., Leonard T.B. Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology. Fundam. Appl. Toxicol. 1985, 5:165-174.
-
(1985)
Fundam. Appl. Toxicol.
, vol.5
, pp. 165-174
-
-
Graichen, M.E.1
Neptun, D.A.2
Dent, J.G.3
Popp, J.A.4
Leonard, T.B.5
-
13
-
-
33750622197
-
Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity
-
Green R.M., Graham M., O'Donovan M.R., Chipman J.K., Hodges N.J. Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity. Mutagenesis 2006, 21:383-390.
-
(2006)
Mutagenesis
, vol.21
, pp. 383-390
-
-
Green, R.M.1
Graham, M.2
O'Donovan, M.R.3
Chipman, J.K.4
Hodges, N.J.5
-
14
-
-
0022553887
-
Chemical enhancement of SA7 virus transformation of hamster embryo cells: evaluation by interlaboratory testing of diverse chemicals
-
Hatch G.G., Anderson T.M., Lubet R.A., Kouri R.E., Putman D.L., Cameron J.W., Nims R.W., Most B., Spalding J.W., Tennant R.W., et al. Chemical enhancement of SA7 virus transformation of hamster embryo cells: evaluation by interlaboratory testing of diverse chemicals. Environ. Mutagen. 1986, 8:515-531.
-
(1986)
Environ. Mutagen.
, vol.8
, pp. 515-531
-
-
Hatch, G.G.1
Anderson, T.M.2
Lubet, R.A.3
Kouri, R.E.4
Putman, D.L.5
Cameron, J.W.6
Nims, R.W.7
Most, B.8
Spalding, J.W.9
Tennant, R.W.10
-
15
-
-
0022993558
-
Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation
-
Kammerer R.C., Froines J.R., Price T. Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Food Chem. Toxicol. 1986, 24:981-985.
-
(1986)
Food Chem. Toxicol.
, vol.24
, pp. 981-985
-
-
Kammerer, R.C.1
Froines, J.R.2
Price, T.3
-
16
-
-
0030880605
-
Small sample inference for fixed effects from restricted maximum likelihood
-
Kenward M.G., Roger J.H. Small sample inference for fixed effects from restricted maximum likelihood. Biometrics 1997, 53:983-997.
-
(1997)
Biometrics
, vol.53
, pp. 983-997
-
-
Kenward, M.G.1
Roger, J.H.2
-
17
-
-
0019307495
-
Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride
-
Lijinsky W., Reuber M.D., Blackwell B.N. Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride. Science 1980, 209:817-819.
-
(1980)
Science
, vol.209
, pp. 817-819
-
-
Lijinsky, W.1
Reuber, M.D.2
Blackwell, B.N.3
-
18
-
-
0021068561
-
Failure of methapyrilene to induce tumors in hamsters or guinea pigs
-
Lijinsky W., Knutsen G., Reuber M.D. Failure of methapyrilene to induce tumors in hamsters or guinea pigs. J. Toxicol. Environ. Health 1983, 12:653-657.
-
(1983)
J. Toxicol. Environ. Health
, vol.12
, pp. 653-657
-
-
Lijinsky, W.1
Knutsen, G.2
Reuber, M.D.3
-
20
-
-
69049104063
-
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: induction of cell defence, apoptosis and hepatic necrosis
-
Mercer A.E., Regan S.L., Hirst C.M., Graham E.E., Antoine D.J., Benson C.A., Williams D.P., Foster J., Kenna J.G., Park B.K. Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: induction of cell defence, apoptosis and hepatic necrosis. Toxicol. Appl. Pharmacol. 2009, 239:297-305.
-
(2009)
Toxicol. Appl. Pharmacol.
, vol.239
, pp. 297-305
-
-
Mercer, A.E.1
Regan, S.L.2
Hirst, C.M.3
Graham, E.E.4
Antoine, D.J.5
Benson, C.A.6
Williams, D.P.7
Foster, J.8
Kenna, J.G.9
Park, B.K.10
-
21
-
-
0021193203
-
Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells
-
Ostling O., Johanson K.J. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Commun. 1984, 123:291-298.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.123
, pp. 291-298
-
-
Ostling, O.1
Johanson, K.J.2
-
22
-
-
0032425968
-
Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene
-
Ratra G.S., Cottrell S., Powell C.J. Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene. Toxicol. Sci. 1998, 46:185-196.
-
(1998)
Toxicol. Sci.
, vol.46
, pp. 185-196
-
-
Ratra, G.S.1
Cottrell, S.2
Powell, C.J.3
-
23
-
-
77956448685
-
Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies
-
Rothfuss A., O'Donovan M., De Boeck M., Brault D., Czich A., Custer L., Hamada S., Plappert-Helbig U., Hayashi M., Howe J., Kraynak A.R., van der Leede B.J., Nakajima M., Priestley C., Thybaud V., Saigo K., Sawant S., Shi J., Storer R., Struwe M., Vock E., Galloway S. Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies. Mutat. Res. 2010, 702:40-69.
-
(2010)
Mutat. Res.
, vol.702
, pp. 40-69
-
-
Rothfuss, A.1
O'Donovan, M.2
De Boeck, M.3
Brault, D.4
Czich, A.5
Custer, L.6
Hamada, S.7
Plappert-Helbig, U.8
Hayashi, M.9
Howe, J.10
Kraynak, A.R.11
van der Leede, B.J.12
Nakajima, M.13
Priestley, C.14
Thybaud, V.15
Saigo, K.16
Sawant, S.17
Shi, J.18
Storer, R.19
Struwe, M.20
Vock, E.21
Galloway, S.22
more..
-
24
-
-
0017101039
-
Preparation of isolated rat liver cells
-
Seglen P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 1976, 13:29-83.
-
(1976)
Methods Cell Biol.
, vol.13
, pp. 29-83
-
-
Seglen, P.O.1
-
25
-
-
0023919963
-
A simple technique for quantitation of low levels of DNA damage in individual cells
-
Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
-
(1988)
Exp. Cell Res.
, vol.175
, pp. 184-191
-
-
Singh, N.P.1
McCoy, M.T.2
Tice, R.R.3
Schneider, E.L.4
-
27
-
-
0032212386
-
A review and investigation into the mechanistic basis of the genotoxicity of antihistamines
-
Snyder R.D. A review and investigation into the mechanistic basis of the genotoxicity of antihistamines. Mutat. Res. 1998, 411:235-248.
-
(1998)
Mutat. Res.
, vol.411
, pp. 235-248
-
-
Snyder, R.D.1
-
28
-
-
4043104039
-
Evaluation of DNA intercalation potential of pharmaceuticals and other chemicals by cell-based and three-dimensional computational approaches
-
Snyder R.D., Ewing D.E., Hendry L.B. Evaluation of DNA intercalation potential of pharmaceuticals and other chemicals by cell-based and three-dimensional computational approaches. Environ. Mol. Mutagen. 2004, 44:163-173.
-
(2004)
Environ. Mol. Mutagen.
, vol.44
, pp. 163-173
-
-
Snyder, R.D.1
Ewing, D.E.2
Hendry, L.B.3
-
29
-
-
0023943565
-
Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene
-
Steinmetz K.L., Tyson C.K., Meierhenry E.F., Spalding J.W., Mirsalis J.C. Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. Carcinogenesis 1988, 9:959-963.
-
(1988)
Carcinogenesis
, vol.9
, pp. 959-963
-
-
Steinmetz, K.L.1
Tyson, C.K.2
Meierhenry, E.F.3
Spalding, J.W.4
Mirsalis, J.C.5
-
30
-
-
0034037611
-
Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing
-
Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F. Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
-
(2000)
Environ. Mol. Mutagen.
, vol.35
, pp. 206-221
-
-
Tice, R.R.1
Agurell, E.2
Anderson, D.3
Burlinson, B.4
Hartmann, A.5
Kobayashi, H.6
Miyamae, Y.7
Rojas, E.8
Ryu, J.C.9
Sasaki, Y.F.10
-
31
-
-
45949114979
-
Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK+/- mouse lymphoma assay
-
Turner N.T., Woolley J.L., Hozier J.C., Sawyer J.R., Clive D. Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK+/- mouse lymphoma assay. Mutat. Res. 1987, 189:285-297.
-
(1987)
Mutat. Res.
, vol.189
, pp. 285-297
-
-
Turner, N.T.1
Woolley, J.L.2
Hozier, J.C.3
Sawyer, J.R.4
Clive, D.5
-
32
-
-
0027946067
-
A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol
-
Vandeputte C., Guizon I., Genestie-Denis I., Vannier B., Lorenzon G. A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol. Cell Biol. Toxicol. 1994, 10:415-421.
-
(1994)
Cell Biol. Toxicol.
, vol.10
, pp. 415-421
-
-
Vandeputte, C.1
Guizon, I.2
Genestie-Denis, I.3
Vannier, B.4
Lorenzon, G.5
-
33
-
-
1542271924
-
Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene
-
Waring J.F., Ulrich R.G., Flint N., Morfitt D., Kalkuhl A., Staedtler F., Lawton M., Beekman J.M., Suter L. Interlaboratory evaluation of rat hepatic gene expression changes induced by methapyrilene. Environ. Health Perspect. 2004, 112:439-448.
-
(2004)
Environ. Health Perspect.
, vol.112
, pp. 439-448
-
-
Waring, J.F.1
Ulrich, R.G.2
Flint, N.3
Morfitt, D.4
Kalkuhl, A.5
Staedtler, F.6
Lawton, M.7
Beekman, J.M.8
Suter, L.9
-
34
-
-
1542376929
-
Glutathione metabolism and its implications for health
-
Wu G., Fang Y.Z., Yang S., Lupton J.R., Turner N.D. Glutathione metabolism and its implications for health. J. Nutr. 2004, 134:489-492.
-
(2004)
J. Nutr.
, vol.134
, pp. 489-492
-
-
Wu, G.1
Fang, Y.Z.2
Yang, S.3
Lupton, J.R.4
Turner, N.D.5
-
35
-
-
84858624411
-
Glutathione in liver diseases and hepatotoxicity
-
Yuan L., Kaplowitz N. Glutathione in liver diseases and hepatotoxicity. Mol. Aspects Med. 2008.
-
(2008)
Mol. Aspects Med.
-
-
Yuan, L.1
Kaplowitz, N.2
|