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Volumn 290, Issue 2-3, 2011, Pages 249-257

The genotoxic potential of methapyrilene using the alkaline Comet assay in vitro and in vivo

Author keywords

Comet assay; Genotoxicity; Methapyrilene; Oxidative DNA damage

Indexed keywords

1 AMINOBENZOTRIAZOLE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LIVER ENZYME; MALEIC ACID DIETHYL ESTER; METHAPYRILENE; SUPEROXIDE DISMUTASE;

EID: 84858624011     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2011.10.002     Document Type: Article
Times cited : (8)

References (35)
  • 2
    • 30344446981 scopus 로고    scopus 로고
    • Gene expression analysis of the hepatotoxicant methapyrilene in primary rat hepatocytes: an interlaboratory study
    • Beekman J.M., Boess F., Hildebrand H., Kalkuhl A., Suter L. Gene expression analysis of the hepatotoxicant methapyrilene in primary rat hepatocytes: an interlaboratory study. Environ. Health Perspect. 2006, 114:92-99.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 92-99
    • Beekman, J.M.1    Boess, F.2    Hildebrand, H.3    Kalkuhl, A.4    Suter, L.5
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 0021349102 scopus 로고
    • A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay
    • Budroe J.D., Shaddock J.G., Casciano D.A. A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay. Mutat. Res. 1984, 135:131-137.
    • (1984) Mutat. Res. , vol.135 , pp. 131-137
    • Budroe, J.D.1    Shaddock, J.G.2    Casciano, D.A.3
  • 6
    • 0021324775 scopus 로고
    • Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay
    • Casciano D.A., Schol H.M. Methapyrilene is inactive in the hepatocyte-mediated Chinese hamster ovary/hypoxanthine-guanine phosphoribosyl transferase mutational assay. Cancer Lett. 1984, 21:337-341.
    • (1984) Cancer Lett. , vol.21 , pp. 337-341
    • Casciano, D.A.1    Schol, H.M.2
  • 7
    • 0023732831 scopus 로고
    • The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats
    • Casciano D.A., Shaddock J.G., Talaska G. The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fischer 344 rats. Mutat. Res. 1988, 208:129-135.
    • (1988) Mutat. Res. , vol.208 , pp. 129-135
    • Casciano, D.A.1    Shaddock, J.G.2    Talaska, G.3
  • 8
    • 0025736679 scopus 로고
    • The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation
    • Casciano D.A., Talaska G., Clive D. The potent hepatocarcinogen methapyrilene induces mutations in L5178Y mouse lymphoma cells in the apparent absence of DNA adduct formation. Mutat. Res. 1991, 263:127-132.
    • (1991) Mutat. Res. , vol.263 , pp. 127-132
    • Casciano, D.A.1    Talaska, G.2    Clive, D.3
  • 9
    • 68349125412 scopus 로고    scopus 로고
    • A novel and simple method of screening compounds for interaction with DNA: a validation study
    • Garas A., Webb E., Pillay V., MacPhee D., Denny W., Zeller H., Cotton R. A novel and simple method of screening compounds for interaction with DNA: a validation study. Mutat. Res. 2009, 678:20-29.
    • (2009) Mutat. Res. , vol.678 , pp. 20-29
    • Garas, A.1    Webb, E.2    Pillay, V.3    MacPhee, D.4    Denny, W.5    Zeller, H.6    Cotton, R.7
  • 10
    • 84858617517 scopus 로고
    • Least Squares Means in the Fixed-Effects General Linear Model, SAS Technical Report No. R-103, SAS Institute.
    • Goodnight, J.H., Harvey, W.R., 1978. Least Squares Means in the Fixed-Effects General Linear Model, SAS Technical Report No. R-103, SAS Institute.
    • (1978)
    • Goodnight, J.H.1    Harvey, W.R.2
  • 12
    • 77957179440 scopus 로고
    • Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology
    • Graichen M.E., Neptun D.A., Dent J.G., Popp J.A., Leonard T.B. Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology. Fundam. Appl. Toxicol. 1985, 5:165-174.
    • (1985) Fundam. Appl. Toxicol. , vol.5 , pp. 165-174
    • Graichen, M.E.1    Neptun, D.A.2    Dent, J.G.3    Popp, J.A.4    Leonard, T.B.5
  • 13
    • 33750622197 scopus 로고    scopus 로고
    • Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity
    • Green R.M., Graham M., O'Donovan M.R., Chipman J.K., Hodges N.J. Subcellular compartmentalization of glutathione: correlations with parameters of oxidative stress related to genotoxicity. Mutagenesis 2006, 21:383-390.
    • (2006) Mutagenesis , vol.21 , pp. 383-390
    • Green, R.M.1    Graham, M.2    O'Donovan, M.R.3    Chipman, J.K.4    Hodges, N.J.5
  • 15
    • 0022993558 scopus 로고
    • Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation
    • Kammerer R.C., Froines J.R., Price T. Mutagenicity studies of selected antihistamines, their metabolites and products of nitrosation. Food Chem. Toxicol. 1986, 24:981-985.
    • (1986) Food Chem. Toxicol. , vol.24 , pp. 981-985
    • Kammerer, R.C.1    Froines, J.R.2    Price, T.3
  • 16
    • 0030880605 scopus 로고    scopus 로고
    • Small sample inference for fixed effects from restricted maximum likelihood
    • Kenward M.G., Roger J.H. Small sample inference for fixed effects from restricted maximum likelihood. Biometrics 1997, 53:983-997.
    • (1997) Biometrics , vol.53 , pp. 983-997
    • Kenward, M.G.1    Roger, J.H.2
  • 17
    • 0019307495 scopus 로고
    • Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride
    • Lijinsky W., Reuber M.D., Blackwell B.N. Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride. Science 1980, 209:817-819.
    • (1980) Science , vol.209 , pp. 817-819
    • Lijinsky, W.1    Reuber, M.D.2    Blackwell, B.N.3
  • 18
    • 0021068561 scopus 로고
    • Failure of methapyrilene to induce tumors in hamsters or guinea pigs
    • Lijinsky W., Knutsen G., Reuber M.D. Failure of methapyrilene to induce tumors in hamsters or guinea pigs. J. Toxicol. Environ. Health 1983, 12:653-657.
    • (1983) J. Toxicol. Environ. Health , vol.12 , pp. 653-657
    • Lijinsky, W.1    Knutsen, G.2    Reuber, M.D.3
  • 20
    • 69049104063 scopus 로고    scopus 로고
    • Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: induction of cell defence, apoptosis and hepatic necrosis
    • Mercer A.E., Regan S.L., Hirst C.M., Graham E.E., Antoine D.J., Benson C.A., Williams D.P., Foster J., Kenna J.G., Park B.K. Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: induction of cell defence, apoptosis and hepatic necrosis. Toxicol. Appl. Pharmacol. 2009, 239:297-305.
    • (2009) Toxicol. Appl. Pharmacol. , vol.239 , pp. 297-305
    • Mercer, A.E.1    Regan, S.L.2    Hirst, C.M.3    Graham, E.E.4    Antoine, D.J.5    Benson, C.A.6    Williams, D.P.7    Foster, J.8    Kenna, J.G.9    Park, B.K.10
  • 21
    • 0021193203 scopus 로고
    • Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells
    • Ostling O., Johanson K.J. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem. Biophys. Res. Commun. 1984, 123:291-298.
    • (1984) Biochem. Biophys. Res. Commun. , vol.123 , pp. 291-298
    • Ostling, O.1    Johanson, K.J.2
  • 22
    • 0032425968 scopus 로고    scopus 로고
    • Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene
    • Ratra G.S., Cottrell S., Powell C.J. Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene. Toxicol. Sci. 1998, 46:185-196.
    • (1998) Toxicol. Sci. , vol.46 , pp. 185-196
    • Ratra, G.S.1    Cottrell, S.2    Powell, C.J.3
  • 24
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Seglen P.O. Preparation of isolated rat liver cells. Methods Cell Biol. 1976, 13:29-83.
    • (1976) Methods Cell Biol. , vol.13 , pp. 29-83
    • Seglen, P.O.1
  • 25
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 27
    • 0032212386 scopus 로고    scopus 로고
    • A review and investigation into the mechanistic basis of the genotoxicity of antihistamines
    • Snyder R.D. A review and investigation into the mechanistic basis of the genotoxicity of antihistamines. Mutat. Res. 1998, 411:235-248.
    • (1998) Mutat. Res. , vol.411 , pp. 235-248
    • Snyder, R.D.1
  • 28
    • 4043104039 scopus 로고    scopus 로고
    • Evaluation of DNA intercalation potential of pharmaceuticals and other chemicals by cell-based and three-dimensional computational approaches
    • Snyder R.D., Ewing D.E., Hendry L.B. Evaluation of DNA intercalation potential of pharmaceuticals and other chemicals by cell-based and three-dimensional computational approaches. Environ. Mol. Mutagen. 2004, 44:163-173.
    • (2004) Environ. Mol. Mutagen. , vol.44 , pp. 163-173
    • Snyder, R.D.1    Ewing, D.E.2    Hendry, L.B.3
  • 29
    • 0023943565 scopus 로고
    • Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene
    • Steinmetz K.L., Tyson C.K., Meierhenry E.F., Spalding J.W., Mirsalis J.C. Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene. Carcinogenesis 1988, 9:959-963.
    • (1988) Carcinogenesis , vol.9 , pp. 959-963
    • Steinmetz, K.L.1    Tyson, C.K.2    Meierhenry, E.F.3    Spalding, J.W.4    Mirsalis, J.C.5
  • 31
    • 45949114979 scopus 로고
    • Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK+/- mouse lymphoma assay
    • Turner N.T., Woolley J.L., Hozier J.C., Sawyer J.R., Clive D. Methapyrilene is a genotoxic carcinogen: studies on methapyrilene and pyrilamine in the L5178Y/TK+/- mouse lymphoma assay. Mutat. Res. 1987, 189:285-297.
    • (1987) Mutat. Res. , vol.189 , pp. 285-297
    • Turner, N.T.1    Woolley, J.L.2    Hozier, J.C.3    Sawyer, J.R.4    Clive, D.5
  • 32
    • 0027946067 scopus 로고
    • A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol
    • Vandeputte C., Guizon I., Genestie-Denis I., Vannier B., Lorenzon G. A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol. Cell Biol. Toxicol. 1994, 10:415-421.
    • (1994) Cell Biol. Toxicol. , vol.10 , pp. 415-421
    • Vandeputte, C.1    Guizon, I.2    Genestie-Denis, I.3    Vannier, B.4    Lorenzon, G.5
  • 34
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu G., Fang Y.Z., Yang S., Lupton J.R., Turner N.D. Glutathione metabolism and its implications for health. J. Nutr. 2004, 134:489-492.
    • (2004) J. Nutr. , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3    Lupton, J.R.4    Turner, N.D.5
  • 35
    • 84858624411 scopus 로고    scopus 로고
    • Glutathione in liver diseases and hepatotoxicity
    • Yuan L., Kaplowitz N. Glutathione in liver diseases and hepatotoxicity. Mol. Aspects Med. 2008.
    • (2008) Mol. Aspects Med.
    • Yuan, L.1    Kaplowitz, N.2


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