Addressing Both Depression and Pain in Late Life: The Methodology of the ADAPT Study

Pain Medicine

Volumn 13, Issue 3, 2012, Pages 405-418

  Karp, Jordan F ^a   Rollman, Bruce L ^a   Reynolds, Charles F ^a   Morse, Jennifer Q ^a   Lotrich, Frank ^a   Mazumdar, Sati ^a   Morone, Natalia ^a   Weiner, Debra K ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Back pain; Clinical trial; Depression; Geriatrics; Survival analysis

Indexed keywords

VENLAFAXINE;

ARTICLE; CHRONIC LOW BACK PAIN; CHRONIC PAIN; COMORBIDITY; DEPRESSION; DISABILITY; DRUG EFFICACY; DRUG MEGADOSE; HUMAN; LOW BACK PAIN; METHODOLOGY; PAIN ASSESSMENT; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROBLEM SOLVING; RANDOMIZED CONTROLLED TRIAL (TOPIC); RATING SCALE; SELF REPORT; SURVIVAL; TREATMENT RESPONSE;

EID: 84858622379     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2011.01322.x     Document Type: Article

References (97)

1. Reid MC, Williams CS, Concato J, Tinetti ME, Gill TM. Depressive symptoms as a risk factor for disabling back pain in community-dwelling older persons. J Am Geriatr Soc 2003;51:1710-7.
2. Fishbain DA, Cutler R, Rosomoff HL, Rosomoff RS. Chronic pain-associated depression: Antecedent or consequence of chronic pain? A review. Clin J Pain 1997;13:116-37.
3. Rudy TE, Kerns RD, Turk DC. Chronic pain and depression: Toward a cognitive-behavioral mediation model. Pain 1988;35:129-40.
4. Lin EH, Katon W, Von Korff M, etal. Effect of improving depression care on pain and functional outcomes among older adults with arthritis: A randomized controlled trial. (see comment) (comment). JAMA 2003;290:2428-9.
5. Dunn KM, Croft PR. Classification of low back pain in primary care: Using "bothersomeness" to identify the most severe cases. Spine 2005;30:1887-92.
6. Karp J, Scott J, Houck P, etal. Pain predicts longer time to remission during treatment of recurrent depression. J Clin Psychiatry 2005;66:591-7.
7. Karp J, Weiner D, Seligman K, etal. Body pain and treatment response in late-life depression. Am J Geriatr Psychiatry 2005;13:188-94.
8. Mavandadi S, Ten Have TR, Katz IR, etal. Effect of depression treatment on depressive symptoms in older adulthood: The moderating role of pain. J Am Geriatr Soc 2007;55:202-11.
9. Fishbain DA, Bruns D, Disorbio JM, Lewis JE. Risk for five forms of suicidality in acute pain patients and chronic pain patients vs pain-free community controls. Pain Med 2009;10:1095-105.
10. Szanto K, Mulsant BH, Houck PR, etal. Emergence, persistence, and resolution of suicidal ideation during treatment of depression in old age. J Affect Disord 2007;98:153-61.
11. Fishbain DA. Polypharmacy treatment approaches to the psychiatric and somatic comorbidities found in patients with chronic pain. Am J Phys Med Rehabil 2005;84:S56-63.
12. Weiner DK, Rudy TE, Morrow L, Slaboda J, Lieber S. The relationship between pain, neuropsychological performance, and physical function in community-dwelling older adults with chronic low back pain. Pain Med 2006;7:60-70.
13. Karp J, Skidmore E, Lotz M, etal. Use of the late-life function and disability instrument to assess disability in major depression. J Am Geriatr Soc 2009;57:1612-19.
14. Karp JF, Reynolds CF, Butters MA, etal. The relationship between pain and mental flexibility in older adult pain clinic patients. Pain Med 2006;7:444-52.
15. Bhalla RK, Butters MA, Mulsant BH, etal. Persistence of neuropsychologic deficits in the remitted state of late-life depression. Am J Geriatr Psychiatry 2006;14:419-27.
16. Martire L, Schulz R, Karp J, etal. Treatment of late-life depression alleviates caregiver burden. J Am Geriatr Soc 2010;58(1):23-9.
17. Moskowitz M, Fishman S. The neurobiological and therapeutic intersection of pain and affective disorders. Focus 2006;IV:465-71.
18. Seligman ME. Learned helplessness. Annu Rev Med 1972;23:407-12.
19. Lyness JM, Caine ED, King DA, Cox C, Yoediono Z. Psychiatric disorders in older primary care patients. J Gen Intern Med 1999;14:249-54.
20. Freburger JK, Holmes GM, Agans RP, etal. The rising prevalence of chronic low back pain. Arch Intern Med 2009;169:251-8.
21. Morone N, Karp J, Lynch C, etal. Impact of chronic musculoskeletal pathology on older adults: A study of differences between knee OA and low back pain. Pain Med 2009;10:693-701.
22. Kroenke K, Bair MJ, Damush TM, etal. Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: A randomized controlled trial. JAMA 2009;301:2099-110.
23. Summerfelt WT, Meltzer HY. Efficacy vs effectiveness in psychiatric research. Psychiatr Serv 1998;49:834-5.
24. Stampfer MJ, Buring JE, Willett W, etal. The 2×2 factorial design: Its application to a randomized trial of aspirin and carotene in U.S. physicians. Stat Med 1985;4:111-6.
25. Pahor M, Guralnik JM, Wan JY, etal. Lower body osteoarticular pain and dose of analgesic medications in older disabled women: The Women's Health and Aging Study. Am J Public Health 1999;89:930-4.
26. Miller MD, Paradis CF, Houck PR, etal. Rating chronic medical illness burden in geropsychiatric practice and research: Application of the Cumulative Illness Rating Scale. Psychiatry Res 1992;41:237-48.
27. Harvey AT, Rudolph RL, Preskorn SH. Evidence of the dual mechanisms of action of venlafaxine. Arch Gen Psychiatry 2000;57:503-9.
28. Nierenberg AA, Farabaugh AH, Alpert JE, etal. Timing of onset of antidepressant response with fluoxetine treatment. Am J Psychiatry 2000;157:1423-8.
29. Skljarevski V, Desaiah D, Liu-Seifert H, etal. Efficacy and safety of duloxetine in patients with chronic low back pain. Spine 2010;35:E578-85.
30. Karp J, Weiner D, Dew M, Begley A, Reynolds C III. Duloxetine and care management treatment of older adults with comorbid major depressive disorder and chronic low back pain: Results of an open-label trial. Int J Geriatr Psychiatry 2010;25(6):633-42.
31. Lyness JM, Niculescu A, Tu X, Reynolds CF III, Caine ED. The relationship of medical comorbidity and depression in older, primary care patients. Psychosomatics 2006;47:435-9.
32. Apkarian AV, Sosa Y, Sonty S, etal. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 2004;24:10410-5.
33. Sheline YI, Sanghavi M, Mintun MA, Gado MH. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 1999;19:5034-43.
34. Montamat SC, Cusack BJ, Vestal RE. Management of drug therapy in the elderly. New Engl J Med 1989;321:303-9.
35. Arean PA, Raue P, Mackin RS, etal. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. Am J Psychiatry 2010;167:1391-8.
36. Dobscha SK, Corson K, Perrin NA, etal. Collaborative care for chronic pain in primary care: A cluster randomized trial. JAMA 2009;301:1242-52.
37. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
38. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med 2001;16:606-13.
39. Löwe B, Kroenke K, Herzog W, Gräfe K. Measuring depression outcome with a brief self-report instrument: Sensitivity to change of the Patient Health Questionnaire (PHQ-9). J Affect Disord 2004;81:61-6.
40. Spitzer RL, Kroenke K, Williams JB. Validation and utility of a self-report version of PRIME-MD: The PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 1999;282:1737-44.
41. Herr KA, Garand L. Assessment and measurement of pain in older adults. Clin Geriatr Med 2001;17:457-78.
42. Melzack R. The short-form McGill Pain Questionnaire. Pain 1987;30:191-7.
43. Felson DT, Naimark A, Anderson J, etal. The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum 1987;30:914-8.
44. Creamer P, Flores R, Hochberg MC. Management of osteoarthritis in older adults. Clin Geriatr Med 1998;14:435-54.
45. Hanks G, Cherny N. Opioid analgesic therapy. In: Doyle D, Hanks G, MacDonald N, eds. Oxford Textbook of Palliative Medicine. Oxford: Oxford University Press; 1998:331-55.
46. Debonnel G, Saint-Andre E, Hebert C, etal. Differential physiological effects of a low dose and high doses of venlafaxine in major depression. Int J Neuropsychopharmacol 2007;10:51-61.
47. Bradley RH, Barkin RL, Jerome J, DeYoung K, Dodge CW. Efficacy of venlafaxine for the long term treatment of chronic pain with associated major depressive disorder. Am J Ther 2003;10:318-23.
48. Begre S, Traber M, Gerber M, von Kanel R. Change in pain severity with open label venlafaxine use in patients with a depressive symptomatology: An observational study in primary care. Eur Psychiatry 2008;23:178-86.
49. Kadiroglu AK, Sit D, Kayabasi H, etal. The effect of venlafaxine HCl on painful peripheral diabetic neuropathy in patients with type 2 diabetes mellitus. J Diabetes Complications 2008;22:241-5.
50. Marchand F, Alloui A, Chapuy E, etal. The antihyperalgesic effect of venlafaxine in diabetic rats does not involve the opioid system. Neurosci Lett 2003;342:105-8.
51. Marchand F, Alloui A, Pelissier T, etal. Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat. Brain Res 2003;980:117-20.
52. Sullivan M, Bentley S, Fan MY, Gardner G. A single-blind placebo run-in study of venlafaxine XR for activity-limiting osteoarthritis pain. Pain Med 2009;10:806-12.
53. Fick DM, Cooper JW, Wade WE, etal. Updating the Beers criteria for potentially inappropriate medication use in older adults: Results of a US consensus panel of experts. Arch Intern Med 2003;163:2716-24.
54. Arean P, Hegel M, Vannoy S, Fan M-Y, Unuzter J. Effectiveness of problem-solving therapy for older, primary care patients with depression: Results from the IMPACT project. Gerontologist 2008;48:311-23.
55. Areán PA, Cook BL. Psychotherapy and combined psychotherapy/pharmacotherapy for late life depression. Biol Psychiatry 2002;52:293-303.
56. Nezu AM, Nezu CM, Felgoise SH, McClure KS, Houts PS. Project Genesis: Assessing the efficacy of problem-solving therapy for distressed adult cancer patients. J Consult Clin Psychol 2003;71:1036-48.
57. Nezu AM, Nezu CM, Jain D, etal. Social problem solving and noncardiac chest pain. Psychosom Med 2007;69(9):944-51.
58. Teri L, Logsdon RG, Uomoto J, McCurry SM. Behavioral treatment of depression in dementia patients: A controlled clinical trial. J Gerontol B Psychol Sci Soc Sci 1997;52:P159-66.
59. Mynors-Wallis LM, Gath DH, Day A, Baker F. Randomised controlled trial of problem solving treatment, antidepressant medication, and combined treatment for major depression in primary care (see comment). BMJ (Clinical Research ed.) 2000;320:26-30.
60. Mynors-Wallis LM, Gath DH, Lloyd-Thomas AR, Tomlinson D. Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care. (see comment). BMJ (Clinical Research ed.) 1995;310:441-5.
61. Warmerdam L, van Straten A, Twisk J, Riper H, Cuijpers P. Internet-based treatment for adults with depressive symptoms: Randomized controlled trial. J BMC Psychiatry 2007;7:72.
62. Hegel M, Arean PA. Problem-Solving Treatment for Primary Care (PST-PC): A Treatment Manual for Depression. Hanover, NH: Dartmouth University; 2003.
63. Alexopoulos GS, Raue P, Arean P. Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction. Am J Geriatr Psychiatry 2003;11:46-52.
64. van den Hout JHC, Vlaeyen JWS, Heuts PHTG, Zijlema JHL, Wijnen JAG. Secondary prevention of work-related disability in nonspecific low back pain: Does problem-solving therapy help? A randomized clinical trial. Clin J Pain 2003;19:87-96.
65. D'Zurilla T, Nezu A. Problem-solving therapies. In: Dobson K, ed. Handbook of Cognitive-Behavioral Therapies. New York: Guilford Press; 2001:211-45.
66. Bandura A. The Exercise of Control. New York: Freeman; 1997.
67. Burton K. The Back Book. England: The Stationary Office Books; 2002.
68. Germain A, Moul DE, Franzen PL, etal. Effects of a brief behavioral treatment for late-life insomnia: Preliminary findings. J Clin Sleep Med 2006;2:403-6.
69. D'Zurilla T, Nezu A, Maydeu-Olivares A. Social Problem Solving Inventory-Revised (SPSI-R). North Tonawanda, NY: Multi-health Systems Inc; 2002.
70. Heapy AA, Stroud MW, Higgins DM, Sellinger JJ. Tailoring cognitive-behavioral therapy for chronic pain: A case example. J Clin Psychol 2006;62:1345-54.
71. Rollman BL, Belnap BH, LeMenager MS, etal. The Bypassing the Blues treatment protocol: Stepped collaborative care for treating post-CABG depression. Psychosom Med 2009;71(2):217-30.
72. Kroenke K, Spitzer R. The PHQ-9: A new depression and diagnostic severity measure. Psychiatr Ann 2002;32:509-21.
73. Farrar JT. What is clinically meaningful: Outcome measures in pain clinical trials. Clin J Pain 2000;16:S106-12.
74. Farrar JT, Portenoy RK, Berlin JA, Kinman JL, Strom BL. Defining the clinically important difference in pain outcome measures. Pain 2001;88:287-94.
75. Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole RM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. [see comment]. Pain 2001;94:149-58.
76. Rollman B, Fischer G, Zhu F, Belnap B. Comparison of electronic physician prompts versus waitroom case-finding on clinical trial enrollment. J Gen Intern Med 2008;23:447-50.
77. Sayar K, Aksu G, Ak I, Tosun M. Venlafaxine treatment of fibromyalgia. Ann Pharmacother 2003;37:1561-5.
78. Weiner DK, Sakamoto S, Perera S, Breuer P. Chronic low back pain in older adults: Prevalence, reliability, and validity of physical examination findings. J Am Geriatr Soc 2006;54:11-20.
79. Kirkaldy-Willis WH, Hill RJ. A more precise diagnosis for low-back pain. Spine 1979;4:102-9.
80. Kernan WN, Viscoli CM, Makuch RW, Brass LM, Horwitz RI. Stratified randomization for clinical trials. J Clin Epidemiol 1999;52:19-26.
81. Roland M, Morris R. A study of the natural history of back pain. Part I: Development of a reliable and sensitive measure of disability in low-back pain. Spine 1983;8:141-4.
82. Anderson KO, Dowds BN, Pelletz RE, Edwards WT, Peeters-Asdourian C. Development and initial validation of a scale to measure self-efficacy beliefs in patients with chronic pain. Pain 1995;63:77-84.
83. Georgotas A, McCue RE, Cooper TB. A placebo-controlled comparison of nortriptyline and phenelzine in maintenance therapy of elderly depressed patients. Arch Gen Psychiatry 1989;46:783-6.
84. Karp J, Whyte E, Lenze E, etal. Rescue pharmacotherapy with duloxetine for SSRI non-responders in late-life depression: Outcome and tolerability. J Clin Psychiatry 2008;69:457-63.
85. Whyte EM, Basinski J, Farhi P, etal. Geriatric depression treatment in nonresponders to selective serotonin reuptake inhibitors. J Clin Psychiatry 2004;65:1634-41.
86. Raskin J, Wiltse CG, Siegal A, etal. Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: An 8-week, double-blind, placebo-controlled trial. Am J Psychiatry 2007;164:900-9.
87. Hopko DR, Lejuez CW, LePage JP, Hopko SD, McNeil DW. A brief behavioral activation treatment for depression. A randomized pilot trial within an inpatient psychiatric hospital. Behav Modif 2003;27:458-69.
88. Katon W, Robinson P, Von Korff M, etal. A multifaceted intervention to improve treatment of depression in primary care. Arch Gen Psychiatry 1996;53:924-32.
89. Glombiewski JA, Hartwich-Tersek J, Rief W. Two psychological interventions are effective in severely disabled, chronic back pain patients: A randomised controlled trial. Int J Behav Med 2010;17:97-107.
90. Cheong J, MacKinnon D, Khoo S. Investigation of mediational processes using parallel process latent growth curve modeling. Struct Equ Modeling 2003;10:238-62.
91. Kraemer HC, Stice E, Kazdin A, Offord D, Kupfer D. How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. Am J Psychiatry 2001;158:848-56.
92. Royall DR, Mahurin RK, Gray KF. Bedside assessment of executive cognitive impairment: The executive interview. J Am Geriatr Soc 1992;40:1221-6.
93. Vanderploeg RD, Schinka JA, Jones T, etal. Elderly norms for the Hopkins Verbal Learning Test-Revised. Clin Neuropsychol 2000;14:318-24.
94. Mazumdar S, Houck PR, Liu KS, etal. Intent-to-treat analysis for clinical trials: Use of data collected after termination of treatment protocol. J Psychiatr Res 2002;36:153-64.
95. Morone NE, Weiner DK, Belnap BH, etal. The impact of pain and depression on recovery after coronary artery bypass grafting. Psychosom Med 2010;72:620-5.
96. Thielke S, Fan M, Sullivan M, Unutzer J. Pain limits the effectiveness of collaborative care for depression. Am J Geriatr Psychiatry 2007;15:699-707.
97. Solomon DH, Rassen JA, Glynn RJ, etal. The comparative safety of opioids for nonmalignant pain in older adults. Arch Intern Med 2010;170(22):1979-86.