Workplace exposure to nanoparticles and the application of provisional nanoreference values in times of uncertain risks

Journal of Nanoparticle Research

Volumn 14, Issue 4, 2012, Pages

  Van Broekhuizen, Pieter ^a   Van Broekhuizen, Fleur ^a   Cornelissen, Ralf ^a   Reijnders, Lucas ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Exposure Measurement; Health effects; Nano reference value; Nanomaterial; Nanoparticle; Occupational Exposure Limit; Risk management

Indexed keywords

AUTOMOTIVE INDUSTRY; CALCITE; CALCIUM CARBONATE; GLASS INDUSTRY; HEALTH RISKS; MANUFACTURE; NANOPARTICLES; NANOSTRUCTURED MATERIALS; PAINT; RISK ASSESSMENT; RISK MANAGEMENT; STATISTICAL METHODS;

CONVENTIONAL COMPONENTS; EQUIPMENT MANUFACTURING; EXPOSURE MEASUREMENT; HEALTH EFFECTS; NANO REFERENCE VALUES; NANO-SIZED PARTICULATES; OCCUPATIONAL EXPOSURE LIMITS; TIME-WEIGHTED AVERAGES;

OCCUPATIONAL RISKS;

CALCIUM CARBONATE; NANOMATERIAL; NANOPARTICLE; PIGMENT;

ARTICLE; CAR; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROPLATING INDUSTRY; GLASS INDUSTRY; HEATING; HUMAN; LIGHT; NANOREFERENCE VALUE; OCCUPATIONAL EXPOSURE; PAINT INDUSTRY; PRIORITY JOURNAL; REFERENCE VALUE; RISK ASSESSMENT; RISK MANAGEMENT; WORK ENVIRONMENT; WORKER;

EID: 84858600113     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-012-0770-3     Document Type: Article

References (53)

1. Abbott LC,MaynardAD(2010) Exposure assessment approaches for engineered nanomaterials. Risk Anal 30(11):1634-1644
2. Aschberger K, Christensen FM (2010) Approaches for establishing human health no effect levels for engineered nanomaterials. J Phys. doi:10.1088/1742-6596/304/1/012078
3. Auffan M, Rose J, Bottero JY, Lowry GV, Jolivet JP, Wiesner MR (2009) Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective. Nat Nanotechnol 4:634-641
4. Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77:347-357 (Pubitemid 38262608)
5. BéruBé K, Balharry D, Sexton K, Koshy L, Jones T (2007) Combustion-derived nanoparticles: mechanisms of pulmonary toxicity. Clin Exp Pharmacol Physiol 34(10): 1044-1050 (Pubitemid 47274565)
6. Borm PJA, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Roel S, Stone V, Kreyling W, Lademann J, Krutmann J (2006) The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol 3:11
7. Brouwer D (2010) Exposure to manufactured nanoparticles in different workplaces. Toxicology 269:120-127
8. Brouwer D, van Duuren-Stuurman B, Berges M, Jankowska E, Bard D, Mark D (2009) From workplace air measurement results toward estimates of exposure? Development of a strategy to assess exposure to manufactured nano-objects. J Nanopart Res 11:1867-1881
9. BSI (2007) BSI-British Standards. Guide to safe handling and disposal of manufactured nanomaterials. Nanotechnologies-Part 2. PD 6699-2:2007 BSI (2007). http://www.bsigroup.com/en/sectorsandservices/Forms/PD-6699-2/ Download-PD6699-2-2007/. Accessed 29 April 2011
10. Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, Bawendi MG, Semmler-Behnke M, Frangioni JV, Tsuda A (2010) Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 28:1300-1304
11. Dekkers S, de Heer C (2010) Tijdelijke nano-referentiewaarden. RIVM Rapport 601044001/2010. http://docs.minszw.nl/pdf/190/2010/190-2010-3-14399.pdf
12. Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, MacNee W, Stone V (2005) Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2:10. doi:10.1186/1743-8977-2- 10 (Pubitemid 44848690)
13. Dorbeck-Jung B (2011) Soft regulation and responsible nanotechnological development in the European Union: Regulating occupational health and safety in the Netherlands. Eur J Law Technol 2(3):1-14
14. EC (2011) Commission recommendation of 18 October 2011 on the definition of nanomaterial (2011/696/EU). L Official Journal of the European Union 275/38 20.10.2011. http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2011:275: 0038:0040:EN:PDF
15. ECHA (2008) Guidance on information requirements and chemical safety assessment. Chap. 14. Occupational exposure estimation
16. Evans DE, Heitbrink WA, Slavin TJ, PetersTM (2008) Ultrafine and respirable particles in an automotive grey iron foundry. Ann Occup Hyg 52(1):9-21
17. Göhler D, Stintz M, Hillemann L, Vorbau M (2010) Characterization of nanoparticle release from surface coatings by the simulation of a sanding process. Ann Occup Hyg 54(6):615-624
18. Heitbrink WA, Evans DE, Ku BK, Maynard AD, Slavin TJ, Peters TM (2009) Relationships among particle number, surface area, and respirable mass concentrations in automotive engine manufacturing. J Occup Environ Hyg 6:19-31. doi:10.1080/15459620802530096
19. Hesterberg TW, Long CM, Lapin CA, Hamade AK, Valberg PA (2010) Diesel exhaust particulate (DEP) and nanoparticle exposures: what do DEP human clinical studies tell us about potential human health hazards of nanoparticles? Inhal Toxicol 22(8):679-694
20. IFA (2009) Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung, criteria for assessment of the effectiveness of protective measures. http://www.dguv.de/ifa/en/fac/nanopartikel/beurteilungsmassstaebe/ index.jsp. Accessed 29 April 2011
21. Kreyling WG, Hirn S, Schleh C (2010) Nanoparticles in the lung. Nat Biotechnol 28(12):1275-1276
22. Lee JH, Kwon M, Ji JH, Kang CS, Ahn KH, Han JH, Yu IJ (2011) Exposure assessment of workplaces manufacturing nanosized TiO2 and silver. Inhal Toxicol 23(4):226-236
23. Marra J, Voetz M, Kiesling HJ (2010) Monitor for detecting and assessing exposure to airborne nanoparticles. J Nanopart Res 12:21-37
24. Murphy FA, Poland CA, Duffin R, Al-Jamal KT, Ali-Boucetta H, Nunes A, Byrne F, Prina-Mello A, Volkov Y, Li S, Mather SJ, Bianco A, Prato M, MacNee W, Wallace WA, Kostarelos K, Donaldson K (2011) Length-dependent retention of carbon nanotubesin the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. Am J Pathol 178(6):2587-2600
25. NIOSH (2010) Occupational exposure to carbon nanotubes and nanofibers. Curr Intell Bull 161-A:1-149
26. NIOSH (2011) Occupational exposure to titanium dioxide. Curr Intell Bull 63:1-119. DHHS (NIOSH) Publication No. 2011-160
27. Oberdorster G, Oberdorster E, Oberdorster J (2004) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7): 823-839
28. Pauluhn J (2010) Poorly soluble particulates: searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation. Toxicology 279(1-3):176-188
29. Peters TM, Heitbrink WA, Evans DE, Slavin TJ, Maynard AD (2006) The mapping of fine and ultrafine particle concentrations in an engine machining and assembly facility. Ann Occup Hyg 50(3):249-257
30. Plitzko S (2009) Workplace exposure to engineered nanoparticles. Inhal Toxicol 21(S1):25-29
31. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, Stone V, Brown S, MacNee W, Donaldson K (2008) Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3:423-428
32. Ramachandran G, Ostraat M, Evans DE, Methner MM, O'Shaughnessy P, D'Arcy J, Geraci CL, Stevenson E, Maynard A, Rickabaugh K (2011) A strategy for assessing workplace exposures to nanomaterials. J Occup Environ Hyg 8(11):673-685
33. Scenihr (2009) Scientific committee on emerging and newly identified health risks. Risk assessment of products of nanotechnologies. European Commission, Health & Consumers DG, Directorate C: Public Health and Risk Assessment. http://ec.europa.eu/health/ph-risk/risk-en.htm. Accessed 29 April 2011
34. Schulte PA, Murashov V, Zumwalde R, Kuempel ED, Geraci CL (2010) Occupational exposure limits for nanomaterials: state of the art. J Nanopart Res 12:1971-1987
35. Schulze C, Kroll A, Lehr CM, Schäfer UF, Beckers K, Schnekenburger J, Schultze Isfort C, Landsiedel R, Wohlleben W (2008) Not ready to use overcoming pitfalls when dispersing nanoparticles in physiological media. Nanotoxicology 2(2):51-61
36. SDU (2006) National MAC-lijst 2006. SDU uitgevers, Den Haag 2006. ISBN 9012 1112 18
37. SER (2009) Advisory report 0901, nanoparticles in the workplace: health and safety precautions. Social Economic Council Netherlands, The Hague, p 42
38. SER (2011) http://www.ser.nl/en/oel-database.aspx. Accessed 29 April 2011
39. SER (2012) http://www.ser.nl/nl/grenswaarden/titaandioxide.aspx. Accessed January 2012
40. SRU (2011) German advisory council on the environment. Precautionary strategies for managing nanomaterials. http://www.umweltrat.de/SharedDocs/ Downloads/EN/02-Special-Reports/2011-08-Precautionary-Strategies-for-managing- Nanomaterials-chapter07.pdf?-blob=publicationFile
41. Stone V, Hankin S, Aitken R, Aschberger K, Baun A, Christensen F, Fernandes T, Hansen SF, Bloch Hartmann N, Hutchinson G, Johnston H, Micheletti C, Peters S, Ross B, Sokull-Kluettgen B, Stark D, Tran L (2010) Engineered nanoparticles: review of health and environmental safety, Edinburgh Napier University. http://nmi.jrc.ec.europa.eu/documents/pdf/ENRHES%20Review.pdf
42. Szymczak W, Menzela N, Keck L (2007) Emission of ultrafine copper particles by universal motors controlled by phase angle modulation. Aerosol Sci 38:520-531 (Pubitemid 46782836)
43. United States Environmental Protection Agency (US EPA) (2009) Integrated science assessment for particulate matter. EPA/600/R-08/139F, December. http://www.epa.gov/ncea/pdfs/partmatt/Dec2009/PM-ISA-full.pdf. Accessed 28 April 2011
44. van Broekhuizen P, Reijnders L (2011) Building blocks for a precautionary approach to the use of nanomaterials: positions taken by trade unions and environmental NGOs in the European nanotechnologies' debate. Risk Anal 3(10): 1646-1657
45. van Broekhuizen P, van Broekhuizen F, Cornelissen R, Reijnders L (2011a) Use of nanomaterials in the European construction industry and some occupational health aspects thereof. J Nanopart Res 13:447-462
46. van Broekhuizen P, van Broekhuizen F, Cornelissen R (2011b) Pilot Nanoreferentiewaarden. Nanodeeltjes en de nanoreferentiewaarde in Nederlandse bedrijven - Eindverslag. Report on behalf of FNV, VNO/NCW, CNV
47. van Broekhuizen P, Dorbeck-Jung B (2012) Acceptance of nano reference values as risk management tool to minimize exposure to nanomaterials at the workplace: lessons from the Netherlands. Manuscript in preparation
48. Vorbau M, Hillemann L, Stintz M (2009) Method for the characterization of the abrasion induced nanoparticle release into air from surface coatings. Aerosol Sci 40: 209-217
49. Vosburgh DJ, Boysen DA, Oleson JJ, Peters TM (2011) Airborne nanoparticle concentrations in the manufacturing of polytetrafluoroethylene (PTFE) apparel. J Occup Environ Hyg 8(3):139-146
50. Wang YF, Tsai PJ, Chen CW, Chen DR, Hsu DJ (2010) Using a modified electrical aerosol detector to predict nanoparticle exposures to different regions of the respiratory tract for workers in a carbon-black manufacturing industry. Environ Sci Technol 44:6767-6774
51. Wehner B, BirmiliW, Gnauk T, Wiedensohler A (2002) Particle number size distributions in a street canyon and their transformation into the urban-air background: measurements and a simple model study. Atmos Environ 36:2215-2223 (Pubitemid 34626284)
52. Wohlleben W, Brill S, Meier MW, Mertler M, Cox G, Hirth S, von Vacano B, Strauss V, Treumann S, Wiench K, Ma-Hock L, Landsiedel R (2011) On the lifecycle of nanocomposites: comparing released fragments and their in vivo hazards from three release mechanisms and four nanocomposites. Small 7(16):2384-2395
53. Yokel RA, MacPhail RC (2011) Engineered nanomaterials: exposures, hazards, and risk prevention. J Occup Med Toxicol 6:7