Design, synthesis, theoretical calculations and biological evaluation of new non-symmetrical choline kinase inhibitors

European Journal of Medicinal Chemistry

Volumn 50, Issue , 2012, Pages 154-162

  Rubio Ruíz, Belén ^a   Conejo García, Ana ^a   Ríos Marco, Pablo ^b   Carrasco Jiménez, María Paz ^b   Segovia, Josefa ^b   Marco, Carmen ^b   Gallo, Miguel A ^a   Espinosa, Antonio ^a   Entrena, Antonio ^a  

^a Facultad de Farmacia   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Antiproliferative agents; Choline kinase inhibitors; Docking studies; Molecular modeling; Pyridinium compounds

Indexed keywords

1 [4 (BROMOMETHYL)BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 (BROMOMETHYL)BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [(6 AMINO 3H PURIN 3 YL)METHYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [(6 AMINO 9H PURIN 9 YL)METHYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [(6-AMINO 9H PURIN 9 YL)METHYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 (BROMOMETHYL)PHENETHYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [4 (BROMOMETHYL)PHENETHYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 (BROMOMETHYL)PHENYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 [(6 AMINO 3H PURIN 3 YL)METHYL]PHENETHYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 [(6 AMINO 3H PURIN 3 YL)METHYL]PHENYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [4 [(6 AMINO 9H PURIN 9 YL)METHYL]PHENETHYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [4 [(6 AMINO 9H PURIN 9 YL)METHYL]PHENETHYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 [(6 AMINO 9H PURIN 9 YL)METHYL]PHENYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [4 [(6 AMINO 9H PURIN 9 YL)METHYL]PHENYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 [4 (BROMOMETHYL)PHENYL]BUTYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [4 [4 (BROMOMETHYL)PHENYL]BUTYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 [4 [(6 AMINO 3H PURIN 3 YL)METHYL]PHENYL]BUTYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [4 [4 [(6 AMINO 3H PURIN 3 YL)METHYL]PHENYL]BUTYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; 1 [4 [4 [4 [(6 AMINO 9H PURIN 9 YL)METHYL]PHENYL]BUTYL]BENZYL] 4 (DIMETHYLAMINO)PYRIDINIUM BROMIDE; 1 [4 [4 [4 [(6 AMINO 9H PURIN 9 YL)METHYL]PHENYL]BUTYL]BENZYL] 4 PYRROLIDINOPYRIDINIUM BROMIDE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; BROMINE DERIVATIVE; CHOLINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR DOCKING; PROTEIN BINDING;

ADENOSINE TRIPHOSPHATE; CELL PROLIFERATION; CHOLINE; CHOLINE KINASE; DRUG DESIGN; ENZYME INHIBITORS; HEP G2 CELLS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858446418     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.01.050     Document Type: Article

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