Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-α production in human whole blood

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 13, 2009, Pages 3485-3488

  Wu, Junjun ^a   Green, Neal ^a   Hotchandani, Rajeev ^a   Hu, Yonghan ^a   Condon, Jeffrey ^a   Huang, Adrian ^a   Kaila, Neelu ^a   Li, Huan Qiu ^a   Guler, Satenig ^a   Li, Wei ^a   Tam, Steve Y ^a   Wang, Qin ^a   Pelker, Jeffrey ^a   Marusic, Suzana ^a   Hsu, Sang ^a   Perry Hall, J ^a   Telliez, Jean Baptiste ^a   Cui, Junqing ^a   Lin, Lih Ling ^a  

^a PFIZER INC   (United States)

Author keywords

Quinoline 3 carbonitrile; TNF ; Tpl2 kinase; Triazole

Indexed keywords

8 CHLORO 4 (3 CHLORO 4 FLUOROPHENYLAMINO) 6 [1 (1 ETHYLPIPERIDIN 4 YL) 1H 1,2,3 TRIAZOL 4 YL]METHYLAMINOQUINOLINE 3 CARBONITRILE; 8 HALO 4 (3 CHLORO 4 FLUOROPHENYLAMINO) 6 [(1H [1,2,3]TRIAZOL 4 YLMETHYL)AMINO]QUINOLINE 3 CARBONITRILE DERIVATIVE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; TPL2 KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CYTOKINE PRODUCTION; DRUG INHIBITION; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; FEMALE; HUMANS; LIPOPOLYSACCHARIDES; MAP KINASE KINASE KINASES; MONOCYTES; NITRILES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 66349091863     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.009     Document Type: Article

References (16)

1. Feldmann M., Brennan F.M., Foxwell B.M., and Maini R.N. Curr. Dir. Autoimmun. 3 (2001) 188
2. Tracey D., Klareskog L., Sasso E.H., Salfeld J.G., and Tak P.P. Pharmacol. Ther. 117 (2008) 244
3. Tsokos, G. C., Ed.; Principles of Molecular Rheumatology; Humana Press, 2000; p. 334.
4. Jarvis B., and Faulds D. Drugs 57 (1999) 945
5. Furst D.E., Breedveld F.C., Kalden J.R., Smolen J.S., Burmester G.R., and Sieper J. Ann. Rheum. Dis. 66 (2007) iii2
6. Elliot M.J., Maini R.N., Feldmann M., Long F.A., Charles P., and Katsokis P. Arthritis Rheum. 36 (1993) 1681
7. Elliot M.J., Maini R.N., Feldmann M., Kalden J., Antoni C., and Smolen J. Lancet 334 (1994) 1105
8. Bang L.M., and Keating G.M. Biodrugs 18 (2004) 121
9. Dumitru C.D., Ceci J.D., Tsatsanis C., Kontoyiannis D., Stamatakis K., Lin J.-H., Patriotis C., Jenkins N.A., Copeland N.G., Kollias G., and Tsichlis P.N. Cell 103 (2000) 1071
10. Chiarello M., Marinissen M.J., and Gutkind J.S. Mol. Cell. Biol. 20 (2000) 1747
11. Gavrin L.K., Green N., Hu Y., Janz K., Kaila N., Li H.-Q., Tam S.Y., Thomason J.R., Gopalsamy A., Ciszewski G., Cuozzo J.W., Hall J.P., Hsu S., Telliez J.-B., and Lin L.-L. Bioorg. Med. Chem. Lett. 15 (2005) 5288
12. Hu Y., Green N., Gavrin L.K., Janz K., Kaila N., Li H.-Q., Thomason J.R., Cuozzo J.W., Hall J.P., Hsu S., Nickerson-Nutter C., Telliez J.-B., Lin L.-L., and Tam S.Y. Bioorg. Med. Chem. Lett. 16 (2006) 6067
13. Green N., Hu Y., Janz K., Li H.-Q., Kaila N., Guler S., Thomason J.R., Joseph-McCarthy D., Tam S.Y., Hotchandani R., Wu J., Huang A., Wang Q., Leung L., Pelker J., Marusic S., Hsu S., Telliez J.-B., Hall J.P., Cuozzo J.W., and Lin L.-L. J. Med. Chem. 50 (2007) 4728
14. Rostovstev V.V., Green L.G., Fokin V.V., and Sharpless K.B. Angew. Chem., Int. Ed. 41 (2002) 2596
15. Wu P., Feldman A.K., Nugent A.K., Hawker C.J., Scheel A., Voit B., Pyun J., Frechet J.M.J., and Sharpless K.B. Angew. Chem., Int. Ed. 43 (2004) 3928
16. Kerns E.H., and Di L. Drug Discovery Today 8 (2003) 316