Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates

Journal of Medicinal Chemistry

Volumn 39, Issue 17, 1996, Pages 3367-3374

  Devraj, Rajesh ^a   Barrett, John F ^b   Fernandez, Jeffrey A ^b   Katzenellenbogen, John A ^c   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); ELLIPTICINE; ELLIPTICINE DERIVATIVE; ESTRADIOL; ESTROGEN RECEPTOR;

ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM NEOPLASMS; DNA TOPOISOMERASES, TYPE II; DRUG DESIGN; ELLIPTICINES; ESTRADIOL; FEMALE; HUMANS; KIDNEY NEOPLASMS; LEUKEMIA; LUNG NEOPLASMS; MALE; MELANOMA; OVARIAN NEOPLASMS; PLACENTA; PREGNANCY; PROSTATIC NEOPLASMS; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029744698     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9602930     Document Type: Article

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