Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Wang, Deqing ^a   Zhuang, Yuan ^a   Tian, Yaping ^a   Thomas, Graham Neil ^b   Ying, Mingzhong ^a   Tomlinson, Brian ^b  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPONENTS; ANIMAL EXPERIMENTS; CARDIO-VASCULAR DISEASE; CHINESE TRADITIONAL MEDICINE; CHOLESTEROL LEVELS; HYDROXYL RADICALS; IN-VITRO; IN-VIVO EXPERIMENTS; ISCHEMIA REPERFUSION; LDL CHOLESTEROL; PLASMA LEVELS; POTENT ANTIOXIDANTS; POTENTIAL MECHANISM; PROTECTIVE EFFECTS; SUPEROXIDES;

CHOLESTEROL; EXPERIMENTS; FREE RADICALS; OXYGEN;

DISEASES;

CALYCOSIN; CALYCOSIN 7 O BETA DEXTRO GLUCOPYRANOSIDE; CHOLESTEROL; DAUCOSTEROL; FLAVONOID; FORMONONETIN; FORMONONETIN 7 O BETA DEXTRO GLUCOPYRANOSIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYL RADICAL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SITOSTEROL; SUPEROXIDE; UNCLASSIFIED DRUG; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTRAGALUS MONGHOLICUS; ASTRAGALUS PLANT; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; HEART MUSCLE ISCHEMIA; HEART PROTECTION; IN VITRO STUDY; MALE; NONHUMAN; RABBIT; REPERFUSION INJURY; ANIMAL; AORTA; BLOOD; CHEMISTRY; CHINESE MEDICINE; DISEASE MODEL; DRUG EFFECT; PATHOLOGY;

ANIMALIA; ASTRAGALUS MONGHOLICUS; ORYCTOLAGUS CUNICULUS;

ANIMALS; AORTA; ASTRAGALUS PLANT; ATHEROSCLEROSIS; CHOLESTEROL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DISEASE MODELS, ANIMAL; FLAVONOIDS; FREE RADICAL SCAVENGERS; MEDICINE, CHINESE TRADITIONAL; RABBITS; REPERFUSION INJURY;

EID: 84858325044     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/282383     Document Type: Article

References (49)

1. Li S. Z., Ben Cao Gang Mu Herb Medicine 1985 Beijing, China Peoples Health Press
2. Cho W. C. S., Leung K. N., In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus Journal of Ethnopharmacology 2007 113 1 132 141 (Pubitemid 47077858)
3. He J., Li Y., Wei S., Guo M., Fu W., Effects of mixture of Astragalus membranaceus, Fructus ligustri lucidi and Eclipta prostrata on immune function in mice Journal of West China University of Medical Sciences 1992 23 4 408 411 (Pubitemid 23023940)
4. Lei Z. Y., Effect of Astragalus membranaceus on cardiovascular system Chinese Journal of Integrated Traditional and Western Medicine 1993 13 7 443 446
5. Wang B., Jiang B. R., Zhou S. N., Clinical research on the treatment of cardiovascular disease by astragalus Chinese Journal of Integrative Medicine 2005 3 162 164
6. Liu J., Hu X., Yang Q., Yu Z., Zhao Z., Yi T., Chen H., Comparison of the immunoregulatory function of different constituents in radix astragali and radix hedysari Journal of Biomedicine and Biotechnology 2010 2010
7. Qiu L. H., Xie X. J., Zhang B. Q., Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation Biological and Pharmaceutical Bulletin 2010 33 4 641 646
8. Cazarolli L. H., Zanatta L., Alberton E. H., Figueiredo M. S., Folador P., Damazio R. G., Pizzolatti M. G., Silva F. R., Flavonoids: prospective drug candidates Mini Reviews in Medicinal Chemistry 2008 8 13 1429 1440
9. Landis-Piwowar K. R., Dou Q. P., Polyphenols: biological activities, molecular targets, and the effect of methylation Current Molecular Pharmacology 2008 1 3 233 243
10. Rahimi R., Ghiasi S., Azimi H., Fakhari S., Abdollahi M., A review of the herbal phosphodiesterase inhibitors; Future perspective of new drugs Cytokine 2010 49 2 123 129
11. Chopra M., Thurnham D. I., Clinical nutrition and metabolism group symposium on 'nutrition and antioxidants': antioxidants and lipoprotein metabolism Proceedings of the Nutrition Society 1999 58 3 663 671
12. Rice-Evans C. A., Miller N. J., Bolwell P. G., Bramley P. M., Pridham J. B., The relative antioxidant activities of plant-derived polyphenolic flavonoids Free Radical Research 1995 22 4 375 383
13. Cheng J., Zhao Y. Y., Wang B., Qiao L., Liang H., Flavonoids from Millettia nitida var. hirsutissima Chemical and Pharmaceutical Bulletin 2005 53 4 419 421 (Pubitemid 40879881)
14. Sun J. Y., Zhong Y., Zuo C. X., Yin J. T., Wang B., Isolation and structure identification of the chemical constituents from Gypsophila oldhamiana Yaoxue Xuebao 2005 40 11 994 996 (Pubitemid 43028221)
15. Xiao H. B., Krucker M., Putzbach K., Albert K., Capillary liquid chromatography-microcoil 1H nuclear magnetic resonance spectroscopy and liquid chromatography-ion trap mass spectrometry for on-line structure elucidation of isoflavones in Radix astragali Journal of Chromatography A 2005 1067 1-2 135 143 (Pubitemid 40363398)
16. Chen Z. K., Hu S. J., The experimental study progress of effect of astragalus membranaceus on cardiovascular diseases Advances in Cardiovascular Disease 2003 24 113 116
17. Lu Y., Li J. Z., Zheng X., Effect of Astragalus Angelica mixture on serum lipids and glomerulosclerosis in rats with nephrotic syndrome Chinese Journal of Integrated Traditional and Western Medicine 1997 17 8 478 480
18. Guan Z. M., Luo J., Li G., The regulation of stragalu on blood lipid a in type 2 diabetic rats Chinese Journal of Practice Medicine 2008 15 82 84
19. Sai D., Li S. Q., Li D. H., Li S. Y., Wang Y. Q., Song J. M., Li S. Q., Effects of radix astragali in ameliorating cardiovascular function Chinese Journal of Clinical Rehabilitation 2006 10 11 21 23
20. Porkkala-Sarataho E., Salonen J. T., Nyyssnen K., Kaikkonen J., Salonen R., Ristonmaa U., Diczfalusy U., Brigelius-Flohe R., Loft S., Poulsen H. E., Long-term effects of vitamin E, vitamin C, and combined supplementation on urinary 7-hydro-8-oxo-2'-deoxyguanosine, serum cholesterol oxidation products, and oxidation resistance of lipids in nondepleted men Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20 9 2087 2093
21. Kinlay S., Behrendt D., Fang J. C., Delagrange D., Morrow J., Witztum J. L., Rifai N., Selwyn A. P., Creager M. A., Ganz P., Long-term effect of combined vitamins E and C on coronary and peripheral endothelial function Journal of the American College of Cardiology 2004 43 4 629 634 (Pubitemid 38229536)
22. Sun Y. P., Zhu B. Q., Sievers R. E., Norkus E. P., Parmley W. W., Deedwania P. C., Effects of antioxidant vitamins C and E on atherosclerosis in lipid-fed rabbits Cardiology 1998 89 3 189 194 (Pubitemid 28116090)
23. Giugliano D., Dietary antioxidants for cardiovascular prevention Nutrition, Metabolism and Cardiovascular Diseases 2000 10 1 38 44
24. Hodis H. N., Mack W. J., LaBree L., Cashin-Hemphill L., Sevanian A., Johnson R., Azen S. P., Serial coronary angiographic evidence antioxidant vitamin intake reduces progression of coronary artery atherosclerosis Journal of the American Medical Association 1995 273 23 1849 1854
25. Singh R. B., Singh N. K., Rastogi S. S., Wander G. S., Aslam M., Onouchi Z., Kummerow F. A., Nangia S., Antioxidant effects of lovastatin and vitamin E on experimental atherosclerosis in rabbits Cardiovascular Drugs and Therapy 1997 11 4 575 580 (Pubitemid 27440247)
26. Suzukawa M., Ayaori M., Shige H., Hisada T., Ishikawa T., Nakamura H., Effect of supplementation with vitamin E on LDL oxidizability and prevention of atherosclerosis BioFactors 1998 7 1-2 51 54 (Pubitemid 28073874)
27. Fuhrman B., Aviram M., Anti-atherogenicity of nutritional antioxidants IDrugs 2001 4 1 82 92 (Pubitemid 33772769)
28. Lee I. T., Tsung M. L., Lee W. J., Ou H. C., Chien Y. H., Wen L. L., Tang Y. J., Yang C. H., Sheu W. H. H., Hypercholesterolemia, not metabolic syndrome, related to adhesion of monocytes to cultured endothelium in nondiabetic subjects Metabolism 2005 54 11 1467 1471 (Pubitemid 41527016)
29. Nagyov A., Kudlkov M., Graniov E., Maglov T., LDL oxidizability and antioxidative status of plasma in vegetarians Annals of Nutrition and Metabolism 1998 42 6 328 332
30. Ismail M. F., Gad M. Z., Hamdy M. A., Study of the hypolipidemic properties of pectin, garlic and ginseng in hypercholesterolemic rabbits Pharmacological Research 1999 39 2 157 166 (Pubitemid 29106167)
31. zer N. K., Azzi A., Effect of vitamin E on the development of atherosclerosis Toxicology 2000 148 2-3 179 185 (Pubitemid 30621358)
32. Graf B. A., Milbury P. E., Blumberg J. B., Flavonols, flavones, flavanones, and human health: epidemiological evidence Journal of Medicinal Food 2005 8 3 281 290 (Pubitemid 41502409)
33. Scalbert A., Manach C., Morand C., Rémésy C., Jiménez L., Dietary polyphenols and the prevention of diseases Critical Reviews in Food Science and Nutrition 2005 45 4 287 306 (Pubitemid 41657352)
34. Hennig B., Reiterer G., Majkova Z., Oesterling E., Meerarani P., Toborek M., Modification of environmental toxicity by nutrients: implications in atherosclerosis Cardiovascular Toxicology 2005 5 2 153 160 (Pubitemid 41058629)
35. Aviram M., Fuhrman B., Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis Atherosclerosis 1998 137 supplement S45 S50 (Pubitemid 28294207)
36. Fuhrman B., Rosenblat M., Hayek T., Coleman R., Aviram M., Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice Journal of Nutrition 2000 130 5 1124 1131 (Pubitemid 30233257)
37. Ishikawa T., Suzukawa M., Ito T., Yoshida H., Ayaori M., Nishiwaki M., Yonemura A., Hara Y., Nakamura H., Effect of tea flavonoid supplementation on the susceptibility of low- density lipoprotein to oxidative modification American Journal of Clinical Nutrition 1997 66 2 261 266 (Pubitemid 27360323)
38. Yokozawa T., Dong E., Nakagawa T., Kim D. W., Hattori M., Nakagawa H., Effects of Japanese black tea on atherosclerotic disorders Bioscience, Biotechnology and Biochemistry 1998 62 1 44 48 (Pubitemid 128475021)
39. Cao G., Sofic E., Prior R. L., Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships Free Radical Biology and Medicine 1997 22 5 749 760 (Pubitemid 27058337)
40. Younes M., Siegers C. P., Inhibitory action of some flavonoids on enhanced spontaneous lipid peroxidation following glutathione depletion Planta Medica 1981 43 3 240 244 (Pubitemid 12214719)
41. He Z. Q., Wang B. Q., Isolation and identification of chemical constituents of Astragalus root Acta Pharmaceutica Sinica 1990 25 9 694 698
42. Carr T. P., Andresen C. J., Rudel L. L., Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts Clinical Biochemistry 1993 26 1 39 42 (Pubitemid 23060970)
43. Benzie I. F. F., Strain J. J., The ferric reducing ability of plasma (FRAP) as a measure of 'antioxidant power': the FRAP assay Analytical Biochemistry 1996 239 1 70 76
44. Yeum K. J., Aldini G., Chung H. Y., Krinsky N. I., Russell R. M., The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical species Journal of Nutrition 2003 133 8 2688 2691 (Pubitemid 36935992)
45. Benzie I. F. F., An automated, specific, spectrophotometric method for measuring ascorbic acid in plasma (EFTSA) Clinical Biochemistry 1996 29 2 111 116 (Pubitemid 26115427)
46. Li Y. X., Fang Y. Z., An new chemiluminescence method for superoxide dismutase assay Progress in Biochemistry and Biophysics 1983 2 59 62
47. Lee M. C., Yoshino F., Shoji H., Takahashi S., Todoki K., Shimada S., Kuse-Barouch K., Characterization by electron spin resonance spectroscopy of reactive oxygen species generated by titanium dioxide and hydrogen peroxide Journal of Dental Research 2005 84 2 178 182 (Pubitemid 43822052)
48. Leva C., Mariscalco G., Ferrarese S., Bruno V. D., Orr A., Cattaneo P., Sala A., The role of zofenopril in myocardial protection during cardioplegia arrest: an isolated rat heart model Journal of Cardiac Surgery 2006 21 1 44 49
49. Demonstration of the production of oxygen-centered free radicals during electrolysis using E.S.R. spin-trapping techniques: Effects on cardiac function in the isolated rat heart Free Radical Biology and Medicine 1998 24: 4 573-579.