In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus

Journal of Ethnopharmacology

Volumn 113, Issue 1, 2007, Pages 132-141

  Cho, William Chi Shing ^a   Leung, Kwok Nam ^b  

^a QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Astragalus membranaceus; Huangqi; Immunomodulating effect; Immunorestorative effect

Indexed keywords

ASTRAGALUS MEMBRANACEUS EXTRACT; CYCLOPHOSPHAMIDE; INTERLEUKIN 2 RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; ASTRAGALUS MEMBRANACEUS; B LYMPHOCYTE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOMODULATION; INNATE IMMUNITY; LYMPHOCYTE TRANSFORMATION; MACROPHAGE; MITOGENESIS; MITOGENICITY; MOUSE; NONHUMAN; PERITONEAL CAVITY; PHAGOCYTOSIS; PLANT ROOT; PROTEIN EXPRESSION; SHEEP; SPLEEN CELL; T CELL DEPLETION; T LYMPHOCYTE SUBPOPULATION; TUMOR;

ANIMALS; ANTIBODY FORMATION; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ASTRAGALUS MEMBRANACEUS; DRUGS, CHINESE HERBAL; ERYTHROCYTES; HUMANS; IMMUNITY; LYMPHOCYTES; MACROPHAGES; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; PLANT EXTRACTS; PLANT ROOTS; RECEPTORS, INTERLEUKIN-2; SHEEP; SPLEEN;

ASTRAGALUS MEMBRANACEUS; MURINAE; MUS; OVIS ARIES;

EID: 34447576629     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2007.05.020     Document Type: Article

References (44)

1. Anon., 2003. Astragalus membranaceus. Monograph. Alternative Medicine Review 8, 72-77.
2. Bensky D., and Gamble A. Chinese Herbal Medicine: Materia Medica. revised ed. (1993), Eastland Press, Seattle
3. Block K.I., and Mead M.N. Immune system effects of echinacea, ginseng, and astragalus: a review. Integrative Cancer Therapies 2 (2003) 247-267
4. Boyum A. Separation of leukocytes from blood and bone marrow. Introduction. Scandinavian Journal of Clinical and Laboratory Investigation Supplementum 97 (1968) 7
5. Chen L.J., Shen M.L., Wang M.Y., Zhai S.K., and Liu M.Z. Effect of Astragalus polysaccharides on phagocytic function in mice. Zhongguo Yao Li Xue Bao 2 (1981) 200-204
6. Cho W.C., and Leung K.N. In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Lett 252 (2007) 43-54
7. Choy Y.M., Leung K.N., Cho C.S., Wong C.K., and Pang P.K. Immunopharmacological studies of low molecular weight polysaccharide from Angelica sinensis. The American Journal of Chinese Medicine 22 (1994) 137-145
8. Chu D.T., Sun Y., and Lin J.R. Immune restoration of local xenogeneic graft-versus-host reaction in cancer patients in vitro and reversal of cyclophosphamide-induced immune suppression in the rat in vivo by fractionated Astragalus membranaceus. Zhong Xi Yi Jie He Za Zhi 9 (1989) 351-354 326
9. Chu D.T., Wong W.L., and Mavligit G.M. Immunotherapy with Chinese medicinal herbs I. Immune restoration of local xenogeneic graft-versus-host reaction in cancer patients by fractionated Astragalus membranaceus in vitro. Journal of Clinical and Laboratory Immunology 25 (1988) 119-123
10. Chu D.T., Wong W.L., and Mavligit G.M. Immunotherapy with Chinese medicinal herbs II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vitro. Journal of Clinical and Laboratory Immunology 25 (1988) 125-129
11. Dubois M., Gilles K.A., Hamilton J.K., Rebers P.A., and Smith F. A colorimetric method for the determination of sugars. Nature 168 (1951) 167
12. Gervais F., Martel R.R., and Skamene E. The effect of the non-steroidal anti-inflammatory drug Etodolac on macrophage migration in vitro and in vivo. Journal of Immunopharmacology 6 (1984) 205-210
13. Hanaue H., Tokuda Y., Machimura T., Kamijoh A., Kondo Y., Ogoshi K., Makuuchi H., Nakasaki H., Tajima T., and Mitomi T. Effects of oral lentinan on T-cell subsets in peripheral venous blood. Clinical Therapeutics 11 (1989) 614-622
14. Hou Y.T., Ma G.L., Wu S.H., Li Y.Y., and Li H.T. Effect of Radix astragali seu hedysari on the interferon system. Chinese Medical Journal (English) 94 (1981) 35-40
15. Hung S.V. Preparation of lymphocytes and accessory cells. In: Klaus G.G.B. (Ed). Lymphocytes: A Practical Approach (1987), IRL Press, Washington, DC 1-34
16. Jacob D.M., and Morrison D.C. Inhibition of mitogenic response to lipopolysaccharide (LPS) in mouse spleen cells by polymyxin B. Journal of Immunology 118 (1977) 21-27
17. Kaminuteski N.E., Roberts J.F., and Guthrie F.E. A rapid spectrophotometric method for assessing macrophage phagocytic activity. Immunology Letters 10 (1985) 329-331
18. Kumazawa Y., Mizunoe K., and Otsuka Y. Immunostimulating polysaccharide separated from hot water extract of Angelica acutiloba Kitagawa (Yamato tohki). Immunology 47 (1982) 75-83
19. Kumazawa Y., Nakatsuru T., Yamada A., Yadomae T., Nishimura C., Otsuka Y., and Nomoto K. Immunopotentiator separated from hot water extract of seed of Benincasa cerifera Savi (Tohgashi). Cancer Immunology Immunotherapy 19 (1985) 79-84
20. Kusum M., Klinbuayaem V., Bunjob M., and Sangkitporn S. Preliminary efficacy and safety of oral suspension SH, combination of five Chinese medicinal herbs, in people living with HIV/AIDS; the phase I/II study. Journal of the Medical Association of Thailand 87 (2004) 1065-1070
21. Lee K.Y., and Jeon Y.J. Macrophage activation by polysaccharide isolated from Astragalus membranaceus. International Immunopharmacology 5 (2005) 1225-1233
22. Lei H., Wang B., Li W.P., Yang Y., Zhou A.W., and Chen M.Z. Anti-aging effect of Astragalosides and its mechanism of action. Acta Pharmacologica Sinica 24 (2003) 230-234
23. Leung M.Y., Liu C., Koon J.C., and Fung K.P. Polysaccharide biological response modifiers. Immunology Letters 105 (2006) 101-114
24. Li S., Zhang Y., and Zhao J. Preparation and suppressive effect of astragalus polysaccharide in glomerulonephritis rats. International Immunopharmacology 7 (2007) 23-28
25. Lis H., and Sharon N. Lectins as molecules and as tools. Annual Review of Biochemistry 55 (1986) 35-67
26. Liu J.P., Yang M., and Du X.M. Herbal medicines for viral myocarditis. Cochrane Database of Systematic Reviews 3 (2004) CD003711
27. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. The Journal of Biological Chemistry 193 (1951) 265-275
28. Ma X.Q., Shi Q., Duan J.A., Dong T.T., and Tsim K.W. Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. Journal of Agricultural and Food Chemistry 50 (2002) 4861-4866
29. McKenna D.J., Hughes K., and Jones K. Astragalus. International Journal of Integrated Medicine 4 (2002) 40-46
30. Philip H.J. Dye exclusion test for cell viability. In: Krus P.F., and Patterson M.K. (Eds). Tissue Culture Methods and Applications (1973), Academic Press Inc., New York 406-410
31. Shao B.M., Dai H., Xu X., Lin Z.B., and Gao X.M. Immune receptors for polysaccharides from Ganoderma lucidum. Biochemical and Biophysical Research Communications 323 (2004) 133-141
32. Shao B.M., Xu W., Dai H., Tu P., Li Z., and Gao X.M. A study on the immune receptors for polysaccharides from the roots of Astragalus membranaceus, a Chinese medicinal herb. Biochemical and Biophysical Research Communications 320 (2004) 1103-1111
33. Sun Y., Hersh E.M., Lee S.L., McLaughlin M., Loo T.L., and Mavligit G.M. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. Journal of Biological Response Modifiers 2 (1983) 227-237
34. Sun Y., Hersh E.M., Talpaz M., Lee S.L., Wong W., Loo T.L., and Mavligit G.M. Immune restoration and/or augmentation of local graft versus host reaction by traditional Chinese medicinal herbs. Cancer 52 (1983) 70-73
35. Tan B.K., and Vanitha J. Immunomodulatory and antimicrobial effects of some traditional Chinese medicinal herbs: a review. Current Medicinal Chemistry 11 (2004) 1423-1430
36. Tian Y.H., Jin F.Y., and Lei H. Effects of processing on contents of saccharides in huangqi. Zhongguo Zhong Yao Za Zhi 28 (2003) 128-129 173
37. Wang D.C. Influence of Astragalus membranaceus (AM) polysaccharide FB on immunologic function of human periphery blood lymphocyte. Zhonghua Zhong Liu Za Zhi 11 (1989) 180-183
38. Wang J.Z., Ito H., and Shimura K. Enhancing effect of antitumour polysaccharide from Astragalus or Radix hedysarum on C3 cleavage production of macrophages in mice. Japanese Journal of Pharmacology 51 (1989) 432-434
39. Wang R.T., Shan B.E., and Li Q.X. Extracorporeal experimental study on immuno-modulatory activity of Astragalus membranaceus extract. Zhongguo Zhong Xi Yi Jie He Za Zhi 22 (2002) 453-456
40. Wu F., and Chen X. A review of pharmacological study on Astragalus membranaceus (Fisch.) Bge. Zhong Yao Cai 27 (2004) 232-234
41. Yin X., Zhang Y., Wu H., Zhu X., Zheng X., Jiang S., Zhuo H., Shen J., Li L., and Qiu J. Protective effects of Astragalus saponin I on early stage of diabetic nephropathy in rats. Journal of Pharmacological Sciences 95 (2004) 256-266
42. Zhang Y.W., Xie D., Chen Y.X., Zhang H.Y., and Xia Z.X. Protective effect of gui qi mixture on the progression of diabetic nephropathy in rats. Experimental and Clinical Endocrinology and Diabetes 114 (2006) 563-568
43. Zhang Z.Z., Liang X.M., Zhang Q., and Lu P.Z. Characterization and recognition key components in Astragalus membranaceus. Yao Xue Xue Bao 36 (2001) 523-527
44. Zhao K.S., Mancinic C., and Doria G. Enhancement of the immune response in mice by Astragalus membranaceus extracts. Immunopharmacology 20 (1990) 225-233