The design and construction of K11: A novel -helical antimicrobial peptide

International Journal of Microbiology

Volumn , Issue , 2012, Pages

  Jin Jiang, Huang ^a   Jin Chun, Lu ^b   Min, Lu ^b   Qing Shan, Huang ^a,b   Guo Dong, Li ^b  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Hi Tech United Bio technological Research and Development Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACINETOBACTER BAUMANNII; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 84858307872     PISSN: 1687918X     EISSN: 16879198     Source Type: Journal    
DOI: 10.1155/2012/764834     Document Type: Article

References (19)

1. Marr A. K., Gooderham W. J., Hancock R. E., Antibacterial peptides for therapeutic use: obstacles and realistic outlook Current Opinion in Pharmacology 2006 6 5 468 472 (Pubitemid 44340665)
2. Ganz T., Lehrer R. I., Antimicrobial peptides of vertebrates Current Opinion in Immunology 1998 10 1 41 44 (Pubitemid 28112077)
3. Zasloff M., Antimicrobial peptides of multicellular organisms Nature 2002 415 6870 389 395 (Pubitemid 34100944)
4. Ginsburg I., Koren E., Are cationic antimicrobial peptides also double-edged swords Expert Review of Anti-Infective Therapy 2008 6 4 453 462
5. Shin S. Y., Lee S. H., Yang S. T., Park E. J., Lee D. G., Lee M. K., Eom S. H., Song W. K., Kim Y., Hahm K. S., Kim J. I., Antibacterial, antitumor and hemolytic activities of -helical antibiotic peptide, P18 and its analogs Journal of Peptide Research 2001 58 6 504 514 (Pubitemid 34169377)
6. Sato H., Feix J. B., Lysine-enriched cecropin-mellitin antimicrobial peptides with enhanced selectivity Antimicrobial Agents and Chemotherapy 2008 52 12 4463 4465
7. Chen Y., Mant C. T., Farmer S. W., Hancock R. E. W., Vasil M. L., Hodges R. S., Rational design of -helical antimicrobial peptides with enhanced activities and specificity/therapeutic index Journal of Biological Chemistry 2005 280 13 12316 12329
8. Giangaspero A., Sandri L., Tossi A., Amphipathic helical antimicrobial peptides European Journal of Biochemistry 2001 268 21 5589 5600
9. Scott M. G., Yan H., Hancock R. E. W., Biological properties of structurally related -helical cationic antimicrobial peptides Infection and Immunity 1999 67 4 2005 2009 (Pubitemid 29144428)
10. Shin S. Y., Lee M. K., Kim K. L., Hahm K. S., Structure-antitumor and hemolytic activity relationships of synthetic peptides derived from cecropin A-magainin 2 and cecropin A-melittin hybrid peptides Journal of Peptide Research 1997 50 4 279 285 (Pubitemid 27440877)
11. Fontenot J. D., Ball J. M., Miller M. A., David C. M., Montelaro R. C., A survey of potential problems and quality control in peptide synthesis by the fluorenylmethoxycarbonyl procedure Peptide Research 1991 4 1 19 25
12. Pag U., Oedenkoven M., Sass V., Shai Y., Shamova O., Antcheva N., Tossi A., Sahl H. G., Analysis of in vitro activities and modes of action of synthetic antimicrobial peptides derived from an -helical sequence template Journal of Antimicrobial Chemotherapy 2008 61 2 341 352
13. Park I. Y., Park C. B., Kim M. S., Kim S. C., Parasin I, an antimicrobial peptide derived from histone H2A in the catfish, Parasilurus asotus FEBS Letters 1998 437 3 258 262 (Pubitemid 28511170)
14. Deléage G., Combet C., Blanchet C., Geourjon C., ANTHEPROT: an integrated protein sequence analysis software with client/server capabilities Computers in Biology and Medicine 2001 31 4 259 267 (Pubitemid 32378727)
15. Stajich J. E., Block D., Boulez K., Brenner S. E., Chervitz S. A., Dagdigian C., Fuellen G., Gilbert J. G. R., Korf I., Lapp H., Lehvslaiho H., Matsalla C., Mungall C. J., Osborne B. I., Pocock M. R., Schattner P., Senger M., Stein L. D., Stupka E., Wilkinson M. D., Birney E., The Bioperl toolkit: Perl modules for the life sciences Genome Research 2002 12 10 1611 1618 (Pubitemid 35175100)
16. Gautier R., Douguet D., Antonny B., Drin G., HELIQUEST: a web server to screen sequences with specific -helical properties Bioinformatics 2008 24 18 2101 2102
17. Chen Y., Guarnieri M. T., Vasil A. I., Vasil M. L., Mant C. T., Hodges R. S., Role of peptide hydrophobicity in the mechanism of action of -helical antimicrobial peptides Antimicrobial Agents and Chemotherapy 2007 51 4 1398 1406 (Pubitemid 46586822)
18. Jiang Z., Vasil A. I., Gera L., Vasil M. L., Hodges R. S., Rational design of -helical antimicrobial peptides to target Gram-negative pathogens, Acinetobacter baumannii and Pseudomonas aeruginosa: utilization of charge, specificity determinants, total hydrophobicity, hydrophobe type and location as design parameters to improve the therapeutic ratio Chemical Biology and Drug Design 2011 77 4 225 240
19. Jiang Z., Vasil A. I., Hale J. D., Hancock R. E. W., Vasil M. L., Hodges R. S., Effects of net charge and the number of positively charged residues on the biological activity of amphipathic -helical cationic antimicrobial peptides Biopolymers 2008 90 3 369 383