Obesogens, stem cells and the maternal programming of obesity

Journal of Developmental Origins of Health and Disease

Volumn 2, Issue 1, 2011, Pages 3-8

  Blumberg, B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

endocrine disrupter; multipotent stromal cell; obesity; obesogen; organotin; PPAR ; sadipocyte

Indexed keywords

EID: 84858294509     PISSN: 20401744     EISSN: 20401752     Source Type: Journal    
DOI: 10.1017/S2040174410000589     Document Type: Conference Paper

References (39)

1. Flegal KM, Carroll MD, Ogden CL, et al. Prevalence and trends in obesity among US adults, 1999-2008. JAMA. 2010; 303, 235-241.
2. World Health Organization Global Strategy on Diet, Physical Activity and Health: Obesity and Overweight. 2009; Retrieved 13 May 2010 from http://www.who.int/dietphysicalactivity/ publications/facts/obesity/en/.
3. Grun F, Blumberg B. Endocrine disrupters as obesogens. Mol Cell Endocrinol. 2009; 304, 19-29.
4. Grun F, Blumberg B. Minireview: The case for obesogens. Mol Endocrinol. 2009; 23, 1127-1134.
5. Nyirenda MJ, Lindsay RS, Kenyon CJ, et al. Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest. 1998; 101, 2174-2181. (Pubitemid 28244101)
6. Achard V, Boullu-Ciocca S, Desbriere R, et al. Perinatal programming of central obesity and the metabolic syndrome: Role of glucocorticoids. Metab Syndr Relat Disord. 2006; 4, 129-137. (Pubitemid 44130372)
7. Hales CN, Barker DJ. The thrifty phenotype hypothesis. Br Med Bull. 2001; 60, 5-20. (Pubitemid 34123501)
8. Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986; 1, 1077-1081. (Pubitemid 16106274)
9. Barker DJ, Osmond C. Low birth weight and hypertension. BMJ. 1988; 297, 134-135.
10. Barker DJ, Osmond C, Golding J, et al. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989; 298, 564-567. (Pubitemid 19072097)
11. Power C, Jefferis BJ. Fetal environment and subsequent obesity: A study of maternal smoking. Int J Epidemiol. 2002; 31, 413-419. (Pubitemid 34537801)
12. Baillie-Hamilton PF. Chemical toxins: A hypothesis to explain the global obesity epidemic. J Altern Complement Med. 2002; 8, 185-192. (Pubitemid 34438491)
13. Heindel JJ. Endocrine disruptors and the obesity epidemic. Toxicol Sci. 2003; 76, 247-249. (Pubitemid 38035417)
14. Badman MK, Flier JS. The gut and energy balance: Visceral allies in the obesity wars. Science. 2005; 307, 1909-1914. (Pubitemid 40404693)
15. Rangwala SM, Lazar MA. Transcriptional control of adipogenesis. Annu Rev Nutr. 2000; 20, 535-559.
16. Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med. 2004; 10, 355-361. (Pubitemid 38508511)
17. Lazar MA. How obesity causes diabetes: Not a tall tale. Science. 2005; 307, 373-375. (Pubitemid 40139971)
18. Tontonoz P, Spiegelman BM. Fat and beyond: The diverse biology of PPARgamma. Annu Rev Biochem. 2008; 77, 289-312.
19. Grun F, Blumberg B. Environmental obesogens: Organotins and endocrine disruption via nuclear receptor signaling. Endocrinology. 2006; 147, S50-S55. (Pubitemid 43764590)
20. Grun F, Watanabe H, Zamanian Z, et al. Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol Endocrinol. 2006; 20, 2141-2155. (Pubitemid 44286710)
21. Newbold RR, Padilla-Banks E, Snyder RJ, et al. Developmental exposure to estrogenic compounds and obesity. Birth Defects Res A Clin Mol Teratol. 2005; 73, 478-480. (Pubitemid 41045293)
22. Newbold RR, Padilla-Banks E, Jefferson WN. Environmental estrogens and obesity. Mol Cell Endocrinol. 2009; 304, 84-89.
23. Rubin BS, Murray MK, Damassa DA, et al. Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels. Environ Health Perspect. 2001; 109, 675-680. (Pubitemid 32785423)
24. Larsen TM, Toubro S, Astrup A. PPARgamma agonists in the treatment of type II diabetes: Is increased fatness commensurate with long-term efficacy? Int J Obes Relat Metab Disord. 2003; 27, 147-161. (Pubitemid 36255796)
25. Rubenstrunk A, Hanf R, Hum DW, et al. Safety issues and prospects for future generations of PPAR modulators. Biochim Biophys Acta. 2007; 1771, 1065-1081. (Pubitemid 47208546)
26. Stahlhut RW, van Wijgaarden E, Dye TD, et al. Concentrations of urinary phthalate metabolites are associated with increased waist circumferece and insulin resistance in adult U.S. males. Environ Health Perspect. 2007; 115, 876-882. (Pubitemid 46902242)
27. Hurst CH, Waxman DJ. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci. 2003; 74, 297-308. (Pubitemid 36958298)
28. Feige JN, Gelman L, Rossi D, et al. The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem. 2007; 282, 19152-19166. (Pubitemid 47100190)
29. Hines EP, White SS, Stanko JP, et al. Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life. Mol Cell Endocrinol. 2009; 304, 97-105.
30. Inadera H, Shimomura A. Environmental chemical tributyltin augments adipocyte differentiation. Toxicol Lett. 2005; 159, 226-234. (Pubitemid 41501589)
31. Kanayama T, Kobayashi N, Mamiya S, et al. Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway. Mol Pharmacol. 2005; 67, 766-774. (Pubitemid 40365324)
32. Carfi M, Croera C, Ferrario D, et al. TBTC induces adipocyte differentiation in human bone marrow long term culture. Toxicology. 2008; 249, 11-18.
33. Blaber SJM. The occurrence of a penis-like outgrowth behind the right tentacle in spent females of Nucella lapillus. Proc Malacol Soc Lon. 1970; 39, 231-233.
34. Gibbs P, Bryan G. Reproductive failure in populations of the dogwhelk, Nucella lapillus, caused by imposex induced by tributyltin from antifouling paints. J Mar Biol Assoc U.K. 1986; 66, 767-777.
35. Shimasaki Y, Kitano T, Oshima Y, et al. Tributyltin causes masculinization in fish. Environ Toxicol Chem. 2003; 22, 141-144. (Pubitemid 35471331)
36. Kirchner S, Kieu T, Chow C, et al. Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes. Mol Endocrinol. 2010; 24, 526-539.
37. Kannan K, Senthilkumar K, Giesy J. Occurrence of butyltin compounds in human blood. Environ Sci Technol. 1999; 33, 1776-1779. (Pubitemid 29232916)
38. Rantakokko P, Turunen A, Verkasalo PK, et al. Blood levels of organotin compounds and their relation to fish consumption in Finland. Sci Total Environ. 2008; 399, 90-95.
39. Anastas P, Eghbali N. Green chemistry: Principles and practice. Chem Soc Rev. 2010; 39, 301-312.