Impact of cell cycle disruption on impaired hepatic regeneration in aged livers with ischemic insult

Journal of Surgical Research

Volumn 173, Issue 2, 2012, Pages 267-277

  Suzuki, Atsushi ^a   Sakaguchi, Takanori ^a   Inaba, Keisuke ^a   Suzuki, Shohachi ^b   Konno, Hiroyuki ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Iwata City Hospital   (Japan)

Author keywords

aging; cell cycle; IL 6 STAT3 pathway; ischemia and reperfusion injury; liver regeneration

Indexed keywords

CYCLIN A; CYCLIN D1; CYCLIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PROTEIN KINASE B; STAT3 PROTEIN;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; GROUPS BY AGE; HISTOPATHOLOGY; LIVER CELL; LIVER ISCHEMIA; LIVER NECROSIS; LIVER REGENERATION; LIVER RESECTION; MALE; NONHUMAN; PORTOSYSTEMIC ANASTOMOSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPLEEN; SURVIVAL RATE;

AGING; ANIMALS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CYCLINS; HEPATECTOMY; HEPATOCYTES; INTERLEUKIN-6; ISCHEMIA; LIVER; LIVER REGENERATION; MALE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED F344; STAT3 TRANSCRIPTION FACTOR; SURVIVAL ANALYSIS;

EID: 84858291179     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.10.012     Document Type: Article

References (43)

1. Hanazaki K, Kajikawa S, Shimozawa N, et al. Hepatic resection for hepatocellular carcinoma in the elderly. JAmColl Surg 2001; 192:38.
2. Popper H. Aging and the liver. Prog Liver Dis 1986;8:659.
3. Kondo K, Chijiiwa K, Funagayama M, et al. Hepatic resection is justified for elderly patients with hepatocellular carcinoma. World J Surg 2008;32:2223.
4. Ijtsma AJ, Boevé LM, van der Hilst CS, et al. The survival paradox of elderly patients after major liver resections. J Gastrointest Surg 2008;12:2196.
5. 14 into the DNA of regenerating rat liver. Cancer Res 1964;24:509.
6. Fry M, Silber J, Loeb LA, et al. Delayed and reduced cell replication and diminishing levels of DNA polymerase-a in regenerating liver of aging mice. J Cell Physiol 1984;118:225.
7. Li W, Liang X, Kellendonk C, et al. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem 2002;277:28411.
8. Huguet C, Gavelli A, Chieco PA, et al. Liver ischemia for hepatic resection: Where is the limit? Surgery 1992;111:251.
9. Okamoto K, Suzuki S, Kurachi K, et al. Beneficial effect of deletion variant of hepatocyte growth factor for impaired hepatic regeneration in the ischemically damaged liver. World J Surg 2002;26:1260.
10. Selzner M, Camargo CA, Clavien P. Ischemia impairs liver regeneration after major tissue loss in rodents: Protective effects of interleukin-6. Hepatology 1999;30:469.
11. Park Y, Hirose R, Coatney JL, et al. Ischemia-reperfusion injury is more severe in old versus young rat livers. J Surg Res 2007; 137:96.
12. Selzner M, Selzner N, Jochum W, et al. Increased ischemic injury in old mouse liver: An ATP-dependent mechanism. Liver Transpl 2007;13:382.
13. Cressman DE, Diamond RH, Taub R. Rapid activation of the Stat3 transcription complex in liver regeneration. Hepatology 1995;21:1443.
14. Haga S, Terui K, Zhang HQ, et al. Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Invest 2003;112:989.
15. Meredith CG, Wade DN. A model of portal-systemic shunting in the rat. Clin Exp Pharmacol Physiol 1981;8:651.
16. Higgins G, Anderson R. Experimental pathology of the liver. Arch Pathol 1931;12:186.
17. Stennicke HR, Salvesen GS. Caspases - controlling intracellular signals by protease zymogen activation. Biochim Biophys Acta 2000;1477:299.
18. Haga S, Ogawa W, Inoue H, et al. Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liverspecific STAT3-deficient mice. J Hepatol 2005;43:799.
19. Harada N, Hatano E, Koizumi N, et al. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res 2004; 121:159.
20. Imose M, Nagaki M, Naiki T, et al. Inhibition of nuclear factor kB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor a in mice. Liver int 2003;23:386.
21. Morales-Ruiz M, Fondevila C,Muñoz-Luque J, et al. Gene transduction of an active mutant of akt exerts cytoprotection and reduces graft injury after liver transplantation. Am J Transplant 2007;7:769.
22. Plümpe J, Malek NP, Bock CT, et al. NF-κB determines between apoptosis and proliferation in hepatocytes during liver regeneration. Am J Physiol Gastrointest Liver Physiol 2000;278:G173.
23. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997;276:60.
24. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 1995;9:1149.
25. Mudryj M, Devoto SH, Hiebert SW, et al. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 1991;65:1243.
26. Kuboki S, Okaya T, Schuster R, et al. Hepatocyte NF-κB activation is hepatoprotective during ischemia-reperfusion injury and is augmented by ischemic hypothermia. Am J Physiol Gastrointest Liver Physiol 2007;292:G201.
27. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995;376:167.
28. Bellas RE, FitzGerald MJ, Fausto N, Sonenshein GE. Inhibition of NF-κB activity induces apoptosis in murine hepatocytes. AmJ Pathol 1997;151:891.
29. Okaya T, Blanchard J, Schuster R, et al. Age-dependent responses to hepatic ischemia/reperfusion injury. Shock 2005; 24:421.
30. Huber N, Sakai N, Eismann T, et al. Age-related decrease in proteasome expression contributes to defective nuclear factor-κB activation during hepatic ischemia/reperfusion. Hepatology 2009; 49:1718.
31. Kühnel F, Zender L, Paul Y, et al. NFκB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J Biol Chem 2000;275:6421.
32. Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996;274:1379.
33. Matsumoto T, O'Malley K, Efron PA, et al. Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning. Surgery 2006;140:793.
34. Guttridge DC, Albanese C, Reuther JY, et al. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 1999;19:5785.
35. O'Farrell AM, Parry DA, Zindy F, et al. Stat3-dependent induction of p19INK4D by IL-10 contributes to inhibition of macrophage proliferation. J Immunol 2000;164:4607.
36. Wüstefeld T, Rakemann T, Kubicka S, et al. Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice. Hepatology 2000;32:514.
37. Debonera F, Wang G, Xie J, et al. Severe preservation injury induces Il-6/STAT3 activation with lack of cell cycle progression after partial liver graft transplantation. Am J Transplant 2004; 4:1964.
38. Gagliano N, Arosio B, Grizzi F, et al. Acute liver CCl(4) intoxication causes low HSP70 gene expression and a delayed transition through the cell cycle in aged rats. Exp Gerontol 2002;37:791.
39. Kitano S, Fawcett TW, Yo Y, et al. Molecular mechanisms of impaired stimulation of DNA synthesis in cultured hepatocytes of aged rats. Am J Physiol 1998;275:C146.
40. Ohtake Y, Maruko A, Ohishi N, et al. Effect of aging on EGFinduced proliferative response in primary cultured periportal and perivenous hepatocytes. J Hepatol 2008;48:246.
41. Chen WD, Wang YD, Zhang L, et al. Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology 2010;51:953.
42. Timchenko NA. Aging and liver regeneration. Trends Endocrinol Metab 2009;20:171.
43. Lee DG, Bell SP. ATPase switches controlling DNA replication initiation. Curr Opin Cell Biol 2000;12:280.