Major stress hormones suppress the response of macrophages through down-regulation of TLR2 and TLR4

Journal of Surgical Research

Volumn 173, Issue 2, 2012, Pages 354-361

  Du, Quan ^a,b   Min, Su ^a   Chen, Li Yong ^b   Ma, Yong Da ^b   Guo, Xiao Li ^b   Wang, Zhen ^b   Wang, Zheng Guo ^b  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

catecholamines; glucocorticoids; lipopolysaccharide; macrophages; Pam3CSK4; Toll like receptors

Indexed keywords

ADRENALIN; CORTICOSTERONE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; LIPOPOLYSACCHARIDE; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; NORADRENALIN; PAM 3 CSK 4; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPINEPHRINE; IMMUNITY, INNATE; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MACROPHAGES; MALE; MYELOID DIFFERENTIATION FACTOR 88; NOREPINEPHRINE; RATS; RATS, WISTAR; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84858280708     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2010.10.016     Document Type: Article

References (40)

1. Zellweger R, Ayala A, Zhu XL, et al. Effect of surgical trauma on splenocyte and peritoneal macrophage immune function. J Trauma 1995;39:645.
2. McCarter MD, Mack VE, Daly JM, et al. Trauma-induced alterations in macrophage function. Surgery 1998;123:96.
3. Perl M, Gebhard F, Bruckner UB, et al. Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge. Crit Care Med 2005;33:1351.
4. Sternberg EM. Neural regulation of innate immunity: A coordinated nonspecific host response to pathogens. Nat Rev Immunol 2006;6:318.
5. Barton GM. A calculated response: Control of inflammation by the innate immune system. J Clin Invest 2008;118:413.
6. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783.
7. Li M, Carpio DF, Zheng Y, et al. An essential role of the NF-κB/Toll-like receptor pathway in induction of inflammatory and tissue-repair gene expression by necrotic cells. J Immunol 2001;166:7128.
8. Mollen KP, Anand RJ, Tsung A, et al. Emerging paradigm: Toll-like receptor 4-sentinel for the detection of tissue damage. Shock 2006;26:430.
9. Bianchi ME. DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 2007;81:1.
10. Levy RM, Prince JM, Yang R, et al. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol 2006;291:R970.
11. Hoth JJ, Hudson WP, Brownlee NA, et al. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock 2007;28:447.
12. Hoth JJ, Wells JD, Brownlee NA, et al. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock 2009;31:376.
13. Kaczorowski DJ, Mollen KP, Edmonds R, et al. Early events in the recognition of danger signals after tissue injury. J Leukoc Biol 2008;83:546.
14. Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med 2007;84:712.
15. Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol 2006;117:979.
16. Webster JI, Tonelli L, Sternberg EM. Neuroendocrine regulation of immunity. Annu Rev Immunol 2002;20:125.
17. Fabian TC, Croce MA, Fabian MJ, et al. Reduced tumor necrosis factor production in endotoxin-spiked whole blood after trauma: Experimental results and clinical correlation. Surgery 1995; 118:63.
18. Kimura Y, Yaegashi Y, Sato N. Tumor necrosis factor-α production after esophageal cancer surgery: Differences in the response to lipopolysaccharide stimulation among whole blood, pleural effusion cells, and bronchoalveolar lavage fluid cells. Surg Today 1999;29:10.
19. Adib-Conquy M, Moine P, Asehnoune K, et al. Toll-like receptor mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation. Am J Respir Crit Care Med 2003;168:158.
20. Wang JH, Doyle M, Manning BJ, et al. Induction of bacterial lipoprotein tolerance is associated with suppression of Toll-like receptor 2 expression. J Biol Chem 2002;277:36068.
21. Nomura F, Akashi S, Sakao Y, et al. Endotoxin tolerance inmouse peritoneal macrophages correlates with down-regulation of surface Toll-like receptor 4 expression. J Immunol 2000;164:3476.
22. Sweet MJ, Campbell CC, Sester DP, et al. Colony-stimulating factor-1 suppresses responses to CpG DNA and expression of Toll-like receptor 9 but enhances responses to lipopolysaccharide in murine macrophages. J Immunol 2002;168:392.
23. Roger T, David J, Glauser MP, et al. MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 2001;414:920.
24. Bosisio D, Polentarutti N, Sironi M, et al. Stimulation of Toll-like receptor 4 expression in human mononuclear phagocytes by interferon- γ: A molecular basis for priming and synergism with bacterial lipopolysaccharide. Blood 2002;99:3427.
25. Mita Y, Dobashi K, Endou K, et al. Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4. Immunol Let 2002;81:71.
26. Vah1 TP, Ulrich-Lai YM, Ostrander MM, et al. Comparative analysis of ACTH and corticosterone sampling methods in rats. Am J Physiol Endocrinol Metab 2005;289:823.
27. Faure E, Thomas L, Xu H, et al. Bacterial lipopolysaccharide and IFN-γ induceToll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: Role of NF-κB activation. J Immunol 2001;166:2018.
28. Liu Y, Wang Y, Yamakuchi M, et al. Upregulation of Toll-like receptor 2 gene expression in macrophage response to peptidoglycan and high concentration of lipopolysaccharide is involved in NF-k b activation. Infect Immun 2001;69:2788.
29. Homma T, Kato A, Hashimoto N, et al. Corticosteroid and cytokines synergistically enhance Toll-like receptor 2 expression in respiratory epithelial cells. Am J Respir Cell Mol Biol 2004; 31:463.
30. Rozkova D, Horvath R, Bartunkova J, et al. Glucocorticoids severely impair differentiation and antigen presenting function of dendritic cells despite upregulation of Toll-like receptors. Clin Immunol 2006;120:260.
31. Matsuguchi T, Musikacharoen T, Ogawa T, et al. Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages. J Immuol 2000;165:5767.
32. Wolfs TG, Buurman WA, van Schadewijk A, et al. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-γ and TNF-α mediated up-regulation during inflammation. J Immunol 2002;168:1286.
33. Elenkov IJ, Wilder RL, Chrousos GP, et al. The sympathetic nerve-an integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev 2000;52:595.
34. Molina PE. Neurobiology of the stress response:contribution of the sympathetic nervous system to the neuroimmune axis in traumatic injury. Shock 2005;24:3.
35. Tajima T, Endo H, Suzuki Y, et al. Immobilization stress-induced increase of hippocampal acetylcholine and of plasma epinephrine, norepinephrine and glucose in rats. Brain Research 1996;720:155.
36. Zinyama BB, Bancroft GJ, Sigola LB. Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumor necrosis factor-α and interleukin-10. Immunology 2001:439.
37. García JJ, del Carmen Sáez M, De la Fuente M, et al. Regulation of phagocytic process of macrophages by noradrenaline and its end metabolite 4-hydroxy-3-metoxyphenyl-glycol. Role of α-and β-adrenoreceptors. Mol Cell Biochem 2003;254:299.
38. Hasko G, Nemeth ZH, Szabo C, et al. Isoproterenol Inhibits IL-10, TNF-a, and nitric oxide production in RAW 264.7 macrophages. Brain Res Bull 1998;45:183.
39. Siegmund B, Eigler A, Hartmann G, et al. Adrenaline enhances LPS induced IL-10 synthesis: Evidence for protein kinase A-mediated pathway. Int J Immunopharmacol 1998;20:57.
40. Szelenyi J, Kiss JP, Vizi ES. Differential involvement of sympathetic nervous system and immune system in the modulation of TNF-a production by α2- and β-adrenoceptors in mice. J Neuroimmunol 2000;103:34.