메뉴 건너뛰기




Volumn 3, Issue 1, 2012, Pages

Preclinical and first-in-human phase I clinical evaluation of Stampidine, a potent anti-HIV Pharmaceutical drug candidate

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84858244055     PISSN: None     EISSN: 21556113     Source Type: Journal    
DOI: 10.4172/2155-6113.1000138     Document Type: Article
Times cited : (21)

References (34)
  • 3
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, et al. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338: 853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5
  • 4
    • 15744390082 scopus 로고    scopus 로고
    • Declining AIDS mortality in Amsterdam: Contributions of declining HIV incidence and effective therapy
    • Smit C, Geskus R, Uitenbroek D, Mulder D, Van Den Hoek A, et al. (2004) Declining AIDS mortality in Amsterdam: contributions of declining HIV incidence and effective therapy. Epidemiology 15: 536-542.
    • (2004) Epidemiology , vol.15 , pp. 536-542
    • Smit, C.1    Geskus, R.2    Uitenbroek, D.3    Mulder, D.4    Van den Hoek, A.5
  • 5
    • 0034446565 scopus 로고    scopus 로고
    • The genetic basis of HIV-1 resistance to reverse transcriptase and protease inhibitors
    • Shafer R, Kantor R, Gonzales MJ (2000) The genetic basis of HIV-1 resistance to reverse transcriptase and protease inhibitors. AIDS Rev 2: 211-228.
    • (2000) AIDS Rev , vol.2 , pp. 211-228
    • Shafer, R.1    Kantor, R.2    Gonzales, M.J.3
  • 6
    • 22544486548 scopus 로고    scopus 로고
    • HIV protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug resistance surveillance
    • Rhee SY, Fessel WJ, Zolopa AR, Hurley L, Liu T, Taylor J, et al. (2005) HIV protease and reverse transcriptase mutations: correlations with antiretroviral therapy in subtype B isolates and implications for drug resistance surveillance. J Infect Dis 192: 456-465.
    • (2005) J Infect Dis , vol.192 , pp. 456-465
    • Rhee, S.Y.1    Fessel, W.J.2    Zolopa, A.R.3    Hurley, L.4    Liu, T.5    Taylor, J.6
  • 7
    • 19344373478 scopus 로고    scopus 로고
    • Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration
    • Kantor R, Katzenstein DA, Efron B, Carvalho AP, Wynhoven B, et al. (2005) Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: results of a global collaboration. PLoS Med 2: e112.
    • (2005) PLoS Med , vol.2
    • Kantor, R.1    Katzenstein, D.A.2    Efron, B.3    Carvalho, A.P.4    Wynhoven, B.5
  • 10
    • 84879824380 scopus 로고    scopus 로고
    • AIDS Vaccine Advocacy Coalition. Ongoing PrEP trials
    • AIDS Vaccine Advocacy Coalition. Global advocacy for HIV prevention. Ongoing PrEP trials.
    • Global advocacy for HIV prevention.
  • 11
    • 78649392094 scopus 로고    scopus 로고
    • Chemoprophylaxis for HIV prevention: New opportunities and new questions
    • Mayer KH, Venkatesh KK (2010) Chemoprophylaxis for HIV prevention: new opportunities and new questions. J Acquir Immune Defic Syndr 55 Suppl 2: S122-127.
    • (2010) J Acquir Immune Defic Syndr , vol.55 , Issue.SUPPL. 2
    • Mayer, K.H.1    Venkatesh, K.K.2
  • 12
    • 79958087207 scopus 로고    scopus 로고
    • Achieving safe conception in HIV-discordant couples: The potential role of oral preexposure prophylaxis (PrEP) in the United States
    • Lampe MA, Smith DK, Anderson GJ, Edwards AE, Nesheim SR (2011) Achieving safe conception in HIV-discordant couples: the potential role of oral preexposure prophylaxis (PrEP) in the United States. Am J Obstet Gynecol 204: 488. e1-8.
    • (2011) Am J Obstet Gynecol , vol.204
    • Lampe, M.A.1    Smith, D.K.2    Anderson, G.J.3    Edwards, A.E.4    Nesheim, S.R.5
  • 13
    • 79957484785 scopus 로고    scopus 로고
    • Preexposure prophylaxis for HIV prevention
    • Kelesidis T, Landovitz RJ (2011) Preexposure prophylaxis for HIV prevention. Curr HIV/AIDS Rep 8: 94-103.
    • (2011) Curr HIV/AIDS Rep , vol.8 , pp. 94-103
    • Kelesidis, T.1    Landovitz, R.J.2
  • 14
    • 81855160859 scopus 로고    scopus 로고
    • Pre-Exposure Prophylaxis and Antiretroviral Resistance: HIV Prevention at a Cost?
    • Hurt CB, Eron JJ Jr, Cohen MS (2011) Pre-Exposure Prophylaxis and Antiretroviral Resistance: HIV Prevention at a Cost? Clin Infect Dis 53: 1265-1270.
    • (2011) Clin Infect Dis , vol.53 , pp. 1265-1270
    • Hurt, C.B.1    Eron Jr., J.J.2    Cohen, M.S.3
  • 15
    • 71749100912 scopus 로고    scopus 로고
    • Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance
    • Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, et al. (2009) Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. J Biol Chem 284: 35092-35100.
    • (2009) J Biol Chem , vol.284 , pp. 35092-35100
    • Das, K.1    Bandwar, R.P.2    White, K.L.3    Feng, J.Y.4    Sarafianos, S.G.5
  • 16
    • 1442349112 scopus 로고    scopus 로고
    • Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations
    • White KL, Chen JM, Margot NA, Wrin T, Petropoulos CJ, et al. (2004) Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations. Antimicrob Agents Chemother 48: 992-1003.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 992-1003
    • White, K.L.1    Chen, J.M.2    Margot, N.A.3    Wrin, T.4    Petropoulos, C.J.5
  • 17
    • 81855160859 scopus 로고    scopus 로고
    • Pre-Exposure Prophylaxis and Antiretroviral Resistance: HIV Prevention at a Cost?
    • Hurt CB, Eron JJ Jr, Cohen MS (2011) Pre-Exposure Prophylaxis and Antiretroviral Resistance: HIV Prevention at a Cost? Clin Infect Dis 53: 1265-1270.
    • (2011) Clin Infect Dis , vol.53 , pp. 1265-1270
    • Hurt, C.B.1    Eron Jr., J.J.2    Cohen, M.S.3
  • 20
    • 33645099474 scopus 로고    scopus 로고
    • Unmet challenges in HIV therapy and potential of stampidine
    • Uckun FM (2006) Unmet challenges in HIV therapy and potential of stampidine. Arzneimittelforschung 56: 117-120.
    • (2006) Arzneimittelforschung , vol.56 , pp. 117-120
    • Uckun, F.M.1
  • 22
    • 34848886926 scopus 로고    scopus 로고
    • Intracellular nucleoside trophosphate concentrations in HIV-infected patients on dual nucleoside reverse transcriptase inhibitor therapy
    • Moore JD, Acosta EP, Johnson VA, Bassett R, Eron JJ, et al. (2007) Intracellular nucleoside trophosphate concentrations in HIV-infected patients on dual nucleoside reverse transcriptase inhibitor therapy. Antivir Ther 12: 981-986.
    • (2007) Antivir Ther , vol.12 , pp. 981-986
    • Moore, J.D.1    Acosta, E.P.2    Johnson, V.A.3    Bassett, R.4    Eron, J.J.5
  • 23
    • 0032542075 scopus 로고    scopus 로고
    • Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives
    • Venkatachalam TK, Tai HL, Vig R, Chen CL, Jan ST, Uckun FM (1998) Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives. Bioorg Med Chem Lett 8: 3121-3126.
    • (1998) Bioorg Med Chem Lett , vol.8 , pp. 3121-3126
    • Venkatachalam, T.K.1    Tai, H.L.2    Vig, R.3    Chen, C.L.4    Jan, S.T.5    Uckun, F.M.6
  • 24
    • 17644412826 scopus 로고    scopus 로고
    • In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs
    • Uckun FM, Qazi S, Venkatachalam TK (2005). In vitro anti-HIV potency of stampidine alone and in combination with standard anti-HIV drugs. Arzneimittelforschung 55: 223-231.
    • (2005) Arzneimittelforschung , vol.55 , pp. 223-231
    • Uckun, F.M.1    Qazi, S.2    Venkatachalam, T.K.3
  • 26
    • 0034962198 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and metabolism of anti-HIV agent D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] in mice
    • Chen CL, Venkatachalam TK, Zhu ZH, Uckun FM (2001) In vivo pharmacokinetics and metabolism of anti-HIV agent D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] in mice. Drug Metab Dispos 29: 1035-1041.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1035-1041
    • Chen, C.L.1    Venkatachalam, T.K.2    Zhu, Z.H.3    Uckun, F.M.4
  • 27
    • 1842833698 scopus 로고    scopus 로고
    • Metabolism of stavudine-5'-[p-bromophenyl methoxy alaninyl phosphate], stampidine, in mice, dogs, and cats
    • Chen CL, Yu G, Venkatachalam T, Uckun FM (2002) Metabolism of stavudine-5'-[p-bromophenyl methoxy alaninyl phosphate], stampidine, in mice, dogs, and cats. Drug Metab Dispos 30: 1523-1531.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1523-1531
    • Chen, C.L.1    Yu, G.2    Venkatachalam, T.3    Uckun, F.M.4
  • 28
    • 17844409371 scopus 로고    scopus 로고
    • Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations
    • Johnston E, Dupnik KM, Gonzales MJ, Winters MA, Rhee SY, et al. (2005) Panel of prototypical infectious molecular HIV-1 clones containing multiple nucleoside reverse transcriptase inhibitor resistance mutations. AIDS 19: 731-733.
    • (2005) AIDS , vol.19 , pp. 731-733
    • Johnston, E.1    Dupnik, K.M.2    Gonzales, M.J.3    Winters, M.A.4    Rhee, S.Y.5
  • 29
    • 0036841755 scopus 로고    scopus 로고
    • In vivo toxicity, pharmacokinetics, and anti-HIV activity of stavudine-5'-(p-bromo phenyl methoxyalaninyl phosphate) (stampidine) in mice
    • Uckun FM, Qazi S, Pendergrass S, Lisowski E, Waurzyniak B, et al. (2002) In vivo toxicity, pharmacokinetics, and anti-HIV activity of stavudine-5'-(p-bromo phenyl methoxyalaninyl phosphate) (stampidine) in mice. Antimicrob Agents Chemother 46: 3428-3436.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3428-3436
    • Uckun, F.M.1    Qazi, S.2    Pendergrass, S.3    Lisowski, E.4    Waurzyniak, B.5
  • 31
    • 33645101334 scopus 로고    scopus 로고
    • Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent
    • DuMez D, Venkatachalam TK, Uckun FM (2006) Large-scale synthesis and formulation of GMP-grade stampidine, a new anti-HIV agent. Arzneimittelforschung 56: 136-151.
    • (2006) Arzneimittelforschung , vol.56 , pp. 136-151
    • DuMez, D.1    Venkatachalam, T.K.2    Uckun, F.M.3
  • 32
    • 0036840520 scopus 로고    scopus 로고
    • Stampidine is a potent inhibitor of zidovudine and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical HIV-1 isolates with thymidine analog mutations
    • Uckun FM, Pendergrass S, Venkatachalam TK, Qazi S, Richman D (2002) Stampidine is a potent inhibitor of zidovudine and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical HIV-1 isolates with thymidine analog mutations. Antimicrob Agents Chemother 46: 3613-3616.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3613-3616
    • Uckun, F.M.1    Pendergrass, S.2    Venkatachalam, T.K.3    Qazi, S.4    Richman, D.5
  • 33
    • 33847719131 scopus 로고    scopus 로고
    • Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study
    • Uckun FM, DuMez D, Qazi S, Tibbles H, Venkatachalam TK (2007) Anti-retroviral activity of GMP-grade stampidine against genotypically and phenotypically nucleoside reverse transcriptase inhibitor resistant recombinant human immunodeficiency virus. An in vitro study. Arzneimittelforschung 57: 112-121.
    • (2007) Arzneimittelforschung , vol.57 , pp. 112-121
    • Uckun, F.M.1    DuMez, D.2    Qazi, S.3    Tibbles, H.4    Venkatachalam, T.K.5
  • 34
    • 33645096955 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats
    • Uckun FM, Waurzyniak B, Tibbles H, Venkatachalam TK, Erbeck D (2006) In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats. Arzneimittelforschung 56: 176-192.
    • (2006) Arzneimittelforschung , vol.56 , pp. 176-192
    • Uckun, F.M.1    Waurzyniak, B.2    Tibbles, H.3    Venkatachalam, T.K.4    Erbeck, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.