메뉴 건너뛰기




Volumn 56, Issue 2 A, 2006, Pages 176-192

In vivo pharmacokinetics and toxicity profile of the anti-HIV agent stampidine in dogs and feline immunodeficiency virus-infected cats

Author keywords

Anti HIV agents; Antiretroviral therapy; CAS 217178 62 6; DDE 113; HI 113; N p (4 Bromophenyl) 2',3' didehydro 3' deoxy 5' thymidylyl L alanine methyl ester; Stampidine, toxicity profile

Indexed keywords

ALANINE AMINOTRANSFERASE; CAS 217178 62 6; CAS 3056 17 5; DDE 113; DIDANOSINE; DOLASETRON MESILATE; HI 113; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAMPIDINE; STAVUDINE; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 33645096955     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296805     Document Type: Article
Times cited : (11)

References (34)
  • 1
    • 0035833452 scopus 로고    scopus 로고
    • Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection
    • Albrecht, M. A., Bosch, R. J., Hammer, S. M. et al., Nelfinavir, efavirenz, or both after the failure of nucleoside treatment of HIV infection. N. Engl. J. Med. 345, 398 (2001)
    • (2001) N. Engl. J. Med. , vol.345 , pp. 398
    • Albrecht, M.A.1    Bosch, R.J.2    Hammer, S.M.3
  • 2
    • 0035869435 scopus 로고    scopus 로고
    • The cost effectiveness of combination antiretroviral therapy for HIV disease
    • Freedberg, K. A., Losina, E., Weinstein, M. C. et al., The cost effectiveness of combination antiretroviral therapy for HIV disease. N. Engl. J. Med. 344, 824 (2001)
    • (2001) N. Engl. J. Med. , vol.344 , pp. 824
    • Freedberg, K.A.1    Losina, E.2    Weinstein, M.C.3
  • 3
    • 0035880929 scopus 로고    scopus 로고
    • Efavirenz as a substitute for protease inhibitors in HIV-1-infected patients with undetectable plasma viral load on HAART: A median follow-up of 64 weeks
    • Rey, D., Schmitt, M. P., Partisani, M. et al., Efavirenz as a substitute for protease inhibitors in HIV-1-infected patients with undetectable plasma viral load on HAART: a median follow-up of 64 weeks. J. Acquir. Immune Defic. Syndr. 27, 459 (2001)
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.27 , pp. 459
    • Rey, D.1    Schmitt, M.P.2    Partisani, M.3
  • 4
    • 0033576814 scopus 로고    scopus 로고
    • Combination therapy with efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors in children infected with human immunodeficiency virus type 1
    • Pediatric AIDS Clinical Trials Group 382 Team
    • Starr, S. E., Fletcher, C. V., Spector, S. A. et al., Combination therapy with efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors in children infected with human immunodeficiency virus type 1. Pediatric AIDS Clinical Trials Group 382 Team. N. Engl. J. Med. 341, 1874 (1999)
    • (1999) N. Engl. J. Med. , vol.341 , pp. 1874
    • Starr, S.E.1    Fletcher, C.V.2    Spector, S.A.3
  • 5
    • 0034985186 scopus 로고    scopus 로고
    • Resistance of human immunodeficiency virus type 1 to reverse transcriptase and protease inhibitors: Genotypic and phenotypic testing
    • Lerma, J. G., Heneine, W., Resistance of human immunodeficiency virus type 1 to reverse transcriptase and protease inhibitors: genotypic and phenotypic testing. J. Clin. Virol. 21, 197 (2001)
    • (2001) J. Clin. Virol. , vol.21 , pp. 197
    • Lerma, J.G.1    Heneine, W.2
  • 6
    • 0034456474 scopus 로고    scopus 로고
    • Resistance against reverse transcriptase inhibitors
    • O'Brien, W. A., Resistance against reverse transcriptase inhibitors. Clin. Infect. Dis. 30 (Suppl. 2), S185 (2000)
    • (2000) Clin. Infect. Dis. , vol.30 , Issue.SUPPL. 2
    • O'Brien, W.A.1
  • 7
    • 0033940444 scopus 로고    scopus 로고
    • Incidence and impact of resistance against approved antiretroviral drugs
    • Pillay, D., Taylor, S., Richman, D. D., Incidence and impact of resistance against approved antiretroviral drugs. Rev. Med. Virol. 10, 231 (2000)
    • (2000) Rev. Med. Virol. , vol.10 , pp. 231
    • Pillay, D.1    Taylor, S.2    Richman, D.D.3
  • 8
    • 0032722339 scopus 로고    scopus 로고
    • Genotypic resistance to zidovudine as a predictor of failure of subsequent therapy with human immunodeficiency virus type-1 nucleoside reverse-transcriptase inhibitors
    • Venturi, G., Romano, L., Catucci, M. et al., Genotypic resistance to zidovudine as a predictor of failure of subsequent therapy with human immunodeficiency virus type-1 nucleoside reverse-transcriptase inhibitors. Eur. J. Clin. Microbiol. Infect. Dis. 18, 274 (1999)
    • (1999) Eur. J. Clin. Microbiol. Infect. Dis. , vol.18 , pp. 274
    • Venturi, G.1    Romano, L.2    Catucci, M.3
  • 9
    • 0035912249 scopus 로고    scopus 로고
    • HIV chemotherapy
    • Richman, D. D., HIV chemotherapy. Nature 410, 995 (2001)
    • (2001) Nature , vol.410 , pp. 995
    • Richman, D.D.1
  • 10
    • 33645109810 scopus 로고    scopus 로고
    • US Patent No. 6,030,957, Aryl phosphate derivatives of d4T having anti-HIV activity (2/29/ 2000)
    • Uckun, F. M., Vig, R., US Patent No. 6,030,957, Aryl phosphate derivatives of d4T having anti-HIV activity (2/29/ 2000)
    • Uckun, F.M.1    Vig, R.2
  • 11
    • 33645109497 scopus 로고    scopus 로고
    • US Patent No. 6,350,736, Aryl phosphate derivatives of d4T having anti-HIV activity (2/26/ 2002)
    • Uckun, F. M., Vig, R., US Patent No. 6,350,736, Aryl phosphate derivatives of d4T having anti-HIV activity (2/26/ 2002)
    • Uckun, F.M.1    Vig, R.2
  • 12
    • 33645110124 scopus 로고    scopus 로고
    • US Patent No. 6,503,890, Aryl phosphate derivatives of d4T having anti-HIV activity (1/7/2003)
    • Uckun, F. M., US Patent No. 6,503,890, Aryl phosphate derivatives of d4T having anti-HIV activity (1/7/2003)
    • Uckun, F.M.1
  • 13
    • 33645109083 scopus 로고    scopus 로고
    • US Patent No. 6,528,495, Aryl phosphate derivatives of d4T having anti-HIV activity (3/4/ 2003)
    • Uckun, F. M., Vig, R., US Patent No. 6,528,495, Aryl phosphate derivatives of d4T having anti-HIV activity (3/4/ 2003)
    • Uckun, F.M.1    Vig, R.2
  • 14
    • 33645105859 scopus 로고    scopus 로고
    • US Patent No. 6,537,975, Aryl phosphate derivatives of d4T having anti-HIV activity (3/25/ 2003)
    • Uckun, F. M., Vig, R., US Patent No. 6,537,975, Aryl phosphate derivatives of d4T having anti-HIV activity (3/25/ 2003)
    • Uckun, F.M.1    Vig, R.2
  • 15
    • 33645102668 scopus 로고    scopus 로고
    • US Patent No. 6,670,336, Aryl phosphate derivatives of d4T having anti-HIV activity (12/30/ 2003)
    • Uckun, F. M., Vig, R., US Patent No. 6,670,336, Aryl phosphate derivatives of d4T having anti-HIV activity (12/30/ 2003)
    • Uckun, F.M.1    Vig, R.2
  • 16
    • 33645104975 scopus 로고    scopus 로고
    • US Patent Application Publication US 2004/0171577 Al, Aryl phosphate derivatives of d4T having anti-HIV activity (9-2-04)
    • Uckun, F. M., Vig, R., US Patent Application Publication US 2004/0171577 Al, Aryl phosphate derivatives of d4T having anti-HIV activity (9-2-04)
    • Uckun, F.M.1    Vig, R.2
  • 17
    • 33645109738 scopus 로고    scopus 로고
    • European Patent Specification EP 1090018 B1, Aryl phosphate derivatives of d4T having anti-HIV activity
    • Uckun, F. M., Vig, R., European Patent Specification EP 1090018 B1, Aryl phosphate derivatives of d4T having anti-HIV activity
    • Uckun, F.M.1    Vig, R.2
  • 18
    • 0032542075 scopus 로고    scopus 로고
    • Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives
    • Venkatachalam, T. K., Tai, H. L., Vig, R. et al., Enhancing effects of a mono-bromo substitution at the para position of the phenyl moiety on the metabolism and anti-HIV activity of d4T-phenyl methoxyalaninyl phosphate derivatives. Bioorg. Med. Chem. Lett. 8, 3121 (1998)
    • (1998) Bioorg. Med. Chem. Lett. , vol.8 , pp. 3121
    • Venkatachalam, T.K.1    Tai, H.L.2    Vig, R.3
  • 19
    • 1642403276 scopus 로고    scopus 로고
    • Phenyl phosphoramidate derivatives of STV as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus
    • Uckun, F. M., Pendergrass, S., Qazi, S. et al., Phenyl phosphoramidate derivatives of STV as anti-HIV agents with potent and selective in-vitro antiviral activity against adenovirus. Eur. J. Med. Chem. 39, 225 (2004)
    • (2004) Eur. J. Med. Chem. , vol.39 , pp. 225
    • Uckun, F.M.1    Pendergrass, S.2    Qazi, S.3
  • 20
    • 0031715789 scopus 로고    scopus 로고
    • D4T-5′-[p-bromophenyl methoxyalaninyl phosphate] as a potent and non-toxic anti-human immunodeficiency virus agent
    • Vig, R., Venkatachalam, T. K., Uckun, F. M., D4T-5′-[p-bromophenyl methoxyalaninyl phosphate] as a potent and non-toxic anti-human immunodeficiency virus agent. Antivir. Chem. Chemother. 9, 445 (1998)
    • (1998) Antivir. Chem. Chemother. , vol.9 , pp. 445
    • Vig, R.1    Venkatachalam, T.K.2    Uckun, F.M.3
  • 21
    • 0036840520 scopus 로고    scopus 로고
    • STAMP is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations
    • Uckun, F. M., Pendergrass, S., Venkatachalam, T. K. et al., STAMP is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations. Antimicrob Agents Chemother. 46, 3613 (2002)
    • (2002) Antimicrob Agents Chemother. , vol.46 , pp. 3613
    • Uckun, F.M.1    Pendergrass, S.2    Venkatachalam, T.K.3
  • 22
    • 0742322029 scopus 로고    scopus 로고
    • In vitro activity of STAMP against primary clinical human immunodeficiency virus isolates
    • Uckun, F. M., Pendergrass, S., Qazi, S. et al., In vitro activity of STAMP against primary clinical human immunodeficiency virus isolates. Arzneim.-Forsch./Drug Res. 54, 69 (2004)
    • (2004) Arzneim.-Forsch./Drug Res. , vol.54 , pp. 69
    • Uckun, F.M.1    Pendergrass, S.2    Qazi, S.3
  • 23
    • 0034962198 scopus 로고    scopus 로고
    • In vivo pharmacokinetics and metabolism of anti-human immunodeficiency virus agent D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] (sampidine) in mice
    • Chen, C. L., Venkatachalam, T. K., Zhu, Z. H. et al., In vivo pharmacokinetics and metabolism of anti-human immunodeficiency virus agent D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] (sampidine) in mice. Drug Metab. Dispos. 29, 1035 (2001)
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 1035
    • Chen, C.L.1    Venkatachalam, T.K.2    Zhu, Z.H.3
  • 24
    • 1842833698 scopus 로고    scopus 로고
    • Metabolism of STV-5'-[p-bromophenyl methoxyalaninyl phosphate], STAMP, in mice, dogs, and cats
    • Chen, C. L., Yu, G., Venkatachalam, T. K. et al., Metabolism of STV-5'-[p-bromophenyl methoxyalaninyl phosphate], STAMP, in mice, dogs, and cats. Drug Metab. Dispos. 30, 1523 (2002)
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 1523
    • Chen, C.L.1    Yu, G.2    Venkatachalam, T.K.3
  • 25
    • 0036841755 scopus 로고    scopus 로고
    • In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of STV-5'-(p-bromophenyl methoxyalaninyl phosphate) (STAMP) in mice
    • Uckun, F. M., Qazi, S., Pendergrass, S. et al., In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of STV-5'-(p-bromophenyl methoxyalaninyl phosphate) (STAMP) in mice. Antimicrob Agents Chemother. 46, 3428 (2002)
    • (2002) Antimicrob Agents Chemother. , vol.46 , pp. 3428
    • Uckun, F.M.1    Qazi, S.2    Pendergrass, S.3
  • 26
    • 0038627530 scopus 로고    scopus 로고
    • Toxicity and pharmacokinetics of STAMP in mice and rats
    • Uckun, F. M., Chen, C. L., Lisowski, E. et al., Toxicity and pharmacokinetics of STAMP in mice and rats. Arzneim.-Forsch./Drug Res. 53, 357 (2003)
    • (2003) Arzneim.-Forsch./Drug Res. , vol.53 , pp. 357
    • Uckun, F.M.1    Chen, C.L.2    Lisowski, E.3
  • 27
    • 0346025452 scopus 로고    scopus 로고
    • Clinical development of microbicides for the prevention of HIV infection
    • D'Cruz, O. J., Uckun, F. M., Clinical development of microbicides for the prevention of HIV infection. Curr. Pharm. Des. 10, 315 (2004)
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 315
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 28
    • 1542513385 scopus 로고    scopus 로고
    • STAMP is a potential non-spermicidal broad-spectrum anti-human immunodeficiency virus microbicide
    • D'Cruz, O. J., Uckun, F. M., STAMP is a potential non-spermicidal broad-spectrum anti-human immunodeficiency virus microbicide. Fertil. Steril. 81 (Suppl. 1), 831 (2004)
    • (2004) Fertil. Steril. , vol.81 , Issue.SUPPL. 1 , pp. 831
    • D'Cruz, O.J.1    Uckun, F.M.2
  • 29
    • 0345169183 scopus 로고    scopus 로고
    • Development and evaluation of a thermoreversible ovule formulation of STAMP, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide
    • D'Cruz, O. J., Samuel, P., Waurzyniak, B. et al., Development and evaluation of a thermoreversible ovule formulation of STAMP, a novel nonspermicidal broad-spectrum anti-human immunodeficiency virus microbicide. Biol. Reprod. 69, 1843 (2003)
    • (2003) Biol. Reprod. , vol.69 , pp. 1843
    • D'Cruz, O.J.1    Samuel, P.2    Waurzyniak, B.3
  • 31
    • 2442644032 scopus 로고    scopus 로고
    • STAMP prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus
    • Uckun, F. M., Petkevich, A. S., Vassilev, A. O. et al., STAMP prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus. BioMed Central Infect. Dis. 4, 1 (2004)
    • (2004) BioMed Central Infect. Dis. , vol.4 , pp. 1
    • Uckun, F.M.1    Petkevich, A.S.2    Vassilev, A.O.3
  • 32
    • 17644412826 scopus 로고    scopus 로고
    • In vitro anti-HIV potency of stapidine alone and in combination with standard anti-HIV drugs
    • Uckun, E, Qazi, S., Venkatachalam, T., In vitro anti-HIV potency of stapidine alone and in combination with standard anti-HIV drugs. Arzneim.-Forsch./Drug Res. 55, 223 (2005)
    • (2005) Arzneim.-Forsch./Drug Res. , vol.55 , pp. 223
    • Uckun, E.1    Qazi, S.2    Venkatachalam, T.3
  • 34
    • 0037378795 scopus 로고    scopus 로고
    • In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats
    • Uckun, F. M., Chen, C. L., Samuel, P., et al., In vivo antiretroviral activity of stampidine in chronically feline immunodeficiency virus-infected cats. Antimicrob. Agents Chemother. 47, 1233 (2003)
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 1233
    • Uckun, F.M.1    Chen, C.L.2    Samuel, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.