메뉴 건너뛰기




Volumn 1, Issue 3, 2009, Pages 131-139

Imaging mass spectrometry: Principle and application

Author keywords

Imaging; Imaging mass spectrometry (IMS); Matrix assisted laser desorption ionization (MALDI); Principal component analysis (PCA); Time of flight mass spectrometer (TOF MS)

Indexed keywords


EID: 84858230951     PISSN: 18672450     EISSN: 18672469     Source Type: Journal    
DOI: 10.1007/s12551-009-0015-6     Document Type: Review
Times cited : (28)

References (50)
  • 1
    • 33845876963 scopus 로고    scopus 로고
    • High-resolution MALDI imaging mass spectrometry allows localization of peptide distributions at cellular length scales in pituitary tissue sections
    • doi:10.1016/j.ijms.2006.09.028
    • Altelaar AF, Taban IM, McDonnell LA, Verhaert PDEM, de Lange RP, Adan RAH, Mooi WJ, Heeren RM, Piersma SR (2007) High-resolution MALDI imaging mass spectrometry allows localization of peptide distributions at cellular length scales in pituitary tissue sections. Int J Mass Spectrom 260: 293-211. doi: 10. 1016/j. ijms. 2006. 09. 028.
    • (2007) Int J Mass Spectrom , vol.260 , pp. 211-293
    • Altelaar, A.F.1    Taban, I.M.2    McDonnell, L.A.3    Verhaert, P.D.E.M.4    de Lange, R.P.5    Adan, R.A.H.6    Mooi, W.J.7    Heeren, R.M.8    Piersma, S.R.9
  • 2
    • 34047187431 scopus 로고    scopus 로고
    • Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry
    • doi:10.1002/rcm.2952
    • Atkinson SJ, Loadman PM, Sutton C, Patterson LH, Clench MR (2007) Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry. Rapid Commun Mass Spectrom 21: 1271-1276. doi: 10. 1002/rcm. 2952.
    • (2007) Rapid Commun Mass Spectrom , vol.21 , pp. 1271-1276
    • Atkinson, S.J.1    Loadman, P.M.2    Sutton, C.3    Patterson, L.H.4    Clench, M.R.5
  • 3
    • 0023857738 scopus 로고
    • Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes
    • doi:10.1021/bi00404a024
    • Aveldano MI (1988) Phospholipid species containing long and very long polyenoic fatty acids remain with rhodopsin after hexane extraction of photoreceptor membranes. Biochemistry 27: 1229-1239. doi: 10. 1021/bi00404a024.
    • (1988) Biochemistry , vol.27 , pp. 1229-1239
    • Aveldano, M.I.1
  • 4
    • 0031304362 scopus 로고    scopus 로고
    • Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS
    • doi:10.1021/ac970888i
    • Caprioli RM, Farmer TB, Gile J (1997) Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal Chem 69: 4751-4760. doi: 10. 1021/ac970888i.
    • (1997) Anal Chem , vol.69 , pp. 4751-4760
    • Caprioli, R.M.1    Farmer, T.B.2    Gile, J.3
  • 5
    • 0033485653 scopus 로고    scopus 로고
    • Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry
    • doi:10.1021/ac990781q
    • Chaurand P, Stoeckli M, Caprioli RM (1999) Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry. Anal Chem 71: 5263-5270. doi: 10. 1021/ac990781q.
    • (1999) Anal Chem , vol.71 , pp. 5263-5270
    • Chaurand, P.1    Stoeckli, M.2    Caprioli, R.M.3
  • 7
    • 33751001298 scopus 로고    scopus 로고
    • New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry
    • doi:10.1021/pr060346u
    • Chaurand P, Norris JL, Cornett DS, Mobley JA, Caprioli RM (2006) New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry. J Proteome Res 5: 2889-2900. doi: 10. 1021/pr060346u.
    • (2006) J Proteome Res , vol.5 , pp. 2889-2900
    • Chaurand, P.1    Norris, J.L.2    Cornett, D.S.3    Mobley, J.A.4    Caprioli, R.M.5
  • 8
    • 33750604754 scopus 로고    scopus 로고
    • A novel histology-directed strategy for MALDI-MS tissue profiling that improves throughput and cellular specificity in human breast cancer
    • doi:M600119-MCP200
    • Cornett DS, Mobley JA, Dias EC, Andersson M, Arteaga CL, Sanders ME, Caprioli RM (2006) A novel histology-directed strategy for MALDI-MS tissue profiling that improves throughput and cellular specificity in human breast cancer. Mol Cell Proteomics 5: 1975-1983. doi: M600119-MCP200.
    • (2006) Mol Cell Proteomics , vol.5 , pp. 1975-1983
    • Cornett, D.S.1    Mobley, J.A.2    Dias, E.C.3    Andersson, M.4    Arteaga, C.L.5    Sanders, M.E.6    Caprioli, R.M.7
  • 9
    • 33845314350 scopus 로고    scopus 로고
    • Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors
    • doi:66/22/10795
    • Denkert C, Budczies J, Kind T, Weichert W, Tablack P, Sehouli J, Niesporek S, Konsgen D, Dietel M, Fiehn O (2006) Mass spectrometry-based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res 66: 10795-10804. doi: 66/22/10795.
    • (2006) Cancer Res , vol.66 , pp. 10795-10804
    • Denkert, C.1    Budczies, J.2    Kind, T.3    Weichert, W.4    Tablack, P.5    Sehouli, J.6    Niesporek, S.7    Konsgen, D.8    Dietel, M.9    Fiehn, O.10
  • 10
    • 42449115396 scopus 로고    scopus 로고
    • Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species
    • doi:JNC5203
    • Ford DA, Monda JK, Brush RS, Anderson RE, Richards MJ, Fliesler SJ (2008) Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species. J Neurochem 105: 1032-1047. doi: JNC5203.
    • (2008) J Neurochem , vol.105 , pp. 1032-1047
    • Ford, D.A.1    Monda, J.K.2    Brush, R.S.3    Anderson, R.E.4    Richards, M.J.5    Fliesler, S.J.6
  • 11
    • 33845897695 scopus 로고    scopus 로고
    • Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer
    • doi:10.1016/j.ijms.2006.09.019
    • Garrett TJ, Prieto-Conaway MC, Kovtoun V, Bui H, Izgarian N, Stafford G, Yost RA (2006) Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer. Int J Mass Spectrom 260: 166-176. doi: 10. 1016/j. ijms. 2006. 09. 019.
    • (2006) Int J Mass Spectrom , vol.260 , pp. 166-176
    • Garrett, T.J.1    Prieto-Conaway, M.C.2    Kovtoun, V.3    Bui, H.4    Izgarian, N.5    Stafford, G.6    Yost, R.A.7
  • 12
    • 45849095696 scopus 로고    scopus 로고
    • High-sensitivity analysis of glycosphingolipids by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight imaging mass spectrometry on transfer membranes
    • doi:S1570-0232(08)00395-4
    • Goto-Inoue N, Hayasaka T, Sugiura Y, Taki T, Li YT, Matsumoto M, Setou M (2008) High-sensitivity analysis of glycosphingolipids by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight imaging mass spectrometry on transfer membranes. J Chromatogr B Analyt Technol Biomed Life Sci 870: 74-83. doi: S1570-0232(08)00395-4.
    • (2008) J Chromatogr B Analyt Technol Biomed Life Sci , vol.870 , pp. 74-83
    • Goto-Inoue, N.1    Hayasaka, T.2    Sugiura, Y.3    Taki, T.4    Li, Y.T.5    Matsumoto, M.6    Setou, M.7
  • 13
    • 0024541436 scopus 로고
    • Functions of sphingolipids and sphingolipid breakdown products in cellular regulation
    • doi:10.1126/science.2643164
    • Hannun YA, Bell RM (1989) Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243: 500-507. doi: 10. 1126/science. 2643164.
    • (1989) Science , vol.243 , pp. 500-507
    • Hannun, Y.A.1    Bell, R.M.2
  • 14
    • 33845973399 scopus 로고    scopus 로고
    • Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes
    • doi:M604534200
    • Hatanaka T, Hatanaka Y, Tsuchida J, Ganapathy V, Setou M (2006) Amino acid transporter ATA2 is stored at the trans-Golgi network and released by insulin stimulus in adipocytes. J Biol Chem 281: 39273-39284. doi: M604534200.
    • (2006) J Biol Chem , vol.281 , pp. 39273-39284
    • Hatanaka, T.1    Hatanaka, Y.2    Tsuchida, J.3    Ganapathy, V.4    Setou, M.5
  • 15
    • 58149241067 scopus 로고    scopus 로고
    • Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina
    • doi:10.1002/rcm.3751
    • Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Nakanishi H, Ohishi K, Nakanishi S, Naito T, Taguchi R, Setou M (2008) Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina. Rapid Commun Mass Spectrom 22: 3415-3426. doi: 10. 1002/rcm. 3751.
    • (2008) Rapid Commun Mass Spectrom , vol.22 , pp. 3415-3426
    • Hayasaka, T.1    Goto-Inoue, N.2    Sugiura, Y.3    Zaima, N.4    Nakanishi, H.5    Ohishi, K.6    Nakanishi, S.7    Naito, T.8    Taguchi, R.9    Setou, M.10
  • 16
    • 67349090599 scopus 로고    scopus 로고
    • TTLL10 can perform tubulin glycylation when co-expressed with TTLL8
    • doi:10.1016/j.febslet.2009.05.003
    • Ikegami K, Setou M (2009) TTLL10 can perform tubulin glycylation when co-expressed with TTLL8. FEBS Lett 583: 1957-1963. doi: 10. 1016/j. febslet. 2009. 05. 003.
    • (2009) FEBS Lett , vol.583 , pp. 1957-1963
    • Ikegami, K.1    Setou, M.2
  • 18
    • 40849112917 scopus 로고    scopus 로고
    • TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1
    • doi:S0014-5793(08)00202-0
    • Ikegami K, Horigome D, Mukai M, Livnat I, MacGregor GR, Setou M (2008) TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1. FEBS Lett 582: 1129-1134. doi: S0014-5793(08)00202-0.
    • (2008) FEBS Lett , vol.582 , pp. 1129-1134
    • Ikegami, K.1    Horigome, D.2    Mukai, M.3    Livnat, I.4    MacGregor, G.R.5    Setou, M.6
  • 19
    • 27544499300 scopus 로고    scopus 로고
    • Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS
    • doi:10.1021/ac050276v
    • Jackson SN, Wang HY, Woods AS (2005) Direct profiling of lipid distribution in brain tissue using MALDI-TOFMS. Anal Chem 77: 4523-4527. doi: 10. 1021/ac050276v.
    • (2005) Anal Chem , vol.77 , pp. 4523-4527
    • Jackson, S.N.1    Wang, H.Y.2    Woods, A.S.3
  • 21
    • 46749109938 scopus 로고    scopus 로고
    • Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein
    • doi:S0014-5793(08)00542-5
    • Kahyo T, Mostoslavsky R, Goto M, Setou M (2008) Sirtuin-mediated deacetylation pathway stabilizes Werner syndrome protein. FEBS Lett 582: 2479-2483. doi: S0014-5793(08)00542-5.
    • (2008) FEBS Lett , vol.582 , pp. 2479-2483
    • Kahyo, T.1    Mostoslavsky, R.2    Goto, M.3    Setou, M.4
  • 22
    • 0024289037 scopus 로고
    • Laser desorption ionization of proteins with molecular masses exceeding 10, 000 daltons
    • doi:10.1021/ac00171a028
    • Karas M, Hillenkamp F (1988) Laser desorption ionization of proteins with molecular masses exceeding 10, 000 daltons. Anal Chem 60: 2299-2301. doi: 10. 1021/ac00171a028.
    • (1988) Anal Chem , vol.60 , pp. 2299-2301
    • Karas, M.1    Hillenkamp, F.2
  • 23
    • 33748865022 scopus 로고    scopus 로고
    • Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry
    • doi:10.1021/ac060788p
    • Khatib-Shahidi S, Andersson M, Herman JL, Gillespie TA, Caprioli RM (2006) Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal Chem 78: 6448-6456. doi: 10. 1021/ac060788p.
    • (2006) Anal Chem , vol.78 , pp. 6448-6456
    • Khatib-Shahidi, S.1    Andersson, M.2    Herman, J.L.3    Gillespie, T.A.4    Caprioli, R.M.5
  • 24
    • 67349200776 scopus 로고    scopus 로고
    • Tubulin tyrosination navigates the kinesin-1 motor domain to axons
    • doi:nn.2314
    • Konishi Y, Setou M (2009) Tubulin tyrosination navigates the kinesin-1 motor domain to axons. Nat Neurosci 12: 559-567. doi: nn. 2314.
    • (2009) Nat Neurosci , vol.12 , pp. 559-567
    • Konishi, Y.1    Setou, M.2
  • 25
    • 34248577404 scopus 로고    scopus 로고
    • Multivariate analysis of matrix-assisted laser desorption/ionization mass spectrometric data related to glycoxidation products of human globins in nephropathic patients
    • doi:S1044-0305(07)00140-7
    • Lapolla A, Ragazzi E, Andretta B, Fedele D, Tubaro M, Seraglia R, Molin L, Traldi P (2007) Multivariate analysis of matrix-assisted laser desorption/ionization mass spectrometric data related to glycoxidation products of human globins in nephropathic patients. J Am Soc Mass Spectrom 18: 1018-1023. doi: S1044-0305(07)00140-7.
    • (2007) J Am Soc Mass Spectrom , vol.18 , pp. 1018-1023
    • Lapolla, A.1    Ragazzi, E.2    Andretta, B.3    Fedele, D.4    Tubaro, M.5    Seraglia, R.6    Molin, L.7    Traldi, P.8
  • 26
    • 26444563501 scopus 로고    scopus 로고
    • Spatial and spectral correlations in MALDI mass spectrometry images by clustering and multivariate analysis
    • doi:10.1021/ac051081q
    • McCombie G, Staab D, Stoeckli M, Knochenmuss R (2005) Spatial and spectral correlations in MALDI mass spectrometry images by clustering and multivariate analysis. Anal Chem 77: 6118-6124. doi: 10. 1021/ac051081q.
    • (2005) Anal Chem , vol.77 , pp. 6118-6124
    • McCombie, G.1    Staab, D.2    Stoeckli, M.3    Knochenmuss, R.4
  • 27
    • 41849133569 scopus 로고    scopus 로고
    • The change of oxidative stress products in diabetes mellitus and diabetic retinopathy
    • doi:92/4/548
    • Pan HZ, Zhang H, Chang D, Li H, Sui H (2008) The change of oxidative stress products in diabetes mellitus and diabetic retinopathy. Br J Ophthalmol 92: 548-551. doi: 92/4/548.
    • (2008) Br J Ophthalmol , vol.92 , pp. 548-551
    • Pan, H.Z.1    Zhang, H.2    Chang, D.3    Li, H.4    Sui, H.5
  • 28
    • 43549095684 scopus 로고    scopus 로고
    • Solvent-free matrix dry-coating for MALDI imaging of phospholipids
    • doi:S1044-0305(08)00119-0
    • Puolitaival SM, Burnum KE, Cornett DS, Caprioli RM (2008) Solvent-free matrix dry-coating for MALDI imaging of phospholipids. J Am Soc Mass Spectrom 19: 882-886. doi: S1044-0305(08)00119-0.
    • (2008) J Am Soc Mass Spectrom , vol.19 , pp. 882-886
    • Puolitaival, S.M.1    Burnum, K.E.2    Cornett, D.S.3    Caprioli, R.M.4
  • 29
    • 24744457360 scopus 로고    scopus 로고
    • Proteomic-based prognosis of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry
    • doi:65/17/7674
    • Schwartz SA, Weil RJ, Thompson RC, Shyr Y, Moore JH, Toms SA, Johnson MD, Caprioli RM (2005) Proteomic-based prognosis of brain tumor patients using direct-tissue matrix-assisted laser desorption ionization mass spectrometry. Cancer Res 65: 7674-7681. doi: 65/17/7674.
    • (2005) Cancer Res , vol.65 , pp. 7674-7681
    • Schwartz, S.A.1    Weil, R.J.2    Thompson, R.C.3    Shyr, Y.4    Moore, J.H.5    Toms, S.A.6    Johnson, M.D.7    Caprioli, R.M.8
  • 31
    • 56449131611 scopus 로고    scopus 로고
    • Protein denaturation improves enzymatic digestion efficiency for direct tissue analysis using mass spectrometry
    • doi:10.1016/j.apsusc.2008.05.120
    • Setou M, Hayasaka T, Shimma S, Sugiura Y, Matsumoto M (2008b) Protein denaturation improves enzymatic digestion efficiency for direct tissue analysis using mass spectrometry. Appl Surf Sci 255: 1555-1559. doi: 10. 1016/j. apsusc. 2008. 05. 120.
    • (2008) Appl Surf Sci , vol.255 , pp. 1555-1559
    • Setou, M.1    Hayasaka, T.2    Shimma, S.3    Sugiura, Y.4    Matsumoto, M.5
  • 32
    • 45849091565 scopus 로고    scopus 로고
    • Mass microscopy to reveal distinct localization of Heme B (m/z 616) in colon cancer liver metastasis
    • Shimma S, Setou M (2007) Mass microscopy to reveal distinct localization of Heme B (m/z 616) in colon cancer liver metastasis. J Mass Spectrom Soc Jpn 55: 230-238.
    • (2007) J Mass Spectrom Soc Jpn , vol.55 , pp. 230-238
    • Shimma, S.1    Setou, M.2
  • 33
    • 33846838319 scopus 로고    scopus 로고
    • A novel approach to in situ proteome analysis using chemical inkjet printing technology and MALDI-QIT-TOF tandem mass spectrometer
    • Shimma S, Furuta M, Ichimura K, Yoshida Y, Setou M (2006a) A novel approach to in situ proteome analysis using chemical inkjet printing technology and MALDI-QIT-TOF tandem mass spectrometer. J Mass Spectrom Soc Jpn 54: 133-140.
    • (2006) J Mass Spectrom Soc Jpn , vol.54 , pp. 133-140
    • Shimma, S.1    Furuta, M.2    Ichimura, K.3    Yoshida, Y.4    Setou, M.5
  • 34
    • 33845947086 scopus 로고    scopus 로고
    • Direct MS/MS analysis in mammalian tissue sections using MALDI-QIT-TOFMS and chemical inkjet technology
    • doi:10.1002/sia.2389
    • Shimma S, Furuta M, Ichimura K, Yoshida Y, Setou M (2006b) Direct MS/MS analysis in mammalian tissue sections using MALDI-QIT-TOFMS and chemical inkjet technology. Surf Int Anal 38: 1712-1714. doi: 10. 1002/sia. 2389.
    • (2006) Surf Int Anal , vol.38 , pp. 1712-1714
    • Shimma, S.1    Furuta, M.2    Ichimura, K.3    Yoshida, Y.4    Setou, M.5
  • 35
    • 34447578029 scopus 로고    scopus 로고
    • MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis
    • doi:10.1016/j.jchromb.2007.02.037
    • Shimma S, Sugiura Y, Hayasaka T, Hoshikawa Y, Noda T, Setou M (2007) MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis. J Chromatogr B Analyt Technol Biomed Life Sci 855: 98-103. doi: 10. 1016/j. jchromb. 2007. 02. 037.
    • (2007) J Chromatogr B Analyt Technol Biomed Life Sci , vol.855 , pp. 98-103
    • Shimma, S.1    Sugiura, Y.2    Hayasaka, T.3    Hoshikawa, Y.4    Noda, T.5    Setou, M.6
  • 36
    • 38849198636 scopus 로고    scopus 로고
    • Mass imaging and identification of biomolecules with MALDI-QIT-TOF-based system
    • doi:10.1021/ac071301v
    • Shimma S, Sugiura Y, Hayasaka T, Zaima N, Matsumoto M, Setou M (2008) Mass imaging and identification of biomolecules with MALDI-QIT-TOF-based system. Anal Chem 80: 878-885. doi: 10. 1021/ac071301v.
    • (2008) Anal Chem , vol.80 , pp. 878-885
    • Shimma, S.1    Sugiura, Y.2    Hayasaka, T.3    Zaima, N.4    Matsumoto, M.5    Setou, M.6
  • 38
    • 0035048372 scopus 로고    scopus 로고
    • Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues
    • doi:10.1038/86573
    • Stoeckli M, Chaurand P, Hallahan DE, Caprioli RM (2001) Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nat Med 7: 493-496. doi: 10. 1038/86573.
    • (2001) Nat Med , vol.7 , pp. 493-496
    • Stoeckli, M.1    Chaurand, P.2    Hallahan, D.E.3    Caprioli, R.M.4
  • 39
    • 0036903299 scopus 로고    scopus 로고
    • Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry
    • doi:10.1016/S0003-2697(02)00386-X
    • Stoeckli M, Staab D, Staufenbiel M, Wiederhold KH, Signor L (2002) Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry. Anal Biochem 311: 33-39. doi: 10. 1016/S0003-2697(02)00386-X.
    • (2002) Anal Biochem , vol.311 , pp. 33-39
    • Stoeckli, M.1    Staab, D.2    Staufenbiel, M.3    Wiederhold, K.H.4    Signor, L.5
  • 40
    • 33846012228 scopus 로고    scopus 로고
    • Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole body tissue sections
    • doi:10.1016/j.ijms.2006.10.007
    • Stoeckli M, Staab D, Schweitzer A (2006) Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole body tissue sections. Int J Mass Spectrom 260: 195-202. doi: 10. 1016/j. ijms. 2006. 10. 007.
    • (2006) Int J Mass Spectrom , vol.260 , pp. 195-202
    • Stoeckli, M.1    Staab, D.2    Schweitzer, A.3
  • 41
    • 33750968870 scopus 로고    scopus 로고
    • Thin sectioning improves the peak intensity and signal-to-noise ratio in direct tissue mass spectrometry
    • Sugiura Y, Shimma S, Setou M (2006a) Thin sectioning improves the peak intensity and signal-to-noise ratio in direct tissue mass spectrometry. J Mass Spectrom Soc Jpn 54: 45-48.
    • (2006) J Mass Spectrom Soc Jpn , vol.54 , pp. 45-48
    • Sugiura, Y.1    Shimma, S.2    Setou, M.3
  • 42
    • 33845543697 scopus 로고    scopus 로고
    • Two-step matrix application technique to improve ionization efficiency for matrix-assisted laser desorption/ionization in imaging mass spectrometry
    • doi:10.1021/ac060974v
    • Sugiura Y, Shimma S, Setou M (2006b) Two-step matrix application technique to improve ionization efficiency for matrix-assisted laser desorption/ionization in imaging mass spectrometry. Anal Chem 78: 8227-8235. doi: 10. 1021/ac060974v.
    • (2006) Anal Chem , vol.78 , pp. 8227-8235
    • Sugiura, Y.1    Shimma, S.2    Setou, M.3
  • 43
    • 52449130577 scopus 로고    scopus 로고
    • Imaging mass spectrometry technology and application on ganglioside study; visualization of age-dependent accumulation of C20-ganglioside molecular species in the mouse hippocampus
    • doi:10.1371/journal.pone.0003232
    • Sugiura Y, Shimma S, Konishi Y, Yamada MK, Setou M (2008) Imaging mass spectrometry technology and application on ganglioside study; visualization of age-dependent accumulation of C20-ganglioside molecular species in the mouse hippocampus. PLoS ONE 3: e3232. doi: 10. 1371/journal. pone. 0003232.
    • (2008) PLoS ONE , vol.3
    • Sugiura, Y.1    Shimma, S.2    Konishi, Y.3    Yamada, M.K.4    Setou, M.5
  • 44
    • 70350379611 scopus 로고    scopus 로고
    • Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry
    • (in press)
    • Sugiura Y, Konishi Y, Zaima N, Kajihara S, Nakanishi H, Taguchi R, Setou M (2009) Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry. J Lipid Res (in press).
    • (2009) J Lipid Res
    • Sugiura, Y.1    Konishi, Y.2    Zaima, N.3    Kajihara, S.4    Nakanishi, H.5    Taguchi, R.6    Setou, M.7
  • 45
    • 34249802348 scopus 로고    scopus 로고
    • Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration
    • doi:v13/a84
    • Suzuki M, Kamei M, Itabe H, Yoneda K, Bando H, Kume N, Tano Y (2007) Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration. Mol Vis 13: 772-778. doi: v13/a84.
    • (2007) Mol Vis , vol.13 , pp. 772-778
    • Suzuki, M.1    Kamei, M.2    Itabe, H.3    Yoneda, K.4    Bando, H.5    Kume, N.6    Tano, Y.7
  • 46
    • 45249118623 scopus 로고    scopus 로고
    • Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution
    • doi:10.1021/ac800081z
    • Taira S, Sugiura Y, Moritake S, Shimma S, Ichiyanagi Y, Setou M (2008) Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution. Anal Chem 80: 4761-4766. doi: 10. 1021/ac800081z.
    • (2008) Anal Chem , vol.80 , pp. 4761-4766
    • Taira, S.1    Sugiura, Y.2    Moritake, S.3    Shimma, S.4    Ichiyanagi, Y.5    Setou, M.6
  • 48
    • 53549088929 scopus 로고    scopus 로고
    • In situ proteomics with imaging mass spectrometry and principal component analysis in the Scrapper-knockout mouse brain
    • doi:10.1002/pmic.200701121
    • Yao I, Sugiura Y, Matsumoto M, Setou M (2008) In situ proteomics with imaging mass spectrometry and principal component analysis in the Scrapper-knockout mouse brain. Proteomics 8: 3692-3701. doi: 10. 1002/pmic. 200701121.
    • (2008) Proteomics , vol.8 , pp. 3692-3701
    • Yao, I.1    Sugiura, Y.2    Matsumoto, M.3    Setou, M.4
  • 49
    • 68149161765 scopus 로고    scopus 로고
    • Imaging of metabolites by MALDI mass spectrometry
    • Zaima N, Hayasaka T, Goto-Inoue N, Setou M (2009a) Imaging of metabolites by MALDI mass spectrometry. J Oleo Sci 58: 415-419.
    • (2009) J Oleo Sci , vol.58 , pp. 415-419
    • Zaima, N.1    Hayasaka, T.2    Goto-Inoue, N.3    Setou, M.4
  • 50
    • 67650617954 scopus 로고    scopus 로고
    • Principal component analysis of direct matrix-assisted laser desorption/ionization mass spectrometric data related to metabolites of fatty liver
    • Zaima N, Matsuyama Y, Setou M (2009b) Principal component analysis of direct matrix-assisted laser desorption/ionization mass spectrometric data related to metabolites of fatty liver. J Oleo Sci 58: 267-273.
    • (2009) J Oleo Sci , vol.58 , pp. 267-273
    • Zaima, N.1    Matsuyama, Y.2    Setou, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.