Molecular imaging of amyloid β peptides in mouse brain sections using mass spectrometry

Analytical Biochemistry

Volumn 311, Issue 1, 2002, Pages 33-39

  Stoeckli, Markus ^a   Staab, Dieter ^a   Staufenbiel, Matthias ^a   Wiederhold, Karl Heinz ^a   Signor, Luca ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DESORPTION; MAMMALS; MASS SPECTROMETRY; MOLECULAR IMAGING; NEURODEGENERATIVE DISEASES; PEPTIDES;

ALZHEIMER'S DISEASE; AMYLOID-BETA PEPTIDES; BIOLOGICAL TISSUES; COMMERCIAL INSTRUMENTS; HIGH SENSITIVITY; INSTRUMENTAL RESOLUTION; MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY; SPATIAL ANALYSIS;

GLYCOPROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; THIAZOLE DERIVATIVE; THIOFLAVINE;

ALZHEIMER DISEASE; ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; BRAIN TISSUE; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; TRANSGENIC MOUSE; AMINO ACID SEQUENCE; ANIMAL; BRAIN; BRAIN LEVEL; CHEMISTRY; FAMILIAL AMYLOID POLYNEUROPATHY; FROZEN SECTION; GENETICS; HUMAN; IMAGE PROCESSING; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; ULTRASTRUCTURE; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID NEUROPATHIES, FAMILIAL; ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN CHEMISTRY; FROZEN SECTIONS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THIAZOLES; TISSUE DISTRIBUTION;

EID: 0036903299     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2697(02)00386-X     Document Type: Article

References (13)

1. R.M. Caprioli, T.B. Farmer, J. Gile, Molecular imaging of biological samples: Localization of peptides and proteins using MALDI-TOF MS, Anal. Chem. 69 (1997) 4751-4760.
2. M. Stoeckli, T.B. Farmer, R.M. Caprioli, Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument, J. Am. Soc. Mass Spectrom. 10 (1999) 67-71.
3. M. Stoeckli, P. Chaurand, D.E. Hallahan, R.M. Caprioli, Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues, Nature Med. 7 (2001) 493-496.
4. L. Li, R.W. Garden, E.V. Romanova, J.V. Sweedler, In situ sequencing of peptides from biological tissues and single cells using MALDI-PSD/CID analysis, Anal. Chem. 71 (1999) 5451-5458.
5. L. Li, R.W. Garden, J.V. Sweedler, Single-cell MALDI: A new tool for direct peptide profiling, Trends Biotechnol. 18 (2000) 151-160.
6. K. Dreisewerd, R. Kingston, M. Geraerts, W.L. Ka, Direct mass spectrometric peptide profiling and sequencing of nervous tissues to identify peptides involved in male copulatory behavior in Lymnaea stagnalis, Int. J. Mass Spectrom. Ion Processes 169/170 (1997) 291-299.
7. P. Chaurand, M. Stoeckli, R.M. Caprioli, Direct profiling of proteins in biological tissue sections by MALDI mass spectrometry, Anal. Chem. 71 (23) (1999) 5263-5270.
8. D.E. Palmer-Toy, D.A. Sarracino, D. Sgroi, R. LeVangie, P.E. Leopold, Direct acquisition of matrix-assisted laser desorption/ionization time-of-flight mass spectra from laser capture micro-dissected tissues, Clin. Chem. (Washington DC) 46 (2000) 1513-1516.
9. C. Sturchler-Pierrat, D. Abramowski, M. Duke, K.H. Wiederhold, C. Mistl, S. Rothacher, B. Ledermann, K. Burki, P. Frey, P.A. Paganetti, C. Waridel, M.E. Calhoun, M. Jucker, A. Probst, M. Staufenbiel, B. Sommer, Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology, Proc. Natl. Acad. Sci. USA 94 (1997) 13287-13292.
10. H.W. Klafki, J. Wiltfang, M. Staufenbiel, Electrophoretic separation of betaA4 peptides (1-40) and (1-42), Anal. Biochem. 237 (1996) 24-29.
11. A.I. Gusev, W.R. Wilkinson, A. Proctor, D.M. Hercules, Direct quantitative analysis of peptides using matrix assisted laser desorption ionization, Fresenius' J. Anal. Chem. 354 (1996) 455-463.
12. W.R. Wilkinson, A.I. Gusev, A. Proctor, M. Houalla, D.M. Hercules, Selection of internal standards for quantitative analysis by matrix-assisted laser desorption-ionization (MALDI) time-of-flight mass spectrometry, Fresenius' J. Anal. Chem. 357 (1997) 241-248.
13. R. Wang, D. Sweeney, S.E. Gandy, S.S. Sisodia, The profile of soluble amyloid β protein in cultured cell media Detection and quantification of amyloid β protein and variants by immunoprecipitation-mass spectrometry, J. Biol. Chem. 271 (1996) 31894-31902.