Probing lactate dehydrogenase activity in tumors by measuring hydrogen/deuterium exchange in hyperpolarized L -[1- 13C,U- 2H]lactate

Journal of the American Chemical Society

Volumn 134, Issue 10, 2012, Pages 4969-4977

  Kennedy, Brett W C ^a,b   Kettunen, Mikko I ^a,b   Hu, De En ^a,b   Brindle, Kevin M ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CANCER RESEARCH UK CAMBRIDGE RESEARCH INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HETERONUCLEAR; HYDROGEN/DEUTERIUM EXCHANGE; HYPERPOLARIZED; IN-VIVO; LACTATE DEHYDROGENASE; LACTATE DEHYDROGENASE ACTIVITIES; LOW LEVEL; PHYSIOLOGICAL CONCENTRATIONS; PYRUVATES; SENSITIVE METHOD; SPECTROSCOPIC IMAGING; SPIN ECHO; TUMOR GRADES;

CATALYSIS; DEUTERIUM; EXPERIMENTS; LAKES; MAGNETIC RESONANCE SPECTROSCOPY; PHASE MODULATION; PHYSIOLOGY; TUMORS;

SPIN POLARIZATION;

ETOPOSIDE; LACTATE DEHYDROGENASE; LACTIC ACID DERIVATIVE; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; FEMALE; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; ISOTOPE LABELING; MONITORING; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; POLARIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; TREATMENT RESPONSE; TUMOR;

CARBON ISOTOPES; KINETICS; L-LACTATE DEHYDROGENASE; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASMS;

EID: 84858230750     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja300222e     Document Type: Article

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