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Volumn 23, Issue 2, 2012, Pages 83-89

Mechanisms of action of topical 5-fluorouracil: Review and implications for the treatment of dermatological disorders

Author keywords

5 fluorouracil; Actinic keratosis; Keratoacanthoma; Mechanisms of action; Photoaging; Psoriasis; Skin cancer; Warts

Indexed keywords

CYTOKERATIN 16; DNA; FLUOROURACIL; GELATINASE B; GLYCOLIC ACID; IMIQUIMOD; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; PROCOLLAGEN; PROTEIN P53; STROMELYSIN; THYMIDINE PHOSPHATE;

EID: 84858211182     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.3109/09546634.2010.507704     Document Type: Review
Times cited : (66)

References (50)
  • 2
    • 0025611018 scopus 로고
    • Metabolism and mechanism of action of 5-Fluorouracil
    • Parker WB, Cheng YC. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol Ther. 1990;48:381-395.
    • (1990) Pharmacol Ther. , vol.48 , pp. 381-395
    • Parker, W.B.1    Cheng, Y.C.2
  • 3
    • 0038387494 scopus 로고    scopus 로고
    • 5-Fluorouracil: Mechanisms of action and clinical strategies
    • DOI 10.1038/nrc1074
    • Longley DB, Harkin DP, Johnston PG. 5-Fluorouracil: Mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3:330-338. (Pubitemid 37328853)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.5 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 4
    • 72449156634 scopus 로고    scopus 로고
    • Clinical applications for topical 5-fluorouracil in the treatment of dermatological disorders
    • Moore AY. Clinical applications for topical 5-fluorouracil in the treatment of dermatological disorders. J Dermatolog Treat. 2009;20(6):328-335.
    • (2009) J Dermatolog Treat. , vol.20 , Issue.6 , pp. 328-335
    • Moore, A.Y.1
  • 6
    • 67449164591 scopus 로고    scopus 로고
    • Topical fluorouracil for actinic keratoses and photoaging: A clinical and molecular analysis
    • Sachs DL, Kang S, Hammerberg C, Helfrich Y, Karimipour D, Orringer J, et al. Topical fluorouracil for actinic keratoses and photoaging: A clinical and molecular analysis. Arch Dermatol. 2009;145:659-666.
    • (2009) Arch Dermatol. , vol.145 , pp. 659-666
    • Sachs, D.L.1    Kang, S.2    Hammerberg, C.3    Helfrich, Y.4    Karimipour, D.5    Orringer, J.6
  • 7
    • 78651048339 scopus 로고
    • Studies in 2-acetyla-minofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma
    • Rutman RJ, Cantarow A, Paschkis KE. Studies in 2-acetyla-minofluorene carcinogenesis. III. The utilization of uracil-2-C14 by preneoplastic rat liver and rat hepatoma. Cancer Res. 1954;14:119-123.
    • (1954) Cancer Res. , vol.14 , pp. 119-123
    • Rutman, R.J.1    Cantarow, A.2    Paschkis, K.E.3
  • 8
    • 0000787521 scopus 로고
    • The synthesis of 5-Fluoropyrimi-dines
    • Duschinsky R, Pleven E. The synthesis of 5-fluoropyrimi-dines. J Am Chem Soc. 1957;79:4559-4560.
    • (1957) J Am Chem Soc. , vol.79 , pp. 4559-4560
    • Duschinsky, R.1    Pleven, E.2
  • 9
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluoroura-cil
    • Diasio RB, Harris BE. Clinical pharmacology of 5-fluoroura-cil. Clin Pharmacokinet. 1989;16:215-237.
    • (1989) Clin Pharmacokinet. , vol.16 , pp. 215-237
    • Diasio, R.B.1    Harris, B.E.2
  • 11
    • 1842330994 scopus 로고
    • The response of skin cancer to topical therapy with 5-Fluorouracil
    • Goldman L. The response of skin cancer to topical therapy with 5-fluorouracil. Cancer Chemother Rep. 1963;28:49-52.
    • (1963) Cancer Chemother Rep. , vol.28 , pp. 49-52
    • Goldman, L.1
  • 13
    • 0014370690 scopus 로고
    • Treatment of skin cancers and keratoses with 5-Fluorouracil
    • Snyderman RK, Starzynski TE. Treatment of skin cancers and keratoses with 5-fluorouracil. Acta Chir Plast. 1968;10: 181-187.
    • (1968) Acta Chir Plast. , vol.10 , pp. 181-187
    • Snyderman, R.K.1    Starzynski, T.E.2
  • 14
    • 0019277437 scopus 로고
    • Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells
    • DOI 10.1002/jcp.1041040305
    • Wohlhueter RM, McIvor RS, Plagemann PG. Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells. J Cell Physiol. 1980;104:309-319. (Pubitemid 11127508)
    • (1980) Journal of Cellular Physiology , vol.104 , Issue.3 , pp. 309-319
    • Wohlhueter, R.M.1    McIvor, R.S.2    Plagemann, P.G.W.3
  • 15
    • 0023655202 scopus 로고
    • Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
    • Yoshioka A, Tanaka S, Hiraoka O, Koyama Y, Hirota Y, Ayusawa D, et al. Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J Biol Chem. 1987;262:8235-8241.
    • (1987) J Biol Chem. , vol.262 , pp. 8235-8241
    • Yoshioka, A.1    Tanaka, S.2    Hiraoka, O.3    Koyama, Y.4    Hirota, Y.5    Ayusawa, D.6
  • 16
    • 0027971010 scopus 로고
    • Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells
    • DOI 10.1007/s002800050201
    • Mitrovski B, Pressacco J, Mandelbaum S, Erlichman C. Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells. Cancer Chemother Pharmacol. 1994;35:109-114. (Pubitemid 24359730)
    • (1994) Cancer Chemotherapy and Pharmacology , vol.35 , Issue.2 , pp. 109-114
    • Mitrovski, B.1    Pressacco, J.2    Mandelbaum, S.3    Erlichman, C.4
  • 17
    • 0003267529 scopus 로고    scopus 로고
    • Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells
    • DOI 10.1016/0006-2952(96)00035-4
    • Aherne GW, Hardcastle A, Raynaud F, Jackman AL. Immu-noreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a non-polyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells. Biochem Pharmacol. 1996; 51:1293-1301. (Pubitemid 26142854)
    • (1996) Biochemical Pharmacology , vol.51 , Issue.10 , pp. 1293-1301
    • Aherne, G.W.1    Hardcastle, A.2    Raynaud, F.3    Jackman, A.L.4
  • 18
    • 0028063847 scopus 로고
    • Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil
    • Ghoshal K, Jacob ST. Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil. Cancer Res. 1994;54:632-636. (Pubitemid 24068314)
    • (1994) Cancer Research , vol.54 , Issue.3 , pp. 632-636
    • Ghoshal, K.1    Jacob, S.T.2
  • 19
    • 0027197954 scopus 로고
    • Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine
    • Patton JR. Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine. Biochemistry. 1993;32:8939-8944. (Pubitemid 23268819)
    • (1993) Biochemistry , vol.32 , Issue.34 , pp. 8939-8944
    • Patton, J.R.1
  • 20
    • 0023929848 scopus 로고
    • 5-Fluorouracil substitution alters pre-mRNA splicing in vitro
    • Doong SL, Dolnick BJ. 5-Fluorouracil substitution alters pre-mRNA splicing in vitro. J Biol Chem. 1988;263: 4467-4473. (Pubitemid 18096631)
    • (1988) Journal of Biological Chemistry , vol.263 , Issue.9 , pp. 4467-4473
    • Doong, S.-L.1    Dolnick, B.J.2
  • 21
    • 0027109075 scopus 로고
    • Cancer. P53, guardian of the genome
    • Lane DP. Cancer. p53, guardian of the genome. Nature. 1992;358:15-16.
    • (1992) Nature. , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 23
    • 34547118327 scopus 로고    scopus 로고
    • Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells
    • DOI 10.1158/1078-0432.CCR-06-2890
    • Ju J, Schmitz JC, Song B, Kudo K, Chu E. Regulation of p53 expression in response to 5-fluorouracil in human cancer RKO cells. Clin Cancer Res. 2007;13:4245-4251. (Pubitemid 47105989)
    • (2007) Clinical Cancer Research , vol.13 , Issue.14 , pp. 4245-4251
    • Ju, J.1    Schmitz, J.C.2    Song, B.3    Kudo, K.4    Chu, E.5
  • 24
    • 0032701521 scopus 로고    scopus 로고
    • Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    • Bunz F, Hwang PM, Torrance C, Waldman T, Zhang Y, Dillehay L, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest. 1999; 104:263-269.
    • (1999) J Clin Invest. , vol.104 , pp. 263-269
    • Bunz, F.1    Hwang, P.M.2    Torrance, C.3    Waldman, T.4    Zhang, Y.5    Dillehay, L.6
  • 26
    • 84858234911 scopus 로고    scopus 로고
    • Irvine, CA: Allergan, Inc.
    • Fluoroplex package insert. Irvine, CA: Allergan, Inc.; 2004.
    • (2004) Fluoroplex Package Insert
  • 27
    • 84858242588 scopus 로고    scopus 로고
    • Costa Mesa, CA: Valeant Pharmaceuticals North America
    • Efudex package insert. Costa Mesa, CA: Valeant Pharmaceuticals North America; 2005.
    • (2005) Efudex Package Insert
  • 28
    • 84858257215 scopus 로고    scopus 로고
    • Bridgewater, NJ: Dermik Laboratories; August
    • Carac package insert. Bridgewater, NJ: Dermik Laboratories; August 2009.
    • (2009) Carac Package Insert
  • 29
    • 0034988533 scopus 로고    scopus 로고
    • A comparison of the skin permeation of three topical 0.5% Fluorouracil formulations with that of a 5% formulation
    • DOI 10.1016/S0149-2918(01)80077-1
    • Levy S, Furst K, Chern W. A comparison of the skin permeation of three topical 0.5% fluorouracil formulations with that of a 5% formulation. Clin Ther. 2001;23:901-907. (Pubitemid 32554571)
    • (2001) Clinical Therapeutics , vol.23 , Issue.6 , pp. 901-907
    • Levy, S.1    Furst, K.2    Chern, W.3
  • 30
    • 0035986664 scopus 로고    scopus 로고
    • Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis
    • DOI 10.1016/S0149-2918(02)80012-1
    • Loven K, Stein L, Furst K, Levy S. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluoro-uracil cream applied to each side of the face in patients with actinic keratosis. Clin Ther. 2002;24:990-1000. (Pubitemid 34734743)
    • (2002) Clinical Therapeutics , vol.24 , Issue.6 , pp. 990-1000
    • Loven, K.1    Stein, L.2    Furst, K.3    Levy, S.4
  • 32
    • 17644448445 scopus 로고
    • Cutaneous absorption and urinary excretion of 6-14c-5-fluorouracil ointment applicated in an ointment to healthy and diseased human skin
    • Erlanger M, Martz G, Ott F, Storck H, Rieder J, Kessler S. Cutaneous absorption and urinary excretion of 6-14C-5-fluorouracil ointment applicated in an ointment to healthy and diseased human skin. Dermatologica. 1970;140 (suppl I):7-14.
    • (1970) Dermatologica. , vol.140 , Issue.SUPPL. I , pp. 7-14
    • Erlanger, M.1    Martz, G.2    Ott, F.3    Storck, H.4    Rieder, J.5    Kessler, S.6
  • 33
    • 0032795865 scopus 로고    scopus 로고
    • Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil
    • Johnson MR, Hageboutros A, Wang K, High L, Smith JB, Diasio RB. Life-threatening toxicity in a dihydropyrimidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil. Clin Cancer Res. 1999;5:2006-2011. (Pubitemid 29399251)
    • (1999) Clinical Cancer Research , vol.5 , Issue.8 , pp. 2006-2011
    • Johnson, M.R.1    Hageboutros, A.2    Wang, K.3    High, L.4    Smith, J.B.5    Diasio, R.B.6
  • 35
    • 0014738161 scopus 로고
    • Fluorouracil: Mechanism of action in human skin and actinic keratoses. I. Effect on DNA synthesis in vivo
    • EaglsteinWH,WeinsteinGD,FrostP.Fluorouracil:Mechanism of action in human skin and actinic keratoses. I. Effect on DNA synthesis in vivo. Arch Dermatol. 1970;101:132-139.
    • (1970) Arch Dermatol. , vol.101 , pp. 132-139
    • Eaglstein, W.H.1    Weinstein, G.D.2    Frost, P.3
  • 36
    • 65249172451 scopus 로고    scopus 로고
    • Effectiveness of 5-Fluorouracil treatment for actinic keratosis-A systematic review of randomized controlled trials
    • Askew DA, Mickan SM, Soyer HP, Wilkinson D. Effectiveness of 5-fluorouracil treatment for actinic keratosis-A systematic review of randomized controlled trials. Int J Dermatol. 2009;48:453-463.
    • (2009) Int J Dermatol. , vol.48 , pp. 453-463
    • Askew, D.A.1    Mickan, S.M.2    Soyer, H.P.3    Wilkinson, D.4
  • 37
    • 3142692799 scopus 로고    scopus 로고
    • Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: A randomized, vehicle-controlled clinical trial
    • DOI 10.1001/archderm.140.7.813
    • Jorizzo J, Weiss J, Furst K, VandePol C, Levy SF. Effect of a 1-week treatment with 0.5% topical fluorouracil on occurrence of actinic keratosis after cryosurgery: A randomized, vehicle-controlled clinical trial. Arch Dermatol. 2004;140: 813-816. (Pubitemid 38917849)
    • (2004) Archives of Dermatology , vol.140 , Issue.7 , pp. 813-816
    • Jorizzo, J.1    Weiss, J.2    Furst, K.3    VandePol, C.4    Levy, S.F.5
  • 38
    • 0031691921 scopus 로고    scopus 로고
    • The new fluor-hydroxy pulse peel: A combination of 5-fluorouracil and glycolic acid
    • PII S107605129800079X
    • Marrero GM, Katz BE. The new fluor-hydroxy pulse peel. A combination of 5-fluorouracil and glycolic acid. Dermatol Surg. 1998;24:973-978. (Pubitemid 28453045)
    • (1998) Dermatologic Surgery , vol.24 , Issue.9 , pp. 973-978
    • Marrero, G.M.1    Katz, B.E.2
  • 39
    • 35348843362 scopus 로고    scopus 로고
    • The treatment of photodamaged skin with 5% 5-fluorouracil peels
    • Ditre CM. The treatment of photodamaged skin with 5% 5-fluorouracil peels. Cosmet Dermatol. 2007;20: 568-572. (Pubitemid 47573241)
    • (2007) Cosmetic Dermatology , vol.20 , Issue.9 , pp. 568-572
    • Ditre, C.M.1
  • 40
    • 34147123685 scopus 로고    scopus 로고
    • 5% 5-Fluorouracil cream for the treatment of small superficial basal cell carcinoma: Efficacy, tolerability, cosmetic outcome, and patient satisfaction
    • Gross K, Kircik L, Kricorian G. 5% 5-Fluorouracil cream for the treatment of small superficial basal cell carcinoma: Efficacy, tolerability, cosmetic outcome, and patient satisfaction. Dermatol Surg. 2007;33:433-440.
    • (2007) Dermatol Surg. , vol.33 , pp. 433-440
    • Gross, K.1    Kircik, L.2    Kricorian, G.3
  • 41
    • 0017990386 scopus 로고
    • Tendency of fluorouracil to conceal deep foci of invasive basal cell carcinoma
    • Mohs FE, Jones DL, Bloom RF. Tendency of fluorouracil to conceal deep foci of invasive basal cell carcinoma. Arch Dermatol. 1978;114:1021-1022.
    • (1978) Arch Dermatol. , vol.114 , pp. 1021-1022
    • Mohs, F.E.1    Jones, D.L.2    Bloom, R.F.3
  • 42
    • 0033958719 scopus 로고    scopus 로고
    • Topical 5-fluorouracil as primary therapy for keratoacanthoma
    • Gray RJ, Meland NB. Topical 5-fluorouracil as primary therapy for keratoacanthoma. Ann Plast Surg. 2000;44:82-85. (Pubitemid 30056303)
    • (2000) Annals of Plastic Surgery , vol.44 , Issue.1 , pp. 82-85
    • Gray, R.J.1    Meland, N.B.2
  • 43
    • 33646042209 scopus 로고    scopus 로고
    • Keratoacanthoma centrifugum marginatum: Response to topical 5-fluorouracil
    • Yuge S. Keratoacanthoma centrifugum marginatum: Response to topical 5-fluorouracil. J Am Acad Dermatol. 2006;54:S218-S219.
    • (2006) J Am Acad Dermatol. , vol.54
    • Yuge, S.1
  • 44
    • 72349100376 scopus 로고    scopus 로고
    • Case series of multiple recurrent reactive kera-toacanthomas developing at surgical margins
    • Hadley JC, Tristani-Firouzi P, Florell SF, Bowen GM, Hadley ML. Case series of multiple recurrent reactive kera-toacanthomas developing at surgical margins. Dermatol Surg. 2009;35:2019-2024.
    • (2009) Dermatol Surg. , vol.35 , pp. 2019-2024
    • Hadley, J.C.1    Tristani-Firouzi, P.2    Florell, S.F.3    Bowen, G.M.4    Hadley, M.L.5
  • 45
    • 33750816807 scopus 로고    scopus 로고
    • Topical combination therapy for cutaneous squamous cell carcinoma in situ with 5-fluorouracil cream and imiquimod cream in patients who have failed topical monotherapy
    • DOI 10.1016/j.jaad.2006.06.031, PII S0190962206018354
    • Ondo AL, Mings SM, Pestak RM, Shanler SD. Topical combination therapy for cutaneous squamous cell carcinoma in situ with 5-fluorouracil cream and imiquimod cream in patients who have failed topical monotherapy. J Am Acad Dermatol. 2006;55:1092-1094. (Pubitemid 44716481)
    • (2006) Journal of the American Academy of Dermatology , vol.55 , Issue.6 , pp. 1092-1094
    • Ondo, A.L.1    Mings, S.M.2    Pestak, R.M.3    Shanler, S.D.4
  • 46
    • 34548824355 scopus 로고    scopus 로고
    • The treatment of actinic keratoses with a combination of 5-Fluorouracil and imiquimod creams
    • Price NM. The treatment of actinic keratoses with a combination of 5-fluorouracil and imiquimod creams. J Drugs Der-matol. 2007;6:778-781.
    • (2007) J Drugs Der-matol. , vol.6 , pp. 778-781
    • Price, N.M.1
  • 48
    • 33745946153 scopus 로고    scopus 로고
    • Topical 5% 5-fluorouracil cream in the treatment of plantar warts: A prospective, randomized, and controlled clinical study
    • Salk RS, Grogan KA, Chang TJ. Topical 5% 5-fluorouracil cream in the treatment of plantar warts: A prospective, randomized, and controlled clinical study. J Drugs Dermatol. 2006;5:418-424.
    • (2006) J Drugs Dermatol. , vol.5 , pp. 418-424
    • Salk, R.S.1    Grogan, K.A.2    Chang, T.J.3
  • 49
    • 0033430379 scopus 로고    scopus 로고
    • Dystrophic psoriatic fingernails treated with 1% 5-fluorouracil in a nail penetration-enhancing vehicle: A double-blind study
    • De Jong EM, Menke HE, van Praag MC, van de Kerkhof PC. Dystrophic psoriatic fingernails treated with 1% 5-fluorouracil in a nail penetration-enhancing vehicle: A double-blind study. Dermatology. 1999;199:313-318. (Pubitemid 30009041)
    • (1999) Dermatology , vol.199 , Issue.4 , pp. 313-318
    • De Jong, E.M.G.J.1    Menke, H.E.2    Van Praag, M.C.G.3    Van De Kerkhof, P.C.M.4
  • 50
    • 0000907387 scopus 로고
    • Skin changes in patients treated with 5-Fluorouracil
    • Falkson G, Schulz EJ. Skin changes in patients treated with 5-fluorouracil. Br J Dermatol. 1962;74:229-236.
    • (1962) Br J Dermatol. , vol.74 , pp. 229-236
    • Falkson, G.1    Schulz, E.J.2


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