Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis

Clinical Therapeutics

Volumn 24, Issue 6, 2002, Pages 990-1000

  Loven, Keith ^a   Stein, Linda ^b   Furst, Katharine ^c   Levy, Sharon ^c  

^a River gate Dermatology and Skin Care Centel   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c Dermik Laboratories   (United States)

Author keywords

Actinic keratosis; Efficacy; Facial irritation; Fluorouracil; Patient satisfaction; Tolerability

Indexed keywords

FLUOROURACIL; ANTINEOPLASTIC ANTIMETABOLITE;

ACTINIC KERATOSIS; AGED; ARTICLE; BURN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG MONITORING; DRUG TOLERABILITY; DRY SKIN; EDEMA; EROSION; ERYTHEMA; EVALUATION; FACE DISORDER; FEMALE; FOLLOW UP; HUMAN; MALE; PAIN; PRURITUS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SKIN IRRITATION; TREATMENT OUTCOME; CHEMISTRY; CLASSIFICATION; COMPARATIVE STUDY; DOSE RESPONSE; DRUG SCREENING; HOSPITALIZATION; KERATOSIS; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION; FEMALE; FLUOROURACIL; HUMANS; KERATOSIS; MALE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0035986664     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(02)80012-1     Document Type: Article

References (13)

1. Noninflammatory destruction of actinic keratoses by fluorouracil
2. Selective cytotoxic effect of topical 5-fluorouracil
3. Effect of topical 5-fluorouracil treatment on actinic keratosis: A light and electron microscopic study
4. Comparative evaluation of the efficacy and safety of masoprocol and 5-fluorouracil for the treatment of actinic keratoses of the head and neck
5. A comparison of the efficacy and safety of Jessner's solution and 35% trichloroacetic acid vs 5% fluorouracil in the treatment of widespread facial actinic keratoses
6. Evaluation of 5-fluorouracil in the treatment of actinic keratosis of the lip
7. Skin changes in patients treated with 5-fluorouracil
8. Exploring a new option in topical AK therapy
9. A comparison of the skin permeation of three topical 0.5% fluorouracil formulations with that of a 5.0% formulation
10. A pharmacokinetic evaluation of 0.5% and 5% fluorouracil topical cream in patients with actinic keratosis
11. The science behind Carac: A review of the studies