-
2
-
-
0030759661
-
Strategic choices facing the pharmaceutical industry: a case for innovation
-
Drews J, (1997) Strategic choices facing the pharmaceutical industry: a case for innovation. Drug Discov Today 2: 72-78.
-
(1997)
Drug Discov Today
, vol.2
, pp. 72-78
-
-
Drews, J.1
-
3
-
-
77957372594
-
Tracking antibiotic resistance genes in the South Platte river basin using molecular signatures of urban, agricultural, and pristine sources
-
Storteboom H, Arabi M, Davis JG, Crimi B, Pruden A, (2010) Tracking antibiotic resistance genes in the South Platte river basin using molecular signatures of urban, agricultural, and pristine sources. Environ Sci Technol 44: 7397-7404.
-
(2010)
Environ Sci Technol
, vol.44
, pp. 7397-7404
-
-
Storteboom, H.1
Arabi, M.2
Davis, J.G.3
Crimi, B.4
Pruden, A.5
-
4
-
-
53649106826
-
Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection
-
Sekirov I, Tam NM, Jogova M, Robertson ML, Li Y, Lupp C, Finlay BB, (2008) Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection. Infect Immun 76: 4726-4736.
-
(2008)
Infect Immun
, vol.76
, pp. 4726-4736
-
-
Sekirov, I.1
Tam, N.M.2
Jogova, M.3
Robertson, M.L.4
Li, Y.5
Lupp, C.6
Finlay, B.B.7
-
5
-
-
38449093286
-
Aquatic plants exposed to pharmaceuticals: effects and risks
-
Brain RA, Hanson ML, Solomon KR, Brooks BW, (2008) Aquatic plants exposed to pharmaceuticals: effects and risks. Rev Environ Contam Toxicol 192: 67-115.
-
(2008)
Rev Environ Contam Toxicol
, vol.192
, pp. 67-115
-
-
Brain, R.A.1
Hanson, M.L.2
Solomon, K.R.3
Brooks, B.W.4
-
6
-
-
68849086908
-
Fluoroquinolone resistance in Mycobacterium tuberculosis: the effect of duration and timing of fluoroquinolone exposure
-
Devasia RA, Blackman A, Gebretsadik T, Griffin M, Shintani A, et al. (2009) Fluoroquinolone resistance in Mycobacterium tuberculosis: the effect of duration and timing of fluoroquinolone exposure. Am J Respir Crit Care Med 180: 365-370.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 365-370
-
-
Devasia, R.A.1
Blackman, A.2
Gebretsadik, T.3
Griffin, M.4
Shintani, A.5
-
7
-
-
62249195493
-
Clostridium difficile and fluoroquinolones: is there a link?
-
Weiss K, (2009) Clostridium difficile and fluoroquinolones: is there a link?. Int J Antimicrob Agents 33: S29-S32.
-
(2009)
Int J Antimicrob Agents
, vol.33
-
-
Weiss, K.1
-
8
-
-
0035711462
-
In vivo drug target discovery: identifying the best targets from the genome
-
Walke DW, Han C, Shaw J, Wann E, Zambrowicz B, Sands A, (2001) In vivo drug target discovery: identifying the best targets from the genome. Curr Opin Biotechnol 12: 626-631.
-
(2001)
Curr Opin Biotechnol
, vol.12
, pp. 626-631
-
-
Walke, D.W.1
Han, C.2
Shaw, J.3
Wann, E.4
Zambrowicz, B.5
Sands, A.6
-
10
-
-
75149125686
-
Recent advances and method development for drug target identification
-
Chan JN, Nislow C, Emili A, (2010) Recent advances and method development for drug target identification. Trends Pharmacol Sci 31: 82-88.
-
(2010)
Trends Pharmacol Sci
, vol.31
, pp. 82-88
-
-
Chan, J.N.1
Nislow, C.2
Emili, A.3
-
11
-
-
8844232706
-
Functional genomics to new drug targets
-
Kramer R, Cohen D, (2004) Functional genomics to new drug targets. Nat Rev Drug Discov 3: 965-972.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 965-972
-
-
Kramer, R.1
Cohen, D.2
-
12
-
-
0038282916
-
Proteomics: drug target discovery on an industrial scale
-
Ryan TE, Patterson SD, (2002) Proteomics: drug target discovery on an industrial scale. Trends Biotechnol 20: S45-S51.
-
(2002)
Trends Biotechnol
, vol.20
-
-
Ryan, T.E.1
Patterson, S.D.2
-
13
-
-
12844271561
-
High-throughput target discovery using cell-based genetics
-
Jackson PD, Harrington JJ, (2005) High-throughput target discovery using cell-based genetics. Drug Discov Today 10: 53-60.
-
(2005)
Drug Discov Today
, vol.10
, pp. 53-60
-
-
Jackson, P.D.1
Harrington, J.J.2
-
14
-
-
13644256840
-
Phenotype-first screening for the identification of novel drug targets
-
Austen M, Dohrmann C, (2005) Phenotype-first screening for the identification of novel drug targets. Drug Discov Today 10: 275-282.
-
(2005)
Drug Discov Today
, vol.10
, pp. 275-282
-
-
Austen, M.1
Dohrmann, C.2
-
16
-
-
33745607880
-
Prioritizing genomic drug targets in pathogens: Application to Mycobacterium tuberculosis
-
Hasan S, Daugelat S, Rao PSS, Schreiber M, (2006) Prioritizing genomic drug targets in pathogens: Application to Mycobacterium tuberculosis. PLoS Comput Biol 2: e61.
-
(2006)
PLoS Comput Biol
, vol.2
-
-
Hasan, S.1
Daugelat, S.2
Rao, P.S.S.3
Schreiber, M.4
-
17
-
-
17144373303
-
Druggability indices for protein targets derived from NMR-based screening data
-
Hajduk PJ, Hut JR, Fesik SW, (2005) Druggability indices for protein targets derived from NMR-based screening data. J Med Chem 48: 2518-2525.
-
(2005)
J Med Chem
, vol.48
, pp. 2518-2525
-
-
Hajduk, P.J.1
Hut, J.R.2
Fesik, S.W.3
-
18
-
-
40549130652
-
PDTD: a web-accessible protein database for drug target identification
-
Gao Z, Li H, Zhang H, Liu X, Kang L, Luo X, et al. (2008) PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics 9: 104.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 104
-
-
Gao, Z.1
Li, H.2
Zhang, H.3
Liu, X.4
Kang, L.5
Luo, X.6
-
19
-
-
33747829590
-
TarFisDock: a web server for identifying drug targets with docking approach
-
Li H, Gao Z, Kang L, Zhang H, Yang K, et al. (2006) TarFisDock: a web server for identifying drug targets with docking approach. Nucleic Acids Res 34: W219-W224.
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Li, H.1
Gao, Z.2
Kang, L.3
Zhang, H.4
Yang, K.5
-
20
-
-
36349010717
-
Prediction of potential drug targets based on simple sequence properties
-
Li Q, Lai L, (2007) Prediction of potential drug targets based on simple sequence properties. BMC Bioinformatics 8: 353.
-
(2007)
BMC Bioinformatics
, vol.8
, pp. 353
-
-
Li, Q.1
Lai, L.2
-
21
-
-
33947600314
-
Support vector machines approach for predicting druggable proteins: recent progress in its exploration and investigation of its usefulness
-
Han LY, Zheng CJ, Xie B, Jia J, Ma XH, et al. (2007) Support vector machines approach for predicting druggable proteins: recent progress in its exploration and investigation of its usefulness. Drug Discov Today 12: 304-313.
-
(2007)
Drug Discov Today
, vol.12
, pp. 304-313
-
-
Han, L.Y.1
Zheng, C.J.2
Xie, B.3
Jia, J.4
Ma, X.H.5
-
22
-
-
33748959163
-
Essential genes on metabolic maps
-
Gerdes S, Edwards R, Kubal M, Fonstein M, Stevens R, et al. (2006) Essential genes on metabolic maps. Curr Opin Biotechnol 17: 448-456.
-
(2006)
Curr Opin Biotechnol
, vol.17
, pp. 448-456
-
-
Gerdes, S.1
Edwards, R.2
Kubal, M.3
Fonstein, M.4
Stevens, R.5
-
23
-
-
2442636351
-
Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery
-
Yeh I, Hanekamp T, Tsoka S, Karp PD, Altman RB, (2004) Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res 14: 917-924.
-
(2004)
Genome Res
, vol.14
, pp. 917-924
-
-
Yeh, I.1
Hanekamp, T.2
Tsoka, S.3
Karp, P.D.4
Altman, R.B.5
-
24
-
-
77049123018
-
Metabolite-centric approaches for the discovery of antibacterials using genome-scale metabolic networks
-
Kim TY, Kim HU, Lee SY, (2009) Metabolite-centric approaches for the discovery of antibacterials using genome-scale metabolic networks. Metab Eng 12: 105-111.
-
(2009)
Metab Eng
, vol.12
, pp. 105-111
-
-
Kim, T.Y.1
Kim, H.U.2
Lee, S.Y.3
-
25
-
-
58149197597
-
DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes
-
Zhang R, Lin Y, (2009) DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res 37: D455-D458.
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Zhang, R.1
Lin, Y.2
-
26
-
-
16344376028
-
Metabolic pathway analysis web service (Pathway Hunter Tool at CUBIC)
-
Rahman SA, Advani P, Schunk R, Schrader R, Schomburg D, (2005) Metabolic pathway analysis web service (Pathway Hunter Tool at CUBIC). Bioinformatics 21: 1189-1193.
-
(2005)
Bioinformatics
, vol.21
, pp. 1189-1193
-
-
Rahman, S.A.1
Advani, P.2
Schunk, R.3
Schrader, R.4
Schomburg, D.5
-
27
-
-
33747890136
-
Observing local and global properties of metabolic pathways: 'load points' and 'choke points' in the metabolic networks
-
Rahman SA, Schomburg D, (2006) Observing local and global properties of metabolic pathways: 'load points' and 'choke points' in the metabolic networks. Bioinformatics 22: 1767-1774.
-
(2006)
Bioinformatics
, vol.22
, pp. 1767-1774
-
-
Rahman, S.A.1
Schomburg, D.2
-
29
-
-
55949133763
-
Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold
-
Vetting MW, Errey JC, Blanchard JS, (2008) Rv0802c from Mycobacterium tuberculosis: the first structure of a succinyltransferase with the GNAT fold. Acta Crystallogr Sect F Struct Biol Cryst Commun 64: 975-985.
-
(2008)
Acta Crystallogr Sect F Struct Biol Cryst Commun
, vol.64
, pp. 975-985
-
-
Vetting, M.W.1
Errey, J.C.2
Blanchard, J.S.3
-
30
-
-
0242437814
-
Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center
-
Bozdogan B, Esel D, Whitener C, Browne FA, Appelbaum PC, (2003) Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center. J Antimicrob Chemother 52: 864-868.
-
(2003)
J Antimicrob Chemother
, vol.52
, pp. 864-868
-
-
Bozdogan, B.1
Esel, D.2
Whitener, C.3
Browne, F.A.4
Appelbaum, P.C.5
-
31
-
-
33845748189
-
Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin
-
Boyle-Vavra S, Daum RS, (2007) Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin. Lab Invest 87: 3-9.
-
(2007)
Lab Invest
, vol.87
, pp. 3-9
-
-
Boyle-Vavra, S.1
Daum, R.S.2
-
32
-
-
33845624561
-
Emerging vancomycin resistance in enterococci in India
-
Ghoshal U, Garg A, Tiwari DP, Ayyagari A, (2006) Emerging vancomycin resistance in enterococci in India. Indian J Pathol Microbiol 49: 620-622.
-
(2006)
Indian J Pathol Microbiol
, vol.49
, pp. 620-622
-
-
Ghoshal, U.1
Garg, A.2
Tiwari, D.P.3
Ayyagari, A.4
-
33
-
-
1542347591
-
Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes
-
Albrich WC, Monnet DL, Harbarth S, (2004) Antibiotic selection pressure and resistance in Streptococcus pneumoniae and Streptococcus pyogenes. Emerg Infect Dis 10: 514-517.
-
(2004)
Emerg Infect Dis
, vol.10
, pp. 514-517
-
-
Albrich, W.C.1
Monnet, D.L.2
Harbarth, S.3
-
34
-
-
36749044962
-
Overview of anti-tuberculosis (TB) drugs and their resistance mechanisms
-
Shi R, Itagaki N, Sugawara I, (2007) Overview of anti-tuberculosis (TB) drugs and their resistance mechanisms. Mini Rev Med Chem 7: 1177-1185.
-
(2007)
Mini Rev Med Chem
, vol.7
, pp. 1177-1185
-
-
Shi, R.1
Itagaki, N.2
Sugawara, I.3
-
35
-
-
75549090848
-
Update of TTD: Therapeutic Target Database
-
Zhu F, Han B, Kumar P, Liu X, Ma X, et al. (2009) Update of TTD: Therapeutic Target Database. Nucleic Acids Res 38: D787-D791.
-
(2009)
Nucleic Acids Res
, vol.38
-
-
Zhu, F.1
Han, B.2
Kumar, P.3
Liu, X.4
Ma, X.5
-
36
-
-
70349739403
-
Assessing the druggability of protein-protein interactions by a supervised machine-learning method
-
Sugaya N, Ikeda K, (2009) Assessing the druggability of protein-protein interactions by a supervised machine-learning method. BMC Bioinformatics 10: 263.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 263
-
-
Sugaya, N.1
Ikeda, K.2
-
37
-
-
33749618171
-
Interrogating the druggable genome with structural informatics
-
Hambly K, Danzer J, Muskal S, Debe DA, (2006) Interrogating the druggable genome with structural informatics. Mol Divers 3: 273-281.
-
(2006)
Mol Divers
, vol.3
, pp. 273-281
-
-
Hambly, K.1
Danzer, J.2
Muskal, S.3
Debe, D.A.4
-
38
-
-
62949101921
-
Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis
-
Janowski R, Panjikar S, Eddine AN, Kaufmann SH, Weiss MS, (2009) Structural analysis reveals DNA binding properties of Rv2827c, a hypothetical protein from Mycobacterium tuberculosis. J Struct Funct Genomics 10: 137-150.
-
(2009)
J Struct Funct Genomics
, vol.10
, pp. 137-150
-
-
Janowski, R.1
Panjikar, S.2
Eddine, A.N.3
Kaufmann, S.H.4
Weiss, M.S.5
|