-
1
-
-
4243874745
-
A Revolution in R&D: How genomics and genetics are transforming the biopharmaceutical industry
-
November
-
Flanagan, A. et al. (2002) A Revolution in R&D: How genomics and genetics are transforming the biopharmaceutical industry. Boston Consulting Group Report 26 November, 1-64 (available online at: http://www.bcg.com/publications/files/eng_genomicsgenetics_rep_11_01.pdf)
-
(2002)
Boston Consulting Group Report
, vol.26
, pp. 1-64
-
-
Flanagan, A.1
-
3
-
-
0020430927
-
Genetic approaches to the analysis of microbial development
-
Botstein D., Maurer R. Genetic approaches to the analysis of microbial development. Ann. Rev. Genet. 16:1982;61-83.
-
(1982)
Ann. Rev. Genet.
, vol.16
, pp. 61-83
-
-
Botstein, D.1
Maurer, R.2
-
4
-
-
0035793052
-
Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach
-
Beger C., et al. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. Proc. Natl. Acad. Sci. U. S. A. 98:2001;130-135.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 130-135
-
-
Beger, C.1
-
6
-
-
0033989156
-
Robust autofocusing in microscopy
-
Geusebroek J-M., et al. Robust autofocusing in microscopy. Cytometry. 36:2000;1-9.
-
(2000)
Cytometry
, vol.36
, pp. 1-9
-
-
Geusebroek, J.-M.1
-
7
-
-
0035711333
-
The use of retroviruses as pharmaceutical tools for target discovery and validation in the field of functional genomics
-
Lorens J.B., et al. The use of retroviruses as pharmaceutical tools for target discovery and validation in the field of functional genomics. Curr. Opin. Biotechnol. 12:2001;613-621.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 613-621
-
-
Lorens, J.B.1
-
8
-
-
0035173040
-
Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalling
-
Holland S.J., et al. Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalling. J. Exp. Med. 194:2001;1263-1276.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 1263-1276
-
-
Holland, S.J.1
-
9
-
-
0034868955
-
A high-throughput alphavirus-based expression cloning system for mammalian cells
-
Koller D., et al. A high-throughput alphavirus-based expression cloning system for mammalian cells. Nature Biotechnol. 19:2001;851-855.
-
(2001)
Nature Biotechnol.
, vol.19
, pp. 851-855
-
-
Koller, D.1
-
10
-
-
0035043465
-
Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo
-
Lilley C.E., et al. Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo. J. Virol. 75:2001;4343-4356.
-
(2001)
J. Virol.
, vol.75
, pp. 4343-4356
-
-
Lilley, C.E.1
-
11
-
-
0036189210
-
Robotic high-throughput assay for isolating apoptosis-inducing genes
-
Grimm S., Kachel V. Robotic high-throughput assay for isolating apoptosis-inducing genes. BioTechniques. 32:2002;670-677.
-
(2002)
BioTechniques
, vol.32
, pp. 670-677
-
-
Grimm, S.1
Kachel, V.2
-
12
-
-
0033989420
-
High-throughput method for isolating plasmid DNA with reduced lipopolysaccharide content
-
Neudecker F., Grimm S. High-throughput method for isolating plasmid DNA with reduced lipopolysaccharide content. BioTechniques. 28:2000;108-110.
-
(2000)
BioTechniques
, vol.28
, pp. 108-110
-
-
Neudecker, F.1
Grimm, S.2
-
13
-
-
0034659202
-
Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes
-
Welch P.J., et al. Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes. Genomics. 66:2000;274-283.
-
(2000)
Genomics
, vol.66
, pp. 274-283
-
-
Welch, P.J.1
-
14
-
-
0036212846
-
Identification of genes that function in the TNF-α-mediated apoptotic pathway using randomised hybrid ribozyme libraries
-
Kawasaki H., et al. Identification of genes that function in the TNF-α-mediated apoptotic pathway using randomised hybrid ribozyme libraries. Nat. Biotechnol. 20:2002;376-380.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 376-380
-
-
Kawasaki, H.1
-
15
-
-
0034234458
-
A novel functional genomics approach identified mTERT as a suppressor of fibroblast transformation
-
Li Q.X., et al. A novel functional genomics approach identified mTERT as a suppressor of fibroblast transformation. Nucleic Acids Res. 28:2000;2605-2612.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 2605-2612
-
-
Li, Q.X.1
-
16
-
-
0035709416
-
Functional genomics and target validation approaches using antisense oligonucleotide technology
-
Dean N.M. Functional genomics and target validation approaches using antisense oligonucleotide technology. Curr. Opin. Biotechnol. 12:2001;622-625.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 622-625
-
-
Dean, N.M.1
-
17
-
-
0037086052
-
Morpholino oligos: Making sense of antisense?
-
Heasman J. Morpholino oligos: making sense of antisense? Dev. Biol. 243:2002;209-214.
-
(2002)
Dev. Biol.
, vol.243
, pp. 209-214
-
-
Heasman, J.1
-
18
-
-
0034928842
-
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos
-
Ando H., et al. Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nat. Genet. 28:2001;317-325.
-
(2001)
Nat. Genet.
, vol.28
, pp. 317-325
-
-
Ando, H.1
-
19
-
-
0035233570
-
RNA interference: Mechanisms and applications
-
Fjose A., et al. RNA interference: mechanisms and applications. Biotechnol. Annu. Rev. 7:2001;31-57.
-
(2001)
Biotechnol. Annu. Rev.
, vol.7
, pp. 31-57
-
-
Fjose, A.1
-
20
-
-
0035164784
-
Double-stranded RNA injection produces non-specific defects in zebrafish
-
Zhao Z., et al. Double-stranded RNA injection produces non-specific defects in zebrafish. Dev. Biol. 229:2001;215-223.
-
(2001)
Dev. Biol.
, vol.229
, pp. 215-223
-
-
Zhao, Z.1
-
21
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir S.M., et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
-
22
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp T.R., et al. A system for stable expression of short interfering RNAs in mammalian cells. Science. 296:2002;550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
-
23
-
-
0036251639
-
Effective expression of small interfering RNA in human cells
-
Paul C.P., et al. Effective expression of small interfering RNA in human cells. Nat. Biotechnol. 20:2002;505-508.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 505-508
-
-
Paul, C.P.1
-
24
-
-
0036168035
-
Antisense and sensibility
-
Dove A. Antisense and sensibility. Nat. Biotechnol. 20:2002;121-124.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 121-124
-
-
Dove, A.1
-
25
-
-
0011220745
-
Drug discovery: A historical perspective
-
Drews J. Drug discovery: a historical perspective. Science. 17:2000;5460-5464.
-
(2000)
Science
, vol.17
, pp. 5460-5464
-
-
Drews, J.1
-
26
-
-
0035204427
-
A peptide carrier for the delivery of biologically active proteins into mammalian cells
-
Morris M.C., et al. A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat. Biotechnol. 19:2001;1173-1176.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 1173-1176
-
-
Morris, M.C.1
-
27
-
-
0035941063
-
Antigen-independent selection of stable intracellular single-chain antibodies
-
Auf der Maur A., et al. Antigen-independent selection of stable intracellular single-chain antibodies. FEBS Lett. 508:2001;407-412.
-
(2001)
FEBS Lett.
, vol.508
, pp. 407-412
-
-
Auf der Maur, A.1
-
28
-
-
0029397107
-
Molecular inactivation. Spatially and temporally defined molecular knockouts
-
Muller B.K., Bonhoeffer F. Molecular inactivation. Spatially and temporally defined molecular knockouts. Curr. Biol. 5:1995;1255-1256.
-
(1995)
Curr. Biol.
, vol.5
, pp. 1255-1256
-
-
Muller, B.K.1
Bonhoeffer, F.2
-
29
-
-
0030641436
-
Using the SELEX combinatorial chemistry process to find high affinity nucleic acid ligands to target molecules
-
Tuerck C. Using the SELEX combinatorial chemistry process to find high affinity nucleic acid ligands to target molecules. Methods Mol. Biol. 67:1997;219-230.
-
(1997)
Methods Mol. Biol.
, vol.67
, pp. 219-230
-
-
Tuerck, C.1
-
30
-
-
0032210799
-
Automated RNA selection
-
Cox J.C., et al. Automated RNA selection. Biotechnol. Prog. 14:1998;845-850.
-
(1998)
Biotechnol. Prog.
, vol.14
, pp. 845-850
-
-
Cox, J.C.1
-
31
-
-
0033621140
-
RNA aptamers as effective protein antagonists in a multicellular organism
-
Shi H., et al. RNA aptamers as effective protein antagonists in a multicellular organism. Proc. Natl. Acad. Sci. U. S. A. 96:1999;10033-10038.
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 10033-10038
-
-
Shi, H.1
-
32
-
-
0034802897
-
Intramers as promising new tools in functional proteomics
-
Famulok M., et al. Intramers as promising new tools in functional proteomics. Chem. Biol. 8:2001;931-939.
-
(2001)
Chem. Biol.
, vol.8
, pp. 931-939
-
-
Famulok, M.1
-
33
-
-
0031876832
-
From peptides to drugs via phage display
-
Kay B., et al. From peptides to drugs via phage display. Drug Discov. Today. 3:1998;370-378.
-
(1998)
Drug Discov. Today
, vol.3
, pp. 370-378
-
-
Kay, B.1
-
34
-
-
0032560507
-
Transdominant genetic analysis of a growth control pathway
-
Caponigro G., et al. Transdominant genetic analysis of a growth control pathway. Proc. Natl. Acad. Sci. U. S. A. 95:1998;7508-7513.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 7508-7513
-
-
Caponigro, G.1
-
35
-
-
0035158568
-
Dominant effector genetics in mammalian cells
-
Xu X., et al. Dominant effector genetics in mammalian cells. Nat. Genet. 27:2001;23-29.
-
(2001)
Nat. Genet.
, vol.27
, pp. 23-29
-
-
Xu, X.1
-
36
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber S.L. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. 287:2000;1964-1969.
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
37
-
-
0034177001
-
Chemical ligands, genomics and drug discovery
-
Lenz G.R., et al. Chemical ligands, genomics and drug discovery. Drug Discov. Today. 5:2000;145-156.
-
(2000)
Drug Discov. Today
, vol.5
, pp. 145-156
-
-
Lenz, G.R.1
-
38
-
-
0035665932
-
FLEXGene repository: From sequenced genomes to gene repositories for high-throughput functional biology and proteomics
-
Brizuela L., et al. FLEXGene repository: from sequenced genomes to gene repositories for high-throughput functional biology and proteomics. Mol. Biochem. Parasitol. 118:2001;155-165.
-
(2001)
Mol. Biochem. Parasitol.
, vol.118
, pp. 155-165
-
-
Brizuela, L.1
-
39
-
-
0037022657
-
Proteome-scale purification of human proteins from bacteria
-
Braun P., et al. Proteome-scale purification of human proteins from bacteria. Proc. Natl. Acad. Sci. U. S. A. 99:2002;2654-2659.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 2654-2659
-
-
Braun, P.1
-
40
-
-
0033527694
-
A biochemical genomics approach for identifying genes by the activity of their products
-
Martzen M.R., et al. A biochemical genomics approach for identifying genes by the activity of their products. Science. 286:1999;1153-1155.
-
(1999)
Science
, vol.286
, pp. 1153-1155
-
-
Martzen, M.R.1
-
41
-
-
0035860499
-
Global analysis of protein activities using proteome chips
-
Zhu H., et al. Global analysis of protein activities using proteome chips. Science. 29:2001;2101-2105.
-
(2001)
Science
, vol.29
, pp. 2101-2105
-
-
Zhu, H.1
-
42
-
-
0034622925
-
Printing proteins as microarrays for high-throughput function determination
-
MacBeath G., Schreiber S.L. Printing proteins as microarrays for high-throughput function determination. Science. 289:2000;1760-1763.
-
(2000)
Science
, vol.289
, pp. 1760-1763
-
-
MacBeath, G.1
Schreiber, S.L.2
-
43
-
-
0037139482
-
Membrane protein arrays
-
Fang Y., et al. Membrane protein arrays. J. Am. Chem. Soc. 124:2002;2394-2395.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 2394-2395
-
-
Fang, Y.1
-
44
-
-
0034066990
-
Chromophore-assisted laser inactivation (CALI) to validate drug targets and pharmacogenomic markers
-
Ilag L.L., et al. Chromophore-assisted laser inactivation (CALI) to validate drug targets and pharmacogenomic markers. Drug Dev. Res. 49:2000;65-73.
-
(2000)
Drug Dev. Res.
, vol.49
, pp. 65-73
-
-
Ilag, L.L.1
-
45
-
-
0036203661
-
Fluorophore-assisted light inactivation: A high-throughput tool for direct target validation of proteins
-
Beck S., et al. Fluorophore-assisted light inactivation: a high-throughput tool for direct target validation of proteins. Proteomics. 2:2002;247-255.
-
(2002)
Proteomics
, vol.2
, pp. 247-255
-
-
Beck, S.1
-
46
-
-
0036204004
-
Functional proteomics using chromophore-assisted laser inactivation
-
Rubenwolf S., et al. Functional proteomics using chromophore-assisted laser inactivation. Proteomics. 2:2002;241-246.
-
(2002)
Proteomics
, vol.2
, pp. 241-246
-
-
Rubenwolf, S.1
|