Fragment screening and HIV therapeutics

Topics in Current Chemistry

Volumn 317, Issue , 2012, Pages 181-200

  Bauman, Joseph D ^a   Patel, Disha ^a   Arnold, Eddy ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Drug design; Fragment screening; HIV; Protease; Reverse transcriptase; Surface plasmon resonance; X ray crystallography

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1; RNA DIRECTED DNA POLYMERASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT; ENZYMOLOGY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MOLECULAR LIBRARY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ANTI-HIV AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; HIV; HIV INFECTIONS; HIV PROTEASE; HIV REVERSE TRANSCRIPTASE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84858133314     PISSN: 03401022     EISSN: None     Source Type: Book Series    
DOI: 10.1007/128-2011-232     Document Type: Article

References (43)

1. World Health Organization (2008) World Health Statistics http://www.who.int/whosis/whostat/2008/en/index.html
2. Mehellou Y, De Clercq E (2010) J Med Chem 53:521
3. Hadjuk PJ, Greer J (2007) Nat Rev Drug Discov 6:211-219
4. Hesterkamp T, Whittaker M (2008) Curr Opin Chem Biol 12:260-268
5. Erlanson DA, Wells JA, Braisted AC (2004) Annu Rev Biophys Biomol Struct 33:199-223
6. Rees DC, Congreve M, Murray CW, Carr R (2004) Nat Rev Drug Discov 3:660-672
7. Congreve M, Chessari G, Tisi D, Woodhead AJ (2008) J Med Chem 51:3661-3680
8. Congreve M, Carr R, Murray C, Jhoti H (2003) Drug Discov Today 8:876-877
9. Zartler ER, Shapiro MJ (2005) Curr Opin Chem Biol 9:366-370
10. Siegal G, Ab E, Schultz J (2007) Drug Discov Today 12:1032-1039
11. Shuker SB, Hajduk PJ, Meadows RP, Fesik SW (1996) Science 274:1531-1534
12. Hadjuk PJ, Meadows RP, Fesik SW (1999) Quart Rev Biophys 32:211-240
13. Jhoti H, Cleasby A, Vedonk M, Williams G (2007) Curr Opin Chem Biol 11:485-493
14. Carr R, Jhoti H (2002) Drug Discov Today 7:522-527
15. Hartshorn MJ, Murray CW, Cleabsy A, Frederickson M, Tickle IJ, Jhoti H (2005) J Med Chem 48:403-413
16. Murray CW, Blundell TL (2010) Curr Opin Struct Biol 20:497-507
17. Davies TG, Tickle IJ (2011) Fragment screening using X-ray crystallography. Top Curr Chem. doi:10.1007/128-179
18. Navratilova I, Hopkins A (2010) ACS Med Chem Lett 1:44-48
19. Neumann T, Junker HD, Schmidt K, Sekul R (2007) Curr Top Med Chem 7:1630-42
20. Huber W, Mueller F (2006) Curr Pharm Des 12:3999-4021
21. Hennig M, Ruf A, HuberW(2011) Combining biophysical screening and X-ray crystallography for fragment-based drug discovery. Top Curr Chem. doi:10.1007/128-225
22. Zartler ER, Shapiro MJ (2008) In: Zartler ER, Shapiro MJ (eds) Fragment-based drug discovery: a practical approach. Wiley, United Kingdom
23. Torres FE, Recht MI, Coyle JE, Bruce RH, Williams G (2010) Curr Opin Struct Biol 20:598-605
24. Ladbury JE, Klebe G, Freire E (2010) Nat Rev Drug Discov 9:23-27
25. Robins T, Plattner J (1993) J Acq Immun Def Syn 6:162-170
26. Kempf DJ, Sham HL (1996) Curr Pharm Des 2:225-246
27. Abdel-Rahman HM, Al-karamany GS, El-Koussi NA, Youssef AF, Kiso Y (2002) Curr Med Chem 9:1905-1922
28. Huff JR (1991) J Med Chem 34:2305-2314
29. Perryman AL, Lin JH, McCammon JA (2004) Prot Sci 13:1108-1123
30. Perryman A, Zhang Q, Soutter HH, Rosenfeld R, McRee DE, Olson AJ, Elder JE, Stout CD (2010) Chem Biol Drug Des 75:257-268
31. Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA (1992) Science 256:1783-1790
32. Jacobo-Molina A, Ding J, Nanni RG, Clark AD, Lu X, Tantillo C, Williams RL, Kamer G, Ferris AL, Clark P (1993) Proc Natl Acad Sci USA 90:6320-6324
33. Jochmans D, Deval J, Kesteleyn B, Van Marck H, Bettens E, De Baere I, Dehertogh P, Ivens T, Van Ginderen M, Van Schoubroeck B, Ehteshami M, Wigerinck P, Gotte M, Hertogs K (2006) J Virol 80:12283-12292
34. Camarasa M-J, Velázquez S, San-Félix A, Pérez-Pérez MJ (2005) Antivir Chem Chemother 16:147-153
35. Tramontano E, Di Santo R (2010) Curr Med Chem 17:2837-2853
36. Gotte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SFJ (2010) Biochim Biophys Acta 1804:1202-1212
37. Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E (2009) J Mol Biol 385:693-713
38. Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E (2008) Nucleic Acids Res 36:5083-5092
39. Verlinde CLMJ, Fan E, Shibata S, Zhang Z, Sun Z, Deng W, Ross J, Kim J, Xiao L, Arakaki T, Bosch J, Caruthers JM, Larson ET, LeTrong I, Napuli A, Kelley A, Mueller N, Zucker F, Van Voorhis WC, Buckner FS, Merritt EA, Hol WGJ (2009) Curr Top Med Chem 9:1678-1687
40. Ballester PJ, Richards WG (2007) J Comput Chem 28:1711-1723
41. Blaney J, Nienaber V, Burley SK (2006) In: Jahnke W, Erlanson DA (eds) Fragment-based Approaches in Drug Discovery. Wiley-VCH Verlag GmbH & Co. KGaA
42. Gietmann M, Elinder M, Seeger C, Brandt P, de Esch IJP, Danielson UH (2011) J Med Chem 54:699-708
43. Brandt P, Geitmann M, Danielson UH (2011) J Med Chem 54:709-718