Pathophysiological role of extrasynaptic GABA A receptors in typical absence epilepsy

Malta Medical Journal

Volumn 23, Issue 3, 2011, Pages

  di Giovanni, Giuseppe ^a   Errington, Adam C ^b   Crunelli, Vincenzo ^b  

^a UNIVERSITY OF MALTA   (Malta)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Absence epilepsy; GABA A Receptors; Patch clamp recording; Spike and wave discharges

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ETHOSUXIMIDE; POTASSIUM CHLORIDE COTRANSPORTER;

4 AMINOBUTYRIC ACID METABOLISM; 4 AMINOBUTYRIC ACID RELEASE; ABSENCE; ELECTROENCEPHALOGRAM; GABAERGIC TRANSMISSION; GRAND MAL SEIZURE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HUMAN; NERVE CELL MEMBRANE CONDUCTANCE; NONHUMAN; PATHOPHYSIOLOGY; POSTSYNAPTIC POTENTIAL; REVIEW; SLOW BRAIN WAVE; THALAMOCORTICAL TRACT; UNCONSCIOUSNESS;

EID: 84858110855     PISSN: 18133339     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Farrant M, Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABA A receptors. Nature Rev Neurosci. 2005;6:215-29.
2. Chavas J, Forero ME, Collin T, Llano I, Marty A. Osmotic tension as a possible link between GABAA receptor activation and intracellular calcium elevation. Neuron 2004;44:701-13.
3. Rivera C, Voipio J, Kaila K. Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2, and carbonic anhydrase CAVII. J Physiol. 2005;562:27-36.
4. Stein V, Nicoll R A. GABA generates excitement. Neuron. 2003;37:375-8.
5. Somogyi P, Fritschy JM, Benke D, Roberts JDB, Sieghart W. The y2 subunit of the GABAA receptor is concentrated in synaptic junctions containing the a1 and P2/3 subunits in hippocampus, cerebellum and globus pallidus. Neuropharmacology. 1996;35(9-10):1425-44.
6. Olsen RW, Sieghart W (September). International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev. 2008;60(3):243-60.
7. Brickley SG, Cull-Candy SG, Farrant M. Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. J Physiol. 1996;497(3)753-9.
8. Nusser Z, Mody I. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. J Neurophysiol. 2002;87(5)2624-28.
9. Cope DW, Hughes SW, Crunelli V. GABAA receptor-mediated tonic inhibition in thalamic neurons. J Neurosci. 2005;25(50)11553-63.
10. Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA. An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol. 2005;94(6)4491-501.
11. Belelli D, Peden DR, Rosahl TW, Wafford KA, Lambert JJ. Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. J Neurosci. 2005;25(50)11513-20.
12. Brickley SG, Cull-Candy SG, Farrant M. Single-channel properties of synaptic and extrasynaptic GABAA receptors suggest differential targeting of receptor subtypes. J Neurosci. 1999;19(8)2960-73.
13. Bai D, Zhu G, Pennefather P, Jackson MF, Macdonald JF, Orser BA. Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by y-aminobutyric acidA receptors in hippocampal neurons. Mol Pharmacol. 2001;59(4)814-24.
14. Yeung JYT, Canning KJ, Zhu G, Pennefather P, MacDonald JF, Orser BA. Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA," Mol Pharmacol. 2003;63(1)2-8.
15. Bright DP, Renzi M, Bartram J, McGee TP, MacKenzie G, Hosie AM, et al., Profound desensitization by ambient GABA limits activation of 5-containing GABAA receptors during spillover. J Neurosci. 2011;31(2)753-63.
16. Nusser Z, Sieghart W, Somogyi P. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci. 1998;18(5):1693-1703.
17. Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience. 2000;101(4)815-50.
18. Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, et al. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by a5 subunit-containing y-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A. 2004;101(10)3662-7.
19. Sperk G, Schwarzer C, Tsunashima K, Fuchs K, Sieghart W. GABAA receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience. 1997;80(4)987-1000.
20. Glykys J, Mody I. Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABAA receptor a5 subunit-deficient mice. J Neurophys. 2006;95(5)2796-2807,.
21. Kasugai Y, Swinny JD, Roberts JD, Dalezios Y, Fukazawa Y, Sieghart W, et al. Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling. E J Neurosci. 2010;32(11):1868-88.
22. Richardson BD, Ling LL, Uteshev VV, Caspary DM. Extrasynaptic GABAA receptors and tonic inhibition in rat auditory thalamus. PLoS One. 2011;6(1)e16508.
23. Bright DP, Aller MI, Brickley SG. Synaptic release generates a tonic GABAA receptor-mediated conductance that modulates burst precision in thalamic relay neurons. J Neurosci. 2007;27(10):2560-9.
24. Wisden W, Laurie DJ, Monyer H, Seeburg PH. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci. 1992;12(3):1040-62.
25. Pavlov I, Savtchenko LP, Kullmann DM, Semyanov A, Walker MC. Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain. J Neurosci. 2009;29(48):15341-50
26. Glykys J, Mody I. Activation of GABAA Receptors: Views from Outside the Synaptic Cleft. Neuron. 2007;56:763-70.
27. Cope DW, Di Giovanni G, Fyson SJ, Orbán G, Errington AC, Lorincz ML, et al. Enhanced tonic GABAA inhibition in typical absence epilepsy. Nature Med. 2009;15(12)1392-8.
28. Avoli M, Rogawski MA., Avanzini G. Generalized epileptic disorders: an update," Epilepsia. 2001;42(4):445-57.
29. Crunelli V, Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks. Nature Rev Neurosci. 2002;3(5):371-82.
30. Blumenfeld H. Cellular and network mechanisms of spike-wave seizures. Epilepsia. 2005;46(9)21-33.
31. Polack PO, Guillemain I, Hu E, Deransart C, Depaulis A, Charpier S. Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures. J Neurosci. 2007;27:6590-6599.
32. Holmes MD, Brown M, Tucker DM. Are "generalized" seizures truly generalized? Evidence of localized mesial frontal and frontopolar discharges in absence. Epilepsia. 2004;45(12):1568-79.
33. Hamandi K, Salek-Haddadi A, Laufs H, Liston A, Friston K, Fish DR, et al. EEG-fMRI of idiopathic and secondarily generalized epilepsies. NeuroImage. 2006;31(4):1700-10.
34. Bai X, Vestal M, Berman R, Negishi M, Spann M, Vega C, et al. Dynamic time course of typical childhood absence seizures: EEG, behavior, and functional magnetic resonance imaging. J Neurosci. 2010;30(17):5884-93.
35. Westmijse I, Ossenblok P, Gunning B, van Luijtelaar G. Onset and propagation of spike and slow wave discharges in human absence epilepsy: a MEG study. Epilepsia. 2009;50(12):2538-48.
36. Szaflarski JP, DiFrancesco M, Hirschauer T, Banks C, Privitera MD, Gotman J, et al. Cortical and subcortical contributions to absence seizure onset examined with EEG/fMRI. Epilepsy Behav. 2010;18(4):404-13.
37. Charpier S, Leresche N, Deniau JM, Mahon S, Hughes SW, Crunelli V. On the putative contribution of GABAB receptors to the electrical events occuring during spontaneous spike and wave discharges. Neuropharmacology. 1999;38(11):1699-1706.
38. Meeren HK, Pijn JP, Van Luijtelaar EL, Coenen AM, Lopes da Silva FH. Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats. J Neurosci. 2002;22:1480-95.
39. Pinault D, Leresche N, Charpier S, Deniau JM, Marescaux C, Vergnes M, Crunelli V. Intracellular recordings in thalamic neurones during spontaneous spike and wave discharges in rats with absence epilepsy. J Physiol. 1998;509(2):449-56.
40. Golshani P, Liu XB, Jones EG. Differences in quantal amplitude reflect GLuR4-subunit number at corticothalamic synapses on two populations of thalamic neurons. Proc Natl Acad Sci U S A. 2001;98(7)4172-77.