Ethanolic extracts of Brazilian red propolis increase ABCA1 expression and promote cholesterol efflux from THP-1 macrophages

Phytomedicine

Volumn 19, Issue 5, 2012, Pages 383-388

  Iio, Akio ^a   Ohguchi, Kenji ^a,b   Maruyama, Hiroe ^c   Tazawa, Shigemi ^c   Araki, Yoko ^c   Ichihara, Kenji ^c   Nozawa, Yoshinori ^a,d   Ito, Masafumi ^a  

^a GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^b SUGIYAMA JOGAKUEN UNIVERSITY   (Japan)

^c Api Company Ltd   (Japan)

^d Tokai Women's Junior College   (Japan)

Author keywords

ABCA1 expression; Cholesterol efflux; LXR ; PPAR ; Red propolis

Indexed keywords

ABC TRANSPORTER A1; ALCOHOL; APOLIPOPROTEIN A1; CHOLESTEROL; ETHANOLIC EXTRACT OF BRAZILIAN RED PROPOLIS; FLOTILLIN 2; FORMONONETIN; HIGH DENSITY LIPOPROTEIN; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROPOLIS; UNCLASSIFIED DRUG;

ARTICLE; BRAZIL; CELL VIABILITY; CHOLESTEROL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GENE SEQUENCE; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; APOLIPOPROTEIN A-I; ATP BINDING CASSETTE TRANSPORTER 1; BIOLOGICAL TRANSPORT; CATTLE; CELL LINE; CELL SURVIVAL; CHOLESTEROL; HUMANS; MACROPHAGES; MODELS, BIOLOGICAL; ORPHAN NUCLEAR RECEPTORS; PLANT EXTRACTS; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROPOLIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 84858080780     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.10.007     Document Type: Article

References (30)

1. J.A. Berliner, and J.W. Heinecke The role of oxidized lipoproteins in atherogenesis Free Radic. Biol. Med. 20 1996 707 727 (Pubitemid 26105783)
2. A. Chawla, W.A. Boisvert, C.H. Lee, B.A. Laffitte, Y. Barak, S.B. Joseph, D. Liao, L. Nagy, P.A. Edwards, L.K. Curtiss, R.M. Evans, and P. Tontonoz A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Mol. Cell 7 2001 161 171 (Pubitemid 32162909)
3. G. Chinetti, S. Lestavel, V. Bocher, A.T. Remaley, B. Neve, I.P. Torra, E. Teissier, A. Minnich, M. Jaye, N. Duverger, H.B. Brewer, J.C. Fruchart, V. Clavey, and B. Staels PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway Nat. Med. 7 2001 53 58 (Pubitemid 32095642)
4. R.P. Choudhury, J.X. Rong, E. Trogan, V.I. Elmalem, H.M. Dansky, J.L. Breslow, J.L. Witztum, J.T. Fallon, and E.A. Fisher High-density lipoproteins retard the progression of atherosclerosis and favorably remodel lesions without suppressing indices of inflammation or oxidation Arterioscler. Thromb. Vasc. Biol. 24 2004 1904 1909 (Pubitemid 39350311)
5. P. Costet, Y. Luo, N. Wang, and A.R. Tall Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor J. Biol. Chem. 275 2000 28240 28245
6. O. Cuesta-Rubio, A.L. Piccinelli, M.C. Fernandez, I.M. Hernández, A. Rosado, and L. Rastrelli Chemical characterization of Cuban propolis by HPLC-PDA, HPLC-MS, and NMR: the brown, red, and yellow Cuban varieties of propolis J. Agric. Food Chem. 55 2007 7502 7509 (Pubitemid 47492307)
7. A. Daugsch, C.S. Moraes, P. Fort, and Y.K. Park Brazilian red propolis - chemical composition and botanical origin Evid. Based Complement. Alternat. Med. 5 2008 435 441
8. C.J. Fielding, and P.E. Fielding Molecular physiology of reverse cholesterol transport J. Lipid Res. 36 1995 211 228
9. H.U. Fuliang, H.R. Hepburn, H. Xuan, M. Chen, S. Daya, and S.E. Radloff Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus Pharmacol. Res. 51 2005 147 152 (Pubitemid 40040545)
10. C.K. Glass, and J.L. Witztum Atherosclerosis. The road ahead Cell 104 2001 503 516
11. J.M. Grange, and R.W. Davey Antibacterial properties of propolis (bee glue) J. R. Soc. Med. 83 1990 159 160 (Pubitemid 20152240)
12. D. Grunberger, R. Banerjee, K. Eisinger, E.M. Oltz, L. Efros, M. Caldwell, V. Estevez, and K. Nakanishi Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis Experientia 44 1988 230 232 (Pubitemid 18066629)
13. M. Hotta, R. Nakata, M. Katsukawa, K. Hori, S. Takahashi, and H. Inoue Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression J. Lipid Res. 51 2010 132 139
14. A. Iio, K. Ohguchi, H. Inoue, H. Maruyama, Y. Araki, Y. Nozawa, and M. Ito Ethanolic extracts of Brazilian red propolis promote adipocyte differentiation through PPARγ activation Phytomedicine 17 2010 974 979
15. 1-adrenoceptor blockade Circ. Res. 101 2007 156 165 (Pubitemid 47196583)
16. H. Izuta, Y. Narahara, M. Shimazawa, S. Mishima, S. Kondo, and H. Hara 1,1-Diphenyl-2-picrylhydrazyl radical scavenging activity of bee products and their constituents determined by ESR Biol. Pharm. Bull. 32 2009 1947 1951
17. S.B. Joseph, E. McKilligin, L. Pei, M.A. Watson, A.R. Collins, B.A. Laffitte, M. Chen, G. Noh, J. Goodman, G.N. Hagger, J. Tran, T.K. Tippin, X. Wang, A.J. Lusis, W.A. Hsueh, R.E. Law, J.L. Collins, T.M. Willson, and P. Tontonoz Synthetic LXR ligand inhibits the development of atherosclerosis in mice Proc. Natl. Acad. Sci. U. S. A. 99 2002 7604 7609 (Pubitemid 34568738)
18. M.T. Khayyal, M.A. el-Ghazaly, and A.S. el-Khatib Mechanisms involved in the antiinflammatory effect of propolis extract Drugs Exp. Clin. Res. 19 1993 197 203 (Pubitemid 24029191)
19. T.S. Lee, C.C. Pan, C.C. Peng, Y.R. Kou, C.Y. Chen, L.C. Ching, T.H. Tsai, S.F. Chen, P.C. Lyu, and S.K. Shyue Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages J. Cell. Biochem. 111 2010 104 110
20. A.J. Lusis Atherosclerosis Nature 407 2000 233 241
21. K. Nakaya, M. Ayaori, T. Hisada, S. Sawada, N. Tanaka, N. Iwamoto, M. Ogura, E. Yakushiji, M. Kusuhara, H. Nakamura, and F. Ohsuzu Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARgamma J. Atheroscler. Thromb. 14 2007 133 141
22. S.E. Panagotopulos, S.R. Witting, E.M. Horace, D.Y. Hui, J.N. Maiorano, and W.S. Davidson The role of apolipoprotein A-I helix 10 in apolipoprotein-mediated cholesterol efflux via the ATP-binding cassette transporter ABCA1 J. Biol. Chem. 277 2002 39477 39484 (Pubitemid 35190924)
23. Y.K. Park, M.H. Koo, J.A. Abreu, M. Ikegaki, J.A. Cury, and P.L. Rosalen Antimicrobial activity of propolis on oral microorganisms Curr. Microbiol. 36 1998 24 28 (Pubitemid 28063218)
24. C. Pascual, R. Gonzalez, and R.G. Torricella Scavenging action of propolis extract against oxygen radicals J. Ethnopharmacol. 41 1994 9 13 (Pubitemid 24053224)
25. A.L. Piccinelli, C. Lotti, L. Campone, O. Cuesta-Rubio, M. Campo Fernandez, and L. Rastrelli Cuban and Brazilian red propolis: botanical origin and comparative analysis by high-performance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry J. Agric. Food Chem. 59 2011 6484 6491
26. G. Schmitz, W.E. Kaminski, M. Porsch-Ozcürümez, J. Klucken, E. Orsó, M. Bodzioch, C. Büchler, and W. Drobnik ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism? Pathobiology 67 1999 236 240 (Pubitemid 30135913)
27. B. Trusheva, M. Popova, V. Bankova, S. Simova, M.C. Marcucci, P.L. Miorin, F. da Rocha Pasin, and I. Tsvetkova Bioactive constituents of Brazilian red propolis Evid. Based Complement. Alternat. Med. 3 2006 249 254
28. A. Venkateswaran, B.A. Laffitte, S.B. Joseph, P.A. Mak, D.C. Wilpitz, P.A. Edwards, and P. Tontonoz Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha Proc. Natl. Acad. Sci. U. S. A. 97 2000 12097 12102
29. J.F. Viles-Gonzalez, V. Fuster, and J.J. Badimon Atherothrombosis: a widespread disease with unpredictable and life-threatening consequences Eur. Heart J. 25 2004 1197 1207 (Pubitemid 38891569)
30. L. Yue, F. Ye, C. Gui, H. Luo, J. Cai, J. Shen, K. Chen, X. Shen, and H. Jiang Ligand-binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation Protein Sci. 14 2005 812 822 (Pubitemid 40283920)