Pitavastatin, a new HMG-CoA reductase inhibitor, induces phototoxicity in human keratinocytes NCTC-2544 through the formation of benzophenanthridine-like photoproducts

Archives of Toxicology

Volumn 86, Issue 3, 2012, Pages 483-496

  Viola, Giampietro ^a   Grobelny, Pawel ^b   Linardi, Maria Antonella ^a   Salvador, Alessia ^a   Dall'Acqua, Stefano ^a   Sobotta, Łukasz ^b   Mielcarek, Jadwiga ^b   Dall'Acqua, Francesco ^a   Vedaldi, Daniela ^a   Basso, Giuseppe ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Lipid peroxidation; Necrosis; Photoproduct; Phototoxicity; Pitavastatin; Protein oxidation

Indexed keywords

6 CYCLOPROPYL 10 FLUORO 7,8 DIHYDROBENZO[K]PHENANTHRIDINE; 6 CYCLOPROPYL 10 FLUOROBENZO[K]PHENANTHRIDINE; ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL; BENZOPHENANTHRIDINE DERIVATIVE; BUTYLATED HYDROXYANISOLE; DIMETHYLTHIOUREA; GLUTATHIONE; PITAVASTATIN; PROPIDIUM IODIDE; SODIUM AZIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; KERATINOCYTE; PHOTOTOXICITY; PRIORITY JOURNAL; ULTRAVIOLET A RADIATION;

ADENOSINE TRIPHOSPHATE; BENZOPHENANTHRIDINES; CELL CYCLE; CELL LINE; CELL SURVIVAL; DERMATITIS, PHOTOTOXIC; FREE RADICALS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KERATINOCYTES; LIPID PEROXIDATION; PHOTOLYSIS; PHOTOSENSITIZING AGENTS; QUINOLINES; ULTRAVIOLET RAYS;

EID: 84858076124     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-011-0772-4     Document Type: Article

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