The phototoxicity of fluvastatin, an HMG-CoA reductase inhibitor, is mediated by the formation of a benzocarbazole-like photoproduct

Toxicological Sciences

Volumn 118, Issue 1, 2010, Pages 236-250

  Viola, Giampietro ^a   Grobelny, Pawel ^b   Linardi, Maria A ^a   Salvador, Alessia ^a   Basso, Giuseppe ^a   Mielcarek, Jadwiga ^b   Dall'Acqua, Stefano ^a   Vedaldi, Daniela ^a   Dall'Acqua, Francesco ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Fluvastatin; Lipid peroxidation; Necrosis; Photoproduct; Phototoxicity; Protein oxidation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE TRIPHOSPHATE; CARBAZOLE DERIVATIVE; CELL ENZYME; FLUINDOSTATIN; FP 6; PHOTOSENSITIZING AGENT; POLYCYCLIC AROMATIC COMPOUND; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE; CELL DEATH; CELL MEMBRANE; CELL VIABILITY; CHROMATOPHORE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IRRADIATION; KERATINOCYTE; LIPID PEROXIDATION; MITOCHONDRION; OXIDATION; PHOTODEGRADATION; PHOTOTOXICITY; RADIATION DOSE; ULTRAVIOLET A RADIATION;

APOPTOSIS; CALCIUM; CARBAZOLES; CELL LINE, TRANSFORMED; CELL MEMBRANE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY ACIDS, MONOUNSATURATED; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; KERATINOCYTES; LIPID PEROXIDATION; PHOTOCHEMICAL PROCESSES; PHOTOSENSITIZING AGENTS; ULTRAVIOLET RAYS;

EID: 77958472084     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq228     Document Type: Article

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