Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression

Journal of Biological Chemistry

Volumn 287, Issue 11, 2012, Pages 7945-7955

  Dey, Siddharth S ^a   Xue, Yuhua ^a,g   Joachimiak, Marcin P ^c,d   Friedland, Gregory D ^e,f   Burnett, John C ^a,h   Zhou, Qiang ^a   Arkin, Adam P ^b,c,d   Schaffer, David V ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California at Berkeley   (United States)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^d Virtual Institute of Microbial Stress and Survival   (United States)

^e JOINT BIOENERGY INSTITUTE   (United States)

^f SANDIA NATIONAL LABORATORIES   (United States)

^g XIAMEN UNIVERSITY   (China)

^h CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL STUDIES; C-TERMINAL DOMAINS; COMPLEX FUNCTIONS; CORRELATED PAIRS; ERROR PRONES; GENE EXPRESSION LEVELS; HIV-1 GENE EXPRESSION; PROTEIN RESIDUES; STRUCTURAL MODELING; VIRAL GENOME; VIRAL PROTEINS; WILD TYPES;

AMINO ACIDS; BINDING SITES; DISEASES; INFORMATION ANALYSIS; PHOSPHORYLATION; RESTORATION; VIRUSES;

GENE EXPRESSION;

POSITIVE TRANSCRIPTION ELONGATION FACTOR B; RNA POLYMERASE II; TRANSACTIVATOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEFECTIVE VIRUS; GENE EXPRESSION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; VIRUS ISOLATION; WILD TYPE;

EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; HEK293 CELLS; HELA CELLS; HIV-1; HUMANS; MUTATION; PHOSPHORYLATION; POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B; PROTEIN STRUCTURE, TERTIARY; RNA POLYMERASE II; SPECIES SPECIFICITY; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84858065741     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.302653     Document Type: Article

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