Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Son, Se Hee ^a   Goo, Young Hwa ^a   Chang, Benny H ^b   Paul, Antoni ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 OXOCHOLESTEROL; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; FAT DROPLET; INTERLEUKIN 6; LIPID; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PERILIPIN; PERILIPIN 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; 7-KETOCHOLESTEROL; AZO COMPOUND; CHOLESTEROL DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE PROTEIN; OIL RED O; PRIMER DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL ISOLATION; CELL TYPE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; ENZYME BINDING; ENZYME INHIBITION; INFLAMMATION; MACROPHAGE; MOUSE; NICK END LABELING; NONHUMAN; PERILIPIN 2 DEFICIENCY; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; ANALYSIS OF VARIANCE; ANIMAL; ATHEROSCLEROSIS; C57BL MOUSE; COMPARATIVE STUDY; CULTURE TECHNIQUE; FOAM CELL; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MUS;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; ATHEROSCLEROSIS; AZO COMPOUNDS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CHOLESTEROL, LDL; DNA PRIMERS; ENDOPLASMIC RETICULUM STRESS; FOAM CELLS; IN SITU NICK-END LABELING; INTERLEUKIN-6; KETOCHOLESTEROLS; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84858037242     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033063     Document Type: Article

References (33)

1. Takahashi K, Takeya M, Sakashita N, (2002) Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals. Med Electron Microsc 35: 179-203.
2. Brown MS, Ho YK, Goldstein JL, (1980) The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters. J Biol Chem 255: 9344-9352.
3. Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, et al. (1996) Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc Natl Acad Sci U S A 93: 14041-14046.
4. Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, et al. (2001) Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages. J Clin Invest 107: 163-171.
5. Feng B, Yao PM, Li Y, Devlin CM, Zhang D, et al. (2003) The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol 5: 781-792.
6. Li Y, Schwabe RF, DeVries-Seimon T, Yao PM, Gerbod-Giannone MC, et al. (2005) Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappa B-and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem 280: 21763-21772.
7. Tabas I, (2002) Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest 110: 905-911.
8. Beckman M, (2006) Cell biology. Great balls of fat. Science 311: 1232-1234.
9. Paul A, Chan L, Bickel PE, (2008) The PAT family of lipid droplet proteins in heart and vascular cells. Curr Hypertens Rep 10: 461-466.
10. Kimmel AR, Brasaemle DL, McAndrews-Hill M, Sztalryd C, Londos C, (2010) Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. J Lipid Res 51: 468-471.
11. Buechler C, Ritter M, Duong CQ, Orso E, Kapinsky M, et al. (2001) Adipophilin is a sensitive marker for lipid loading in human blood monocytes. Biochim Biophys Acta 1532: 97-104.
12. Paul A, Chang BH, Li L, Yechoor VK, Chan L, (2008) Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res 102: 1492-1501.
13. Chen JS, Greenberg AS, Tseng YZ, Wang SM, (2001) Possible involvement of protein kinase C in the induction of adipose differentiation-related protein by Sterol ester in RAW 264.7 macrophages. J Cell Biochem 83: 187-199.
14. Larigauderie G, Furman C, Jaye M, Lasselin C, Copin C, et al. (2004) Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis. Arterioscler Thromb Vasc Biol 24: 504-510.
15. Wei P, Taniguchi S, Sakai Y, Imamura M, Inoguchi T, et al. (2005) Expression of adipose differentiation-related Protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages. J Biochem (Tokyo) 138: 399-412.
16. Chang BH, Li L, Paul A, Taniguchi S, Nannegari V, et al. (2006) Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol 26: 1063-1076.
17. Davies JQ, Gordon S, (2005) Isolation and culture of murine macrophages. Methods Mol Biol 290: 91-103.
18. Timmins JM, Ozcan L, Seimon TA, Li G, Malagelada C, et al. (2009) Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest 119: 2925-2941.
19. Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, et al. (2009) Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res 104: 455-465.
20. Leonarduzzi G, Poli G, Sottero B, Biasi F, (2007) Activation of the mitochondrial pathway of apoptosis by oxysterols. Front Biosci 12: 791-799.
21. Thorp E, Li G, Seimon TA, Kuriakose G, Ron D, et al. (2009) Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP. Cell Metab 9: 474-481.
22. Rozen S, Skaletsky H, (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.
23. Xu G, Sztalryd C, Lu X, Tansey JT, Gan J, et al. (2005) Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway. J Biol Chem 280: 42841-42847.
24. Moore KJ, Tabas I, (2011) Macrophages in the pathogenesis of atherosclerosis. Cell 145: 341-355.
25. Lyons MA, Brown AJ, (1999) 7-Ketocholesterol. Int J Biochem Cell Biol 31: 369-375.
26. Hotamisligil GS, (2010) Endoplasmic reticulum stress and atherosclerosis. Nat Med 16: 396-399.
27. Boyce M, Yuan J, (2006) Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 13: 363-373.
28. Malhotra JD, Kaufman RJ, (2007) The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 18: 716-731.
29. Tabas I, (2009) Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress. Antioxid Redox Signal 11: 2333-2339.
30. Li G, Scull C, Ozcan L, Tabas I, (2010) NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol 191: 1113-1125.
31. Ross R, (1999) Atherosclerosis-an inflammatory disease. N Engl J Med 340: 115-126.
32. Li Y, Tabas I, (2007) The inflammatory cytokine response of cholesterol-enriched macrophages is dampened by stimulated pinocytosis. J Leukoc Biol 81: 483-491.
33. Zhu X, Lee JY, Timmins JM, Brown JM, Boudyguina E, et al. (2008) Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem 283: 22930-22941.