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Volumn 11, Issue 5, 2012, Pages 917-921

Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification

Author keywords

AMP activated protein kinase; Cytokinesis; Isoforms; Phosphorylation; Subcellular localization

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ALPHA 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE GAMMA 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE GAMMA 2; UNCLASSIFIED DRUG;

EID: 84857926956     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.11.5.19412     Document Type: Article
Times cited : (29)

References (34)
  • 1
    • 33847072201 scopus 로고    scopus 로고
    • AMP-activated protein kinase as a drug target
    • PMID:16879084
    • Hardie DG. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 2007; 47:185-210; PMID:16879084; http://dx.doi.org/10.1146/ annurev.pharmtox.47.120505.105304.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 185-210
    • Hardie, D.G.1
  • 2
    • 0037799908 scopus 로고    scopus 로고
    • AMPKbeta subunit targets metabolic stress sensing to glycogen
    • PMID:12747837
    • Polekhina G, Gupta A, Michell BJ, van Denderen B, Murthy S, Feil SC, et al. AMPKbeta subunit targets metabolic stress sensing to glycogen. Curr Biol 2003; 13:867-71; PMID:12747837; http://dx.doi. org/10.1016/S0960-9822(03)00292- 6.
    • (2003) Curr Biol , vol.13 , pp. 867-871
    • Polekhina, G.1    Gupta, A.2    Michell, B.J.3    Van Denderen, B.4    Murthy, S.5    Feil, S.C.6
  • 3
    • 33845332346 scopus 로고    scopus 로고
    • Predominant alpha2/ beta2/gamma3 AMPK activation during exercise in human skeletal muscle
    • PMID:17038425
    • Birk JB, Wojtaszewski JF. Predominant alpha2/ beta2/gamma3 AMPK activation during exercise in human skeletal muscle. J Physiol 2006; 577:1021-32; PMID:17038425; http://dx.doi.org/10.1113/jphysiol. 2006.120972.
    • (2006) J Physiol , vol.577 , pp. 1021-1032
    • Birk, J.B.1    Wojtaszewski, J.F.2
  • 4
    • 0037381848 scopus 로고    scopus 로고
    • Exercise increases nuclear AMPKalpha2 in human skeletal muscle
    • PMID:12663462
    • McGee SL, Howlett KF, Starkie RL, Cameron-Smith D, Kemp BE, Hargreaves M. Exercise increases nuclear AMPKalpha2 in human skeletal muscle. Diabetes 2003; 52:926-8; PMID:12663462; http://dx.doi. org/10.2337/diabetes.52.4.926.
    • (2003) Diabetes , vol.52 , pp. 926-928
    • McGee, S.L.1    Howlett, K.F.2    Starkie, R.L.3    Cameron-Smith, D.4    Kemp, B.E.5    Hargreaves, M.6
  • 5
    • 70349921265 scopus 로고    scopus 로고
    • A-769662 activates AMPK beta1- containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle
    • PMID:19657063
    • Treebak JT, Birk JB, Hansen BF, Olsen GS, Wojtaszewski JF. A-769662 activates AMPK beta1- containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle. Am J Physiol Cell Physiol 2009; 297:1041-52; PMID:19657063; http://dx.doi. org/10.1152/ajpcell.00051. 2009.
    • (2009) Am J Physiol Cell Physiol , vol.297 , pp. 1041-1052
    • Treebak, J.T.1    Birk, J.B.2    Hansen, B.F.3    Olsen, G.S.4    Wojtaszewski, J.F.5
  • 6
    • 0032529139 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Greater AMP dependence and preferential nuclear localization, of complexes containing the alpha2 isoform
    • PMID:9693118
    • Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, et al. AMP-activated protein kinase: greater AMP dependence and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J 1998; 334:177-87; PMID:9693118.
    • (1998) Biochem J , vol.334 , pp. 177-187
    • Salt, I.1    Celler, J.W.2    Hawley, S.A.3    Prescott, A.4    Woods, A.5    Carling, D.6
  • 7
    • 33744541891 scopus 로고    scopus 로고
    • Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres
    • PMID:16608880
    • Gregor M, Zeöld A, Oehler S, Marobela KA, Fuchs P, Weigel G, et al. Plectin scaffolds recruit energy-controlling AMP-activated protein kinase (AMPK) in differentiated myofibres. J Cell Sci 2006; 119:1864-75; PMID:16608880; http://dx.doi.org/10.1242/ jcs.02891.
    • (2006) J Cell Sci , vol.119 , pp. 1864-1875
    • Gregor, M.1    Zeöld, A.2    Oehler, S.3    Marobela, K.A.4    Fuchs, P.5    Weigel, G.6
  • 8
    • 0034654362 scopus 로고    scopus 로고
    • Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding
    • PMID:10698692
    • Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D. Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding. Biochem J 2000; 346:659-69; PMID:10698692; http://dx.doi.org/10.1042/ 0264-6021:3460659.
    • (2000) Biochem J , vol.346 , pp. 659-669
    • Cheung, P.C.1    Salt, I.P.2    Davies, S.P.3    Hardie, D.G.4    Carling, D.5
  • 9
    • 85047691317 scopus 로고    scopus 로고
    • CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
    • PMID:14722619
    • Scott JW, Hawley SA, Green KA, Anis M, Stewart G, Scullion GA, et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J Clin Invest 2004; 113:274-84; PMID:14722619.
    • (2004) J Clin Invest , vol.113 , pp. 274-284
    • Scott, J.W.1    Hawley, S.A.2    Green, K.A.3    Anis, M.4    Stewart, G.5    Scullion, G.A.6
  • 10
    • 0035872209 scopus 로고    scopus 로고
    • Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis
    • PMID:11371514
    • Blair E, Redwood C, Ashrafian H, Oliveira M, Broxholme J, Kerr B, et al. Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. Hum Mol Genet 2001; 10:1215-20; PMID:11371514; http://dx.doi.org/10.1093/hmg/10.11.1215.
    • (2001) Hum Mol Genet , vol.10 , pp. 1215-1220
    • Blair, E.1    Redwood, C.2    Ashrafian, H.3    Oliveira, M.4    Broxholme, J.5    Kerr, B.6
  • 11
    • 63849261100 scopus 로고    scopus 로고
    • Structure and function of AMP-activated protein kinase
    • (Oxf) PMID:19245650
    • Oakhill JS, Scott JW, Kemp BE. Structure and function of AMP-activated protein kinase. Acta Physiol (Oxf) 2009; 196:3-14; PMID:19245650; http://dx.doi. org/10.1111/j.1748-16.2009.01977.x.
    • (2009) Acta Physiol , vol.196 , pp. 3-14
    • Oakhill, J.S.1    Scott, J.W.2    Kemp, B.E.3
  • 12
    • 34250827107 scopus 로고    scopus 로고
    • Energy-dependent regulation of cell structure by AMP-activated protein kinase
    • PMID:17486097
    • Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 2007; 447:1017-20; PMID:17486097; http://dx.doi. org/10.1038/nature05828.
    • (2007) Nature , vol.447 , pp. 1017-1020
    • Lee, J.H.1    Koh, H.2    Kim, M.3    Kim, Y.4    Lee, S.Y.5    Karess, R.E.6
  • 13
    • 78649654888 scopus 로고    scopus 로고
    • Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis
    • PMID:20861308
    • Ma X, Jana SS, Conti MA, Kawamoto S, Claycomb WC, Adelstein RS. Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis. Mol Biol Cell 2010; 21:3952-62; PMID:20861308; http://dx.doi. org/10.1091/mbc.E10-04-0293.
    • (2010) Mol Biol Cell , vol.21 , pp. 3952-3962
    • Ma, X.1    Jana, S.S.2    Conti, M.A.3    Kawamoto, S.4    Claycomb, W.C.5    Adelstein, R.S.6
  • 14
    • 68449094064 scopus 로고    scopus 로고
    • The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis
    • PMID:19556893
    • Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis. Cell Cycle 2009; 8:2385-98; PMID:19556893; http:// dx.doi.org/10.4161/cc.8.15.9082.
    • (2009) Cell Cycle , vol.8 , pp. 2385-2398
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 16
    • 70449753858 scopus 로고    scopus 로고
    • AMPK: Evidence for an energy- sensing cytokinetic tumor suppressor
    • PMID:19844168
    • Vazquez-Martin A, Oliveras-Ferraros C, Lopez-Bonet E, Menendez JA. AMPK: Evidence for an energy- sensing cytokinetic tumor suppressor. Cell Cycle 2009; 8:3679-83; PMID:19844168; http://dx.doi. org/10.4161/cc.8.22.9905.
    • (2009) Cell Cycle , vol.8 , pp. 3679-3683
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Lopez-Bonet, E.3    Menendez, J.A.4
  • 17
    • 78649570550 scopus 로고    scopus 로고
    • Role of AMPK throughout meiotic maturation in the mouse oocyte: Evidence for promotion of polar body formation and suppression of premature activation
    • PMID:20830737
    • Downs SM, Ya R, Davis CC. Role of AMPK throughout meiotic maturation in the mouse oocyte: evidence for promotion of polar body formation and suppression of premature activation. Mol Reprod Dev 2010; 77:888-99; PMID:20830737; http://dx.doi. org/10.1002/mrd.21229.
    • (2010) Mol Reprod Dev , vol.77 , pp. 888-899
    • Downs, S.M.1    Ya, R.2    Davis, C.C.3
  • 18
    • 77953121697 scopus 로고    scopus 로고
    • AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation
    • PMID:20495555
    • Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, et al. AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol 2010; 12:583-90; PMID:20495555; http://dx.doi. org/10.1038/ncb2060.
    • (2010) Nat Cell Biol , vol.12 , pp. 583-590
    • Nakano, A.1    Kato, H.2    Watanabe, T.3    Min, K.D.4    Yamazaki, S.5    Asano, Y.6
  • 19
    • 77956294919 scopus 로고    scopus 로고
    • Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation
    • PMID:20647423
    • Bungard D, Fuerth BJ, Zeng PY, Faubert B, Maas NL, Viollet B, et al. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 2010; 329:1201-5; PMID:20647423; http://dx.doi.org/10. 1126/science.1191241.
    • (2010) Science , vol.329 , pp. 1201-1205
    • Bungard, D.1    Fuerth, B.J.2    Zeng, P.Y.3    Faubert, B.4    Maas, N.L.5    Viollet, B.6
  • 20
    • 0028218727 scopus 로고
    • Differential detergent fractionation of isolated hepatocytes: Biochemical, immunochemical and two-dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments
    • PMID:8026443
    • Ramsby ML, Makowski GS, Khairallah EA. Differential detergent fractionation of isolated hepatocytes: biochemical, immunochemical and two-dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments. Electrophoresis 1994; 15:265-77; PMID:8026443; http://dx.doi. org/10.1002/elps.1150150146.
    • (1994) Electrophoresis , vol.15 , pp. 265-277
    • Ramsby, M.L.1    Makowski, G.S.2    Khairallah, E.A.3
  • 21
    • 67650882500 scopus 로고    scopus 로고
    • AMPKalpha1 regulates the antioxidant status of vascular endothelial cells
    • PMID:19442239
    • Colombo SL, Moncada S. AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochem J 2009; 421:163-9; PMID:19442239; http://dx.doi. org/10.1042/BJ20090613.
    • (2009) Biochem J , vol.421 , pp. 163-169
    • Colombo, S.L.1    Moncada, S.2
  • 22
    • 34250182374 scopus 로고    scopus 로고
    • Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
    • PMID:17420279
    • Suzuki A, Okamoto S, Lee S, Saito K, Shiuchi T, Minokoshi Y. Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol 2007; 27:4317-27; PMID:17420279; http://dx.doi. org/10.1128/MCB.02222-06.
    • (2007) Mol Cell Biol , vol.27 , pp. 4317-4327
    • Suzuki, A.1    Okamoto, S.2    Lee, S.3    Saito, K.4    Shiuchi, T.5    Minokoshi, Y.6
  • 23
    • 84355161919 scopus 로고    scopus 로고
    • Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis
    • PMID:22137581
    • Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, et al. Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis. Mol Cell 2011; 44:878-92; PMID:22137581; http://dx.doi.org/10.1016/j.molcel.2011.11.005.
    • (2011) Mol Cell , vol.44 , pp. 878-892
    • Banko, M.R.1    Allen, J.J.2    Schaffer, B.E.3    Wilker, E.W.4    Tsou, P.5    White, J.L.6
  • 24
    • 84857956747 scopus 로고    scopus 로고
    • NUAK2: An emerging acral melanoma oncogene
    • PMID:21911917
    • Namiki T, Coelho SG, Hearing VJ. NUAK2: an emerging acral melanoma oncogene. Oncotarget 2011; 2:695-704; PMID:21911917.
    • (2011) Oncotarget , vol.2 , pp. 695-704
    • Namiki, T.1    Coelho, S.G.2    Hearing, V.J.3
  • 25
    • 79954529883 scopus 로고    scopus 로고
    • Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus
    • PMID:21474997
    • Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, Menendez JA. Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus. Cell Cycle 2011; 10:1295-302; PMID:21474997; http://dx.doi.org/10.4161/ cc.10.8.15342.
    • (2011) Cell Cycle , vol.10 , pp. 1295-1302
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Cufí, S.3    Menendez, J.A.4
  • 26
    • 77955917717 scopus 로고    scopus 로고
    • Ionizing radiation activates AMP-activated kinase (AMPK): A target for radiosensitization of human cancer cells
    • PMID:20615625
    • Sanli T, Rashid A, Liu C, Harding S, Bristow RG, Cutz JC, et al. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. Int J Radiat Oncol Biol Phys 2010; 78:221-9; PMID:20615625; http://dx.doi. org/10.1016/j.ijrobp.2010.03.005.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , pp. 221-229
    • Sanli, T.1    Rashid, A.2    Liu, C.3    Harding, S.4    Bristow, R.G.5    Cutz, J.C.6
  • 27
    • 79961116788 scopus 로고    scopus 로고
    • Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease
    • PMID:21768291
    • Ju TC, Chen HM, Lin JT, Chang CP, Chang WC, Kang JJ, et al. Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease. J Cell Biol 2011; 194:209-27; PMID:21768291; http://dx.doi.org/10.1083/jcb.201105010.
    • (2011) J Cell Biol , vol.194 , pp. 209-227
    • Ju, T.C.1    Chen, H.M.2    Lin, J.T.3    Chang, C.P.4    Chang, W.C.5    Kang, J.J.6
  • 28
    • 77958066938 scopus 로고    scopus 로고
    • Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase
    • PMID:20685962
    • Kazgan N, Williams T, Forsberg LJ, Brenman JE. Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase. Mol Biol Cell 2010; 21:3433-42; PMID:20685962; http://dx.doi. org/10.1091/mbc.E10-04-0347.
    • (2010) Mol Biol Cell , vol.21 , pp. 3433-3442
    • Kazgan, N.1    Williams, T.2    Forsberg, L.J.3    Brenman, J.E.4
  • 29
    • 34047161436 scopus 로고    scopus 로고
    • Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase
    • PMID:17289942
    • Townley R, Shapiro L. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 2007; 315:1726-9; PMID:17289942; http://dx.doi.org/10.1126/science.1137503.
    • (2007) Science , vol.315 , pp. 1726-1729
    • Townley, R.1    Shapiro, L.2
  • 30
    • 17844400342 scopus 로고    scopus 로고
    • 5'AMP activated protein kinase expression in human skeletal muscle: Effects of strength training and type 2 diabetes
    • PMID:15718261
    • Wojtaszewski JF, Birk JB, Frøsig C, Holten M, Pilegaard H, Dela F. 5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes. J Physiol 2005; 564:563-73; PMID:15718261; http://dx.doi.org/10.1113/ jphysiol.2005.082669.
    • (2005) J Physiol , vol.564 , pp. 563-573
    • Wojtaszewski, J.F.1    Birk, J.B.2    Frøsig, C.3    Holten, M.4    Pilegaard, H.5    Dela, F.6
  • 31
    • 79251553419 scopus 로고    scopus 로고
    • The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia
    • PMID:20881209
    • Foretz M, Hébrard S, Guihard S, Leclerc J, Do Cruzeiro M, Hamard G, et al. The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia. FASEB J 2011; 25:337-47; PMID:20881209; http:// dx.doi.org/10.1096/fj. 10-169383.
    • (2011) FASEB J , vol.25 , pp. 337-347
    • Foretz, M.1    Hébrard, S.2    Guihard, S.3    Leclerc, J.4    Do Cruzeiro, M.5    Hamard, G.6
  • 32
    • 78649649752 scopus 로고    scopus 로고
    • Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells
    • PMID:20844250
    • Bogachus LD, Turcotte LP. Genetic downregulation of AMPK-alpha isoforms uncovers the mechanism by which metformin decreases FA uptake and oxidation in skeletal muscle cells. Am J Physiol Cell Physiol 2010; 299:1549-61; PMID:20844250; http://dx.doi. org/10.1152/ajpcell.00279.2010.
    • (2010) Am J Physiol Cell Physiol , vol.299 , pp. 1549-1561
    • Bogachus, L.D.1    Turcotte, L.P.2
  • 33
    • 56049112796 scopus 로고    scopus 로고
    • Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes
    • PMID:19022182
    • Scott JW, van Denderen BJ, Jorgensen SB, Honeyman JE, Steinberg GR, Oakhill JS, et al. Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol 2008; 15:1220-30; PMID:19022182; http://dx.doi. org/10.1016/j.chembiol.2008.10.005.
    • (2008) Chem Biol , vol.15 , pp. 1220-1230
    • Scott, J.W.1    Van Denderen, B.J.2    Jorgensen, S.B.3    Honeyman, J.E.4    Steinberg, G.R.5    Oakhill, J.S.6
  • 34
    • 77953533500 scopus 로고    scopus 로고
    • The AMPK-FoxO3A axis as a target for cancer treatment
    • PMID:20190568
    • Chiacchiera F, Simone C. The AMPK-FoxO3A axis as a target for cancer treatment. Cell Cycle 2010; 9:1091-6; PMID:20190568; http://dx.doi.org/10.4161/ cc.9.6.11035.
    • (2010) Cell Cycle , vol.9 , pp. 1091-1096
    • Chiacchiera, F.1    Simone, C.2


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