The AMPKγ1 subunit plays an essential role in erythrocyte membrane elasticity, and its genetic inactivation induces splenomegaly and anemia

FASEB Journal

Volumn 25, Issue 1, 2011, Pages 337-347

  Foretz, Marc ^a   Hébrard, Sophie ^a   Guihard, Soizic ^a   Leclerc, Jocelyne ^a   Do Cruzeiro, Marcio ^a   Hamard, Ghislaine ^a   Niedergang, Florence ^a   Gaudry, Muriel ^a   Viollet, Benoit ^a  

^a INSTITUT COCHIN   (France)

Author keywords

Knockout mice; Membrane deformability; Osmotic resistance; Protein kinase; RBC

Indexed keywords

ACTIN; ADDUCIN; CYTOSKELETON PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE GAMMA 1; SPECTRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BLOOD ANALYSIS; CELL ENERGY; CONTROLLED STUDY; ELASTICITY; ENZYME METABOLISM; ERYTHROCYTE; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; ERYTHROCYTE MEMBRANE ELASTICITY; ERYTHROPHAGOCYTOSIS; ERYTHROPOIESIS; FEMALE; GENE DISRUPTION; GENE INACTIVATION; GENE INDUCTION; GENE LOCUS; GENE TARGETING; HEMOLYSIS; HEMOLYTIC ANEMIA; HOMOLOGOUS RECOMBINATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SHEAR STRESS; SPLENOMEGALY;

AMP-ACTIVATED PROTEIN KINASES; ANEMIA; ANEMIA, HEMOLYTIC; ANIMALS; BLOTTING, WESTERN; ELASTICITY; ERYTHROBLASTS; ERYTHROCYTE COUNT; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE MEMBRANE; FEMALE; HYPERPLASIA; IRON; MACROPHAGES; MALE; MEMBRANE PROTEINS; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; SPLEEN; SPLENOMEGALY;

EUKARYOTA; MUS;

EID: 79251553419     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-169383     Document Type: Article

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