Relationship between structure and P-glycoprotein inhibitory activity of dimeric peptides related to the Dmt-Tic pharmacophore

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 6, 2012, Pages 2192-2194

  Ambo, Akihiro ^a   Ohkatsu, Hiromichi ^a   Minamizawa, Motoko ^a   Watanabe, Hideko ^a   Sugawara, Shigeki ^a   Nitta, Kazuo ^a   Tsuda, Yuko ^b   Okada, Yoshio ^b   Sasaki, Yusuke ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Dimeric peptide analogs; Dmt Tic pharmacophore; P glycoprotein inhibitory activity; Structure activity relationship

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; GLYCOPROTEIN P INHIBITOR; VERAPAMIL;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; PHARMACOPHORE;

ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; DIPEPTIDES; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; HUMANS; K562 CELLS; P-GLYCOPROTEIN; SOLID-PHASE SYNTHESIS TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES; VERAPAMIL;

EID: 84857915261     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.107     Document Type: Article

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