p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women

Journal of Clinical Pathology - Molecular Pathology

Volumn 53, Issue 1, 2000, Pages 24-30

  Servomaa, K ^a   Kiuru, A ^b   Kosma, V M ^d   Hirvikoski, P ^d   Rytomaa T ^c  

^a Finland's Environmental Administration   (Finland)

^b STUK RADIATION AND NUCLEAR SAFETY AUTHORITY   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

K ras; p53; Rectal carcinoma

Indexed keywords

ONCOPROTEIN; PROTEIN P53; RAS PROTEIN;

ADULT; AGED; ARTICLE; CODON; COLON CARCINOMA; FEMALE; FINLAND; GENDER; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MUTATION RATE; ONCOGENE K RAS; PRIORITY JOURNAL; RECTUM CARCINOMA; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

AGE FACTORS; AGED; FEMALE; GENES, P53; GENES, RAS; HUMANS; MIDDLE AGED; MUTATION; PARAFFIN EMBEDDING; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; RECTAL NEOPLASMS; SEQUENCE ANALYSIS, DNA;

EID: 0033959761     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.53.1.24     Document Type: Article

References (23)

1. 1 Harris CC, Hollstein M. Clinical implications of the p53 tumour-suppressor gene. N Engl J Med 1993;329:1318-27.
2. 2 Greenblatt MS, Bennett WP, Hollstein M, et al. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;55:4855-78.
3. 3 Bennett WP. Does radiation cause molecular signatures? In: Boice JD, Jr, ed. Implications of new data on radiation cancer risk. NCRP Proceedings. Bethesda, USA: National Council on Radiation Protection and Measurements, 1997;18:223-7.
4. 4 Hainaut P, Hernandez T, Robinson A, et al. IARC database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools. Nucleic Acids Res 1998;26:205-13.
5. 5 Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
6. 6 Breivik J, Meling GI, Spurkland A, et al. K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location. Br J Cancer 1994; 69:367-71.
7. 7 Ilyas M, Tomlinson IP. Genetic pathways in colorectal cancer. Histopathology 1996;28:389-99.
8. 8 Hakulinen T, Kenward M, Luostarinen T, et al. Cancer in Finland in 1954-2008. Incidence, mortality and prevalence by region. Helsinki: Finnish Foundation for Cancer Research, 1989.
9. 9 Bufill JA. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 1990;113:779-88.
10. 10 Potter JD. Nutrition and colorectal cancer. Cancer Causes Control 1996;7:127-46.
11. 11 Rytömaa T, Servomaa K, Kiuru A, et al. Molecular epidemiological study of human rectal cancer induced by radiotherapy. Radioprotection 1997;32:257-8.
12. 12 Pukkala E, Vertio H. Syöpä Suomessa. Helsinki: Finnish cancer registry, 1994 [In Finnish.]
13. 13 Yanez L, Groffen J, Valenzuela DM. c-K-ras mutations in human carcinomas occur preferentially in codon 12. Oncogene 1987;1:315-18.
14. 14 Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-32.
15. 15 Bell SM, Scott N, Cross D, et al. Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology 1993;104:57-64.
16. 16 Kojima M, Konishi F, Tsukamoto T, et al. Ki-ras point mutation in different types of colorectal carcinomas in early stages. Dis Colon Rectum 1997;40:161-7.
17. 17 Hirvikoski P, Auvinen A, Servomaa K, et al. K-ras and p53 mutations and overexpression as prognostic factors in female rectal carcinoma. Anticancer Res 1999;19:685-92.
18. 18 Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients. Cancer Res 1995;55:5217-21.
19. 19 Servomaa K, Kiuru A, Grenman R, et al. p53 mutations associated with increased sensitivity to ionizing radiation in human head and neck cancer cell lines. Cell Prolif 1996;29: 219-30.
20. 20 Pekkola-Heino K, Servomaa K, Kiuru A, et al. Increased radiosensitivity is associated with p53 mutations in cell lines derived from oral cavity carcinoma. Acta Otolaryngol (Stockh) 1996;116:341-4.
21. 21 Ichii S, Takeda S, Horii A, et al. Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP). Oncogene 1993;8:2399-405.
22. 22 Hasegawa H, Ueda M, Watanabe M, et al. K-ras gene mutations in early colorectal cancer ... Hat elevated vs polyp-forming cancer... Oncogene 1995;10:1413-16.
23. 23 Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.