Decoding the cardiac message: The 2011 Thomas W. Smith memorial lecture

Circulation Research

Volumn 110, Issue 5, 2012, Pages 755-763

  Dorn, Gerald W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

genetic mutation; microRNA; RNA silencing; transcriptional regulation

Indexed keywords

DNA; MESSENGER RNA; RNA;

CARDIOVASCULAR SYSTEM; GENE EXPRESSION; GENE INTERACTION; GENE MUTATION; GENE SILENCING; GENE TARGETING; GENETIC REGULATION; HEART DISEASE; HUMAN; MOLECULAR GENETICS; PRIORITY JOURNAL; REVIEW; RNA INTERFERENCE; RNA STRUCTURE; STRESS;

ANIMALS; GENOME-WIDE ASSOCIATION STUDY; HEART; HUMANS; MICRORNAS; MUTATION; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84857882566     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.256768     Document Type: Review

References (68)

1. Bartlett J. [comp]. Familiar Quotations. 10th ed., rev. and enlarged by Nathan Haskell Dole. Boston: Little, Brown; 1919. Bartleby.com; 2000.
2. Mendel G. Versuche über Pflanzenhybriden. Verhandlungen des naturforschenden Vereins Brünn. 1866;4:3-47.
3. De Vries H. Sur la loi de disjonction des hybrides. CR Acad Sci Paris. 1900;130:845-848.
4. Correns CG. Mendel's Regel über das Verhalten der Nachkommenschaft der Rassenbastarde. Ber Deut Botan Gessel. 1900;18:158-168.
5. Miescher F. Ueber die chemische Zusammensetzung der Eiterzellen. Medizinisch-chemische Untersuchungen. 1871;4:441-460.
6. Hoppe-Seyler F. Ueber die chemische Zusammensetzung des Eiters. Medizinisch-chemische Untersuchungen. 1871;4:486-501.
7. Avery OT, Macleod CM, McCarty M. Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J Exp Med. 1944;79:137-158.
8. Hershey AD, Chase M. Independent functions of viral protein and nucleic acid in growth of bacteriophage. J Gen Physiol. 1952;36:39-56.
9. Franklin RE, Gosling RG. Molecular configuration in sodium thymonucleate. Nature. 1953;171:740-741.
10. Wilkins MH, Stokes AR, Wilson HR. Molecular structure of deoxypentose nucleic acids. Nature. 1953;171:738-740.
11. Watson JD, Crick FH. Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature. 1953;171:737-738.
12. Hayes B. The invention of the genetic code. Am Sci. 1998;86:8-14. (Pubitemid 128500300)
13. Garrod AE. The incidence of alkaptonuria: a study in chemical individuality. Lancet. 1902;ii:1616-1620.
14. Tanigawa G, Jarcho JA, Kass S, Solomon SD, Vosberg HP, Seidman JG, Seidman CE. A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene. Cell. 1990; 62:991-998.
15. Geisterfer-Lowrance AA, Kass S, Tanigawa G, Vosberg HP, McKenna W, Seidman CE, Seidman JG. A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation. Cell. 1990;62:999-1006.
16. Seidman CE, Seidman JG. Identifying sarcomere gene mutations in hypertrophic cardiomyopathy: a personal history. Circ Res. 2011;108: 743-750.
17. Olson EN. Gene regulatory networks in the evolution and development of the heart. Science. 2006;313:1922-1927. (Pubitemid 44497993)
18. Potthoff MJ, Olson EN. MEF2: a central regulator of diverse developmental programs. Development. 2007;134:4131-4140.
19. Hill JA, Olson EN. Cardiac plasticity. N Engl J Med. 2008;358: 1370-1380.
20. Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet. 2009;10:32-42.
21. Matkovich SJ, Van Booven DJ, Youker KA, Torre-Amione G, Diwan A, Eschenbacher WH, Dorn LE, Watson MA, Margulies KB, Dorn GW 2nd. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation. 2009;119:1263-1271.
22. Heidecker B, Kittleson MM, Kasper EK, Wittstein IS, Champion HC, Russell SD, Hruban RH, Rodriguez ER, Baughman KL, Hare JM. Transcriptomic biomarkers for the accurate diagnosis of myocarditis. Circulation. 2011;123:1174-1184.
23. Frey N, Katus HA, Olson EN, Hill JA. Hypertrophy of the heart: a new therapeutic target? Circulation. 2004;109:1580-1589. (Pubitemid 38451712)
24. Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860-921. (Pubitemid 32165345)
25. Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science. 2001;291:1304-1351. (Pubitemid 32173090)
26. Green RE, Krause J, Briggs AW, et al. A draft sequence of the Neandertal genome. Science. 2010;328:710-722.
27. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843-854. (Pubitemid 24014542)
28. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-811. (Pubitemid 28099681)
29. Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 2000;403: 901-906. (Pubitemid 30130993)
30. Pasquinelli AE, Reinhart BJ, Slack F, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408:86-89.
31. Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science. 2001;294:862-864. (Pubitemid 33032105)
32. Lau NC, Lim LP, Weinstein EG, Bartel DP. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 2001;294:858-862. (Pubitemid 33032104)
33. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 2001;294: 853-858. (Pubitemid 33032103)
34. Rivas FV, Tolia NH, Song JJ, Aragon JP, Liu J, Hannon GJ, Joshua-Tor L. Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol. 2005;12:340-349. (Pubitemid 43093089)
35. Fabian MR, Mathonnet G, Sundermeier T, et al. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell. 2009;35:868-880.
36. Fukaya T, Tomari Y. PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro. EMBO J. 2011;30: 4998-5009.
37. Liu J, Rivas FV, Wohlschlegel J, Yates JR III, Parker R, Hannon GJ. A role for the P-body component GW182 in microRNA function. Nat Cell Biol. 2005;7:1261-1266.
38. Limbird LE. Cell Surface Receptors: A Short Course on Theory and Methods. 3rd ed. New York, NY: Springer; 2004.
39. Rehmsmeier M, Steffen P, Hochsmann M, Giegerich R. Fast and effective prediction of microRNA/target duplexes. RNA. 2004;10: 1507-1517. (Pubitemid 39288185)
40. van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA, Olson EN. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A. 2006;103:18255-18260. (Pubitemid 44871645)
41. Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, vanLaake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation. 2007;116: 258-267. (Pubitemid 47196561)
42. Margulies KB, Matiwala S, Cornejo C, Olsen H, Craven WA, Bednarik D. Mixed messages: transcription patterns in failing and recovering human myocardium. Circ Res. 2005;96:592-599. (Pubitemid 40463469)
43. Barth AS, Kumordzie A, Frangakis C, Margulies KB, Cappola TP, Tomaselli GF. Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circ: Cardiovasc Genet. 2011;4:475-483.
44. van Rooij E, Quiat D, Johnson BA, Sutherland LB, Qi X, Richardson JA, Kelm RJ Jr, Olson EN. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell. 2009;17: 662-673.
45. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120:15-20. (Pubitemid 40094598)
46. Matkovich SJ, Zhang Y, Van Booven DJ, Dorn GW II. Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq. Circ Res. 2010;106:1459-1467.
47. Matkovich SJ, Van Booven DJ, Eschenbacher WH, Dorn GW 2nd. RISC RNA sequencing for context-specific identification of in vivo microRNA targets. Circ Res. 2011;108:18-26.
48. Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res. 2008;18: 610-621. (Pubitemid 351482785)
49. Buermans HP, Ariyurek Y, van Ommen G, den Dunnen JT, t Hoen PA. New methods for next generation sequencing based microRNA expression profiling. BMC Genomics. 2010;11:716.
50. Dorn GW 2nd. MicroRNAs: redefining mechanisms in cardiac disease. J Cardiovasc Pharmacol. 2010;56:589-595.
51. Karginov FV, Conaco C, Xuan Z, Schmidt BH, Parker JS, Mandel G, Hannon GJ. A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A. 2007;104:19291-19296.
52. Chi SW, Zang JB, Mele A, Darnell RB. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature. 2009;460:479-486.
53. Hafner M, Landthaler M, Burger L, et al. Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010;141:129-141.
54. Wen J, Parker BJ, Jacobsen A, Krogh A. MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action. RNA. 2011;17:820-834.
55. Care A, Catalucci D, Felicetti F, et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007;13:613-618. (Pubitemid 46828487)
56. Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R, Olson EN. MicroRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 2008;22:3242-3254.
57. Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, van dMI, Herias V, van Leeuwen RE, Schellings MW, Barenbrug P, Maessen JG, Heymans S, Pinto YM, Creemers EE. MiR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ Res. 2009;104: 170-178.
58. Xu C, Lu Y, Pan Z, Chu W, Luo X, Lin H, Xiao J, Shan H, Wang Z, Yang B. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J Cell Sci. 2007;120:3045-3052. (Pubitemid 47517087)
59. Luo X, Lin H, Pan Z, Xiao J, Zhang Y, Lu Y, Yang B, Wang Z. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J Biol Chem. 2008;283:20045-20052.
60. Vo NK, Dalton RP, Liu N, Olson EN, Goodman RH. Affinity purification of microRNA-133a with the cardiac transcription factor, Hand2. Proc Natl Acad Sci U S A. 2010;107:19231-19236.
61. Baek D, Villen J, Shin C, Camargo FD, Gygi SP, Bartel DP. The impact of microRNAs on protein output. Nature. 2008;455:64-71.
62. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science. 2007;316:575-579. (Pubitemid 46683138)
63. Montgomery RL, Hullinger TG, Semus HM, Dickinson BA, Seto AG, Lynch JM, Stack C, Latimer PA, Olson EN, van Rooij E. Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation. 2011;124:1537-1547.
64. Chen K, Rajewsky N. Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet. 2006;38:1452-1456. (Pubitemid 44837570)
65. Saunders MA, Liang H, Li WH. Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A. 2007;104: 3300-3305. (Pubitemid 46364154)
66. Brest P, Lapaquette P, Souidi M, Lebrigand K, Cesaro A, Vouret-Craviari V, Mari B, Barbry P, Mosnier JF, Hebuterne X, Harel-Bellan A, Mograbi B, Darfeuille-Michaud A, Hofman P. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet. 2011;43:242-245.
67. Mencia A, Modamio-Hoybjor S, Redshaw N, Morin M, Mayo-Merino F, Olavarrieta L, Aguirre LA, del Castillo I, Steel KP, Dalmay T, Moreno F, Moreno-Pelayo MA. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet. 2009; 41:609-613.
68. Dorn GW 2nd, Matkovich SJ, Eschenbacher WH, Zhang Y, Hu Y, Dorn LE. A human 3+ miR-499 mutation alters cardiac mRNA targeting and function. Circ Res. In press.