Quantification of kinetics for enzyme-catalysed reactions: Implications for diffusional limitations at the 10 ml scale

Biotechnology Letters

Volumn 30, Issue 6, 2008, Pages 995-1000

  Matosevic, S ^a   Micheletti, M ^a   Woodley, J M ^b   Lye, G J ^a   Baganz, F ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Bioreactor; Kinetics; Mass transfer; Microwell; Transketolase

Indexed keywords

L-ERYTHRULOSE; STIRRING CONDITIONS; TRANSKETOLASE;

BIOREACTORS; CATALYSIS; DIFFUSION; MATHEMATICAL MODELS; STATISTICAL METHODS;

ENZYME KINETICS;

ERYTHRULOSE; TETROSE; TRANSKETOLASE; UNCLASSIFIED DRUG;

ARTICLE; BIOREACTOR; CATALYSIS; DIFFUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM;

BIOREACTORS; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; KINETICS; TETROSES; TRANSKETOLASE;

EID: 42549135071     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-008-9645-1     Document Type: Article

References (9)

1. Barker L, Rolka H, Rolka D et al (2001) Equivalence testing for binomial random variables: which test to use? Am Stat 55:279-287
2. Doig SD, Pickering SC, Lye GJ, Woodley JM (2002) The use of microscale processing technologies for quantification of biocatalytic Baeyer-Villiger oxidation kinetics. Biotechnol Bioeng 80(1):42-49
3. Hermann R, Lehmann M, Büchs J (2003) Characterization of gas-liquid mass transfer phenomena in microtiter plates. Biotechnol Bioeng 81(2):178-186
4. Hibbert EG, Baganz F, Hailes HC, Ward JM, Lye GJ, Woodley JM, Dalby PA (2005) Directed evolution of biocatalytic processes. Biomol Eng 22(1-3):11-19
5. Huh MH (1994) Equivalence testing as an alternative to significance testing. J Korean Stat Soc 23:199-206
6. Linek V, Kordač M, Moucha T (2006) Evaluation of the optical sulfite oxidation method for the determination of the interfacial mass transfer area in small-scale bioreactors. Biochem Eng J 26(3):264-268
7. Losey MW, Schmidt MA, Jensen K (2001) Microfabricated multiphase packed-bed reactors: characterization of mass transfer and reactions. Ind Eng Chem Res 40:2555-2562
8. Lye GJ, Ayazi-Shamlou P, Baganz F, Dalby PA, Woodley JM (2003) Accelerated design of bioconversion processes using automated microscale processing techniques. Trends Biotechnol 21:29-37
9. Mitra RK, Woodley JM (1996) A useful assay for transketolase in asymmetric syntheses. Biotechnol Tech 10:167-172