Catechol-O-methyltransferase in complex with substituted 3́-deoxyribose bisubstrate inhibitors

Acta Crystallographica Section D: Biological Crystallography

Volumn 68, Issue 3, 2012, Pages 253-260

  Ellermann, Manuel ^a   Lerner, Christian ^b   Burgy, Guillaume ^b   Ehler, Andreas ^b   Bissantz, Caterina ^b   Jakob Roetne, Roland ^b   Paulini, Ralph ^a   Allemann, Oliver ^a   Tissot, Helose ^a   Grünstein, Dan ^a   Stihle, Martine ^b   Diederich, Francois ^a   Rudolph, Markus G ^b  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

bisubstrate inhibitors; catechol O methyltransferase; modified ribose; molecular recognition; organofluorine; structure based drug design

Indexed keywords

CATECHOL DERIVATIVE; CATECHOL METHYLTRANSFERASE; DEOXYRIBOSE; DOPAMINE; LEVODOPA; RIBOSE; S ADENOSYLMETHIONINE;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; METABOLISM; PARKINSON DISEASE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CATECHOL O-METHYLTRANSFERASE; CATECHOLS; CRYSTALLOGRAPHY, X-RAY; DEOXYRIBOSE; DOPAMINE; DRUG DESIGN; LEVODOPA; MODELS, MOLECULAR; PARKINSON DISEASE; RIBOSE; S-ADENOSYLMETHIONINE;

EID: 84857832445     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444912001138     Document Type: Article

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