Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood

Multiple Sclerosis Journal

Volumn 18, Issue 3, 2012, Pages 299-304

  Calabrese, Roberta ^a,b   Zampieri, Michele ^a,b   Mechelli, Rosella ^c   Annibali, Viviana ^c   Guastafierro, Tiziana ^a,b   Ciccarone, Fabio ^a,b   Coarelli, Giulia ^c   Umeton, Renato ^c   Salvetti, Marco ^c   Caiafa, Paola ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Pasteur Institute   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

DNA Methylation; epigenetics; multiple sclerosis; PAD2

Indexed keywords

BISULFITE; ENZYME PAD2; ENZYME PAD4; MYELIN BASIC PROTEIN; PROTEIN ARGININE DEIMINASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CPG ISLAND; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION; HUMAN; MALE; METHYLATION; MULTIPLE SCLEROSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PROTEIN METHYLATION; PROTEIN SYNTHESIS; UPREGULATION;

EID: 84857805315     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458511421055     Document Type: Article

References (27)

1. Compston A, Coles A. Multiple sclerosis. Lancet. 2008 ; 372: 1502-1517
2. Boggs JM. Myelin basic protein: a multifunctional protein. Cell Mol Life Sci. 2006 ; 63: 1945-1961 (Pubitemid 44359737)
3. Mastronardi FG, Noor A, Wood DD, Paton T, Moscarello MA. Peptidyl argininedeiminase 2 CpG island in multiple sclerosis white matter is hypomethylated. J Neurosci Res. 2007 ; 85: 2006-2016 (Pubitemid 47051489)
4. Casaccia-Bonnefil P, Pandozy G, Mastronardi F. Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol. 2008 ; 86: 368-378
5. Kurtuncu M, Tuzun E. Multiple sclerosis: could it be an epigenetic disease?. Med Hypotheses. 2008 ; 71: 945-947
6. Urdinguio RG, Sanchez-Mut JV, Esteller M. Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol. 2009 ; 8: 1056-1072
7. Musse AA, Li Z, Ackerley CA, Bienzle D, Lei H, Poma R, et al. Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Model Mech. 2008 ; 1: 229-240
8. Voskuhl RR. Myelin protein expression in lymphoid tissues: implications for peripheral tolerance. Immunol Rev. 1998 ; 164: 81-92 (Pubitemid 28438398)
9. Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, et al. Human PAD4 regulates histone arginine methylation levels via demethylimination. Science. 2004 ; 306: 279-283 (Pubitemid 39336873)
10. Mastronardi FG, Wood DD, Mei J, Raijmakers R, Tseveleki V, Dosch HM, et al. Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation. J Neurosci. 2006 ; 26: 11387-11396 (Pubitemid 44772168)
11. Wood DD, Ackerley CA, Brand B, Zhang L, Raijmakers R, Mastronardi FG, et al. Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities. Lab Invest. 2008 ; 88: 354-364 (Pubitemid 351432768)
12. Chang X, Yamada R, Suzuki A, Sawada T, Yoshino S, Tokuhiro S, et al. Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis. Rheumatology. 2005 ; 44: 40-50 (Pubitemid 40124330)
13. Vossenaar ER, Radstake TR, van der Heijden A, van Mansum MA, Dieteren C, de Rooij DJ, et al. Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann Rheum Dis. 2004 ; 63: 373-381 (Pubitemid 38453302)
14. Zampieri M, Ciccarone F, Guastafierro T, Bacalini MG, Calabrese R, Moreno-Villanueva M, et al. Validation of suitable internal control genes for expression studies in aging. Mech Ageing Dev. 2010 ; 131: 89-95
15. Moscarello MA, Mastronardi FG, Wood DD. The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis. Neurochem Res. 2007 ; 32: 251-256 (Pubitemid 46238870)
16. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002 ; 3: RESEARCH0034
17. Andersen CL, Jensen JL, Orntoft TF. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 2004 ; 64: 5245-5250 (Pubitemid 39006544)
18. Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn GJ. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays. 2003 ; 25: 1106-1118 (Pubitemid 37411770)
19. Pritzker LB, Joshi S, Gowan JJ, Harauz G, Moscarello MA. Deimination of myelin basic protein. 1. Effect of deimination of arginyl residues of myelin basic protein on its structure and susceptibility to digestion by cathepsin D. Biochemistry. 2000 ; 39: 5374-5381 (Pubitemid 30257077)
20. Carrillo-Vico A, Leech MD, Anderton SM. Contribution of myelin autoantigen citrullination to T cell autoaggression in the central nervous system. J Immunol. 2010 ; 184: 2839-2846
21. MacKenzie-Graham AJ, Pribyl TM, Kim S, Porter VR, Campagnoni AT, Voskuhl RR. Myelin protein expression is increased in lymph nodes of mice with relapsing experimental autoimmune encephalomyelitis. J Immunol. 1997 ; 159: 4602-4610 (Pubitemid 127470623)
22. Tranquill LR, Cao L, Ling NC, Kalbacher H, Martin RM, Whitaker JN. Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients. Mult Scler. 2000 ; 6: 220-225
23. Deraos G, Chatzantoni K, Matsoukas MT, Tselios T, Deraos S, Katsara M, et al. Citrullination of linear and cyclic altered peptide ligands from myelin basic protein (MBP(87-99)) epitope elicits a Th1 polarized response by T cells isolated from multiple sclerosis patients: implications in triggering disease. J Med Chem. 2008 ; 51: 7834-7842
24. de Seze J, Dubucquoi S, Lefranc D, Virecoulon F, Nuez I, Dutoit V, et al. IgG reactivity against citrullinated myelin basic protein in multiple sclerosis. J Neuroimmunol. 2001 ; 117: 149-155 (Pubitemid 32595502)
25. Kurreeman F, Liao K, Chibnik L, Hickey B, Stahl E, Gainer V, et al. Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am J Hum Genet. 2011 ; 88: 57-69
26. Shimoyama S, Nagadoi A, Tachiwana H, Yamada M, Sato M, Kurumizaka H, et al. Deimination stabilizes histone H2A/H2B dimers as revealed by electrospray ionization mass spectrometry. J Mass Spectrom. 2010 ; 45: 900-908
27. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nature. 2009 ; 461: 747-753