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Volumn 5, Issue 3, 2011, Pages 784-793

Elevated intact proinsulin levels are indicative of beta-cell dysfunction, insulin resistance, and cardiovascular risk: Impact of the antidiabetic agent pioglitazone

Author keywords

Beta cell dysfunction; Cardiovascular risk; Diabetes; Insulin resistance; Pioglitazone; Proinsulin

Indexed keywords

ATORVASTATIN; GLIBENCLAMIDE; GLIMEPIRIDE; METFORMIN PLUS PIOGLITAZONE; PIOGLITAZONE; PROINSULIN; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; BIOLOGICAL MARKER; INSULIN;

EID: 84857796399     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229681100500333     Document Type: Article
Times cited : (42)

References (50)
  • 3
    • 0031791047 scopus 로고    scopus 로고
    • Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
    • DOI 10.1210/jc.83.2.604
    • Røder ME, Porte D Jr, Schwartz RS, Kahn SE. Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1998;83(2):604-8. (Pubitemid 28496546)
    • (1998) Journal of Clinical Endocrinology and Metabolism , vol.83 , Issue.2 , pp. 604-608
    • Roder, M.E.1    Porte Jr., D.2    Schwartz, R.S.3    Kahn, S.E.4
  • 6
    • 3042690588 scopus 로고    scopus 로고
    • Role of intact proinsulin in diagnosis and treatment of type 2 diabetes mellitus
    • DOI 10.1089/152091504774198124
    • Pfützner A, Pfützner AH, Larbig M, Forst T. Role of intact proinsulin in diagnosis and treatment of type 2 diabetes mellitus. Diabetes Technol Ther. 2004;6(3):405-12. (Pubitemid 38821628)
    • (2004) Diabetes Technology and Therapeutics , vol.6 , Issue.3 , pp. 405-412
    • Pfutzner, A.1    Pfutzner, A.H.2    Larbig, M.3    Forst, T.4
  • 8
    • 60549111796 scopus 로고    scopus 로고
    • A biomarker concept for assessment of insulin resistance, beta-cell function and chronic systemic inflammation in type 2 diabetes mellitus
    • Pfützner A, Weber MM, Forst T. A biomarker concept for assessment of insulin resistance, beta-cell function and chronic systemic inflammation in type 2 diabetes mellitus. Clin Lab. 2008;54(11-12):485-90.
    • (2008) Clin Lab , vol.54 , Issue.11-12 , pp. 485-490
    • Pfützner, A.1    Weber, M.M.2    Forst, T.3
  • 9
    • 18844465935 scopus 로고    scopus 로고
    • Fasting Intact Proinsulin Is A Highly Specific Predictor of Insulin Resistance in Type 2 Diabetes
    • DOI 10.2337/diacare.27.3.682
    • Pfützner A, Kunt T, Hohberg C, Mondok A, Pahler S, Konrad T, Lübben G, Forst T. Fasting intact proinsulin is a highly specific predictor of insulin resistance in type 2 diabetes. Diabetes Care. 2004;27(3):682-7. (Pubitemid 38280533)
    • (2004) Diabetes Care , vol.27 , Issue.3 , pp. 682-687
    • Pfutzner, A.1    Kunt, T.2    Hohberg, C.3    Mondok, A.4    Pahler, S.5    Konrad, T.6    Lubben, G.7    Forst, T.8
  • 10
    • 4744355176 scopus 로고    scopus 로고
    • Intact and total proinsulin: New aspects for diagnosis and treatment of type 2 diabetes mellitus and insulin resistance
    • Pfützner A, Kann PH, Pfützner AH, Kunt T, Larbig M, Weber MM, Forst T. Intact and total proinsulin: new aspects for diagnosis and treatment of type 2 diabetes mellitus and insulin resistance. Clin Lab. 2004;50(9-10):567- 73. (Pubitemid 39307366)
    • (2004) Clinical Laboratory , vol.50 , Issue.9-10 , pp. 567-573
    • Pfutzner, A.1    Kann, P.H.2    Pfutzner, A.H.3    Kunt, T.4    Larbig, M.5    Weber, M.M.6    Forst, T.7
  • 11
    • 0026608746 scopus 로고
    • Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience
    • Galloway JA, Hooper SA, Spradlin CT, Howey DC, Frank BH, Bowsher RR, Anderson JH. Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience. Diabetes Care. 1992;15(5):666-92.
    • (1992) Diabetes Care , vol.15 , Issue.5 , pp. 666-692
    • Galloway, J.A.1    Hooper, S.A.2    Spradlin, C.T.3    Howey, D.C.4    Frank, B.H.5    Bowsher, R.R.6    Anderson, J.H.7
  • 16
    • 0033671131 scopus 로고    scopus 로고
    • High proinsulin levels precede first-ever stroke in a nondiabetic population
    • Lindahl B, Dinesen B, Eliasson M, Røder M, Hallmans G, Stegmayr B. High proinsulin levels precede first-ever stroke in a nondiabetic population. Stroke. 2000;31(12):2936-41.
    • (2000) Stroke , vol.31 , Issue.12 , pp. 2936-2941
    • Lindahl, B.1    Dinesen, B.2    Eliasson, M.3    Røder, M.4    Hallmans, G.5    Stegmayr, B.6
  • 17
    • 0030045866 scopus 로고    scopus 로고
    • Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: The Hoorn Study
    • Nijpels G, Popp-Snijders C, Kostense PJ, Bouter LM, Heine RJ. Fasting proinsulin and 2-h post-load glucose levels predict the conversion to NIDDM in subjects with impaired glucose tolerance: the Hoorn Study. Diabetologia. 1996;39(1):113-8. (Pubitemid 26029738)
    • (1996) Diabetologia , vol.39 , Issue.1 , pp. 113-118
    • Nijpels, G.1    Popp-Snijders, C.2    Kostense, P.J.3    Bouter, L.M.4    Heine, R.J.5
  • 18
    • 0037035446 scopus 로고    scopus 로고
    • Proinsulin is an independent predictor of coronary heart disease: Report from a 27-year follow-up study
    • DOI 10.1161/01.CIR.0000015855.04844.E7
    • Zethelius B, Byberg L, Hales CN, Lithell H, Berne C. Proinsulin is an independent predictor of coronary heart disease: report from a 27-year follow-up study. Circulation. 2002;105(18):2153-8. (Pubitemid 34517158)
    • (2002) Circulation , vol.105 , Issue.18 , pp. 2153-2158
    • Zethelius, B.1    Byberg, L.2    Hales, C.N.3    Lithell, H.4    Berne, C.5
  • 19
    • 15944414254 scopus 로고    scopus 로고
    • Proinsulin concentration is an independent predictor of all-cause and cardiovascular mortality: An 11-year follow-up of the Hoorn study
    • DOI 10.2337/diacare.28.4.860
    • Alssema M, Dekker JM, Nijpels G, Stehouwer CD, Bouter LM, Heine RJ; Hoorn Study. Proinsulin concentration is an independent predictor of all-cause and cardiovascular mortality: an 11-year follow-up of the Hoorn Study. Diabetes Care. 2005;28(4):860-5. (Pubitemid 40434486)
    • (2005) Diabetes Care , vol.28 , Issue.4 , pp. 860-865
    • Alssema, M.1    Dekker, J.M.2    Nijpels, G.3    Stehouwer, C.D.A.4    Bouter, L.M.5    Heine, R.J.6
  • 21
    • 0029393892 scopus 로고
    • Role of insulin and proinsulin in diabetic vascular disease
    • Wareham NJ, Byrne CD, Hales CN. Role of insulin and proinsulin in diabetic vascular disease. Metabolism. 1995;44 (10 Suppl 4):76-82.
    • (1995) Metabolism , vol.44 , Issue.10 SUPPL. 4 , pp. 76-82
    • Wareham, N.J.1    Byrne, C.D.2    Hales, C.N.3
  • 22
    • 0036203254 scopus 로고    scopus 로고
    • Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: Prospective data from the Caerphilly Study
    • DOI 10.1007/s00125-001-0756-7
    • Yudkin JS, May M, Elwood P, Yarnell JW, Greenwood R, Davey Smith G; Caerphilly Study. Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly Study. Diabetologia. 2002;45(3):327-36. (Pubitemid 34267354)
    • (2002) Diabetologia , vol.45 , Issue.3 , pp. 327-336
    • Yudkin, J.S.1    May, M.2    Elwood, P.3    Yarnell, J.W.G.4    Greenwood, R.5    Davey, S.G.6
  • 23
    • 0029938211 scopus 로고    scopus 로고
    • Are insulin and proinsulin independent risk markers for premature coronary artery disease?
    • Katz RJ, Ratner RE, Cohen RM, Eisenhower E, Verme D. Are insulin and proinsulin independent risk markers for premature coronary artery disease? Diabetes. 1996;45(6):736-41. (Pubitemid 26166768)
    • (1996) Diabetes , vol.45 , Issue.6 , pp. 736-741
    • Katz, R.J.1    Ratner, R.E.2    Cohen, R.M.3    Eisenhower, E.4    Verme, D.5
  • 24
    • 34248633732 scopus 로고    scopus 로고
    • Insulin Resistance, the Metabolic Syndrome, and Risk of Incident Cardiovascular Disease. A Population-Based Study
    • DOI 10.1016/j.jacc.2007.01.088, PII S0735109707009126
    • Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S. Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease: a population-based study. J Am Coll Cardiol. 2007;49(21):2112-9. (Pubitemid 46771048)
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.21 , pp. 2112-2119
    • Jeppesen, J.1    Hansen, T.W.2    Rasmussen, S.3    Ibsen, H.4    Torp-Pedersen, C.5    Madsbad, S.6
  • 25
    • 12344311879 scopus 로고    scopus 로고
    • IRIS II study: Sensitivity and specificity of intact proinsulin, adiponectin, and the proinsulin/adiponectin ratio as markers for insulin resistance
    • Langenfeld MR, Forst T, Standl E, Strotmann HJ, Lübben G, Pahler S, Kann P, Pfützner A; IRIS II study. IRIS II Study: sensitivity and specificity of intact proinsulin, adiponectin, and the proinsulin/adiponectin ratio as markers for insulin resistance. Diabetes Technol Ther. 2004;6(6):836-43. (Pubitemid 40129331)
    • (2004) Diabetes Technology and Therapeutics , vol.6 , Issue.6 , pp. 836-843
    • Langenfeld, M.R.1    Forst, T.2    Standl, E.3    Strotmann, H.-J.4    Lubben, G.5    Pahler, S.6    Kann, P.7    Pfutzner, A.8
  • 26
    • 0036022456 scopus 로고    scopus 로고
    • Effect of pioglitazone on blood proinsulin levels in patients with type 2 diabetes mellitus
    • Kubo K. Effect of pioglitazone on blood proinsulin levels in patients with type 2 diabetes mellitus. Endocr J. 2002;49(3):323-8. (Pubitemid 34832304)
    • (2002) Endocrine Journal , vol.49 , Issue.3 , pp. 323-328
    • Kubo, K.1
  • 27
    • 2942605695 scopus 로고    scopus 로고
    • An increase in insulin sensitivity and basal beta-cell fuction in diabetic subjects treated with pioglitazone in a placebo-controlled randomized study
    • DOI 10.1111/j.1464-5491.2004.01218.x
    • Wallace TM, Levy JC, Matthews DR. An increase in insulin sensitivity and basal beta-cell function in diabetic subjects treated with pioglitazone in a placebo-controlled randomized study. Diabet Med. 2004;21(6):568-76. (Pubitemid 38746276)
    • (2004) Diabetic Medicine , vol.21 , Issue.6 , pp. 568-576
    • Wallace, T.M.1    Levy, J.C.2    Matthews, D.R.3
  • 28
    • 24944509975 scopus 로고    scopus 로고
    • Pioneer study: PPARgamma activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control
    • DOI 10.1055/s-2005-870320
    • Pfützner A, Hohberg C, Lübben G, Pahler S, Pfützner AH, Kann P, Forst T. Pioneer study: PPARgamma activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control. Horm Metab Res. 2005;37(8):510-5. (Pubitemid 41306402)
    • (2005) Hormone and Metabolic Research , vol.37 , Issue.8 , pp. 510-515
    • Pfutzner, A.1    Hohberg, C.2    Lubben, G.3    Pahler, S.4    Pfutzner, A.H.5    Kann, P.6    Forst, T.7
  • 29
    • 33745908261 scopus 로고    scopus 로고
    • Glycaemic and nonglycaemic effects of pioglitazone in triple oral therapy of patients with type 2 diabetes
    • DOI 10.1111/j.1365-2796.2006.01665.x
    • Dorkhan M, Magnusson M, Frid A, Grubb A, Groop L, Jovinge S. Glycaemic and nonglycaemic effects of pioglitazone in triple oral therapy of patients with type 2 diabetes. J Intern Med. 2006;260(2):125-33. (Pubitemid 44051337)
    • (2006) Journal of Internal Medicine , vol.260 , Issue.2 , pp. 125-133
    • Dorkhan, M.1    Magnusson, M.2    Frid, A.3    Grubb, A.4    Groop, L.5    Jovinge, S.6
  • 30
    • 33947304608 scopus 로고    scopus 로고
    • Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk - The PIOSTAT Study
    • DOI 10.1016/j.metabol.2006.11.007, PII S002604950600432X
    • Forst T, Pfützner A, Lübben G, Weber M, Marx N, Karagiannis E, Koehler C, Baurecht W, Hohberg C, Hanefeld M. Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk-the PIOSTAT Study. Metabolism. 2007;56(4):491-6. (Pubitemid 46437254)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.4 , pp. 491-496
    • Forst, T.1    Pfutzner, A.2    Lubben, G.3    Weber, M.4    Marx, N.5    Karagiannis, E.6    Koehler, C.7    Baurecht, W.8    Hohberg, C.9    Hanefeld, M.10
  • 32
    • 42149104644 scopus 로고    scopus 로고
    • Reduced postprandial proinsulinaemia and 32-33 split proinsulinaemia after a mixed meal in type 2 diabetic patients following sensitization to insulin with pioglitazone
    • DOI 10.1111/j.1365-2265.2007.03113.x
    • Cooper MB, Al Majali K, Bailey CJ, Betteridge DJ. Reduced postprandial proinsulinaemia and 32-33 split proinsulinaemia after a mixed meal in type 2 diabetic patients following sensitization to insulin with pioglitazone. Clin Endocrinol (Oxf). 2008;68(5):738-46. (Pubitemid 351533447)
    • (2008) Clinical Endocrinology , vol.68 , Issue.5 , pp. 738-746
    • Cooper, M.B.1    Al, M.K.2    Bailey, C.J.3    Betteridge, D.J.4
  • 33
    • 69249219226 scopus 로고    scopus 로고
    • Earlier triple therapy with pioglitazone in patients with type 2 diabetes
    • F-PIO-100 Study Investigators
    • Charpentier G, Halimi S; F-PIO-100 Study Investigators. Earlier triple therapy with pioglitazone in patients with type 2 diabetes. Diabetes Obes Metab. 2009;11(9):844-54.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.9 , pp. 844-854
    • Charpentier, G.1    Halimi, S.2
  • 34
    • 65449181587 scopus 로고    scopus 로고
    • Successful switch from insulin therapy to treatment with pioglitazone in type 2 diabetes patients with residual beta-cell function: Results from the PioSwitch study
    • Hohberg C, Pfützner A, Forst T, Lübben G, Karagiannis E, Borchert M, Schöndorf T. Successful switch from insulin therapy to treatment with pioglitazone in type 2 diabetes patients with residual beta-cell function: results from the PioSwitch study. Diabetes Obes Metab. 2009;11(5):464-71.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.5 , pp. 464-471
    • Hohberg, C.1    Pfützner, A.2    Forst, T.3    Lübben, G.4    Karagiannis, E.5    Borchert, M.6    Schöndorf, T.7
  • 35
    • 77957322891 scopus 로고    scopus 로고
    • Combined pioglitazone and metformin treatment maintains the beneficial effect of short-term insulin infusion in patients with type 2 diabetes: Results from a pilot study
    • Musholt PB, Schöndorf T, Pfützner A, Hohberg C, Kleine I, Fuchs W, Hehenwarter S, Dikta G, Kerschgens B, Forst T. Combined pioglitazone and metformin treatment maintains the beneficial effect of short-term insulin infusion in patients with type 2 diabetes: results from a pilot study. J Diabetes Sci Technol. 2009;3(6):1442-50.
    • (2009) J Diabetes Sci Technol , vol.3 , Issue.6 , pp. 1442-1450
    • Musholt, P.B.1    Schöndorf, T.2    Pfützner, A.3    Hohberg, C.4    Kleine, I.5    Fuchs, W.6    Hehenwarter, S.7    Dikta, G.8    Kerschgens, B.9    Forst, T.10
  • 36
    • 77957659168 scopus 로고    scopus 로고
    • Limitations of the HOMA-B score for assessment of beta-cell functionality in interventional trials-results from the PIOglim study
    • Pfützner A, Derwahl M, Jacob S, Hohberg C, Blümner E, Lehmann U, Fuchs W, Forst T. Limitations of the HOMA-B score for assessment of beta-cell functionality in interventional trials-results from the PIOglim study. Diabetes Technol Ther. 2010;12(8):599-604.
    • (2010) Diabetes Technol Ther , vol.12 , Issue.8 , pp. 599-604
    • Pfützner, A.1    Derwahl, M.2    Jacob, S.3    Hohberg, C.4    Blümner, E.5    Lehmann, U.6    Fuchs, W.7    Forst, T.8
  • 37
    • 24944465241 scopus 로고    scopus 로고
    • Pharmacological PPARgamma stimulation in contrast to beta cell stimulation results in an improvement in adiponectin and proinsulin intact levels and reduces intima media thickness in patients with type 2 diabetes
    • DOI 10.1055/s-2005-870322
    • Forst T, Hohberg C, Fuellert SD, Lübben G, Konrad T, Löbig M, Weber MM, Sachara C, Gottschall V, Pfützner A. Pharmacological PPARgamma stimulation in contrast to beta cell stimulation results in an improvement in adiponectin and proinsulin intact levels and reduces intima media thickness in patients with type 2 diabetes. Horm Metab Res. 2005;37(8):521-7. (Pubitemid 41306404)
    • (2005) Hormone and Metabolic Research , vol.37 , Issue.8 , pp. 521-527
    • Forst, T.1    Hohberg, C.2    Fuellert, S.D.3    Lubben, G.4    Konrad, T.5    Lobig, M.6    Weber, M.M.7    Sachara, C.8    Gottschall, V.9    Pfutzner, A.10
  • 38
    • 10344248699 scopus 로고    scopus 로고
    • Rosiglitazone, but not glyburide, reduces circulating proinsulin and the proinsulin:insulin ratio in type 2 diabetes
    • DOI 10.1210/jc.2004-0705
    • Smith SA, Porter LE, Biswas N, Freed MI. Rosiglitazone, but not glyburide, reduces circulating proinsulin and the proinsulin:insulin ratio in type 2 diabetes. J Clin Endocrinol Metab. 2004;89(12):6048-53. (Pubitemid 39628413)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.12 , pp. 6048-6053
    • Smith, S.A.1    Porter, L.E.2    Biswas, N.3    Freed, M.I.4
  • 39
    • 7444230907 scopus 로고    scopus 로고
    • Effect of rosiglitazone versus insulin on the pancreatic beta-cell function of subjects with type 2 diabetes
    • DOI 10.2337/diacare.27.11.2585
    • Ovalle F, Bell DS. Effect of rosiglitazone versus insulin on the pancreatic beta-cell function of subjects with type 2 diabetes. Diabetes Care. 2004;27(11):2585-9. (Pubitemid 39441455)
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2585-2589
    • Ovalle, F.1    Bell, D.S.H.2
  • 40
    • 28444495456 scopus 로고    scopus 로고
    • Impact of rosiglitazone on beta-cell function, insulin resistance, and adiponectin concentrations: Results from a double-blind oral combination study with glimepiride
    • DOI 10.1016/j.metabol.2005.06.021, PII S0026049505002714
    • Pfützner A, Schöndorf T, Seidel D, Winkler K, Matthaei S, Hamann A, Forst T. Impact of rosiglitazone on beta-cell function, insulin resistance, and adiponectin concentrations: results from a double-blind oral combination study with glimepiride. Metabolism. 2006;55(1):20-5. (Pubitemid 41736242)
    • (2006) Metabolism: Clinical and Experimental , vol.55 , Issue.1 , pp. 20-25
    • Pfutzner, A.1    Schondorf, T.2    Seidel, D.3    Winkler, K.4    Matthaei, S.5    Hamann, A.6    Forst, T.7
  • 41
    • 33845339600 scopus 로고    scopus 로고
    • A one-year study comparing the efficacy and safety of rosiglitazone and glibenclamide in the treatment of type 2 diabetes
    • DOI 10.1016/j.numecd.2005.12.003, PII S0939475305002516
    • Hanefeld M, Patwardhan R, Jones NP; Rosiglitazone Clinical Trials Study Group. A one-year study comparing the efficacy and safety of rosiglitazone and glibenclamide in the treatment of type 2 diabetes. Nutr Metab Cardiovasc Dis. 2007;17(1):13-23. (Pubitemid 44881317)
    • (2007) Nutrition, Metabolism and Cardiovascular Diseases , vol.17 , Issue.1 , pp. 13-23
    • Hanefeld, M.1    Patwardhan, R.2    Jones, N.P.3
  • 42
    • 39449108262 scopus 로고    scopus 로고
    • Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with type 2 diabetes inadequately controlled on metformin alone
    • DOI 10.1055/s-2007-984441
    • Hamann A, Garcia-Puig J, Paul G, Donaldson J, Stewart M. Comparison of fixed-dose rosiglitazone/metformin combination therapy with sulphonylurea plus metformin in overweight individuals with type 2 diabetes inadequately controlled on metformin alone. Exp Clin Endocrinol Diabetes. 2008;116(1):6-13. (Pubitemid 351270902)
    • (2008) Experimental and Clinical Endocrinology and Diabetes , vol.116 , Issue.1 , pp. 6-13
    • Hamann, A.1    Garcia-Puig, J.2    Paul, G.3    Donaldson, J.4    Stewart, M.5
  • 43
    • 77649256227 scopus 로고    scopus 로고
    • Effect of rosiglitazone and ramipril on {beta}-cell function in people with impaired glucose tolerance or impaired fasting glucose: The DREAM Trial
    • Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication (DREAM) Investigators
    • Hanley AJ, Zinman B, Sheridan P, Yusuf S, Gerstein HC; Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication (DREAM) Investigators. Effect of rosiglitazone and ramipril on {beta}-cell function in people with impaired glucose tolerance or impaired fasting glucose: the DREAM Trial. Diabetes Care. 2010;33(3):608-13.
    • (2010) Diabetes Care , vol.33 , Issue.3 , pp. 608-613
    • Hanley, A.J.1    Zinman, B.2    Sheridan, P.3    Yusuf, S.4    Gerstein, H.C.5
  • 44
    • 0028137716 scopus 로고
    • Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with Type 2 diabetes mellitus
    • Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP. Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus. Diabet Med. 1994;11(1):71-8. (Pubitemid 24040546)
    • (1994) Diabetic Medicine , vol.11 , Issue.1 , pp. 71-78
    • Davies, J.M.1    Metcalfe, J.2    Day, J.L.3    Grenfell, A.4    Hales, C.N.5    Gray, I.P.6
  • 45
    • 0035678808 scopus 로고    scopus 로고
    • Changes in physical activity are associated with changes in metabolic cardiovascular risk factors
    • DOI 10.1007/s001250100022
    • Byberg L, Zethelius B, McKeigue PM, Lithell HO. Changes in physical activity are associated with changes in metabolic cardiovascular risk factors. Diabetologia. 2001;44(12):2134-9. (Pubitemid 34015465)
    • (2001) Diabetologia , vol.44 , Issue.12 , pp. 2134-2139
    • Byberg, L.1    Zethelius, B.2    McKeigue, P.M.3    Lithell, H.O.4
  • 46
    • 8944248809 scopus 로고    scopus 로고
    • Effect of metformin on intact proinsulin and des 31,32 proinsulin concentrations in subjects with non-insulin-dependent (Type 2) diabetes mellitus
    • DOI 10.1002/(SICI)1096-9136(199608)13:8<753::AI
    • Nagi DK, Ali VM, Yudkin JS. Effect of metformin on intact proinsulin and des 31,32 proinsulin concentrations in subjects with non-insulin-dependent (type 2) diabetes mellitus. Diabet Med. 1996;13(8):753-7. (Pubitemid 26252956)
    • (1996) Diabetic Medicine , vol.13 , Issue.8 , pp. 753-757
    • Nagi, D.K.1    Ali, V.M.2    Yudkin, J.S.3
  • 47
    • 0033157221 scopus 로고    scopus 로고
    • Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes
    • Hermann LS, Ranstam J, Vaaler S, Melander A. Effects of antihyperglycaemic therapies on proinsulin and relation between proinsulin and cardiovascular risk factors in type 2 diabetes. Diabetes Obes Metab. 1999;1(4):227-32.
    • (1999) Diabetes Obes Metab , vol.1 , Issue.4 , pp. 227-232
    • Hermann, L.S.1    Ranstam, J.2    Vaaler, S.3    Melander, A.4
  • 48
    • 0028314832 scopus 로고
    • Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus
    • Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP. Effect of sulphonylurea therapy on plasma insulin, intact and 32/33 split proinsulin in subjects with type 2 diabetes mellitus. Diabet Med. 1994;11(3):293-8. (Pubitemid 24144146)
    • (1994) Diabetic Medicine , vol.11 , Issue.3 , pp. 293-298
    • Davies, M.I.1    Metcalfe, J.2    Day, J.L.3    Grenfell, A.4    Hales, C.N.5    Gray, I.P.6
  • 50
    • 33748432872 scopus 로고    scopus 로고
    • The switch from sulfonylurea to preprandial short-acting insulin analog substitution has an immediate and comprehensive beta-cell protective effect in patients with type 2 diabetes mellitus
    • DOI 10.1089/dia.2006.8.375
    • Pfützner A, Lorra B, Abdollahnia MR, Kann PH, Mathieu D, Pehnert C, Oligschleger C, Kaiser M, Forst T. The switch from sulfonylurea to preprandial short-acting insulin analog substitution has an immediate and comprehensive beta-cell protective effect in patients with type 2 diabetes mellitus. Diabetes Technol Ther. 2006;8(3):375-84. (Pubitemid 46100531)
    • (2006) Diabetes Technology and Therapeutics , vol.8 , Issue.3 , pp. 375-384
    • Pfutzner, A.1    Lorra, B.2    Abdollahnia, M.R.3    Kann, P.H.4    Mathieu, D.5    Pehnert, C.6    Oligschleger, C.7    Kaiser, M.8    Forst, T.9


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