Clinical and laboratory evaluation of a new specific ELISA for intact proinsulin

Diabetes, Stoffwechsel und Herz

Volumn 17, Issue 4, 2008, Pages 275-281

  Siebenhaar, Renate ^a   Weise, A ^a   Safinowski, M ^a   Reisinger, K ^a   Musholt, P B ^a   Reimer, T ^a   Forst, T ^a   Pfutzner A ^a  

^a Institute for Clinical Research and Development   (Germany)

Author keywords

Immunoassay; Insulin resistance; Intact proinsulin; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; BIOLOGICAL MARKER; EDETIC ACID; PROINSULIN;

ACCURACY; ADULT; ARTICLE; BLOOD ANALYSIS; CELL FUNCTION; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DIET RESTRICTION; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; IMMUNOASSAY; INCUBATION TIME; INSULIN RESISTANCE; INTERMETHOD COMPARISON; LABORATORY TEST; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; PANCREAS ISLET BETA CELL; PATIENT MONITORING; TREATMENT OUTCOME;

EID: 57149104983     PISSN: 18617603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Zethelius B, Byberg L, Hales CN, Lithell H, Berne C: Proinsulin is an independent predictor of coronary heart disease: report from a 27-year follow-up study. Circulation 2002; 7: 2153-2158
2. Schneider DJ, Nordt TK, Sobel BE: Stimulation by proinsulin of expression of plasminogen activator inhibitor type-I in endothelial cells. Diabetes 1992; 41: 890-895
3. Nordt TK, Bode C, Sobel BE: Stimulation in vivo of expression of intra-abdominal adipose tissue plasminogen activator inhibitor type I by proinsulin. Diabetologia 2001; 44: 1121-1124
4. Yudkin JS, May M, Elwood P, Yarnell JW, Greenwood R, Davey SG: Concentrations of proinsulin-like-molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly study. Diabetologia 2002; 45: 327-336
5. Lindahl B, Dinesen B, Eliasson M, Roeder M, Jansson JH, Huhtasaari F, Hallmans G: High proinsulin concentration precedes acute myocardial infarction in a nondiabetic population. Metabolism 1999; 48: 1197-1202
6. Lindahl B, Dinesen B, Eliasson M, Roeder M, Hallmans G, Stegmayr B: High proinsulin levels precede first-ever stroke in a nondiabetic population. Stroke 2000; 31: 2936-2941
7. Katz RJ, Ratner RE, Cohen RM, Eisenhower E, Werme D: Are insulin and proinsulin independent risk markers for premature coronary artery disease? Diabetes 1996; 45: 736-741
8. Kahn SE, Leonetti D, Prigeon RL, Boyko EJ, Bergstrom RW, Fujimoto WY: Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity: Clinical Research Center Study. J Clin Endocrinol Metab 1995; 80: 1399-1406
9. Yudkin JS, Denver AE, Mohamed-Ali V, Ramaiya KL, Nagi DK, Goubet S, McLarty DG, Swai A: The relationship of concentrations of insulin and proinsulin-like molecules with coronary heart disease prevalence and incidence: a study of two ethnic groups. Diabetes Care 1997; 20: 1093-1100
10. Galloway JA, Hooper SA, Spradlin CT, Howey DC, Frank BH, Bowsher RR, Anderson JH: Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience. Diabetes Care 1992; 15: 666-692
11. Røder ME, Porte D, Schwartz RS, Kahn SE: Disproportionately elevated proinsulin levels reflect the degree of impaired β-cell secretory capacity in patients with non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab 1998; 83: 604-608
12. Hostens K, Ling Z, Van Schravendijk C, Pipeleers D: Prolonged exposure of human beta-cells to high glucose concentrations increases their release of proinsulin during acute stimulation with glucose or arginine. J Clin Endocrinol Metab 1999; 84: 1386-1390
13. Seaquist ER, Kahn SE, Clark PM, Hales CN, Porte D Jr, Robertson RP : Hyperproinsulinemia is associated with increased beta-cell demand after hemipancreatectomy in humans. J Clin Invest 1996; 97: 455-460
14. Haffner SM, Mykkänen L, Stern MP, Valdez RA, Heisserman JA, Bowsher RR: Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects. Diabetes 1993; 42: 1297-1302
15. Luzio SD, Lucas I, Owen DR: Importance of validation of immunoassays for intact proinsulin. Clin Chem Lab Med 2001; 39: 631-633
16. Pfützner A, Kunt T, Löbig M, Knesovic M, Forst T: Clinical and laboratory evaluation characteristics of new chemiluminescence assays for intact and total proinsulin. Clin Chem Lab Med 2003; 41: 1234-1238
17. Pfützner A, Kunt T, Hohberg C, Mondok A, Pahler S, Konrad T, Lübben G, Forst T: Fasting intact proinsulin is a highly specific indicator of insulin resistance in type 2 diabetes. Diabetes Care 2004; 27: 682-687
18. Pacini G, Bergman RN: MINIMOD: a computer program to calculate insulin sensitivity and pancreatic responsibility from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 1986; 23: 113-122
19. Kubo K: Effect of Pioglitazone on blood proinsulin levels in patients with type 2 diabetes. Endocrine Journal 2002; 49: 323-328
20. Pfützner A, Pfützner AH, Larbig M, Forst T: Role of intact proinsulin in diagnosis and treatment of type 2 diabetes mellitus. Diab Technol Ther 2004; 6: 405-412
21. Pfützner A, Hohberg C, Lübben G, Pahler S, Pfützner AH, Kann P, Forst T. Pioneer Study: PPARγ-Activation Results in an Overall Improvement of Clinical and Metabolic Markers associated with Insulin Resistance independent from Long-Term Glucose Control. Horm Metab Res 2005: 37: 510-515
22. Pfützner A, Pfützner AH, Kann PH, Stute R, Löbig M, Yang JW, Mistry J, Forst T: Clinical and laboratory evaluation of a new specific ELISA for intact proinsulin. Clin Lab 2005; 51: 243-249
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419
24. Hedblad B, Nilsson P, Janzon L, Berglund G: Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. Results from a cross-sectional study in Malmo, Sweden. Diabet Med 2000; 17: 299-307