메뉴 건너뛰기




Volumn 3, Issue 6, 2009, Pages 1442-1450

Combined pioglitazone and metformin treatment maintains the beneficial effect of short-term insulin infusion in patients with type 2 diabetes: Results from a pilot study

Author keywords

Cardiovascular risk; Glycemic control; Pioglitazone; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ADIPONECTIN, HUMAN; ANTIDIABETIC AGENT; BIOLOGICAL MARKER; C REACTIVE PROTEIN; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; INSULIN; METFORMIN; PIOGLITAZONE; PROINSULIN;

EID: 77957322891     PISSN: None     EISSN: 19322968     Source Type: Journal    
DOI: 10.1177/193229680900300626     Document Type: Article
Times cited : (3)

References (38)
  • 1
    • 0022515703 scopus 로고
    • The effect of short term intensive insulin therapy in non-insulin-dependent diabetics who had failed on sulphonylurea therapy
    • Samanta A, Burden AC, Jones GR, Clarkson L. The effect of short term intensive insulin therapy in non-insulin-dependent diabetics who had failed on sulphonylurea therapy. Diabetes Res. 1986;3(5):269-71. (Pubitemid 16057253)
    • (1986) Diabetes Research , vol.3 , Issue.5 , pp. 269-271
    • Samanta, A.1    Burden, A.C.2    Jones, G.R.3    Clarkson, L.4
  • 2
    • 33750035469 scopus 로고    scopus 로고
    • Improvement of glycemic control after a 3-5 day insulin infusion in type 2-diabetic patients with insulin resistance can be maintained with glitazone therapy
    • DOI 10.1007/s00508-006-0656-4
    • Biesenbach G, Grafinger P, Raml A. Improvement of glycemic control after a 3-5 day insulin infusion in type 2-diabetic patients with insulin resistance can be maintained with glitazone therapy. Wien Klin Wochenschr. 2006;118(17-18):543-8. (Pubitemid 44579747)
    • (2006) Wiener Klinische Wochenschrift , vol.118 , Issue.17-18 , pp. 543-548
    • Biesenbach, G.1    Grafinger, P.2    Raml, A.3
  • 4
    • 33748117019 scopus 로고    scopus 로고
    • Pioglitazone: An antidiabetic drug with cardiovascular therapeutic effects
    • Pfützner A, Schneider CA, Forst T. Pioglitazone: an antidiabetic drug with cardiovascular therapeutic effects. Expert Rev Cardiovasc Ther. 2006;4(4):445-59.
    • (2006) Expert Rev Cardiovasc Ther , vol.4 , Issue.4 , pp. 445-459
    • Pfützner, A.1    Schneider, C.A.2    Forst, T.3
  • 5
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • DOI 10.1007/BF00280883
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-9. (Pubitemid 15018832)
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 6
    • 0034061181 scopus 로고    scopus 로고
    • Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. Results from a cross-sectional study in Malmo, Sweden
    • DOI 10.1046/j.1464-5491.2000.00280.x
    • Hedblad B, Nilsson P, Janzon L, Berglund G. Relation between insulin resistance and carotid intima-media thickness and stenosis in non-diabetic subjects. Results from a cross-sectional study in Malmö, Sweden. Diabet Med. 2000;17(4):299-307. (Pubitemid 30266125)
    • (2000) Diabetic Medicine , vol.17 , Issue.4 , pp. 299-307
    • Hedblad, B.1    Nilsson, P.2    Janzon, L.3    Berglund, G.4
  • 8
    • 33847041377 scopus 로고    scopus 로고
    • Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes
    • Eguchi K, Tomizawa H, Ishikawa J, Hoshide S, Numao T, Fukuda T, Shimada K, Kario K. Comparison of the effects of pioglitazone and metformin on insulin resistance and hormonal markers in patients with impaired glucose tolerance and early diabetes. Hypertens Res. 2007;30(1):23-30.
    • (2007) Hypertens Res , vol.30 , Issue.1 , pp. 23-30
    • Eguchi, K.1    Tomizawa, H.2    Ishikawa, J.3    Hoshide, S.4    Numao, T.5    Fukuda, T.6    Shimada, K.7    Kario, K.8
  • 9
    • 39449138164 scopus 로고    scopus 로고
    • Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease
    • DOI 10.1016/j.atherosclerosis.2007.05.006, PII S0021915007003358
    • Forst T, Karagiannis E, Lübben G, Hohberg C, Schöndorf T, Dikta G, Drexler M, Morcos M, Dänschel W, Borchert M, Pfützner A. Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease. Atherosclerosis. 2008;197(1):311-7. (Pubitemid 351273253)
    • (2008) Atherosclerosis , vol.197 , Issue.1 , pp. 311-317
    • Forst, T.1    Karagiannis, E.2    Lubben, G.3    Hohberg, C.4    Schondorf, T.5    Dikta, G.6    Drexler, M.7    Morcos, M.8    Danschel, W.9    Borchert, M.10    Pfutzner, A.11
  • 10
    • 0034919411 scopus 로고    scopus 로고
    • The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus
    • DOI 10.1097/00019501-200108000-00011
    • Rosenblatt S, Miskin B, Glazer NB, Prince MJ, Robertson KE, Pioglitazone 026 Study Group. The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus. Coron Artery Dis. 2001;12(5):413-23. (Pubitemid 32664824)
    • (2001) Coronary Artery Disease , vol.12 , Issue.5 , pp. 413-423
    • Rosenblatt, S.1    Miskin, B.2    Glazer, N.B.3    Prince, M.J.4    Robertson, K.E.5
  • 12
    • 10344240901 scopus 로고    scopus 로고
    • Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: A double-blind, randomized trial
    • DOI 10.1210/jc.2003-030861
    • Schernthaner G, Matthews DR, Charbonnel B, Hanefeld M, Brunetti P, Quartet Study Group. Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: a double-blind, randomized trial. J Clin Endocrinol Metab. 2004;89(12):6068-76. (Pubitemid 39628416)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.12 , pp. 6068-6076
    • Schernthaner, G.1    Matthews, D.R.2    Charbonnel, B.3    Hanefeld, M.4    Brunetti, P.5
  • 13
    • 3843149515 scopus 로고    scopus 로고
    • Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity, glycaemic control, and lipid profiles in patients with Type 2 diabetes
    • DOI 10.1111/j.1464-5491.2004.01258.x
    • Tan MH, Johns D, Strand J, Halse J, Madsbad S, Eriksson JW, Clausen J, Konkoy CS, Herz M, GLAC Study Group. Sustained effects of pioglitazone vs. glibenclamide on insulin sensitivity, glycaemic control, and lipid profiles in patients with type 2 diabetes. Diabet Med. 2004;21(8):859-66. (Pubitemid 39036999)
    • (2004) Diabetic Medicine , vol.21 , Issue.8 , pp. 859-866
    • Tan, M.H.1    Johns, D.2    Strand, J.3    Halse, J.4    Madsbad, S.5    Eriksson, J.W.6    Clausen, J.7    Konkoy, C.S.8    Herz, M.9
  • 14
    • 16844371130 scopus 로고    scopus 로고
    • A long-term comparison of pioglitazone and gliclazide in patients with Type 2 diabetes mellitus: A randomized, double-blind, parallel-group comparison trial
    • DOI 10.1111/j.1464-5491.2004.01426.x
    • Charbonnel BH, Matthews DR, Schernthaner G, Hanefeld M, Brunetti P, Quartet Study Group. A long-term comparison of pioglitazone and gliclazide in patients with type 2 diabetes mellitus: a randomized, double-blind, parallel-group comparison trial. Diabet Med. 2005;22(4):399-405. (Pubitemid 40516237)
    • (2005) Diabetic Medicine , vol.22 , Issue.4 , pp. 399-405
    • Charbonnel, B.H.1    Matthews, D.R.2    Schernthaner, G.3    Hanefeld, M.4    Brunetti, P.5
  • 15
    • 24944509975 scopus 로고    scopus 로고
    • Pioneer study: PPARgamma activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control
    • Pfützner A, Hohberg C, Lübben G, Pahler S, Pfützner AH, Kann P, Forst T. Pioneer study: PPARgamma activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control. Horm Metab Res. 2005;37(8):510-5.
    • (2005) Horm Metab Res , vol.37 , Issue.8 , pp. 510-515
    • Pfützner, A.1    Hohberg, C.2    Lübben, G.3    Pahler, S.4    Pfützner, A.H.5    Kann, P.6    Forst, T.7
  • 16
    • 0034933056 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: A randomized, placebo-controlled study
    • DOI 10.1016/S0002-9343(01)00713-6, PII S0002934301007136
    • Kipnes MS, Krosnick A, Rendell MS, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study. Am J Med. 2001;111(1):10-7. (Pubitemid 32635256)
    • (2001) American Journal of Medicine , vol.111 , Issue.1 , pp. 10-17
    • Kipnes, M.S.1    Krosnick, A.2    Rendell, M.S.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 17
    • 1042268736 scopus 로고    scopus 로고
    • One-Year Glycemic Control with A Suifonyurea Plus Pioglitazone Versus A Sulfonylurea Plus Metformin in Patients with Type 2 Diabetes
    • DOI 10.2337/diacare.27.1.141
    • Hanefeld M, Brunetti P, Schernthaner GH, Matthews DR, Charbonnel BH, Quartet Study Group. One-year glycemic control with a sulfonylurea plus pioglitazone versus a sulfonylurea plus metformin in patients with type 2 diabetes. Diabetes Care. 2004;27(1):141-7. (Pubitemid 38196723)
    • (2004) Diabetes Care , vol.27 , Issue.1 , pp. 141-147
    • Hanefeld, M.1    Brunetti, P.2    Schernthaner, G.H.3    Matthews, D.R.4    Charbonnel, B.H.5
  • 18
    • 0034531195 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: A randomized, placebo-controlled study
    • DOI 10.1016/S0149-2918(00)83039-8
    • Einhorn D, Rendell M, Rosenzweig J, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: a randomized, placebo-controlled study. The Pioglitazone 027 Study Group. Clin Ther. 2000;22(12):1395-409. (Pubitemid 32056079)
    • (2000) Clinical Therapeutics , vol.22 , Issue.12 , pp. 1395-1409
    • Einhorn, D.1    Rendell, M.2    Rosenzweig, J.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 19
    • 16344382941 scopus 로고    scopus 로고
    • Long-term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: A randomized, comparative study
    • DOI 10.1002/dmrr.478
    • Matthews DR, Charbonnel BH, Hanefeld M, Brunetti P, Schernthaner G. Long-term therapy with addition of pioglitazone to metformin compared with the addition of gliclazide to metformin in patients with type 2 diabetes: a randomized, comparative study. Diabetes Metab Res Rev. 2005;21(2):167-74. (Pubitemid 40467663)
    • (2005) Diabetes/Metabolism Research and Reviews , vol.21 , Issue.2 , pp. 167-174
    • Matthews, D.R.1    Charbonnel, B.H.2    Hanefeld, M.3    Brunetti, P.4    Schernthaner, G.5
  • 20
    • 37549070713 scopus 로고    scopus 로고
    • Protection of pancreatic beta-cells: Is it feasible?
    • DOI 10.1016/j.numecd.2007.05.004, PII S0939475307001159
    • Bonora E. Protection of pancreatic beta-cells: is it feasible? Nutr Metab Cardiovasc Dis. 2008;18(1):74-83. (Pubitemid 50020512)
    • (2008) Nutrition, Metabolism and Cardiovascular Diseases , vol.18 , Issue.1 , pp. 74-83
    • Bonora, E.1
  • 21
    • 3042690588 scopus 로고    scopus 로고
    • Role of intact proinsulin in diagnosis and treatment of type 2 diabetes mellitus
    • Pfützner A, Pfützner AH, Larbig M, Forst T. Role of intact proinsulin in diagnosis and treatment of type 2 diabetes mellitus. Diabetes Technol Ther. 2004;6(3):405-12.
    • (2004) Diabetes Technol Ther , vol.6 , Issue.3 , pp. 405-412
    • Pfützner, A.1    Pfützner, A.H.2    Larbig, M.3    Forst, T.4
  • 23
    • 33947304608 scopus 로고    scopus 로고
    • Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk - The PIOSTAT Study
    • DOI 10.1016/j.metabol.2006.11.007, PII S002604950600432X
    • Forst T, Pfützner A, Lübben G, Weber M, Marx N, Karagiannis E, Koehler C, Baurecht W, Hohberg C, Hanefeld M. Effect of simvastatin and/or pioglitazone on insulin resistance, insulin secretion, adiponectin, and proinsulin levels in nondiabetic patients at cardiovascular risk - the PIOSTAT Study. Metabolism. 2007;56(4):491-6. (Pubitemid 46437254)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.4 , pp. 491-496
    • Forst, T.1    Pfutzner, A.2    Lubben, G.3    Weber, M.4    Marx, N.5    Karagiannis, E.6    Koehler, C.7    Baurecht, W.8    Hohberg, C.9    Hanefeld, M.10
  • 24
    • 27844547103 scopus 로고    scopus 로고
    • Biological background and role of adiponectin as marker for insulin resistance and cardiovascular risk
    • Schöndorf T, Maiworm A, Emmison N, Forst T, Pfützner A. Biological background and role of adiponectin as marker for insulin resistance and cardiovascular risk. Clin Lab. 2005;51(9-10):489-94.
    • (2005) Clin Lab , vol.51 , Issue.9-10 , pp. 489-494
    • Schöndorf, T.1    Maiworm, A.2    Emmison, N.3    Forst, T.4    Pfützner, A.5
  • 26
    • 33751104986 scopus 로고    scopus 로고
    • Effects of pioglitazone and metformin on plasma adiponectin in newly detected type 2 diabetes mellitus
    • DOI 10.1111/j.1365-2265.2006.02658.x
    • Sharma PK, Bhansali A, Sialy R, Malhotra S, Pandhi P. Effects of pioglitazone and metformin on plasma adiponectin in newly detected type 2 diabetes mellitus. Clin Endocrinol (Oxf). 2006;65(6):722-8. (Pubitemid 44772351)
    • (2006) Clinical Endocrinology , vol.65 , Issue.6 , pp. 722-728
    • Sharma, P.K.1    Bhansali, A.2    Sialy, R.3    Malhotra, S.4    Pandhi, P.5
  • 27
    • 3242745192 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    • DOI 10.2337/diabetes.53.8.2169
    • Tiikkainen M, Häkkinen AM, Korsheninnikova E, Nyman T, Mäkimattila S, Yki-Järvinen H. Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes. Diabetes. 2004;53(8):2169-76. (Pubitemid 38970772)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2169-2176
    • Tiikkainen, M.1    Hakkinen, A.-M.2    Korsheninnikova, E.3    Nyman, T.4    Makimattila, S.5    Yki-Jarvinen, H.6
  • 29
    • 33646250674 scopus 로고    scopus 로고
    • Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels
    • Otto C, Otto B, Göke B, Pfeiffer AF, Lehrke M, Vogeser M, Spranger J, Parhofer KG. Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels. J Endocrinol Invest. 2006;29(3):231-6.
    • (2006) J Endocrinol Invest , vol.29 , Issue.3 , pp. 231-236
    • Otto, C.1    Otto, B.2    Göke, B.3    Pfeiffer, A.F.4    Lehrke, M.5    Vogeser, M.6    Spranger, J.7    Parhofer, K.G.8
  • 30
    • 12444304182 scopus 로고    scopus 로고
    • Adiponectin: Action, regulation and association to insulin sensitivity
    • Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev. 2005;6(1):13-21.
    • (2005) Obes Rev , vol.6 , Issue.1 , pp. 13-21
    • Lihn, A.S.1    Pedersen, S.B.2    Richelsen, B.3
  • 31
    • 2142695734 scopus 로고    scopus 로고
    • Clinical Usefulness of Very High and Very Low Levels of C-Reactive Protein Across the Full Range of Framingham Risk Scores
    • DOI 10.1161/01.CIR.0000125690.80303.A8
    • Ridker PM, Cook N. Clinical usefulness of very high and very low levels of C-reactive protein across the full range of Framingham Risk Scores. Circulation. 2004;109(16):1955-9. (Pubitemid 38544485)
    • (2004) Circulation , vol.109 , Issue.16 , pp. 1955-1959
    • Ridker, P.M.1    Cook, N.2
  • 32
    • 0037469255 scopus 로고    scopus 로고
    • C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: An 8-year follow-up of 14 719 initially healthy American women
    • Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107(3):391-7.
    • (2003) Circulation , vol.107 , Issue.3 , pp. 391-397
    • Ridker, P.M.1    Buring, J.E.2    Cook, N.R.3    Rifai, N.4
  • 33
    • 33646684527 scopus 로고    scopus 로고
    • Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus
    • Pfützner A, Standl E, Strotmann HJ, Schulze J, Hohberg C, Lübben G, Pahler S, Schöndorf T, Forst T. Association of high-sensitive C-reactive protein with advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus. Clin Chem Lab Med. 2006;44(5):556-60.
    • (2006) Clin Chem Lab Med , vol.44 , Issue.5 , pp. 556-560
    • Pfützner, A.1    Standl, E.2    Strotmann, H.J.3    Schulze, J.4    Hohberg, C.5    Lübben, G.6    Pahler, S.7    Schöndorf, T.8    Forst, T.9
  • 35
    • 33947303644 scopus 로고    scopus 로고
    • Pioglitazone produces rapid and persistent reduction of vascular inflammation in patients with hypertension and type 2 diabetes mellitus who are receiving angiotensin II receptor blockers
    • DOI 10.1016/j.metabol.2007.01.002, PII S0026049507000170
    • Takase H, Nakazawa A, Yamashita S, Toriyama T, Sato K, Ueda R, Dohi Y. Pioglitazone produces rapid and persistent reduction of vascular inflammation in patients with hypertension and type 2 diabetes mellitus who are receiving angiotensin II receptor blockers. Metabolism. 2007;56(4):559-64. (Pubitemid 46437253)
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.4 , pp. 559-564
    • Takase, H.1    Nakazawa, A.2    Yamashita, S.3    Toriyama, T.4    Sato, K.5    Ueda, R.6    Dohi, Y.7
  • 37
    • 33846273797 scopus 로고    scopus 로고
    • Anti-Inflammatory Effects of Pioglitazone and/or Simvastatin in High Cardiovascular Risk Patients With Elevated High Sensitivity C-Reactive Protein. The PIOSTAT Study
    • DOI 10.1016/j.jacc.2006.08.054, PII S0735109706026404
    • Hanefeld M, Marx N, Pfützner A, Baurecht W, Lübben G, Karagiannis E, Stier U, Forst T. Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein: the PIOSTAT Study. J Am Coll Cardiol. 2007;49(3):290-7. (Pubitemid 46110954)
    • (2007) Journal of the American College of Cardiology , vol.49 , Issue.3 , pp. 290-297
    • Hanefeld, M.1    Marx, N.2    Pfutzner, A.3    Baurecht, W.4    Lubben, G.5    Karagiannis, E.6    Stier, U.7    Forst, T.8
  • 38
    • 34548672388 scopus 로고    scopus 로고
    • Short-term low-dosage pioglitazone treatment improves vascular dysfunction in patients with type 2 diabetes
    • DOI 10.1507/endocrj.K06-203
    • Maegawa H, Nishio Y, Nakao K, Ugi S, Maeda K, Uzu T, Kashiwagi A. Short-term low-dosage pioglitazone treatment improves vascular dysfunction in patients with type 2 diabetes. Endocr J. 2007;54(4):613-8. (Pubitemid 47414611)
    • (2007) Endocrine Journal , vol.54 , Issue.4 , pp. 613-618
    • Maegawa, H.1    Nishio, Y.2    Nakao, K.3    Ugi, S.4    Maeda, K.5    Uzu, T.6    Kashiwagi, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.