Optimization of an improved single-column chromatographic process for the separation of enantiomers

Journal of Chromatography A

Volumn 1231, Issue , 2012, Pages 22-30

  Kazi, Monzure Khoda ^a   Medi, Bijan ^a   Amanullah, Mohammad ^a  

^a Nanyang Technological University   (Singapore)

Author keywords

Constrained multi objective optimization; Enantioseparation; Genetic algorithm; Single column chromatography; SMB

Indexed keywords

CHROMATOGRAPHIC PROCESS; CONSTRAINED MULTI-OBJECTIVE OPTIMIZATIONS; CUSTOMIZED COMPONENTS; CYCLE TIME; DECISION VARIABLES; ENANTIOSEPARATIONS; FEED CONCENTRATION; FEED INJECTION; FRACTION COLLECTION; GUAIFENESIN; INJECTION VOLUME; MAXIMUM PRODUCTIVITY; MULTI-OBJECTIVE OPTIMIZATION TECHNIQUES; NONDOMINATED SOLUTIONS; ONLINE MONITORING; PARETO FRONT; SIMULATED MOVING BED PROCESS; SIMULTANEOUS SEPARATION; SINGLE-COLUMN CHROMATOGRAPHIC PROCESS; SMB;

CHIRALITY; CHROMATOGRAPHY; DECISION MAKING; ENANTIOMERS; GENETIC ALGORITHMS; MULTIOBJECTIVE OPTIMIZATION; SEPARATION;

CONSTRAINED OPTIMIZATION;

GUAIFENESIN;

ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYCLE TIME; DESORBENT FLOW RATE; EVOLUTIONARY ALGORITHM; FEED CONCENTRATION; IMPROVED SINGLE COLUMN CHROMATOGRAPHIC PROCESS; MATHEMATICAL VARIABLE; NON DOMINATED SORTING GENETIC ALGORITHM; ONLINE MONITORING; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PRODUCTIVITY; SEPARATION TECHNIQUE; THREE CUT INTERVAL; VOLUME INJECTION;

ALGORITHMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTER SIMULATION; EQUIPMENT DESIGN; EXPECTORANTS; GUAIFENESIN; MODELS, CHEMICAL; STEREOISOMERISM;

EID: 84857794864     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.01.057     Document Type: Article

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